Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Zhu ZT et al. | [Inhibitive effect of puerarin on increased NO production by neonatal cardiomyocytes during hypoxia/reoxygenation injury]. | 2001 | Zhongguo Zhong Yao Za Zhi | pmid:12776339 |
Huang YF et al. | [Determination of puerarin in xinmaitong oral liquid by HPLC]. | 2001 | Zhongguo Zhong Yao Za Zhi | pmid:12776346 |
Chen R et al. | [Simultaneous quantification of five impurities in puerarin and its injections by HPLC method with correction factor]. | 2011 | Zhongguo Zhong Yao Za Zhi | pmid:22032137 |
Liu Y et al. | [Corneal penetration of PAMAM dendrimers-coated puerarin liposomes]. | 2010 | Zhongguo Zhong Yao Za Zhi | pmid:20349711 |
Cheng Y et al. | [Protective effects of puerarin against 1-methyl-4-phenylpyridinium-induced mitochondrial apoptotic death in differentiated SH-SY5Y cells]. | 2011 | Zhongguo Zhong Yao Za Zhi | pmid:21842654 |
Wang C et al. | [Therapeutic effect of puerarin on rats with pre-eclampsia]. | 2006 | Zhonghua Fu Chan Ke Za Zhi | pmid:16640862 |
Xu HX et al. | [Mechanism of advanced glycation end-products in the inducement of apoptosis of human gingival fibroblast and related effect of puerarin in the process]. | 2011 | Zhonghua Kou Qiang Yi Xue Za Zhi | pmid:21418943 |
Chen C et al. | [Effects of puerarin on proliferation, apoptosis and Kv1.5 gene expression of pulmonary artery smooth muscle cells induced by hypoxia]. | 2011 | Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi | pmid:22357486 |
Luo ZK et al. | [A clinical efficacy and safety study on coronary heart disease and angina treatment with Puerarin Injection]. | 2012 | Zhonghua Liu Xing Bing Xue Za Zhi | pmid:22883272 |
Han P et al. | [Potential antiviral drug Pueraria crude extract and puerarin protect against ethanol-induced cytotoxicity in embryonic mouse hippocampal cultures]. | 2005 | Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi | pmid:16261207 |
Li XY et al. | [The effect of intravenous puerarin on acute myocardial infarction]. | 1985 | Zhonghua Xin Xue Guan Bing Za Zhi | pmid:4092596 |
Ji O et al. | [Effect of flavonoids of puerarin on the proliferation and apoptosis of retinoic acid resistant acute promyelocytic leukemia cell line NB4-R1 cells]. | 2013 | Zhonghua Xue Ye Xue Za Zhi | pmid:23688762 |
Hao LN et al. | [Peroxynitrite-induced formation of diabetic cataract and its prevention by puerarin in rat]. | 2004 | Zhonghua Yan Ke Za Zhi | pmid:15312625 |
Hao LN et al. | [Protective effects of puerarin on lens epithelial cells in rat diabetic cataract]. | 2011 | Zhonghua Yan Ke Za Zhi | pmid:21612681 |
Hao LN et al. | [The effect of puerarin on prevention of oxidative damage of cultured lens capsule epithelial cells]. | 2008 | Zhonghua Yan Ke Za Zhi | pmid:18683704 |
Kang RX | [The intraocular pressure depressive effect of puerarin]. | 1993 | Zhonghua Yan Ke Za Zhi | pmid:7912669 |
Han P et al. | [Effect of pueraria crude extreact and puerarin on ethanol-induced expression of heat shock protein 70 in embryonic mouse hippocampal cultures]. | 2005 | Zhonghua Yi Xue Za Zhi | pmid:16324368 |
Xu YZ et al. | [Effects of puerarin on proliferation of vascular smooth muscle cells induced by thrombin]. | 2006 | Zhonghua Yi Xue Za Zhi | pmid:16677576 |
Li QX et al. | [Effect of compound Puerarin on the collage IV in streptozotocin-induced diabetic nephropathy rats]. | 2008 | Zhonghua Yu Fang Yi Xue Za Zhi | pmid:18763636 |