Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
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Authors | Title | Published | Journal | PubMed Link |
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Guo XF et al. | Synergistic antitumor effect of puerarin combined with 5-fluorouracil on gastric carcinoma. | 2015 | Mol Med Rep | pmid:25434307 |
Zhang Y et al. | The Puerarin improves renal function in STZ-induced diabetic rats by attenuating eNOS expression. | 2015 | Ren Fail | pmid:25707518 |
Yang X et al. | Puerarin decreases bone loss and collagen destruction in rats with ligature-induced periodontitis. | 2015 | J. Periodont. Res. | pmid:25645818 |
Qu J et al. | Puerarin alleviates noise-induced hearing loss via affecting PKCγ and GABAB receptor expression. | 2015 | J. Neurol. Sci. | pmid:25592416 |
Guo HD et al. | Large scale purification of puerarin from Puerariae Lobatae Radix through resins adsorption and acid hydrolysis. | 2015 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:25553536 |
Wang X et al. | De novo transcriptome sequencing in Pueraria lobata to identify putative genes involved in isoflavones biosynthesis. | 2015 | Plant Cell Rep. | pmid:25547742 |
Wang J et al. | Puerarin attenuates airway inflammation by regulation of eotaxin-3. | 2015 | Immunol. Lett. | pmid:25530546 |
Liang XL et al. | Mechanisms of improvement of intestinal transport of baicalin and puerarin by extracts of Radix Angelicae Dahuricae. | 2015 | Phytother Res | pmid:25312586 |
Yang S et al. | Protective effects of puerarin against tetrabromobisphenol a-induced apoptosis and cardiac developmental toxicity in zebrafish embryo-larvae. | 2015 | Environ. Toxicol. | pmid:24596333 |
Kang OH et al. | Puerarin ameliorates hepatic steatosis by activating the PPARα and AMPK signaling pathways in hepatocytes. | 2015 | Int. J. Mol. Med. | pmid:25605057 |