SCHEMBL105486
Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with SCHEMBL105486?
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
PubChem Associated disorders and diseases
What pathways are associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with SCHEMBL105486?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
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What functions are associated with SCHEMBL105486?
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What lipids are associated with SCHEMBL105486?
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What genes are associated with SCHEMBL105486?
Related references are published most in these journals:
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What common seen animal models are associated with SCHEMBL105486?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
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NCBI Entrez Crosslinks
All references with SCHEMBL105486
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Liao D et al. | N-trimethyl chitosan (TMC)-modified microemulsions for improved oral bioavailability of puerarin: preparation and evaluation. | 2015 | Drug Deliv | pmid:24467620 |
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| Zhang L et al. | Puerarin transport across a Calu-3 cell monolayer - an in vitro model of nasal mucosa permeability and the influence of paeoniflorin and menthol. | 2016 | Drug Des Devel Ther | pmid:27468226 |
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| Wu JY et al. | A microemulsion of puerarin-phospholipid complex for improving bioavailability: preparation, in vitro and in vivo evaluations. | 2018 | Drug Dev Ind Pharm | pmid:29513046 |
| Tang X et al. | Phytoestrogens induce differential estrogen receptor beta-mediated responses in transfected MG-63 cells. | 2008 Aug-Dec | Endocrine | pmid:18937077 |
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| Zhang H et al. | Puerarin protects Alzheimer's disease neuronal cybrids from oxidant-stress induced apoptosis by inhibiting pro-death signaling pathways. | 2011 | Exp. Gerontol. | pmid:20933077 |
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| Liu CM et al. | Puerarin protects the rat liver against oxidative stress-mediated DNA damage and apoptosis induced by lead. | 2012 | Exp. Toxicol. Pathol. | pmid:21146379 |
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| Pan ZY et al. | The myocardial protective effects of puerarin on STZ-induced diabetic rats. | 2009 | Fen Zi Xi Bao Sheng Wu Xue Bao | pmid:19537197 |
| Cao L et al. | Pharmacokinetics of puerarin in pregnant rats at different stages of gestation after oral administration. | 2013 | Fitoterapia | pmid:23500385 |
| Malaivijitnond S et al. | Puerarin exhibits weak estrogenic activity in female rats. | 2010 | Fitoterapia | pmid:20117180 |
| Liu G et al. | Hydroxylation modification and free radical scavenging activity of puerarin-7-O-fructoside. | 2011 | Folia Microbiol. (Praha) | pmid:21818614 |
| Clarke DB et al. | Determination of phytoestrogens in dietary supplements by LC-MS/MS. | 2008 | Food Addit Contam Part A Chem Anal Control Expo Risk Assess | pmid:18478479 |
| Fan JP et al. | Optimization of ionic liquid based ultrasonic assisted extraction of puerarin from Radix Puerariae Lobatae by response surface methodology. | 2012 | Food Chem | pmid:22980805 |
| Wang S et al. | Optimization of ionic liquids-based microwave-assisted hydrolysis of puerarin and daidzein derivatives from Radix Puerariae Lobatae extract. | 2018 | Food Chem | pmid:29606431 |
| Ma JQ et al. | Puerarin ameliorates carbon tetrachloride-induced oxidative DNA damage and inflammation in mouse kidney through ERK/Nrf2/ARE pathway. | 2014 | Food Chem. Toxicol. | pmid:24975872 |
| Yu C et al. | Decreased expression of aromatase in the Ishikawa and RL95-2 cells by the isoflavone, puerarin, is associated with inhibition of c-jun expression and AP-1 activity. | 2008 | Food Chem. Toxicol. | pmid:18848966 |
| Liu CM et al. | Protective role of puerarin on lead-induced alterations of the hepatic glutathione antioxidant system and hyperlipidemia in rats. | 2011 | Food Chem. Toxicol. | pmid:22001170 |
| Guo C et al. | Anti-fibrotic effects of puerarin on CCl4-induced hepatic fibrosis in rats possibly through the regulation of PPAR-γ expression and inhibition of PI3K/Akt pathway. | 2013 | Food Chem. Toxicol. | pmid:23500774 |
| Li R et al. | Puerarin mediates hepatoprotection against CCl4-induced hepatic fibrosis rats through attenuation of inflammation response and amelioration of metabolic function. | 2013 | Food Chem. Toxicol. | pmid:23146695 |
| Xia DZ et al. | Hepatoprotective activity of puerarin against carbon tetrachloride-induced injuries in rats: a randomized controlled trial. | 2013 | Food Chem. Toxicol. | pmid:23764356 |
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| Tu YM et al. | A high concentration of fatty acids induces TNF-α as well as NO release mediated by the P2X4 receptor, and the protective effects of puerarin in RAW264.7 cells. | 2017 | Food Funct | pmid:28937704 |
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| Chen YY et al. | Puerarin protects human umbilical vein endothelial cells against high glucose-induced apoptosis by upregulating heme oxygenase-1 and inhibiting calpain activation. | 2012 | Fundam Clin Pharmacol | pmid:21352351 |
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