SCHEMBL105486

Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with SCHEMBL105486?

SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with SCHEMBL105486

MeSH term MeSH ID Detail
Body Weight D001835 333 associated lipids
Adenocarcinoma D000230 166 associated lipids
Hemolysis D006461 131 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Inflammation D007249 119 associated lipids
Hypertension D006973 115 associated lipids
Insulin Resistance D007333 99 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Brain Ischemia D002545 89 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Alzheimer Disease D000544 76 associated lipids
Coronary Disease D003327 70 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Reperfusion Injury D015427 65 associated lipids
Parkinson Disease D010300 53 associated lipids
Fatty Liver D005234 48 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Arthritis D001168 41 associated lipids
Per page 10 20 50 | Total 43

PubChem Associated disorders and diseases

What pathways are associated with SCHEMBL105486

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with SCHEMBL105486?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with SCHEMBL105486?


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Function Cross reference Weighted score Related literatures

What lipids are associated with SCHEMBL105486?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with SCHEMBL105486?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with SCHEMBL105486?

Knock-out

Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with SCHEMBL105486

Download all related citations
Per page 10 20 50 100 | Total 919
Authors Title Published Journal PubMed Link
Liu CM et al. Puerarin protects the rat liver against oxidative stress-mediated DNA damage and apoptosis induced by lead. 2012 Exp. Toxicol. Pathol. pmid:21146379
Sun L et al. Involvement of abscisic acid in ozone-induced puerarin production of Pueraria thomsnii Benth. suspension cell cultures. 2012 Plant Cell Rep. pmid:21947422
Zhu G et al. Involvement of activation of PI3K/Akt pathway in the protective effects of puerarin against MPP+-induced human neuroblastoma SH-SY5Y cell death. 2012 Neurochem. Int. pmid:22265823
Zheng GM et al. Puerarin suppresses production of nitric oxide and inducible nitric oxide synthase in lipopolysaccharide-induced N9 microglial cells through regulating MAPK phosphorylation, O-GlcNAcylation and NF-κB translocation. 2012 Int. J. Oncol. pmid:22246431
Lin F et al. Protective effect of Puerarin on β-amyloid-induced neurotoxicity in rat hippocampal neurons. 2012 Arzneimittelforschung pmid:22278629
Tang XL et al. Dynamic oxidative stress and DNA damage induced by oestrogen deficiency and protective effects of puerarin and 17β-oestradiol in ovariectomized rats. 2012 Basic Clin. Pharmacol. Toxicol. pmid:22333267
Pang W et al. Effect of puerarin on the release of interleukin-8 in co-culture of human bronchial epithelial cells and neutrophils. 2012 Chin J Integr Med pmid:22457139
Zhao Y and Zhou Y Puerarin improve insulin resistance of adipocyte through activating Cb1 binding protein path. 2012 Chin J Integr Med pmid:22457141
Chen C et al. Puerarin induces mitochondria-dependent apoptosis in hypoxic human pulmonary arterial smooth muscle cells. 2012 PLoS ONE pmid:22457823
Hao LN et al. Puerarin decreases apoptosis of retinal pigment epithelial cells in diabetic rats by reducing peroxynitrite level and iNOS expression. 2012 Sheng Li Xue Bao pmid:22513471
Yao XJ et al. Puerarin exerts antipyretic effect on lipopolysaccharide-induced fever in rats involving inhibition of pyrogen production from macrophages. 2012 J Ethnopharmacol pmid:22401764
Yu N et al. The effects of sperminated pullulans on cornea permeability to puerarin and the toxicity. 2012 J Ocul Pharmacol Ther pmid:22690870
Wang R et al. [Protective effects of puerarin on 60Co-gamma-induced acute injury of sertoli cells of testis in mice]. 2012 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:22686089
Luo CF et al. UDP-glucuronosyltransferase 1A1 is the principal enzyme responsible for puerarin metabolism in human liver microsomes. 2012 Arch. Toxicol. pmid:22648071
Yang F et al. Osteoblast response to puerarin-loaded porous titanium surfaces: an in vitro study. 2012 J Biomed Mater Res A pmid:22374837
Zhang H et al. Insight into the structural deformations of beta-cyclodextrin caused by alcohol cosolvents and guest molecules. 2012 J Phys Chem B pmid:22376204
Hou Q et al. [Puerarin combined with avandia for diabetic nephropathy]. 2012 Zhong Nan Da Xue Xue Bao Yi Xue Ban pmid:22349389
Liu B et al. Physicochemical [corrected] properties of the inclusion complex of puerarin and glucosyl-β-cyclodextrin. 2012 J. Agric. Food Chem. pmid:23215052
Xue C et al. [Determination of five components in Pueraria labta decoction with reference extraction method]. 2012 Zhongguo Zhong Yao Za Zhi pmid:23234135
Sun XY et al. [Optimal extraction of puerarin from Pueraria lobata based on central composite design and response surface methodology]. 2012 Zhong Yao Cai pmid:23236837
Wang X et al. Identification and assay of 3'-O-methyltaxifolin by UPLC-MS in rat plasma. 2012 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:23217303
Wen Y et al. Simultaneous determination of lidamycin enediyne chromophore (LDC) and its aromatized derivative (LDCA) using puerarin as internal standard in rat plasma by LC-MS/MS. 2012 Biomed. Chromatogr. pmid:21830226
Luo J and Xu H Outcome measures of chinese herbal medicine for coronary heart disease: an overview of systematic reviews. 2012 Evid Based Complement Alternat Med pmid:22606207
Yan F et al. Effects of some antihypertensive drugs on the metabolism and pharmacokinetics of indapamide in rats. 2012 J Pharm Pharm Sci pmid:22579001
Wang J and Xiong X Current situation and perspectives of clinical study in integrative medicine in china. 2012 Evid Based Complement Alternat Med pmid:22550539
Wu Y et al. Optimisation of ultrasound-assisted extraction of puerarin and total isoflavones from Puerariae Lobatae Radix (Pueraria lobata (Wild.) Ohwi) with response surface methodology. 2012 Sep-Oct Phytochem Anal pmid:22259187
Xie J et al. Improvement in solubility and bioavailability of puerarin by mechanochemical preparation. 2013 Drug Dev Ind Pharm pmid:22591175
Luo CF et al. Metabolic profile of puerarin in rats after intragastric administration of puerarin solid lipid nanoparticles. 2013 Int J Nanomedicine pmid:23486407
Cao L et al. Pharmacokinetics of puerarin in pregnant rats at different stages of gestation after oral administration. 2013 Fitoterapia pmid:23500385
Guo C et al. Anti-fibrotic effects of puerarin on CCl4-induced hepatic fibrosis in rats possibly through the regulation of PPAR-γ expression and inhibition of PI3K/Akt pathway. 2013 Food Chem. Toxicol. pmid:23500774
Liu CM et al. Protective effect of puerarin on lead-induced mouse cognitive impairment via altering activities of acetyl cholinesterase, monoamine oxidase and nitric oxide synthase. 2013 Environ. Toxicol. Pharmacol. pmid:23501611
Cheng M et al. Puerarin accelerates re-endothelialization in a carotid arterial injury model: impact on vasodilator concentration and vascular cell functions. 2013 J. Cardiovasc. Pharmacol. pmid:23792702
Xu L et al. Puerarin, isolated from Pueraria lobata (Willd.), protects against hepatotoxicity via specific inhibition of the TGF-β1/Smad signaling pathway, thereby leading to anti-fibrotic effect. 2013 Phytomedicine pmid:23856441
Li R et al. Puerarin attenuates neuronal degeneration and blocks oxidative stress to elicit a neuroprotective effect on substantia nigra injury in 6-OHDA-lesioned rats. 2013 Brain Res. pmid:23603411
Zhang E et al. [Formulation optimization and drug release in vitro of membrane controlled tablets of puerarin inclusion compound]. 2013 Zhongguo Zhong Yao Za Zhi pmid:23596875
Li N et al. Determination of glibenclamide and puerarin in rat plasma by UPLC-MS/MS: application to their pharmacokinetic interaction study. 2013 Talanta pmid:23597896
Wang Y et al. Puerarin stimulates proliferation and differentiation and protects against cell death in human osteoblastic MG-63 cells via ER-dependent MEK/ERK and PI3K/Akt activation. 2013 Phytomedicine pmid:23639192
Chen F et al. Puerarin-induced immune hemolytic anemia. 2013 Int. J. Hematol. pmid:23661032
Cao WL et al. [Effect of puerarin on hemorheology and pulmonary pressure in rat pneumo-cardiac disease]. 2013 Zhongguo Ying Yong Sheng Li Xue Za Zhi pmid:23662397
Huang ZG et al. [Effect of puerarin combined with felodipine on mRNA and protein expression of apelin and APJ in renovascular hypertensive rat]. 2013 Zhongguo Zhong Yao Za Zhi pmid:23668014
Zhang Y et al. Effects of puerarin on cholinergic enzymes in the brain of ovariectomized guinea pigs. 2013 Int. J. Neurosci. pmid:23668913
Chen X et al. Puerarin improves metabolic function leading to hepatoprotective effects in chronic alcohol-induced liver injury in rats. 2013 Phytomedicine pmid:23669266
Wang Q et al. Magnetic solid-phase extraction and determination of puerarin in rat plasma using C(18)-functionalized magnetic silica nanoparticles by high performance liquid chromatography. 2013 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:23246846
Peng JH et al. Puerarin ameliorates experimental alcoholic liver injury by inhibition of endotoxin gut leakage, Kupffer cell activation, and endotoxin receptors expression. 2013 J. Pharmacol. Exp. Ther. pmid:23277536
Nakamura K et al. Enzymatic cleavage of the C-glucosidic bond of puerarin by three proteins, Mn(2+), and oxidized form of nicotinamide adenine dinucleotide. 2013 Biol. Pharm. Bull. pmid:23328408
Tao HQ et al. HP-β-CD-PLGA nanoparticles improve the penetration and bioavailability of puerarin and enhance the therapeutic effects on brain ischemia-reperfusion injury in rats. 2013 Naunyn Schmiedebergs Arch. Pharmacol. pmid:23192284
Yin R et al. UFLC-MS/MS method for simultaneous determination of luteolin-7-O-gentiobioside, luteolin-7-O-β-D-glucoside and luteolin-7-O-β-D-glucuronide in beagle dog plasma and its application to a pharmacokinetic study after administration of traditional Chinese medicinal preparation: Kudiezi injection. 2013 J Pharm Biomed Anal pmid:23146236
Li R et al. Puerarin mediates hepatoprotection against CCl4-induced hepatic fibrosis rats through attenuation of inflammation response and amelioration of metabolic function. 2013 Food Chem. Toxicol. pmid:23146695
Zou Y et al. Protective effect of puerarin against beta-amyloid-induced oxidative stress in neuronal cultures from rat hippocampus: involvement of the GSK-3β/Nrf2 signaling pathway. 2013 Free Radic. Res. pmid:23088308
Wang Y et al. In vitro and in vivo anticancer activity of a novel puerarin nanosuspension against colon cancer, with high efficacy and low toxicity. 2013 Int J Pharm pmid:23089583
Zhang J et al. Effects of puerarin on the inflammatory role of burn-related procedural pain mediated by P2X(7) receptors. 2013 Burns pmid:23044342
Bai S et al. Effects of felodipine combined with puerarin on ACE2-Ang (1-7)-Mas axis in renovascular hypertensive rat. 2013 Regul. Pept. pmid:23523569
Tian F et al. The neuroprotective mechanism of puerarin treatment of acute spinal cord injury in rats. 2013 Neurosci. Lett. pmid:23570727
Li R et al. Puerarin attenuates neuronal degeneration in the substantia nigra of 6-OHDA-lesioned rats through regulating BDNF expression and activating the Nrf2/ARE signaling pathway. 2013 Brain Res. pmid:23747813
Li R et al. Puerarin, isolated from Kudzu root (Willd.), attenuates hepatocellular cytotoxicity and regulates the GSK-3β/NF-κB pathway for exerting the hepatoprotection against chronic alcohol-induced liver injury in rats. 2013 Int. Immunopharmacol. pmid:23751897
Liu X et al. Pharmacokinetic comparisons of puerarin, daidzin and the glucuronide metabolite of puerarin after administration of total flavonoid from Gegen alone and total flavonoid from Gegen combined with total saponin from Sanqi in rats under different physiological states. 2013 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:23774247
Wong KH et al. Differentiation of Pueraria lobata and Pueraria thomsonii using partial least square discriminant analysis (PLS-DA). 2013 J Pharm Biomed Anal pmid:23777642
Xia DZ et al. Hepatoprotective activity of puerarin against carbon tetrachloride-induced injuries in rats: a randomized controlled trial. 2013 Food Chem. Toxicol. pmid:23764356
Wang L et al. Protective effects of puerarin on experimental chronic lead nephrotoxicity in immature female rats. 2013 Hum Exp Toxicol pmid:23315276
Wu K et al. Anti-diabetic effects of puerarin, isolated from Pueraria lobata (Willd.), on streptozotocin-diabetogenic mice through promoting insulin expression and ameliorating metabolic function. 2013 Food Chem. Toxicol. pmid:23927877
Wu X et al. Isolation, identification and pharmacokinetic analysis of fructosyl puerarins from enzymatic glycosylation. 2013 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:23948238
Cheng Y et al. Effects of puerarin on cardiac differentiation and ventricular specialization of murine embryonic stem cells. 2013 Cell. Physiol. Biochem. pmid:24080853
Zhao LX et al. The permeability of puerarin loaded poly(butylcyanoacrylate) nanoparticles coated with polysorbate 80 on the blood-brain barrier and its protective effect against cerebral ischemia/reperfusion injury. 2013 Biol. Pharm. Bull. pmid:23902970
Ji M et al. Puerarin suppresses proliferation of endometriotic stromal cells in part via differential recruitment of nuclear receptor coregulators to estrogen receptor-α. 2013 J. Steroid Biochem. Mol. Biol. pmid:23907019
Tu L et al. Effects of particle size on the pharmacokinetics of puerarin nanocrystals and microcrystals after oral administration to rat. 2013 Int J Pharm pmid:24120729
Cui YH et al. [Adsorption and isolation of macroporous resin for three isoflavonoids from puerariae lobatae radix]. 2013 Zhong Yao Cai pmid:24134015
Singh AK et al. Anti-inflammatory potency of nano-formulated puerarin and curcumin in rats subjected to the lipopolysaccharide-induced inflammation. 2013 J Med Food pmid:24138167
Jiang L et al. Simultaneous determination of gastrodin and puerarin in rat plasma by HPLC and the application to their interaction on pharmacokinetics. 2013 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:23314488
Liu AC et al. LC-MS/MS method for the determination of a new puerarin derivative and its application in pharmacokinetic studies in rats. 2013 Chin J Nat Med pmid:24359785
Zhu H et al. Effect of puerarin on matrix metalloproteinase-2 in human fetal scleral fibroblasts treated with low frequency electromagnetic fields. 2013 J Tradit Chin Med pmid:24660593
Tang TT et al. Mechanisms of microemulsion enhancing the oral bioavailability of puerarin: comparison between oil-in-water and water-in-oil microemulsions using the single-pass intestinal perfusion method and a chylomicron flow blocking approach. 2013 Int J Nanomedicine pmid:24277986
Ji O et al. [Effect of flavonoids of puerarin on the proliferation and apoptosis of retinoic acid resistant acute promyelocytic leukemia cell line NB4-R1 cells]. 2013 Zhonghua Xue Ye Xue Za Zhi pmid:23688762
Gu L et al. Polyamidomine dendrimers: an excellent drug carrier for improving the solubility and bioavailability of puerarin. 2013 Sep-Oct Pharm Dev Technol pmid:22303809
Liu M et al. Puerarin alleviates neuropathic pain by inhibiting neuroinflammation in spinal cord. 2014 Mediators Inflamm. pmid:25089076
Wang L et al. Puerarin facilitates T-tubule development of murine embryonic stem cell-derived cardiomyocytes. 2014 Cell. Physiol. Biochem. pmid:25059232
Qu Q et al. Inhibitory effects of phytochemicals on metabolic capabilities of CYP2D6(*)1 and CYP2D6(*)10 using cell-based models in vitro. 2014 Acta Pharmacol. Sin. pmid:24786236
Shao J et al. Spectroscopic and molecular docking studies of the in vitro interaction between puerarin and cytochrome P450. 2014 Molecules pmid:24743933
Liu Y et al. Amelioration of stroke-induced neurological deficiency by lyophilized powder of catapol and puerarin. 2014 Int. J. Biol. Sci. pmid:24719562
Ma JQ et al. Puerarin attenuates carbon tetrachloride-induced liver oxidative stress and hyperlipidaemia in mouse by JNK/c-Jun/CYP7A1 pathway. 2014 Basic Clin. Pharmacol. Toxicol. pmid:24698568
Chen G et al. Puerarin inhibits angiotensin II-induced cardiac hypertrophy via the redox-sensitive ERK1/2, p38 and NF-κB pathways. 2014 Acta Pharmacol. Sin. pmid:24608673
Li B et al. Puerarin enhances bone mass by promoting osteoblastogenesis and slightly lowering bone marrow adiposity in ovariectomized rats. 2014 Biol. Pharm. Bull. pmid:25590084
Jung HR et al. Simultaneous determination of puerarin and its active metabolite in human plasma by UPLC-MS/MS: application to a pharmacokinetic study. 2014 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:25264914
Zhang X et al. Puerarin protects dopaminergic neurons in Parkinson's disease models. 2014 Neuroscience pmid:25218963
Yan Y et al. Simultaneous determination of puerarin, daidzin, daidzein, paeoniflorin, albiflorin, liquiritin and liquiritigenin in rat plasma and its application to a pharmacokinetic study of Ge-Gen Decoction by a liquid chromatography-electrospray ionization-tandem mass spectrometry. 2014 J Pharm Biomed Anal pmid:24637051
Wang S et al. Efficient glycosylation of puerarin by an organic solvent-tolerant strain of Lysinibacillus fusiformis. 2014 Enzyme Microb. Technol. pmid:24629266
Li H et al. Biopharmaceutics classification of puerarin and comparison of perfusion approaches in rats. 2014 Int J Pharm pmid:24607203
She S et al. Effects of puerarin in STZ-induced diabetic rats by oxidative stress and the TGF-β1/Smad2 pathway. 2014 Food Funct pmid:24595557
Liu G et al. Puerarin protects against lead-induced cytotoxicity in cultured primary rat proximal tubular cells. 2014 Hum Exp Toxicol pmid:24505050
Tang L et al. The protective effects of puerarin in cardiomyocytes from anoxia/reoxygenation injury are mediated by PKCε. 2014 Cell Biochem. Funct. pmid:24496955
Tang F et al. Puerarin protects against Staphylococcus aureus-induced injury of human alveolar epithelial A549 cells via downregulating alpha-hemolysin secretion. 2014 Microb. Drug Resist. pmid:24372183
Zhou Y et al. Puerarin alleviates cognitive impairment and oxidative stress in APP/PS1 transgenic mice. 2014 Int. J. Neuropsychopharmacol. pmid:24345484
Wang N et al. Puerarin protected the brain from cerebral ischemia injury via astrocyte apoptosis inhibition. 2014 Neuropharmacology pmid:24333675
Liu Q et al. MDR1 and OAT1/OAT3 mediate the drug-drug interaction between puerarin and methotrexate. 2014 Pharm. Res. pmid:24242937
Li Z et al. Puerarin protects pancreatic β-cell survival via PI3K/Akt signaling pathway. 2014 J. Mol. Endocrinol. pmid:24827001
Guo YJ et al. In vivo inhibitory effects of puerarin on selected rat cytochrome P450 isoenzymes. 2014 Pharmazie pmid:24855829
Wu J et al. Efficacy and safety of puerarin injection in treatment of diabetic peripheral neuropathy: a systematic review and meta-analysis of randomized controlled trials. 2014 J Tradit Chin Med pmid:25185357
Liu S et al. Puerarin blocks the signaling transmission mediated by P2X3 in SG and DRG to relieve myocardial ischemic damage. 2014 Brain Res. Bull. pmid:24447636
Xu J et al. A new flavonoid glycoside from the rhizomes and roots of Smilax scobinicaulis. 2014 Nat. Prod. Res. pmid:24483603
Mahdy HM et al. Puerarin ameliorates 3-nitropropionic acid-induced neurotoxicity in rats: possible neuromodulation and antioxidant mechanisms. 2014 Neurochem. Res. pmid:24346712
Zhou YX et al. Puerarin: a review of pharmacological effects. 2014 Phytother Res pmid:24339367