| MeSH term | MeSH ID | Detail |
|---|---|---|
| Alcohol-Related Disorders | D019973 | 3 associated lipids |
| Lead Poisoning | D007855 | 4 associated lipids |
| Urinary Incontinence | D014549 | 4 associated lipids |
| Dyspepsia | D004415 | 5 associated lipids |
| Hepatitis, Alcoholic | D006519 | 5 associated lipids |
| Hypertension, Renovascular | D006978 | 10 associated lipids |
| Amnesia | D000647 | 12 associated lipids |
| Glucose Intolerance | D018149 | 13 associated lipids |
| Angina, Unstable | D000789 | 14 associated lipids |
| Brain Infarction | D020520 | 17 associated lipids |
| Angina Pectoris | D000787 | 27 associated lipids |
| Ventricular Remodeling | D020257 | 28 associated lipids |
| Endometriosis | D004715 | 29 associated lipids |
| Stroke | D020521 | 32 associated lipids |
| Memory Disorders | D008569 | 33 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Neurotoxicity Syndromes | D020258 | 34 associated lipids |
| Fever | D005334 | 35 associated lipids |
| Infarction, Middle Cerebral Artery | D020244 | 35 associated lipids |
SCHEMBL105486
Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with SCHEMBL105486?
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
PubChem Associated disorders and diseases
What pathways are associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with SCHEMBL105486?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with SCHEMBL105486?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with SCHEMBL105486?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with SCHEMBL105486?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with SCHEMBL105486?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with SCHEMBL105486
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Yan B et al. | Determination of puerarin in rat cortex by high-performance liquid chromatography after intravenous administration of Puerariae flavonoids. | 2006 | Biomed. Chromatogr. | pmid:16078309 |
| Yu Z and Li W | Induction of apoptosis by puerarin in colon cancer HT-29 cells. | 2006 | Cancer Lett. | pmid:16055262 |
| Li L and Zhang CR | Production of puerarin and isoflavones in cell suspension cultures of Pueraria lobata (Willd.): effects of medium supplementation with casein hydrolysate and coconut milk. | 2006 | J Environ Biol | pmid:16850870 |
| Wang Q et al. | Puerarin injection for unstable angina pectoris. | 2006 | Cochrane Database Syst Rev | pmid:16856037 |
| Zhang S et al. | Reversal of chemical-induced liver fibrosis in Wistar rats by puerarin. | 2006 | J. Nutr. Biochem. | pmid:16426832 |
| Weiping S et al. | Self-assembly of an amphiphilic derivative of chitosan and micellar solubilization of puerarin. | 2006 | Colloids Surf B Biointerfaces | pmid:16466908 |
| Yan LP et al. | Puerarin decreases serum total cholesterol and enhances thoracic aorta endothelial nitric oxide synthase expression in diet-induced hypercholesterolemic rats. | 2006 | Life Sci. | pmid:16472823 |
| Yu AH et al. | [Preparation of puerarin solid self-microemulsion]. | 2006 | Zhong Yao Cai | pmid:17076244 |
| Qi H et al. | Optimization and physicochemical characterization of thermosensitive poloxamer gel containing puerarin for ophthalmic use. | 2006 | Chem. Pharm. Bull. | pmid:17077546 |
| Wu CJ et al. | Promoting effect of borneol on the permeability of puerarin eye drops and timolol maleate eye drops through the cornea in vitro. | 2006 | Pharmazie | pmid:17020156 |
| Yeung DK et al. | Puerarin, an isoflavonoid derived from Radix puerariae, potentiates endothelium-independent relaxation via the cyclic AMP pathway in porcine coronary artery. | 2006 | Eur. J. Pharmacol. | pmid:17027964 |
| Chen L et al. | Simultaneous analysis of nine active components in Gegen Qinlian preparations by high-performance liquid chromatography with diode array detection. | 2006 | J Sep Sci | pmid:17069251 |
| Kim JM et al. | Constituents of the roots of Pueraria lobata inhibit formation of advanced glycation end products (AGEs). | 2006 | Arch. Pharm. Res. | pmid:17121174 |
| Park EK et al. | Intestinal bacteria activate estrogenic effect of main constituents puerarin and daidzin of Pueraria thunbergiana. | 2006 | Biol. Pharm. Bull. | pmid:17142977 |
| Liu R et al. | Pharmacokinetics of puerarin and ginsenoside Rg1 of CBN injection and the relation with platelet aggregation in rats. | 2006 | Am. J. Chin. Med. | pmid:17163592 |
| Pan J et al. | [Isolation and purification of puerarin from puerarin extractive by chelate complex chromatography]. | 2006 | Se Pu | pmid:17165543 |
| Chen M et al. | [Determination of puerarin in Kangshen granule by reversed-phase high performance liquid chromatography]. | 2006 | Se Pu | pmid:17165545 |
| Ren F et al. | Quantitative determination of puerarin in dog plasma by HPLC and study on the relative bioavailability of sustained release tablets. | 2006 | J Pharm Biomed Anal | pmid:16413737 |
| Zhang S et al. | Puerarin induces angiogenesis in myocardium of rat with myocardial infarction. | 2006 | Biol. Pharm. Bull. | pmid:16651724 |
| Li Y et al. | Pharmacokinetic, tissue distribution, and excretion of puerarin and puerarin-phospholipid complex in rats. | 2006 | Drug Dev Ind Pharm | pmid:16638679 |
| Wang C et al. | [Therapeutic effect of puerarin on rats with pre-eclampsia]. | 2006 | Zhonghua Fu Chan Ke Za Zhi | pmid:16640862 |
| Li JX et al. | [Effect of puerarin on ADMA-DDAH system in human umbilical vein endothelial cells cultured with oxidized free radical]. | 2006 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:17205823 |
| Deng X et al. | [Pharmacokinetics of puerarin in the aqueous humor and vitreous of rabbit eye following systemic administration]. | 2006 | Yan Ke Xue Bao | pmid:17378162 |
| Li DZ et al. | [Protective effect of puerarin on endothelial dysfunction of heat shock protein 60 induced specific immunity in apolipoprotein E-null mice]. | 2006 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:17569333 |
| Tian H et al. | Liquid chromatography-mass spectrometric analysis of puerarin and its metabolite in human urine. | 2006 | J Sep Sci | pmid:17313111 |
| Delmonte P et al. | Determination of isoflavones in dietary supplements containing soy, Red Clover and kudzu: extraction followed by basic or acid hydrolysis. | 2006 | J Chromatogr A | pmid:16413562 |
| Kirakosyan A et al. | Isoflavone levels in five soybean (Glycine max) genotypes are altered by phytochrome-mediated light treatments. | 2006 | J. Agric. Food Chem. | pmid:16390177 |
| Penetar DM et al. | Pharmacokinetic profile of the isoflavone puerarin after acute and repeated administration of a novel kudzu extract to human volunteers. | 2006 Jul-Aug | J Altern Complement Med | pmid:16884345 |
| Yu Z et al. | Determination of safflor yellow A, puerarin, ferulic acid, ginsenoside Rg1, and Rb1 in the Traditional Chinese Medicinal preparation Naodesheng injection by high-performance liquid chromatography. | 2006 May-Jun | J Chromatogr Sci | pmid:16774713 |
| Wu B et al. | Meta-analysis of traditional Chinese patent medicine for ischemic stroke. | 2007 | Stroke | pmid:17463317 |
| Cherdshewasart W et al. | Major isoflavonoid contents of the phytoestrogen rich-herb Pueraria mirifica in comparison with Pueraria lobata. | 2007 | J Pharm Biomed Anal | pmid:16930918 |
| Xi J and Guo R | Acid-base equilibrium of puerarin in CTAB micelles. | 2007 | J Pharm Biomed Anal | pmid:16935449 |
| Liang JQ et al. | [The protective function of puerarin to the injury of the lung and its mechanisms during diabetes]. | 2007 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21162284 |
| Prasain JK et al. | Pharmacokinetic study of puerarin in rat serum by liquid chromatography tandem mass spectrometry. | 2007 | Biomed. Chromatogr. | pmid:17221935 |
| Wu C et al. | Preparation and evaluation of a Carbopol/HPMC-based in situ gelling ophthalmic system for puerarin. | 2007 | Yakugaku Zasshi | pmid:17202799 |
| Yang GJ et al. | The simultaneous separation and determination of six flavonoids and troxerutin in rat urine and chicken plasma by reversed-phase high-performance liquid chromatography with ultraviolet-visible detection. | 2007 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:17588830 |
| Kim YS et al. | The role of intestinal microflora on daidzein excretion in urine in humans treated with Chungpesagantang. | 2007 | Arch. Pharm. Res. | pmid:17489365 |
| Rachoń D et al. | Dietary daidzein and puerarin do not affect pituitary LH expression but exert uterotropic effects in ovariectomized rats. | 2007 | Maturitas | pmid:17258874 |
| Singh AK et al. | Herbal mixtures consisting of puerarin and either polyenylphosphatidylcholine or curcumin provide comprehensive protection against alcohol-related disorders in P rats receiving free choice water and 15% ethanol in pure water. | 2007 | J Med Food | pmid:17887948 |
| Xu XH et al. | Inhibition of excitatory amino acid efflux contributes to protective effects of puerarin against cerebral ischemia in rats. | 2007 | Biomed. Environ. Sci. | pmid:17948770 |
| Cherdshewasart W and Sriwatcharakul S | Major isoflavonoid contents of the 1-year-cultivated phytoestrogen-rich herb, Pueraria mirifica. | 2007 | Biosci. Biotechnol. Biochem. | pmid:17928711 |
| Xu YC et al. | Structure-activity relationships of flavonoids for vascular relaxation in porcine coronary artery. | 2007 | Phytochemistry | pmid:17395220 |
| Wang J et al. | Detection of flavonoids and assay for their antioxidant activity based on enlargement of gold nanoparticles. | 2007 | Anal Bioanal Chem | pmid:17479255 |
| Gao R et al. | Gradient high-performance liquid chromatography for the simultaneous determination of chlorogenic acid and baicalin in plasma and its application in the study of pharmacokinetics in rats. | 2007 | J Pharm Biomed Anal | pmid:16859859 |
| Sun XH et al. | Activation of large-conductance calcium-activated potassium channels by puerarin: the underlying mechanism of puerarin-mediated vasodilation. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17652634 |
| Gu YZ et al. | [Preparation of puerarin liposome and its oral absorption in rat]. | 2007 | Zhong Yao Cai | pmid:18074848 |
| Zhang GW et al. | [Studies on the interaction between puerarin and bovine serum albumin]. | 2007 | Guang Pu Xue Yu Guang Pu Fen Xi | pmid:18051529 |
| Hwang YP et al. | Protective effects of puerarin on carbon tetrachloride-induced hepatotoxicity. | 2007 | Arch. Pharm. Res. | pmid:18038910 |
| Yang H et al. | [Studies on effect of microemulsion in enhancing solubility of baicalin and puerarin]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:18161289 |
| Liu R et al. | [Inhibitory effect of quercetin, rutin and puerarin on LDL oxidation induced by Cu2+]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:18161305 |