| MeSH term | MeSH ID | Detail |
|---|---|---|
| Alcohol-Related Disorders | D019973 | 3 associated lipids |
| Urinary Incontinence | D014549 | 4 associated lipids |
| Lead Poisoning | D007855 | 4 associated lipids |
| Hepatitis, Alcoholic | D006519 | 5 associated lipids |
| Dyspepsia | D004415 | 5 associated lipids |
| Hypertension, Renovascular | D006978 | 10 associated lipids |
| Amnesia | D000647 | 12 associated lipids |
| Glucose Intolerance | D018149 | 13 associated lipids |
| Angina, Unstable | D000789 | 14 associated lipids |
| Brain Infarction | D020520 | 17 associated lipids |
| Angina Pectoris | D000787 | 27 associated lipids |
| Ventricular Remodeling | D020257 | 28 associated lipids |
| Endometriosis | D004715 | 29 associated lipids |
| Stroke | D020521 | 32 associated lipids |
| Memory Disorders | D008569 | 33 associated lipids |
| Neurotoxicity Syndromes | D020258 | 34 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Infarction, Middle Cerebral Artery | D020244 | 35 associated lipids |
| Fever | D005334 | 35 associated lipids |
SCHEMBL105486
Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with SCHEMBL105486?
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
PubChem Associated disorders and diseases
What pathways are associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with SCHEMBL105486?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with SCHEMBL105486?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with SCHEMBL105486?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with SCHEMBL105486?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with SCHEMBL105486?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with SCHEMBL105486
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Yu M et al. | Analysis of binding interaction between pegylated puerarin and bovine serum albumin by spectroscopic methods and dynamic light scattering. | 2011 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:21945127 |
| Wang Z et al. | Study on the interaction of puerarin with lysozyme by spectroscopic methods. | 2008 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:18262462 |
| Loutchanwoot P and Vortherms T | Effects of puerarin on estrogen-regulated gene expression in gonadotropin-releasing hormone pulse generator of ovariectomized rats. | 2018 | Steroids | pmid:29733861 |
| Wu B et al. | Meta-analysis of traditional Chinese patent medicine for ischemic stroke. | 2007 | Stroke | pmid:17463317 |
| Liu YK et al. | On-line solid-phase extraction-HPLC-fluorescence detection for simultaneous determination of puerarin and daidzein in human serum. | 2010 | Talanta | pmid:20801320 |
| Liu L et al. | Determination of puerarin in pharmaceutical and biological samples by capillary zone electrophoresis with UV detection. | 2012 | Talanta | pmid:22365684 |
| Li N et al. | Determination of glibenclamide and puerarin in rat plasma by UPLC-MS/MS: application to their pharmacokinetic interaction study. | 2013 | Talanta | pmid:23597896 |
| Jing S et al. | A novel electrochemical sensor based on WO nanorods-decorated poly(sodium 4-styrenesulfonate) functionalized graphene nanocomposite modified electrode for detecting of puerarin. | 2017 | Talanta | pmid:28738611 |
| He JT et al. | Biotin-avidin amplified enzyme-linked immunosorbent assay for determination of isoflavone daidzein. | 2005 | Talanta | pmid:18969844 |
| Cong X et al. | Puerarin ameliorates heat stress-induced oxidative damage and apoptosis in bovine Sertoli cells by suppressing ROS production and upregulating Hsp72 expression. | 2017 | Theriogenology | pmid:27771118 |
| Lu N et al. | Nitrite-glucose-glucose oxidase system directly induces rat heart homogenate oxidation and tyrosine nitration: effects of some flavonoids. | 2009 | Toxicol In Vitro | pmid:19286453 |
| Hwang YP and Jeong HG | Mechanism of phytoestrogen puerarin-mediated cytoprotection following oxidative injury: estrogen receptor-dependent up-regulation of PI3K/Akt and HO-1. | 2008 | Toxicol. Appl. Pharmacol. | pmid:18845176 |
| Liu CM et al. | Puerarin protects rat kidney from lead-induced apoptosis by modulating the PI3K/Akt/eNOS pathway. | 2012 | Toxicol. Appl. Pharmacol. | pmid:22172631 |
| Kim KM et al. | Puerarin suppresses AGEs-induced inflammation in mouse mesangial cells: a possible pathway through the induction of heme oxygenase-1 expression. | 2010 | Toxicol. Appl. Pharmacol. | pmid:20060010 |
| Hwang YP et al. | Puerarin activates endothelial nitric oxide synthase through estrogen receptor-dependent PI3-kinase and calcium-dependent AMP-activated protein kinase. | 2011 | Toxicol. Appl. Pharmacol. | pmid:21884717 |
| Gomuttapong S et al. | Testing of the estrogenic activity and toxicity of Stephania venosa herb in ovariectomized rats. | 2012 | Toxicol. Mech. Methods | pmid:22394346 |
| Zhu J et al. | Puerarin reduces endothelial progenitor cells senescence through augmentation of telomerase activity. | 2008 Aug-Sep | Vascul. Pharmacol. | pmid:18692596 |
| Meng XH et al. | Puerarin protects against high glucose-induced acute vascular dysfunction: role of heme oxygenase-1 in rat thoracic aorta. | 2009 Mar-Apr | Vascul. Pharmacol. | pmid:19073281 |
| Yang L et al. | [Screening and identification of a fungal strain functioning in hydroxylation of puerarin]. | 2009 | Wei Sheng Wu Xue Bao | pmid:20222440 |
| Li Q et al. | [Study of regulation of Puerarin on blood P-selectin and the expression of aorta VCAM mRNA in diabetes]. | 2007 | Wei Sheng Yan Jiu | pmid:18095572 |
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| KopeÄná-Zapletalová M et al. | Interaction of isoflavonoids with human liver microsomal cytochromes P450: inhibition of CYP enzyme activities. | 2017 | Xenobiotica | pmid:27312150 |
| Zhao Q et al. | Effects of glycyrrhizin on the pharmacokinetics of puerarin in rats. | 2018 | Xenobiotica | pmid:29099639 |
| Bai QH et al. | [Puerarin antagonizes activation effect of LPS on N9 microglia cells]. | 2010 | Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi | pmid:20230684 |
| Wu C et al. | Preparation and evaluation of a Carbopol/HPMC-based in situ gelling ophthalmic system for puerarin. | 2007 | Yakugaku Zasshi | pmid:17202799 |
| Pan HP and Li G | Protecting mechanism of puerarin on the brain neurocyte of rat in acute local ischemia brain injury and local cerebral ischemia-reperfusion injury. | 2008 | Yakugaku Zasshi | pmid:18981705 |
| Yasuda T et al. | [A simultaneous determination of daidzin and puerarin and determination of daidzein in Oriental pharmaceutical decoctions containing puerariae radix by ion-pair high-performance liquid chromatography]. | 1993 | Yakugaku Zasshi | pmid:8301541 |
| Hayakawa J et al. | [Studies on physical and chemical quality evaluation of crude drug preparations. I. Analysis of Pueraria Radix and species Puerariae]. | 1984 | Yakugaku Zasshi | pmid:6737221 |
| Deng X et al. | [Pharmacokinetics of puerarin in the aqueous humor and vitreous of rabbit eye following systemic administration]. | 2006 | Yan Ke Xue Bao | pmid:17378162 |
| Shi RL and Zhang JJ | [Protective effect of puerarin on vascular endothelial cell apoptosis induced by chemical hypoxia in vitro]. | 2003 | Yao Xue Xue Bao | pmid:12778743 |
| Duan HJ et al. | [Effects of puerarin on renal function, expressions of MMP-2 and TIMP-2 in diabetic rats]. | 2004 | Yao Xue Xue Bao | pmid:15493832 |
| Zhang B et al. | [Protective effects of hydroxyethylpuerarin against brain astrocytes injury induced by hydrogen peroxide]. | 2006 | Yao Xue Xue Bao | pmid:16671550 |
| Huang MQ et al. | [Puerarin inhibits DNA damage of HaCaT cells induced by UVB via ceramide pathway]. | 2012 | Yao Xue Xue Bao | pmid:22812004 |
| Wang L et al. | [The pathway of absorption and conveying of puerarin microemulsion-in-oil]. | 2009 | Yao Xue Xue Bao | pmid:19806923 |
| An R et al. | [Intestinal absorption of different combinations of active compounds from Gegenqinlian decoction by rat single pass intestinal perfusion in situ]. | 2012 | Yao Xue Xue Bao | pmid:23460978 |
| Zhang X et al. | [Pharmacokinetics of puerarin and hydrochlorothiazide from maijunan tablets in rats]. | 2009 | Yao Xue Xue Bao | pmid:20055185 |
| Li BJ et al. | [Fingerprints of Tongmai Keli by HPLC-DAD-MS]. | 2010 | Yao Xue Xue Bao | pmid:21361041 |
| Xu LX et al. | Determination of 4'-methoxy-puerarin in puerarin by reversed phase HPLC. | 1991 | Yao Xue Xue Bao | pmid:1789117 |
| Jiang XL and Xu LN | [Beneficial effect of puerarin on experimental microcirculatory disturbance in mice]. | 1989 | Yao Xue Xue Bao | pmid:2816384 |
| Fan LL et al. | [The antidysrhythmic effect of puerariae isoflavones]. | 1985 | Yao Xue Xue Bao | pmid:3834744 |
| Shen ZF and Xie MZ | [Hypoglycemic effect of the combined use of puerarin and aspirin in mice]. | 1985 | Yao Xue Xue Bao | pmid:3835796 |
| Xu LX et al. | [Differential pulse polarographic determination of flavonoids in Pueraria lobata]. | 1987 | Yao Xue Xue Bao | pmid:3661208 |
| Cai H et al. | [Effects of puerarin on proliferation and differentiation of umbilical cord mesenchymal stem cells into osteoblasts in vitro]. | 2011 | Yao Xue Xue Bao | pmid:21882538 |
| Zhao SP and Zhang YZ | [Quantitative TLC-densitometry of isoflavones in Pueraria lobata (Willd.) Ohwi]. | 1985 | Yao Xue Xue Bao | pmid:4072688 |
| Shen XL et al. | Inhibition of [3H] flunitrazepam binding to rat brain membranes in vitro by puerarin and daidzein. | 1996 | Yao Xue Xue Bao | pmid:8762462 |
| Fan LL et al. | [Effect of puerarin on regional myocardial blood flow and cardiac hemodynamics in dogs with acute myocardial ischemia]. | 1984 | Yao Xue Xue Bao | pmid:6544546 |
| Fang QN et al. | [Separation and determination of puerarin by high performance liquid chromatography]. | 1983 | Yao Xue Xue Bao | pmid:6677057 |
| Jin XL et al. | [Determination of puerarin in plasma by high performance liquid chromatography]. | 1997 | Yao Xue Xue Bao | pmid:11596224 |
| Xu XH and Zhang ZG | [Effect of puerarin on learning-memory behavior and synaptic structure of hippocampus in the aging mice induced by D-galactose]. | 2002 | Yao Xue Xue Bao | pmid:12579889 |
| Yue PF et al. | [Preparation and characterization of the puerarin submicron emulsion]. | 2007 | Yao Xue Xue Bao | pmid:17702404 |