| MeSH term | MeSH ID | Detail |
|---|---|---|
| Alcohol-Related Disorders | D019973 | 3 associated lipids |
| Lead Poisoning | D007855 | 4 associated lipids |
| Urinary Incontinence | D014549 | 4 associated lipids |
| Hepatitis, Alcoholic | D006519 | 5 associated lipids |
| Dyspepsia | D004415 | 5 associated lipids |
| Hypertension, Renovascular | D006978 | 10 associated lipids |
| Amnesia | D000647 | 12 associated lipids |
| Glucose Intolerance | D018149 | 13 associated lipids |
| Angina, Unstable | D000789 | 14 associated lipids |
| Brain Infarction | D020520 | 17 associated lipids |
| Angina Pectoris | D000787 | 27 associated lipids |
| Ventricular Remodeling | D020257 | 28 associated lipids |
| Endometriosis | D004715 | 29 associated lipids |
| Stroke | D020521 | 32 associated lipids |
| Memory Disorders | D008569 | 33 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Neurotoxicity Syndromes | D020258 | 34 associated lipids |
| Fever | D005334 | 35 associated lipids |
| Infarction, Middle Cerebral Artery | D020244 | 35 associated lipids |
SCHEMBL105486
Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with SCHEMBL105486?
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
PubChem Associated disorders and diseases
What pathways are associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with SCHEMBL105486?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with SCHEMBL105486?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with SCHEMBL105486?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with SCHEMBL105486?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with SCHEMBL105486?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with SCHEMBL105486
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zhu X et al. | The effect of puerarin against IL-1β-mediated leukostasis and apoptosis in retinal capillary endothelial cells (TR-iBRB2). | 2014 | Mol. Vis. | pmid:25593509 |
| Hou JY et al. | Mucoadhesive microparticles for gastroretentive delivery: preparation, biodistribution and targeting evaluation. | 2014 | Mar Drugs | pmid:25470180 |
| Tiyasatkulkovit W et al. | Pueraria mirifica extract and puerarin enhance proliferation and expression of alkaline phosphatase and type I collagen in primary baboon osteoblasts. | 2014 | Phytomedicine | pmid:25442257 |
| Liu Y et al. | Amelioration of stroke-induced neurological deficiency by lyophilized powder of catapol and puerarin. | 2014 | Int. J. Biol. Sci. | pmid:24719562 |
| Ma JQ et al. | Puerarin attenuates carbon tetrachloride-induced liver oxidative stress and hyperlipidaemia in mouse by JNK/c-Jun/CYP7A1 pathway. | 2014 | Basic Clin. Pharmacol. Toxicol. | pmid:24698568 |
| Chen G et al. | Puerarin inhibits angiotensin II-induced cardiac hypertrophy via the redox-sensitive ERK1/2, p38 and NF-κB pathways. | 2014 | Acta Pharmacol. Sin. | pmid:24608673 |
| Jung HR et al. | Simultaneous determination of puerarin and its active metabolite in human plasma by UPLC-MS/MS: application to a pharmacokinetic study. | 2014 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:25264914 |
| Zhang X et al. | Puerarin protects dopaminergic neurons in Parkinson's disease models. | 2014 | Neuroscience | pmid:25218963 |
| Fu R et al. | Digital gene expression analysis of the pathogenesis and therapeutic mechanisms of ligustrazine and puerarin in rat atherosclerosis. | 2014 | Gene | pmid:25218235 |
| Kim MH et al. | Mechanisms of action of phytochemicals from medicinal herbs in the treatment of Alzheimer's disease. | 2014 | Planta Med. | pmid:25210998 |
| Wang J et al. | Synergistic effects of puerarin combined with 5-fluorouracil on esophageal cancer. | 2014 | Mol Med Rep | pmid:25189132 |
| Zhang WG et al. | Puerarin inhibits growth and induces apoptosis in SMMC-7721 hepatocellular carcinoma cells. | 2014 | Mol Med Rep | pmid:25175767 |
| Wang C et al. | Puerarin protects against β-amyloid-induced microglia apoptosis via a PI3K-dependent signaling pathway. | 2014 | Neurochem. Res. | pmid:25173404 |
| Xie N et al. | Puerarin protects hippocampal neurons against cell death in pilocarpine-induced seizures through antioxidant and anti-apoptotic mechanisms. | 2014 | Cell. Mol. Neurobiol. | pmid:25151533 |
| Maji AK et al. | Pueraria tuberosa: a review on its phytochemical and therapeutic potential. | 2014 | Nat. Prod. Res. | pmid:24980468 |
| Ma JQ et al. | Puerarin ameliorates carbon tetrachloride-induced oxidative DNA damage and inflammation in mouse kidney through ERK/Nrf2/ARE pathway. | 2014 | Food Chem. Toxicol. | pmid:24975872 |
| Wang C et al. | The proliferation, differentiation, and mineralization effects of puerarin on osteoblasts in vitro. | 2014 | Chin J Nat Med | pmid:24969524 |
| Wei SY et al. | Progress on the pharmacological research of puerarin: a review. | 2014 | Chin J Nat Med | pmid:24969520 |
| Park WS et al. | Anti-graying effect of the extract of Pueraria thunbergiana via upregulation of cAMP/MITF-M signaling pathway. | 2014 | J. Dermatol. Sci. | pmid:24924521 |
| Yu P et al. | Determination of puerarin in rat plasma using PEGylated magnetic carbon nanotubes by high performance liquid chromatography. | 2014 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:24768919 |
| Kim SB et al. | In vitro and in vivo evaluation of the effect of puerarin on hepatic cytochrome p450-mediated drug metabolism. | 2014 | Planta Med. | pmid:24710899 |
| Lu XL et al. | Protective effects of puerarin against Aß40-induced vascular dysfunction in zebrafish and human endothelial cells. | 2014 | Eur. J. Pharmacol. | pmid:24690262 |
| Liu S et al. | Puerarin alleviates aggravated sympathoexcitatory response induced by myocardial ischemia via regulating P2X3 receptor in rat superior cervical ganglia. | 2014 | Neurochem. Int. | pmid:24657446 |
| Tang L et al. | The protective effects of puerarin in cardiomyocytes from anoxia/reoxygenation injury are mediated by PKCε. | 2014 | Cell Biochem. Funct. | pmid:24496955 |
| Tang F et al. | Puerarin protects against Staphylococcus aureus-induced injury of human alveolar epithelial A549 cells via downregulating alpha-hemolysin secretion. | 2014 | Microb. Drug Resist. | pmid:24372183 |
| Zhou Y et al. | Puerarin alleviates cognitive impairment and oxidative stress in APP/PS1 transgenic mice. | 2014 | Int. J. Neuropsychopharmacol. | pmid:24345484 |
| Wang N et al. | Puerarin protected the brain from cerebral ischemia injury via astrocyte apoptosis inhibition. | 2014 | Neuropharmacology | pmid:24333675 |
| Liu Q et al. | MDR1 and OAT1/OAT3 mediate the drug-drug interaction between puerarin and methotrexate. | 2014 | Pharm. Res. | pmid:24242937 |
| Liu Y et al. | Induction of adhesion molecule expression in co-culture of human bronchial epithelial cells and neutrophils suppressed by puerarin via down-regulating p38 mitogen-activated protein kinase and nuclear factor κB pathways. | 2014 | Chin J Integr Med | pmid:24122632 |
| Chen YG et al. | Metabolic differentiations of Pueraria lobata and Pueraria thomsonii using ¹H NMR spectroscopy and multivariate statistical analysis. | 2014 | J Pharm Biomed Anal | pmid:23746990 |
| Zhu G et al. | Neuroprotective effects of puerarin on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine induced Parkinson's disease model in mice. | 2014 | Phytother Res | pmid:23512787 |
| Zhou A et al. | Lymphatic transport of puerarin occurs after oral administration of different lipid-based formulations to unconscious lymph duct-cannulated rats. | 2014 | Pharm Dev Technol | pmid:23978005 |
| Wang JW et al. | Puerarin ameliorates oxidative stress in a rodent model of traumatic brain injury. | 2014 | J. Surg. Res. | pmid:24079811 |
| Yuan Y et al. | Puerarin attenuates pressure overload-induced cardiac hypertrophy. | 2014 | J Cardiol | pmid:23906530 |
| Li Z et al. | Puerarin protects pancreatic β-cell survival via PI3K/Akt signaling pathway. | 2014 | J. Mol. Endocrinol. | pmid:24827001 |
| Xu J et al. | A new flavonoid glycoside from the rhizomes and roots of Smilax scobinicaulis. | 2014 | Nat. Prod. Res. | pmid:24483603 |
| Mahdy HM et al. | Puerarin ameliorates 3-nitropropionic acid-induced neurotoxicity in rats: possible neuromodulation and antioxidant mechanisms. | 2014 | Neurochem. Res. | pmid:24346712 |
| Zhou YX et al. | Puerarin: a review of pharmacological effects. | 2014 | Phytother Res | pmid:24339367 |
| Zhong Y et al. | Puerarin attenuated early diabetic kidney injury through down-regulation of matrix metalloproteinase 9 in streptozotocin-induced diabetic rats. | 2014 | PLoS ONE | pmid:24454919 |
| Bao MH et al. | Puerarin protects endothelial cells from oxidized low density lipoprotein induced injuries via the suppression of LOX-1 and induction of eNOS. | 2014 | Can. J. Physiol. Pharmacol. | pmid:24708212 |
| Mahdy HM et al. | The anti-apoptotic and anti-inflammatory properties of puerarin attenuate 3-nitropropionic-acid induced neurotoxicity in rats. | 2014 | Can. J. Physiol. Pharmacol. | pmid:24593790 |
| Wang XC et al. | [Effect of chaperone-mediated autophagy in MPP(+) -induced SH-SY5Y cells and interventional effect of puerarin]. | 2014 | Zhongguo Zhong Yao Za Zhi | pmid:24754178 |
| Qu H et al. | Development of an enzyme-linked immunosorbent assay based on anti-puerarin monoclonal antibody and its applications. | 2014 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:24583873 |
| Liao ZG et al. | Transport properties of puerarin and effect of extract of Radix Angelicae dahuricae on puerarin intestinal absorption using in situ and in vitro models. | 2014 | Phytother Res | pmid:24756954 |
| Lu Q et al. | Puerarin attenuates calcification of vascular smooth muscle cells. | 2014 | Am. J. Chin. Med. | pmid:24707866 |
| Wang Y et al. | Simultaneous determination of four components in Baige capsule by HPLC: application to pharmacokinetics and tissue distribution of normal and middle cerebral artery occlusion rats. | 2014 | Biomed. Chromatogr. | pmid:24122939 |
| Gu L et al. | Polyamidomine dendrimers: an excellent drug carrier for improving the solubility and bioavailability of puerarin. | 2013 Sep-Oct | Pharm Dev Technol | pmid:22303809 |
| Tao HQ et al. | HP-β-CD-PLGA nanoparticles improve the penetration and bioavailability of puerarin and enhance the therapeutic effects on brain ischemia-reperfusion injury in rats. | 2013 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:23192284 |
| Tu L et al. | Effects of particle size on the pharmacokinetics of puerarin nanocrystals and microcrystals after oral administration to rat. | 2013 | Int J Pharm | pmid:24120729 |
| Cui YH et al. | [Adsorption and isolation of macroporous resin for three isoflavonoids from puerariae lobatae radix]. | 2013 | Zhong Yao Cai | pmid:24134015 |