SCHEMBL105486

Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with SCHEMBL105486?

SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with SCHEMBL105486

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Alzheimer Disease D000544 76 associated lipids
Amnesia D000647 12 associated lipids
Angina Pectoris D000787 27 associated lipids
Angina, Unstable D000789 14 associated lipids
Arthritis D001168 41 associated lipids
Body Weight D001835 333 associated lipids
Burns D002056 34 associated lipids
Cataract D002386 34 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Brain Ischemia D002545 89 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Coronary Disease D003327 70 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Diabetes Mellitus, Experimental D003921 85 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Dyspepsia D004415 5 associated lipids
Endometriosis D004715 29 associated lipids
Fatty Liver D005234 48 associated lipids
Per page 10 20 50 | Total 43

PubChem Associated disorders and diseases

What pathways are associated with SCHEMBL105486

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with SCHEMBL105486?

Related references are published most in these journals:

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What functions are associated with SCHEMBL105486?


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Function Cross reference Weighted score Related literatures

What lipids are associated with SCHEMBL105486?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with SCHEMBL105486?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with SCHEMBL105486?

Knock-out

Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with SCHEMBL105486

Download all related citations
Per page 10 20 50 100 | Total 919
Authors Title Published Journal PubMed Link
Gao Q et al. Opening the calcium-activated potassium channel participates in the cardioprotective effect of puerarin. 2007 Eur. J. Pharmacol. pmid:17692311
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Wu JY et al. A microemulsion of puerarin-phospholipid complex for improving bioavailability: preparation, in vitro and in vivo evaluations. 2018 Drug Dev Ind Pharm pmid:29513046
Zhang L et al. Puerarin transport across a Calu-3 cell monolayer - an in vitro model of nasal mucosa permeability and the influence of paeoniflorin and menthol. 2016 Drug Des Devel Ther pmid:27468226
Zhang L et al. Puerarin transport across rat nasal epithelial cells and the influence of compatibility with peoniflorin and menthol. 2017 Drug Des Devel Ther pmid:28919709
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Liao D et al. N-trimethyl chitosan (TMC)-modified microemulsions for improved oral bioavailability of puerarin: preparation and evaluation. 2015 Drug Deliv pmid:24467620
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Huang FJ and Chan WH Apoptotic effects on maturation of mouse oocytes, fertilization and fetal development by puerarin. 2016 Drug Chem Toxicol pmid:26712108
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Weiping S et al. Self-assembly of an amphiphilic derivative of chitosan and micellar solubilization of puerarin. 2006 Colloids Surf B Biointerfaces pmid:16466908
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Liu B et al. Puerarin for ischaemic stroke. 2016 Cochrane Database Syst Rev pmid:26891451
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Zhao J et al. Botanical drug puerarin coordinates with nerve growth factor in the regulation of neuronal survival and neuritogenesis via activating ERK1/2 and PI3K/Akt signaling pathways in the neurite extension process. 2015 CNS Neurosci Ther pmid:25310912
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Li X et al. Puerarin protects against endothelial dysfunction and end-organ damage in Ang II-induced hypertension. 2017 Clin. Exp. Hypertens. pmid:28060542
Kim Y et al. Pharmacokinetics and Safety of DW1029M, a Botanical Drug for the Treatment of Diabetic Nephropathy, Following Single Doses in Healthy Subjects. 2017 Clin Pharmacol Drug Dev pmid:28301092
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Fan LL et al. The protective effect of puerarin against myocardial reperfusion injury. Study on cardiac function. 1992 Chin. Med. J. pmid:1576864
Lu XR et al. Puerarin beta-adrenergic receptor blocking effect. 1987 Chin. Med. J. pmid:2885157
Sheu SY et al. Stimulatory effect of puerarin on bone formation through co-activation of nitric oxide and bone morphogenetic protein-2/mitogen-activated protein kinases pathways in mice. 2012 Chin. Med. J. pmid:23075718
Fan LL et al. Pharmacologic studies on radix puerariae: effect of puerarin on regional myocardial blood flow and cardiac hemodynamics in dogs with acute myocardial ischemia. 1985 Chin. Med. J. pmid:3938713
Hao LN et al. Inducible nitric oxide synthase and Fas/FasL with C3 expression of mouse retinal pigment epithelial cells in response to stimulation by peroxynitrite and antagonism of puerarin. 2011 Chin. Med. J. pmid:21933599
Fan LL et al. Protective effect of puerarin against myocardial reperfusion injury. Myocardial metabolism and ultrastructure. 1992 Chin. Med. J. pmid:1451545
Qian Y et al. Blocking effect of puerarin on calcium channel in isolated guinea pig ventricular myocytes. 1999 Chin. Med. J. pmid:11717945
Sang HF et al. Effect of puerarin on neural function and histopathological damages after transient spinal cord ischemia in rabbits. 2004 Chin. J. Traumatol. pmid:15294110
Song J et al. Simultaneous determination of multiple marker constituents in concentrated Gegen Tang granule by high performance liquid chromatography. 2007 Chin Med pmid:17578586
Zhang L et al. Intestinal absorbability of three Radix Puerariae isoflavones including daidzein, daidzin and puerarin. 2011 Chin Med pmid:22108408
Zhang Z et al. Preventive effects of Flos Perariae (Gehua) water extract and its active ingredient puerarin in rodent alcoholism models. 2010 Chin Med pmid:20974012
Su SY and Hsieh CL Anti-inflammatory effects of Chinese medicinal herbs on cerebral ischemia. 2011 Chin Med pmid:21740583
Wong SM et al. Myocardial post-conditioning with Danshen-Gegen decoction protects against isoproterenol-induced myocardial injury via a PKCε/mKATP-mediated pathway in rats. 2011 Chin Med pmid:21320349
Yao M et al. Quantitative analysis of two isoflavones in Pueraria lobata flowers from eleven Chinese provinces using high performance liquid chromatography. 2010 Chin Med pmid:20416072
Yuan SY et al. Puerarin prevents bone loss in ovariectomized mice and inhibits osteoclast formation in vitro. 2016 Chin J Nat Med pmid:27114313
Liu AC et al. Pre-treatment with puerarin affects pharmacokinetics of warfarin, but not clopidogrel, in experimental rats. 2015 Chin J Nat Med pmid:25908622
Wang C et al. The proliferation, differentiation, and mineralization effects of puerarin on osteoblasts in vitro. 2014 Chin J Nat Med pmid:24969524
Wei SY et al. Progress on the pharmacological research of puerarin: a review. 2014 Chin J Nat Med pmid:24969520
Chen G et al. Puerarin attenuates angiotensin II-induced cardiac fibroblast proliferation via the promotion of catalase activity and the inhibition of hydrogen peroxide-dependent Rac-1 activation. 2018 Chin J Nat Med pmid:29425589
Liu AC et al. LC-MS/MS method for the determination of a new puerarin derivative and its application in pharmacokinetic studies in rats. 2013 Chin J Nat Med pmid:24359785
Wu HQ et al. Protective effects and mechanism of puerarin on learning-memory disorder after global cerebral ischemia-reperfusion injury in rats. 2009 Chin J Integr Med pmid:19271171
Liu Y et al. Induction of adhesion molecule expression in co-culture of human bronchial epithelial cells and neutrophils suppressed by puerarin via down-regulating p38 mitogen-activated protein kinase and nuclear factor κB pathways. 2014 Chin J Integr Med pmid:24122632
Zhang MY et al. In vitro and in vivo effects of puerarin on promotion of osteoblast bone formation. 2012 Chin J Integr Med pmid:22457138
Pang W et al. Effect of puerarin on the release of interleukin-8 in co-culture of human bronchial epithelial cells and neutrophils. 2012 Chin J Integr Med pmid:22457139
Zhao Y and Zhou Y Puerarin improve insulin resistance of adipocyte through activating Cb1 binding protein path. 2012 Chin J Integr Med pmid:22457141
Li SW et al. Comparison on Anticoagulation and Antiplatelet Aggregation Effects of Puerarin with Heparin Sodium and Tirofiban Hydrochloride: An In Vitro Study. 2018 Chin J Integr Med pmid:29067595
Wang HQ et al. Puerarin Up-regulates Methyl-CpG Binding Protein 2 Phosphorylation in Hippocampus of Vascular Dementia Rats. 2018 Chin J Integr Med pmid:29327124
Kong H et al. Effect of Puerarin on the Pharmacokinetics of Baicalin in Gegen Qinlian Decoction () in Mice. 2018 Chin J Integr Med pmid:25908218
Qi H et al. Optimization and physicochemical characterization of thermosensitive poloxamer gel containing puerarin for ophthalmic use. 2006 Chem. Pharm. Bull. pmid:17077546
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Song XB et al. Puerarin protects against cadmium-induced proximal tubular cell apoptosis by restoring mitochondrial function. 2016 Chem. Biol. Interact. pmid:27717697
Liu CM et al. Puerarin protects mouse liver against nickel-induced oxidative stress and inflammation associated with the TLR4/p38/CREB pathway. 2016 Chem. Biol. Interact. pmid:26607348
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Tang L et al. The protective effects of puerarin in cardiomyocytes from anoxia/reoxygenation injury are mediated by PKCε. 2014 Cell Biochem. Funct. pmid:24496955
Gan M and Yin X Puerarin induced in mantle cell lymphoma apoptosis and its possible mechanisms involving multi-signaling pathway. 2015 Cell Biochem. Biophys. pmid:25173778
Li D et al. In vitro enzymatic modification of puerarin to puerarin glycosides by maltogenic amylase. 2004 Carbohydr. Res. pmid:15542087
Yu Z and Li W Induction of apoptosis by puerarin in colon cancer HT-29 cells. 2006 Cancer Lett. pmid:16055262
Bao MH et al. Puerarin protects endothelial cells from oxidized low density lipoprotein induced injuries via the suppression of LOX-1 and induction of eNOS. 2014 Can. J. Physiol. Pharmacol. pmid:24708212
Mahdy HM et al. The anti-apoptotic and anti-inflammatory properties of puerarin attenuate 3-nitropropionic-acid induced neurotoxicity in rats. 2014 Can. J. Physiol. Pharmacol. pmid:24593790
Liu S et al. Puerarin attenuates severe burn-induced acute myocardial injury in rats. 2015 Burns pmid:26514700
Zhang J et al. Effects of puerarin on the inflammatory role of burn-related procedural pain mediated by P2X(7) receptors. 2013 Burns pmid:23044342
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