SCHEMBL105486

Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with SCHEMBL105486?

SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with SCHEMBL105486

MeSH term MeSH ID Detail
Alcohol-Related Disorders D019973 3 associated lipids
Lead Poisoning D007855 4 associated lipids
Urinary Incontinence D014549 4 associated lipids
Dyspepsia D004415 5 associated lipids
Hepatitis, Alcoholic D006519 5 associated lipids
Hypertension, Renovascular D006978 10 associated lipids
Amnesia D000647 12 associated lipids
Glucose Intolerance D018149 13 associated lipids
Angina, Unstable D000789 14 associated lipids
Brain Infarction D020520 17 associated lipids
Angina Pectoris D000787 27 associated lipids
Ventricular Remodeling D020257 28 associated lipids
Endometriosis D004715 29 associated lipids
Stroke D020521 32 associated lipids
Memory Disorders D008569 33 associated lipids
Cataract D002386 34 associated lipids
Burns D002056 34 associated lipids
Neurotoxicity Syndromes D020258 34 associated lipids
Fever D005334 35 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with SCHEMBL105486

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with SCHEMBL105486?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with SCHEMBL105486?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with SCHEMBL105486?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with SCHEMBL105486?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with SCHEMBL105486?

Knock-out

Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with SCHEMBL105486

Download all related citations
Per page 10 20 50 100 | Total 919
Authors Title Published Journal PubMed Link
Wu P et al. [Study on effect of Puerarin on nitric oxide system in rats' tissue and its mechanism]. 2001 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:12577337
Luo ZR and Zheng B [Effect of Puerarin on platelet activating factors CD63 and CD62P, plasminogen activator inhibitor and C-reactive protein in patients with unstable angia pectoris]. 2001 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:12577374
Xu XH and Zhang ZG [Effect of puerarin on learning-memory behavior and synaptic structure of hippocampus in the aging mice induced by D-galactose]. 2002 Yao Xue Xue Bao pmid:12579889
Shi WG et al. [Study on interventing effect of puerarin on insulin resistance in patients with coronary heart disease]. 2002 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:12585165
Overstreet DH et al. Herbal remedies for alcoholism: promises and possible pitfalls. 2003 Alcohol. Clin. Exp. Res. pmid:12605067
Bae HS et al. Hepatoprotective activity of reduohanxiao-tang (yuldahanso-tang) is related to the inhibition of beta-glucuronidase. 2003 Am. J. Chin. Med. pmid:12723760
Zhu ZT et al. [Inhibitive effect of puerarin on increased NO production by neonatal cardiomyocytes during hypoxia/reoxygenation injury]. 2001 Zhongguo Zhong Yao Za Zhi pmid:12776339
Huang YF et al. [Determination of puerarin in xinmaitong oral liquid by HPLC]. 2001 Zhongguo Zhong Yao Za Zhi pmid:12776346
Qi BL and Qi BM [Effect of the purariae-isofiavones on estrogen level in normal and ovariectomized rats]. 2002 Zhongguo Zhong Yao Za Zhi pmid:12776591
Shi RL and Zhang JJ [Protective effect of puerarin on vascular endothelial cell apoptosis induced by chemical hypoxia in vitro]. 2003 Yao Xue Xue Bao pmid:12778743