| MeSH term | MeSH ID | Detail |
|---|---|---|
| Alcohol-Related Disorders | D019973 | 3 associated lipids |
| Urinary Incontinence | D014549 | 4 associated lipids |
| Lead Poisoning | D007855 | 4 associated lipids |
| Hepatitis, Alcoholic | D006519 | 5 associated lipids |
| Dyspepsia | D004415 | 5 associated lipids |
| Hypertension, Renovascular | D006978 | 10 associated lipids |
| Amnesia | D000647 | 12 associated lipids |
| Glucose Intolerance | D018149 | 13 associated lipids |
| Angina, Unstable | D000789 | 14 associated lipids |
| Brain Infarction | D020520 | 17 associated lipids |
| Angina Pectoris | D000787 | 27 associated lipids |
| Ventricular Remodeling | D020257 | 28 associated lipids |
| Endometriosis | D004715 | 29 associated lipids |
| Stroke | D020521 | 32 associated lipids |
| Memory Disorders | D008569 | 33 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Neurotoxicity Syndromes | D020258 | 34 associated lipids |
| Fever | D005334 | 35 associated lipids |
| Infarction, Middle Cerebral Artery | D020244 | 35 associated lipids |
SCHEMBL105486
Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with SCHEMBL105486?
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
PubChem Associated disorders and diseases
What pathways are associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with SCHEMBL105486?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with SCHEMBL105486?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with SCHEMBL105486?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with SCHEMBL105486?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with SCHEMBL105486?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with SCHEMBL105486
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zhou PQ et al. | [Clinical observation of puerarin in treating patients with vertebral artery insufficiency due to cervical spondylosis: a report of 123 cases]. | 2006 | Zhong Xi Yi Jie He Xue Bao | pmid:16409979 |
| Xiong FL et al. | Puerarin protects rat pancreatic islets from damage by hydrogen peroxide. | 2006 | Eur. J. Pharmacol. | pmid:16321378 |
| Yan B et al. | Determination of puerarin in rat cortex by high-performance liquid chromatography after intravenous administration of Puerariae flavonoids. | 2006 | Biomed. Chromatogr. | pmid:16078309 |
| Yu Z and Li W | Induction of apoptosis by puerarin in colon cancer HT-29 cells. | 2006 | Cancer Lett. | pmid:16055262 |
| Yan LP et al. | Puerarin decreases serum total cholesterol and enhances thoracic aorta endothelial nitric oxide synthase expression in diet-induced hypercholesterolemic rats. | 2006 | Life Sci. | pmid:16472823 |
| Yu AH et al. | [Preparation of puerarin solid self-microemulsion]. | 2006 | Zhong Yao Cai | pmid:17076244 |
| Qi H et al. | Optimization and physicochemical characterization of thermosensitive poloxamer gel containing puerarin for ophthalmic use. | 2006 | Chem. Pharm. Bull. | pmid:17077546 |
| Wu CJ et al. | Promoting effect of borneol on the permeability of puerarin eye drops and timolol maleate eye drops through the cornea in vitro. | 2006 | Pharmazie | pmid:17020156 |
| Yeung DK et al. | Puerarin, an isoflavonoid derived from Radix puerariae, potentiates endothelium-independent relaxation via the cyclic AMP pathway in porcine coronary artery. | 2006 | Eur. J. Pharmacol. | pmid:17027964 |
| Chen L et al. | Simultaneous analysis of nine active components in Gegen Qinlian preparations by high-performance liquid chromatography with diode array detection. | 2006 | J Sep Sci | pmid:17069251 |
| Kim JM et al. | Constituents of the roots of Pueraria lobata inhibit formation of advanced glycation end products (AGEs). | 2006 | Arch. Pharm. Res. | pmid:17121174 |
| Park EK et al. | Intestinal bacteria activate estrogenic effect of main constituents puerarin and daidzin of Pueraria thunbergiana. | 2006 | Biol. Pharm. Bull. | pmid:17142977 |
| Liu R et al. | Pharmacokinetics of puerarin and ginsenoside Rg1 of CBN injection and the relation with platelet aggregation in rats. | 2006 | Am. J. Chin. Med. | pmid:17163592 |
| Pan J et al. | [Isolation and purification of puerarin from puerarin extractive by chelate complex chromatography]. | 2006 | Se Pu | pmid:17165543 |
| Chen M et al. | [Determination of puerarin in Kangshen granule by reversed-phase high performance liquid chromatography]. | 2006 | Se Pu | pmid:17165545 |
| Ren F et al. | Quantitative determination of puerarin in dog plasma by HPLC and study on the relative bioavailability of sustained release tablets. | 2006 | J Pharm Biomed Anal | pmid:16413737 |
| Zhang S et al. | Puerarin induces angiogenesis in myocardium of rat with myocardial infarction. | 2006 | Biol. Pharm. Bull. | pmid:16651724 |
| Li Y et al. | Pharmacokinetic, tissue distribution, and excretion of puerarin and puerarin-phospholipid complex in rats. | 2006 | Drug Dev Ind Pharm | pmid:16638679 |
| Wang C et al. | [Therapeutic effect of puerarin on rats with pre-eclampsia]. | 2006 | Zhonghua Fu Chan Ke Za Zhi | pmid:16640862 |
| Yu Z et al. | Simultaneous determination of components in preparation Naodesheng injection by high performance liquid chromatograph-atmospheric pressure chemical ionization mass spectrometry (HPLC-MS/APCI). | 2006 | Chem. Pharm. Bull. | pmid:16595973 |
| Wu XP et al. | [Protective effects of puerarin against myocardial injury in patients with hypertension during perioperational period]. | 2006 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:16613276 |
| Zhang B et al. | [Protective effects of hydroxyethylpuerarin against brain astrocytes injury induced by hydrogen peroxide]. | 2006 | Yao Xue Xue Bao | pmid:16671550 |
| Xu YZ et al. | [Effects of puerarin on proliferation of vascular smooth muscle cells induced by thrombin]. | 2006 | Zhonghua Yi Xue Za Zhi | pmid:16677576 |
| Xu YZ et al. | [Puerarin suppresses the proliferation of vscular smooth muscule cells and c-fos and bcl-2 protein expression]. | 2006 | Zhongguo Zhong Yao Za Zhi | pmid:16722382 |
| Wang FW et al. | [Protective effect of puerarin on stress-induced gastric mucosal injury in rats]. | 2006 | Zhongguo Zhong Yao Za Zhi | pmid:16722386 |
| Hao LN et al. | Puerarin decreases lens epithelium cell apoptosis induced partly by peroxynitrite in diabetic rats. | 2006 | Sheng Li Xue Bao | pmid:17173194 |
| Kirakosyan A et al. | Regulation of isoflavone production in hydroponically grown Pueraria montana (kudzu) by cork pieces, XAD-4, and methyl jasmonate. | 2006 | Plant Cell Rep. | pmid:16841218 |
| Deng X et al. | [Pharmacokinetics of puerarin in the aqueous humor and vitreous of rabbit eye following systemic administration]. | 2006 | Yan Ke Xue Bao | pmid:17378162 |
| Li DZ et al. | [Protective effect of puerarin on endothelial dysfunction of heat shock protein 60 induced specific immunity in apolipoprotein E-null mice]. | 2006 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:17569333 |
| Tian H et al. | Liquid chromatography-mass spectrometric analysis of puerarin and its metabolite in human urine. | 2006 | J Sep Sci | pmid:17313111 |
| Chen SB et al. | High-performance thin-layer chromatographic fingerprints of isoflavonoids for distinguishing between Radix Puerariae Lobate and Radix Puerariae Thomsonii. | 2006 | J Chromatogr A | pmid:16714027 |
| Zhang SP et al. | [The experimental study of Radix Puerariae inhibiting glycation in rats induced by D-galactose]. | 2006 | Zhong Yao Cai | pmid:16850728 |
| Lv JH et al. | [Improvement effects of puerarin on glycated brain damages in rats induced by D-galactose]. | 2006 | Zhongguo Zhong Yao Za Zhi | pmid:17048591 |
| Tian H et al. | [Separation and identification of isoflavonoids in Pueraria lobata extracts and its preparations by reversed-phase capillary liquid chromatography coupled with electrospray ionization quadrupole time of flight mass spectrometry]. | 2005 | Se Pu | pmid:16350789 |
| Liu SD and Mo HP | [Occurrence and prevention of adverse reaction induced by puerarin injection]. | 2005 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:16248254 |
| Meezan E et al. | Contrasting effects of puerarin and daidzin on glucose homeostasis in mice. | 2005 | J. Agric. Food Chem. | pmid:16248582 |
| Han P et al. | [Potential antiviral drug Pueraria crude extract and puerarin protect against ethanol-induced cytotoxicity in embryonic mouse hippocampal cultures]. | 2005 | Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi | pmid:16261207 |
| Bo J et al. | Protection by puerarin against MPP+-induced neurotoxicity in PC12 cells mediated by inhibiting mitochondrial dysfunction and caspase-3-like activation. | 2005 | Neurosci. Res. | pmid:16112764 |
| Cui S et al. | Self-microemulsifying drug delivery systems (SMEDDS) for improving in vitro dissolution and oral absorption of Pueraria lobata isoflavone. | 2005 | Drug Dev Ind Pharm | pmid:16093200 |
| He HJ et al. | [Effects of sucrose and light on the growth and production of secondary metabolites in Pueraria phaseoloides hairy roots]. | 2005 | Sheng Wu Gong Cheng Xue Bao | pmid:16468362 |
| Zang HM et al. | [Experimental study of the effects of puerarin on biological characters of osteoblasts in vitro]. | 2005 | Zhongguo Zhong Yao Za Zhi | pmid:16494032 |
| Mercer LD et al. | Dietary polyphenols protect dopamine neurons from oxidative insults and apoptosis: investigations in primary rat mesencephalic cultures. | 2005 | Biochem. Pharmacol. | pmid:15627486 |
| Jun M et al. | Suppression of arachidonic acid metabolism and nitric oxide formation by kudzu isoflavones in murine macrophages. | 2005 | Mol Nutr Food Res | pmid:16254887 |
| Romero MR et al. | Effect of artemisinin/artesunate as inhibitors of hepatitis B virus production in an "in vitro" replicative system. | 2005 | Antiviral Res. | pmid:16122816 |
| He JT et al. | Biotin-avidin amplified enzyme-linked immunosorbent assay for determination of isoflavone daidzein. | 2005 | Talanta | pmid:18969844 |
| Lee DY and He M | Recent advances in aryl C-glycoside synthesis. | 2005 | Curr Top Med Chem | pmid:16305534 |
| Simons AL et al. | Human gut microbial degradation of flavonoids: structure-function relationships. | 2005 | J. Agric. Food Chem. | pmid:15884869 |
| Zhang Y et al. | Analysis of the estrogenic components in kudzu root by bioassay and high performance liquid chromatography. | 2005 | J. Steroid Biochem. Mol. Biol. | pmid:15857757 |
| Yan B et al. | HPLC method for the determination and pharmacokinetic studies on puerarin in cerebral ischemia reperfusion rat plasma after intravenous administration of puerariae radix isoflavone. | 2005 | J Pharm Biomed Anal | pmid:15708670 |
| Jiang RW et al. | A comparative study on aqueous root extracts of Pueraria thomsonii and Pueraria lobata by antioxidant assay and HPLC fingerprint analysis. | 2005 | J Ethnopharmacol | pmid:15588661 |