SCHEMBL105486

Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with SCHEMBL105486?

SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with SCHEMBL105486

MeSH term MeSH ID Detail
Body Weight D001835 333 associated lipids
Adenocarcinoma D000230 166 associated lipids
Hemolysis D006461 131 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Inflammation D007249 119 associated lipids
Hypertension D006973 115 associated lipids
Insulin Resistance D007333 99 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Brain Ischemia D002545 89 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Alzheimer Disease D000544 76 associated lipids
Coronary Disease D003327 70 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Reperfusion Injury D015427 65 associated lipids
Parkinson Disease D010300 53 associated lipids
Fatty Liver D005234 48 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Arthritis D001168 41 associated lipids
Per page 10 20 50 | Total 43

PubChem Associated disorders and diseases

What pathways are associated with SCHEMBL105486

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with SCHEMBL105486?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with SCHEMBL105486?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with SCHEMBL105486?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with SCHEMBL105486?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with SCHEMBL105486?

Knock-out

Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with SCHEMBL105486

Download all related citations
Per page 10 20 50 100 | Total 919
Authors Title Published Journal PubMed Link
Miao WN et al. [Effect of Puerarin on K+ channel of isolated ventricular myocyte in guinea pig]. 2002 Zhongguo Ying Yong Sheng Li Xue Za Zhi pmid:21179804
Yao H et al. [The role of mitochondrial K+ channels in the cardioprotection of puerarin against hypoxia/reoxygenation injury in rats]. 2010 Zhongguo Ying Yong Sheng Li Xue Za Zhi pmid:21328988
Yue HW and Hu XQ [Pharmacologic value of radix Puerariae and puerarine on cardiovascular system]. 1996 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:9387770
Li SM et al. [Effect of puerarin on plasma endothelin, renin activity and angiotensin II in patients with acute myocardial infarction]. 1997 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:9863126
Zhao Z et al. [Clinical study of puerarin in treatment of patients with unstable angina]. 1998 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:11477926
Meng P et al. [Clinical observation of the treatment of infantile viral myocarditis with puerarin]. 1999 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:11783152
Chen J et al. [Effect of puerarin on fibrinolytic activity and lipid peroxide in patients with coronary heart disease]. 1999 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:11783153
Ren P et al. [Observation on efficacy of puerarin in treating diabetic retinopathy]. 2000 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:11789184
Wu P et al. [Study on effect of Puerarin on nitric oxide system in rats' tissue and its mechanism]. 2001 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:12577337
Luo ZR and Zheng B [Effect of Puerarin on platelet activating factors CD63 and CD62P, plasminogen activator inhibitor and C-reactive protein in patients with unstable angia pectoris]. 2001 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:12577374
Shi WG et al. [Study on interventing effect of puerarin on insulin resistance in patients with coronary heart disease]. 2002 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:12585165
Xie RQ et al. [Myocardial protection and mechanism of Puerarin Injection on patients of coronary heart disease with ischemia/reperfusion]. 2003 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:14714357
Yu CQ [Treatment of endometriosis by puerarin]. 2008 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:19213335
Hou HG et al. [Puerarin in the treatment of poisoning of acute organophosphorous compound with toxic myocarditis]. 2008 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:18928024
Ye XY et al. [Effect of puerarin injection on the mRNA expressions of AT1 and ACE2 in spontaneous hypertension rats]. 2008 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:19065898
Jiang XX et al. [Effect of puerarin preconditioning on cytokine levels in patients undergoing cardiopulmonary bypass in perioperative period]. 2009 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:20214329
Yang S et al. [Effect of puerarin on liver injury in KKAy mice with type 2 diabetes mellitus]. 2009 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:19848202
Gao L et al. [Of berberine and puerarin on dexamethasone-induced insulin resistance in porcine ovarian thecal cells]. 2009 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:19852296
Han J et al. [Inhibitory effects of puerarin on invasion and metastasis of oophoroma cells HO-8910]. 2009 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:19852298
Li DZ et al. [Protective effect of puerarin on endothelial dysfunction of heat shock protein 60 induced specific immunity in apolipoprotein E-null mice]. 2006 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:17569333
Liu SD and Mo HP [Occurrence and prevention of adverse reaction induced by puerarin injection]. 2005 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:16248254
Xiao LZ et al. [Study on the effect and mechanism of puerarin on the size of infarction in patients with acute myocardial infarction]. 2004 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:15495821
Xiao LZ et al. [Comparative study on effects of puerarin and granulocyte colony-stimulating factor in treating acute myocardial infarction]. 2005 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:15842138
Wu XP et al. [Protective effects of puerarin against myocardial injury in patients with hypertension during perioperational period]. 2006 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:16613276
Wang YL et al. [Myocardial protective effect of puerarin injection in children with severe pneumonia]. 2005 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:16025962
Li JX et al. [Effect of puerarin on ADMA-DDAH system in human umbilical vein endothelial cells cultured with oxidized free radical]. 2006 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:17205823
Li DY et al. [Clinical significance of matrix metalloproteinase-9 and tissue factors secreted by cultured monocyte-derived macrophage of patients with coronary heart disease in vitro and the intervenient effect of puerarin on them]. 2007 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:17879530
Wang R et al. [Protective effects of puerarin on 60Co-gamma-induced acute injury of sertoli cells of testis in mice]. 2012 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:22686089
Han JQ et al. [Effects of puerarin on the neurocyte apoptosis and p-Akt (Ser473) expressions in rats with cerebral ischemia/reperfusion injury]. 2012 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:23173255
Zhang JQ and Zhou YP [Inhibition of aldose reductase from rat lens by some Chinese herbs and their components]. 1989 Zhongguo Zhong Yao Za Zhi pmid:2511877
Yu S et al. [Comparison of constituents in Pueraria thomsonii Benth before and after processing]. 1992 Zhongguo Zhong Yao Za Zhi pmid:1292491
Zhou Y et al. [Comparative study on pharmacological effects of various species of Pueraria]. 1995 Zhongguo Zhong Yao Za Zhi pmid:8679082
Chen L et al. [Effect of puerarin on cerebral blood flow in dogs]. 1995 Zhongguo Zhong Yao Za Zhi pmid:8679097
Zhang X et al. [Determination of puerarin in radix Puerariae and yufengningxin tablets by HPLC]. 1995 Zhongguo Zhong Yao Za Zhi pmid:8561884
Zhang L et al. [Determination of puerarin in various kinds of radix Puerariae from different places]. 1995 Zhongguo Zhong Yao Za Zhi pmid:7576135
Tan S et al. [Determination of puerarin in gegen ginlian tablets by RP-HPLC]. 1996 Zhongguo Zhong Yao Za Zhi pmid:9812678
Wang L et al. [Protective effect of puerarin on acute cerebral ischemia in rats]. 1997 Zhongguo Zhong Yao Za Zhi pmid:11243176
Zhu H et al. [Application and characteristics of macroreticular resin in purification study of different effective ingredients in Chinese medicines]. 1998 Zhongguo Zhong Yao Za Zhi pmid:11599359
Liu Q et al. [Effect of puerarin on coronary collateral circulation in dogs with experimental acute myocardial infarction]. 1999 Zhongguo Zhong Yao Za Zhi pmid:12205891
Jiang B et al. [Stable life prediction for a complex injection of Chinese materia medica by initial average rate stability test]. 2000 Zhongguo Zhong Yao Za Zhi pmid:12212078
Zhu ZT et al. [Inhibitive effect of puerarin on increased NO production by neonatal cardiomyocytes during hypoxia/reoxygenation injury]. 2001 Zhongguo Zhong Yao Za Zhi pmid:12776339
Huang YF et al. [Determination of puerarin in xinmaitong oral liquid by HPLC]. 2001 Zhongguo Zhong Yao Za Zhi pmid:12776346
Qi BL and Qi BM [Effect of the purariae-isofiavones on estrogen level in normal and ovariectomized rats]. 2002 Zhongguo Zhong Yao Za Zhi pmid:12776591
Ma YS et al. [Studies permeation of puerarin and its phospholipid complex through mouse skin in vitro]. 2000 Zhongguo Zhong Yao Za Zhi pmid:12512448
Liu S et al. [A study on processing of the root of Pueraria lobata (Willd.) ohwi by HPLC]. 1998 Zhongguo Zhong Yao Za Zhi pmid:12242820
Su B et al. [Rapid determination of puerarin in Xiaoke pill powder by near-infrared spectroscopy]. 2011 Zhongguo Zhong Yao Za Zhi pmid:21710725
Wu GL et al. [Effect of puerarin on levels of TGF-beta1 and alpha-SMA in rats with alcoholic injury liver]. 2008 Zhongguo Zhong Yao Za Zhi pmid:19166018
Jing L and Gao ZY [Retrospective analysis on Chinese medicinal treatment on 302 chronic heart failure patients of coronary heart disease and diabetes]. 2008 Zhongguo Zhong Yao Za Zhi pmid:19166020
Hu HT et al. [Effects of puerarin with aspirin on the markers of damaged vascular endothelial cells in patients with acute cerebral infarction]. 2008 Zhongguo Zhong Yao Za Zhi pmid:19260323
Wen BY et al. [Metabolic kinetic of puerarin in beagle liver microsomal by HPLC-ESI-MS]. 2008 Zhongguo Zhong Yao Za Zhi pmid:19260325
Han J et al. [Protective effect of 3'-methoxy puerarin on cerebral ischemic injury/ reperfusion in rats]. 2009 Zhongguo Zhong Yao Za Zhi pmid:19771877
Zou GX et al. [New method of multi-components quantitation by one marker new method for quality evaluation of Guanmaikang capsula]. 2008 Zhongguo Zhong Yao Za Zhi pmid:19007008
Cui JH et al. [Preparation and in vitro evaluation of gastroretentive dosage form containing puerarin-HP-beta-CD inclusion complex]. 2008 Zhongguo Zhong Yao Za Zhi pmid:19086628
Sun W et al. [Effects of puerarin on ADRP gene expression in fatty tissue of type 2 diabetes mellitus rats]. 2008 Zhongguo Zhong Yao Za Zhi pmid:19086646
Liu Y et al. [Corneal penetration of PAMAM dendrimers-coated puerarin liposomes]. 2010 Zhongguo Zhong Yao Za Zhi pmid:20349711
Zhang D et al. [Isoflavones from vines of Pueraria lobata]. 2009 Zhongguo Zhong Yao Za Zhi pmid:20353004
Jin G et al. [Effects of puerarin on expression of apelin and its receptor of 2K1C renal hypertension rats]. 2009 Zhongguo Zhong Yao Za Zhi pmid:20353015
Deng Y et al. [Preparation and lacrimal pharmacokinetics of eye drops of puerarin liposomes in rabbit tears]. 2010 Zhongguo Zhong Yao Za Zhi pmid:20422993
He D et al. [Improvement of solubility of puerarin through deoxycholate/phospholipid mixed micelle preparing technology]. 2010 Zhongguo Zhong Yao Za Zhi pmid:20822006
Guo D et al. [Study on pharmacokinetics and biodistribution of pur derivative nanopaticles in mice]. 2010 Zhongguo Zhong Yao Za Zhi pmid:21355276
Yao C et al. [Ocular pharmacokinetics of puerarin in anesthetic rabbits by microdialysis]. 2011 Zhongguo Zhong Yao Za Zhi pmid:22097338
Zhang X et al. [Puerarin induced apoptosis of pulmonary artery smooth muscle cell by mitochondrial pathway]. 2011 Zhongguo Zhong Yao Za Zhi pmid:22097342
Wang Q and Xu X [Progresses in research of hemolysis induced by puerarin injection]. 2011 Zhongguo Zhong Yao Za Zhi pmid:21837990
Cheng Y et al. [Protective effects of puerarin against 1-methyl-4-phenylpyridinium-induced mitochondrial apoptotic death in differentiated SH-SY5Y cells]. 2011 Zhongguo Zhong Yao Za Zhi pmid:21842654
Zhou HY et al. [Separation and determination of puerarin, daidzin and daidzein in stems and leaves of Pueraria thomsonii by RP-HPLC]. 2007 Zhongguo Zhong Yao Za Zhi pmid:17655152
Yang H et al. [Studies on effect of microemulsion in enhancing solubility of baicalin and puerarin]. 2007 Zhongguo Zhong Yao Za Zhi pmid:18161289
Liu R et al. [Inhibitory effect of quercetin, rutin and puerarin on LDL oxidation induced by Cu2+]. 2007 Zhongguo Zhong Yao Za Zhi pmid:18161305
Ding MP et al. [Effects of puerarin on expression of nuclear factor kappaB after cerebral ischemia/reperfusion in rats]. 2007 Zhongguo Zhong Yao Za Zhi pmid:18330247
Pan HP et al. [Protection of puerarin on the cerebral injury in the rats with acute local ischemia]. 2005 Zhongguo Zhong Yao Za Zhi pmid:15810455
Dong K et al. [Endothelium-independent vasorelaxant effect of puerarin on rat thoracic aorta]. 2004 Zhongguo Zhong Yao Za Zhi pmid:15631089
Pan HP et al. [Experimental study of puerarin injection on the hemorheology in acute blood-stasis model rats]. 2003 Zhongguo Zhong Yao Za Zhi pmid:15617506
Feng CG et al. [Progress in research of aldose reductase inhibitors in traditional medicinal herbs]. 2005 Zhongguo Zhong Yao Za Zhi pmid:16335816
Jin WS et al. [Determination of puerarin, daidzin and daidzein in root of Pueraria lobata of different origin by HPLC]. 2003 Zhongguo Zhong Yao Za Zhi pmid:15015267
Zhang FR et al. [Effects of puerarin on number and activity of endothelial progenitor cells from peripheral blood]. 2004 Zhongguo Zhong Yao Za Zhi pmid:15506293
Song CY and Bi HM [Effects of puerarin on plasma membrane GLUT4 content in skeletal muscle from insulin-resistant Sprague-Dawley rats under insulin stimulation]. 2004 Zhongguo Zhong Yao Za Zhi pmid:15719689
Guo XG et al. [Effect of puerarin on L-type calcium channel in isolated rat ventricular myocytes]. 2004 Zhongguo Zhong Yao Za Zhi pmid:15706853
Han J et al. [Effect of puerarin and daidzein on proliferating vascular smooth muscle cells]. 2004 Zhongguo Zhong Yao Za Zhi pmid:15706898
Pan HP et al. [Effect of puerarin on the expression of Hsp70 in the rats with cerebral injury induced by acute local ischemia]. 2005 Zhongguo Zhong Yao Za Zhi pmid:16011103
Zhao Y et al. [Experimental study of protective effect of pueraria compound on the cerebral ischemic injury]. 2005 Zhongguo Zhong Yao Za Zhi pmid:16011106
Zang HM et al. [Experimental study of the effects of puerarin on biological characters of osteoblasts in vitro]. 2005 Zhongguo Zhong Yao Za Zhi pmid:16494032
Xu YZ et al. [Puerarin suppresses the proliferation of vscular smooth muscule cells and c-fos and bcl-2 protein expression]. 2006 Zhongguo Zhong Yao Za Zhi pmid:16722382
Wang FW et al. [Protective effect of puerarin on stress-induced gastric mucosal injury in rats]. 2006 Zhongguo Zhong Yao Za Zhi pmid:16722386
Wang Y et al. [Effect of puerarin and ligustrazine on cultured hippocampal neurons injury induced by Abeta25-35]. 2008 Zhongguo Zhong Yao Za Zhi pmid:18533503
Zhang YB et al. [Protective effects of 3'-methoxy-puerarin on rat brain suffering from ischemia]. 2008 Zhongguo Zhong Yao Za Zhi pmid:18536378
Li JW et al. [Inhibition of puerarin on pulmonary hypertension in rats with hypoxia and hypercapnia]. 2008 Zhongguo Zhong Yao Za Zhi pmid:18536380
Yang ZD et al. [Chemical constituents in root of Hemerocallis fulva]. 2008 Zhongguo Zhong Yao Za Zhi pmid:18536463
Chen R et al. [Simultaneous quantification of five impurities in puerarin and its injections by HPLC method with correction factor]. 2011 Zhongguo Zhong Yao Za Zhi pmid:22032137
Wang Q et al. [Distribution of puerarin contained in Zige freeze-dried powder injection in rat liver and kidney]. 2012 Zhongguo Zhong Yao Za Zhi pmid:22994007
Han J et al. [Study on 3'-methoxy puerarin to dynamic changes of amino acids in rat brain ischemia-reperfusion]. 2012 Zhongguo Zhong Yao Za Zhi pmid:22792810
Deng L et al. [Effect of catalpol and puerarin freeze-dried powder on coagulability, hemorheology and no in rats with Qi-deficiency and blood-stasis syndrome]. 2012 Zhongguo Zhong Yao Za Zhi pmid:22860464
Liang X et al. [Intestinal absorption effect of Angelica dahurica extract on puerarin of puerariae Lobatae Radix]. 2012 Zhongguo Zhong Yao Za Zhi pmid:22860465
Zhang E et al. [Formulation optimization and drug release in vitro of membrane controlled tablets of puerarin inclusion compound]. 2013 Zhongguo Zhong Yao Za Zhi pmid:23596875
Huang ZG et al. [Effect of puerarin combined with felodipine on mRNA and protein expression of apelin and APJ in renovascular hypertensive rat]. 2013 Zhongguo Zhong Yao Za Zhi pmid:23668014
Xue C et al. [Determination of five components in Pueraria labta decoction with reference extraction method]. 2012 Zhongguo Zhong Yao Za Zhi pmid:23234135
Hu JJ et al. [Effect of pretreatment with puerarin on activation of LPS-induced RAW264. 7 cells]. 2012 Zhongguo Zhong Yao Za Zhi pmid:23311164
Liu XY et al. [Stability of PEGylated puerarin under different storage conditions]. 2012 Zhongguo Zhong Yao Za Zhi pmid:23373208
Deng Y et al. [Effect of phenformin hydrochloride on pharmacokinetics of puerarin in rats]. 2012 Zhongguo Zhong Yao Za Zhi pmid:23270242
Wang XC et al. [Effect of chaperone-mediated autophagy in MPP(+) -induced SH-SY5Y cells and interventional effect of puerarin]. 2014 Zhongguo Zhong Yao Za Zhi pmid:24754178
Xu XH [Effects of puerarin on fatty superoxide in aged mice induced by D-galactose]. 2003 Zhongguo Zhong Yao Za Zhi pmid:15015271
Lv JH et al. [Improvement effects of puerarin on glycated brain damages in rats induced by D-galactose]. 2006 Zhongguo Zhong Yao Za Zhi pmid:17048591