| MeSH term | MeSH ID | Detail |
|---|---|---|
| Alcohol-Related Disorders | D019973 | 3 associated lipids |
| Lead Poisoning | D007855 | 4 associated lipids |
| Urinary Incontinence | D014549 | 4 associated lipids |
| Dyspepsia | D004415 | 5 associated lipids |
| Hepatitis, Alcoholic | D006519 | 5 associated lipids |
| Hypertension, Renovascular | D006978 | 10 associated lipids |
| Amnesia | D000647 | 12 associated lipids |
| Glucose Intolerance | D018149 | 13 associated lipids |
| Angina, Unstable | D000789 | 14 associated lipids |
| Brain Infarction | D020520 | 17 associated lipids |
| Angina Pectoris | D000787 | 27 associated lipids |
| Ventricular Remodeling | D020257 | 28 associated lipids |
| Endometriosis | D004715 | 29 associated lipids |
| Stroke | D020521 | 32 associated lipids |
| Memory Disorders | D008569 | 33 associated lipids |
| Neurotoxicity Syndromes | D020258 | 34 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Fever | D005334 | 35 associated lipids |
| Infarction, Middle Cerebral Artery | D020244 | 35 associated lipids |
SCHEMBL105486
Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with SCHEMBL105486?
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
PubChem Associated disorders and diseases
What pathways are associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with SCHEMBL105486?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with SCHEMBL105486?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with SCHEMBL105486?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with SCHEMBL105486?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with SCHEMBL105486?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with SCHEMBL105486
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ren P et al. | [Observation on efficacy of puerarin in treating diabetic retinopathy]. | 2000 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:11789184 |
| Jiang B et al. | [Stable life prediction for a complex injection of Chinese materia medica by initial average rate stability test]. | 2000 | Zhongguo Zhong Yao Za Zhi | pmid:12212078 |
| Duan S et al. | [Effect of puerarin on heart function and serum oxidized-LDL in the patients with chronic cardiac failure]. | 2000 | Hunan Yi Ke Da Xue Xue Bao | pmid:12212215 |
| Fu C et al. | [The study of ethanol-water used as reversed-phase high performance liquid chromatographic mobile phase]. | 1999 | Se Pu | pmid:12552885 |
| Okamura N et al. | Simultaneous high-performance liquid chromatographic determination of puerarin, daidzin, paeoniflorin, liquiritin, cinnamic acid, cinnamaldehyde and glycyrrhizin in Kampo medicines. | 1999 | J Pharm Biomed Anal | pmid:10704126 |
| Xuan B et al. | Improvement of ocular blood flow and retinal functions with puerarin analogs. | 1999 | J Ocul Pharmacol Ther | pmid:10385129 |
| Qian Y et al. | Blocking effect of puerarin on calcium channel in isolated guinea pig ventricular myocytes. | 1999 | Chin. Med. J. | pmid:11717945 |
| Meng P et al. | [Clinical observation of the treatment of infantile viral myocarditis with puerarin]. | 1999 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:11783152 |
| Chen J et al. | [Effect of puerarin on fibrinolytic activity and lipid peroxide in patients with coronary heart disease]. | 1999 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:11783153 |
| Liu Q et al. | [Effect of puerarin on coronary collateral circulation in dogs with experimental acute myocardial infarction]. | 1999 | Zhongguo Zhong Yao Za Zhi | pmid:12205891 |
| Liu S et al. | [A study on processing of the root of Pueraria lobata (Willd.) ohwi by HPLC]. | 1998 | Zhongguo Zhong Yao Za Zhi | pmid:12242820 |
| Kim DH et al. | Metabolism of puerarin and daidzin by human intestinal bacteria and their relation to in vitro cytotoxicity. | 1998 | Biol. Pharm. Bull. | pmid:9657051 |
| Keung WM and Vallee BL | Daidzin and its antidipsotropic analogs inhibit serotonin and dopamine metabolism in isolated mitochondria. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9482862 |
| Lin RC and Li TK | Effects of isoflavones on alcohol pharmacokinetics and alcohol-drinking behavior in rats. | 1998 | Am. J. Clin. Nutr. | pmid:9848526 |
| Dong LP and Wang TY | Effects of puerarin against glutamate excitotoxicity on cultured mouse cerebral cortical neurons. | 1998 | Zhongguo Yao Li Xue Bao | pmid:10375780 |
| Wang CY et al. | Analysis of Puerariae radix and its medicinal preparations by capillary electrophoresis. | 1998 | J Chromatogr A | pmid:9588018 |
| Zhu H et al. | [Application and characteristics of macroreticular resin in purification study of different effective ingredients in Chinese medicines]. | 1998 | Zhongguo Zhong Yao Za Zhi | pmid:11599359 |
| Zhao Z et al. | [Clinical study of puerarin in treatment of patients with unstable angina]. | 1998 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:11477926 |
| Ning Y et al. | [Effects of purerarin on blood superoxide dismutase activities and plasma malondialdehyde levels in patients with angina pectoris]. | 1997 | Hunan Yi Ke Da Xue Xue Bao | pmid:9868043 |
| Fan S et al. | [Effects of both puerarin and gypsum on the firing of pyrogen-treated thermosensitive neurons in the region POAH of anesthetized cats]. | 1997 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:10074325 |
| Li SM et al. | [Effect of puerarin on plasma endothelin, renin activity and angiotensin II in patients with acute myocardial infarction]. | 1997 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:9863126 |
| Wang L et al. | [Protective effect of puerarin on acute cerebral ischemia in rats]. | 1997 | Zhongguo Zhong Yao Za Zhi | pmid:11243176 |
| Jin XL et al. | [Determination of puerarin in plasma by high performance liquid chromatography]. | 1997 | Yao Xue Xue Bao | pmid:11596224 |
| Lin RC et al. | Isoflavonoid compounds extracted from Pueraria lobata suppress alcohol preference in a pharmacogenetic rat model of alcoholism. | 1996 | Alcohol. Clin. Exp. Res. | pmid:8800381 |
| Shen XL et al. | Inhibition of [3H] flunitrazepam binding to rat brain membranes in vitro by puerarin and daidzein. | 1996 | Yao Xue Xue Bao | pmid:8762462 |
| Overstreet DH et al. | Suppression of alcohol intake after administration of the Chinese herbal medicine, NPI-028, and its derivatives. | 1996 | Alcohol. Clin. Exp. Res. | pmid:8730211 |
| Yue HW and Hu XQ | [Pharmacologic value of radix Puerariae and puerarine on cardiovascular system]. | 1996 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:9387770 |
| Tan S et al. | [Determination of puerarin in gegen ginlian tablets by RP-HPLC]. | 1996 | Zhongguo Zhong Yao Za Zhi | pmid:9812678 |
| Ji HL and Wang TY | Puerarin inhibits tetrodotoxin-resistant sodium current in rat dorsal root ganglion neurons. | 1996 | Zhongguo Yao Li Xue Bao | pmid:9772657 |
| Yasuda T et al. | Urinary and biliary metabolites of puerarin in rats. | 1995 | Biol. Pharm. Bull. | pmid:7742802 |
| Zhou Y et al. | [Comparative study on pharmacological effects of various species of Pueraria]. | 1995 | Zhongguo Zhong Yao Za Zhi | pmid:8679082 |
| Chen L et al. | [Effect of puerarin on cerebral blood flow in dogs]. | 1995 | Zhongguo Zhong Yao Za Zhi | pmid:8679097 |
| Zhang X et al. | [Determination of puerarin in radix Puerariae and yufengningxin tablets by HPLC]. | 1995 | Zhongguo Zhong Yao Za Zhi | pmid:8561884 |
| Zhang L et al. | [Determination of puerarin in various kinds of radix Puerariae from different places]. | 1995 | Zhongguo Zhong Yao Za Zhi | pmid:7576135 |
| Keung WM and Vallee BL | Therapeutic lessons from traditional Oriental medicine to contemporary Occidental pharmacology. | 1994 | EXS | pmid:8032168 |
| Wang LY et al. | [Effects of puerarin on cat vascular smooth muscle in vitro]. | 1994 | Zhongguo Yao Li Xue Bao | pmid:8010117 |
| Kang RX | [The intraocular pressure depressive effect of puerarin]. | 1993 | Zhonghua Yan Ke Za Zhi | pmid:7912669 |
| Yasuda T et al. | [A simultaneous determination of daidzin and puerarin and determination of daidzein in Oriental pharmaceutical decoctions containing puerariae radix by ion-pair high-performance liquid chromatography]. | 1993 | Yakugaku Zasshi | pmid:8301541 |
| Fan LL et al. | The protective effect of puerarin against myocardial reperfusion injury. Study on cardiac function. | 1992 | Chin. Med. J. | pmid:1576864 |
| Yu S et al. | [Comparison of constituents in Pueraria thomsonii Benth before and after processing]. | 1992 | Zhongguo Zhong Yao Za Zhi | pmid:1292491 |
| Fan LL et al. | Protective effect of puerarin against myocardial reperfusion injury. Myocardial metabolism and ultrastructure. | 1992 | Chin. Med. J. | pmid:1451545 |
| Jin XL and Zhu XY | [Pharmacokinetics of puerarin in rats, rabbits, and dogs]. | 1992 | Zhongguo Yao Li Xue Bao | pmid:1442117 |
| Xu LX et al. | Determination of 4'-methoxy-puerarin in puerarin by reversed phase HPLC. | 1991 | Yao Xue Xue Bao | pmid:1789117 |
| Zhang JQ and Zhou YP | [Inhibition of aldose reductase from rat lens by some Chinese herbs and their components]. | 1989 | Zhongguo Zhong Yao Za Zhi | pmid:2511877 |
| Jiang XL and Xu LN | [Beneficial effect of puerarin on experimental microcirculatory disturbance in mice]. | 1989 | Yao Xue Xue Bao | pmid:2816384 |
| Song XP et al. | [Effects of puerarin on blood pressure and plasma renin activity in spontaneously hypertensive rats]. | 1988 | Zhongguo Yao Li Xue Bao | pmid:3055814 |
| Lu XR et al. | Puerarin beta-adrenergic receptor blocking effect. | 1987 | Chin. Med. J. | pmid:2885157 |
| Xu LX et al. | [Differential pulse polarographic determination of flavonoids in Pueraria lobata]. | 1987 | Yao Xue Xue Bao | pmid:3661208 |
| Lu XR et al. | [Blocking effect of puerarin on beta-adrenoceptors of isolated organs and the whole animal]. | 1986 | Zhongguo Yao Li Xue Bao | pmid:2886005 |
| Meng GR | [Factors influencing the quality of a Chinese herbal medicine decoction]. | 1986 | Zhong Yao Tong Bao | pmid:2952321 |