| MeSH term | MeSH ID | Detail |
|---|---|---|
| Alcohol-Related Disorders | D019973 | 3 associated lipids |
| Urinary Incontinence | D014549 | 4 associated lipids |
| Lead Poisoning | D007855 | 4 associated lipids |
| Hepatitis, Alcoholic | D006519 | 5 associated lipids |
| Dyspepsia | D004415 | 5 associated lipids |
| Hypertension, Renovascular | D006978 | 10 associated lipids |
| Amnesia | D000647 | 12 associated lipids |
| Glucose Intolerance | D018149 | 13 associated lipids |
| Angina, Unstable | D000789 | 14 associated lipids |
| Brain Infarction | D020520 | 17 associated lipids |
| Angina Pectoris | D000787 | 27 associated lipids |
| Ventricular Remodeling | D020257 | 28 associated lipids |
| Endometriosis | D004715 | 29 associated lipids |
| Stroke | D020521 | 32 associated lipids |
| Memory Disorders | D008569 | 33 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Neurotoxicity Syndromes | D020258 | 34 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Fever | D005334 | 35 associated lipids |
| Infarction, Middle Cerebral Artery | D020244 | 35 associated lipids |
SCHEMBL105486
Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with SCHEMBL105486?
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
PubChem Associated disorders and diseases
What pathways are associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with SCHEMBL105486?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with SCHEMBL105486?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with SCHEMBL105486?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with SCHEMBL105486?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with SCHEMBL105486?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with SCHEMBL105486
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Feng ZQ et al. | The synthesis of puerarin derivatives and their protective effect on the myocardial ischemia and reperfusion injury. | 2010 | J Asian Nat Prod Res | pmid:20924897 |
| Li J et al. | Puerarin attenuates amyloid-beta-induced cognitive impairment through suppression of apoptosis in rat hippocampus in vivo. | 2010 | Eur. J. Pharmacol. | pmid:20868658 |
| Zhang W et al. | Puerarin improves insulin resistance and modulates adipokine expression in rats fed a high-fat diet. | 2010 | Eur. J. Pharmacol. | pmid:20869961 |
| Zhang HY et al. | [The protective effect of puerarin on Abeta(25-35)-induced PC12 cell injury]. | 2010 | Zhong Yao Cai | pmid:20873562 |
| Zhang XP et al. | Protective effects of ligustrazine, kakonein and Panax notoginsenosides on multiple organs in rats with severe acute pancreatitis. | 2010 | Methods Find Exp Clin Pharmacol | pmid:21225014 |
| Wang L and Zhao Y | [Effect of decoction method on pharmacokinetics of puerarin in dogs]. | 2010 | Zhong Yao Cai | pmid:21243776 |
| Pan E et al. | [Absorption transport mechanism of puerarin oil-in-oil nanoemulsion]. | 2010 | Zhongguo Zhong Yao Za Zhi | pmid:21246816 |
| Rudra A et al. | Doxorubicin-loaded phosphatidylethanolamine-conjugated nanoliposomes: in vitro characterization and their accumulation in liver, kidneys, and lungs in rats. | 2010 | Int J Nanomedicine | pmid:21042545 |
| Zhu L et al. | [Molecular mechanism of protective effect of puerarin solid lipid nanoparticle on cerebral ischemia-reperfusion injury in gerbils]. | 2010 | Zhong Yao Cai | pmid:21548369 |
| Boonchird C et al. | Differential binding with ERalpha and ERbeta of the phytoestrogen-rich plant Pueraria mirifica. | 2010 | Braz. J. Med. Biol. Res. | pmid:20027484 |
| Kim SJ et al. | Peroxyl radical scavenging capacity of extracts and isolated components from selected medicinal plants. | 2010 | Arch. Pharm. Res. | pmid:20607491 |
| Yang X et al. | Puerarin inhibits C-reactive protein expression via suppression of nuclear factor kappaB activation in lipopolysaccharide-induced peripheral blood mononuclear cells of patients with stable angina pectoris. | 2010 | Basic Clin. Pharmacol. Toxicol. | pmid:20346059 |
| Liu Y et al. | [Corneal penetration of PAMAM dendrimers-coated puerarin liposomes]. | 2010 | Zhongguo Zhong Yao Za Zhi | pmid:20349711 |
| Liu XJ et al. | The effects of genistein and puerarin on the activation of nuclear factor-kappaB and the production of tumor necrosis factor-alpha in asthma patients. | 2010 | Pharmazie | pmid:20225658 |
| Bai QH et al. | [Puerarin antagonizes activation effect of LPS on N9 microglia cells]. | 2010 | Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi | pmid:20230684 |
| Choi CH et al. | Enzymatic synthesis of glycosylated puerarin using maltogenic amylase from Bacillus stearothermophilus expressed in Bacillus subtilis. | 2010 | J. Sci. Food Agric. | pmid:20393999 |
| Zhao M et al. | Protective effect of puerarin on acute alcoholic liver injury. | 2010 | Am. J. Chin. Med. | pmid:20387222 |
| Thielemann A et al. | Comparison of urodynamic effects of phytoestrogens equol, puerarin and genistein with these of estradiol 17beta in ovariectomized rats. | 2010 | Exp. Gerontol. | pmid:19903517 |
| Hu W et al. | Puerarin inhibits adhesion molecule expression in tnf-alpha-stimulated human endothelial cells via modulation of the nuclear factor kappaB pathway. | 2010 | Pharmacology | pmid:20016245 |
| Shao HM et al. | [Inhibitory effect of flavonoids of puerarin on proliferation of different human acute myeloid leukemia cell lines in vitro]. | 2010 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:20416155 |
| Semalty A et al. | Development and evaluation of pharmacosomes of aceclofenac. | 2010 | Indian J Pharm Sci | pmid:21694988 |
| Tang YH et al. | [Apoptosis of NB4 cells induced by flavonoids of puerarin in vitro]. | 2010 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:20416161 |
| Gao C et al. | Pharmacokinetic interaction between puerarin and edaravone, and effect of borneol on the brain distribution kinetics of puerarin in rats. | 2010 | J. Pharm. Pharmacol. | pmid:20487220 |
| Zhang H et al. | Investigation of the inclusions of puerarin and daidzin with beta-cyclodextrin by molecular dynamics simulation. | 2010 | J Phys Chem B | pmid:20297792 |
| Kato E and Kawabata J | Glucose uptake enhancing activity of puerarin and the role of C-glucoside suggested from activity of related compounds. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20605096 |
| Liu X et al. | A validated stability-indicating HPLC method for the determination of PEGylated puerarin in aqueous solutions. | 2010 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:20580327 |
| Zhang R et al. | [Protective effect of puerarin against calcium overload after focal cerebral ischemia injury in rats]. | 2010 | Nan Fang Yi Ke Da Xue Xue Bao | pmid:20584654 |
| Yao W et al. | Preparation and characterization of puerarin-dendrimer complexes as an ocular drug delivery system. | 2010 | Drug Dev Ind Pharm | pmid:20545508 |
| Xu J et al. | PVA hydrogels containing beta-cyclodextrin for enhanced loading and sustained release of ocular therapeutics. | 2010 | J Biomater Sci Polym Ed | pmid:20507706 |
| Zhang Z et al. | Preventive effects of Flos Perariae (Gehua) water extract and its active ingredient puerarin in rodent alcoholism models. | 2010 | Chin Med | pmid:20974012 |
| Zhu G et al. | Puerarin protects dopaminergic neurons against 6-hydroxydopamine neurotoxicity via inhibiting apoptosis and upregulating glial cell line-derived neurotrophic factor in a rat model of Parkinson's disease. | 2010 | Planta Med. | pmid:20509103 |
| Malaivijitnond S et al. | Puerarin exhibits weak estrogenic activity in female rats. | 2010 | Fitoterapia | pmid:20117180 |
| Zheng J et al. | The effects of puerarin on CYP2D6 and CYP1A2 activities in vivo. | 2010 | Arch. Pharm. Res. | pmid:20195825 |
| Xu J et al. | Preparation and evaluation of a contact lens vehicle for puerarin delivery. | 2010 | J Biomater Sci Polym Ed | pmid:20178685 |
| Hien TT et al. | Molecular mechanism of suppression of MDR1 by puerarin from Pueraria lobata via NF-kappaB pathway and cAMP-responsive element transcriptional activity-dependent up-regulation of AMP-activated protein kinase in breast cancer MCF-7/adr cells. | 2010 | Mol Nutr Food Res | pmid:20077420 |
| Kim KM et al. | Puerarin suppresses AGEs-induced inflammation in mouse mesangial cells: a possible pathway through the induction of heme oxygenase-1 expression. | 2010 | Toxicol. Appl. Pharmacol. | pmid:20060010 |
| Pongkitwitoon B et al. | Enzyme-linked immunosorbent assay for total isoflavonoids in Pueraria candollei using anti-puerarin and anti-daidzin polyclonal antibodies. | 2010 | Planta Med. | pmid:20033865 |
| Deng Y et al. | [Preparation and lacrimal pharmacokinetics of eye drops of puerarin liposomes in rabbit tears]. | 2010 | Zhongguo Zhong Yao Za Zhi | pmid:20422993 |
| He D et al. | [Improvement of solubility of puerarin through deoxycholate/phospholipid mixed micelle preparing technology]. | 2010 | Zhongguo Zhong Yao Za Zhi | pmid:20822006 |
| Mun JG et al. | Tracking deposition of a 14C-radiolabeled kudzu hairy root-derived isoflavone-rich fraction into bone. | 2010 | Exp. Biol. Med. (Maywood) | pmid:20851832 |
| Liang S et al. | P2X receptors and modulation of pain transmission: focus on effects of drugs and compounds used in traditional Chinese medicine. | 2010 | Neurochem. Int. | pmid:20863868 |
| Choi CW et al. | Yeast α-glucosidase inhibition by isoflavones from plants of Leguminosae as an in vitro alternative to acarbose. | 2010 | J. Agric. Food Chem. | pmid:20734984 |
| Chen TR et al. | Evaluation of quality of Radix Puerariae herbal medicine by isoflavonoids. | 2010 | J. Pharm. Pharmacol. | pmid:20609068 |
| Fan X et al. | Pharmacological neuroprotection after perinatal hypoxic-ischemic brain injury. | 2010 | Curr Neuropharmacol | pmid:21629441 |
| Chen CC et al. | Hazardous effects of curcumin on mouse embryonic development through a mitochondria-dependent apoptotic signaling pathway. | 2010 | Int J Mol Sci | pmid:21152277 |
| Li Q et al. | Neuroprotective properties of picroside II in a rat model of focal cerebral ischemia. | 2010 | Int J Mol Sci | pmid:21151457 |
| Xu R et al. | Two new flavones from Tridax procumbens Linn. | 2010 | Molecules | pmid:20877227 |
| Gruber JV and Holtz R | Examining the genomic influence of skin antioxidants in vitro. | 2010 | Mediators Inflamm. | pmid:20706672 |
| O'Brien KA | Alternative perspectives: how chinese medicine understands hypercholesterolemia. | 2010 | Cholesterol | pmid:21490916 |
| Patel RP and Barnes S | Isoflavones and PPAR Signaling: A Critical Target in Cardiovascular, Metastatic, and Metabolic Disease. | 2010 | PPAR Res | pmid:21461045 |