SCHEMBL105486
Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
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Introduction
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with SCHEMBL105486?
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
PubChem Associated disorders and diseases
What pathways are associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with SCHEMBL105486?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
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What functions are associated with SCHEMBL105486?
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What lipids are associated with SCHEMBL105486?
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What genes are associated with SCHEMBL105486?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with SCHEMBL105486?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
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NCBI Entrez Crosslinks
All references with SCHEMBL105486
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Yan B et al. | Determination of puerarin in rat cortex by high-performance liquid chromatography after intravenous administration of Puerariae flavonoids. | 2006 | Biomed. Chromatogr. | pmid:16078309 |
| Yu Z and Li W | Induction of apoptosis by puerarin in colon cancer HT-29 cells. | 2006 | Cancer Lett. | pmid:16055262 |
| Weiping S et al. | Self-assembly of an amphiphilic derivative of chitosan and micellar solubilization of puerarin. | 2006 | Colloids Surf B Biointerfaces | pmid:16466908 |
| Yan LP et al. | Puerarin decreases serum total cholesterol and enhances thoracic aorta endothelial nitric oxide synthase expression in diet-induced hypercholesterolemic rats. | 2006 | Life Sci. | pmid:16472823 |
| Yu AH et al. | [Preparation of puerarin solid self-microemulsion]. | 2006 | Zhong Yao Cai | pmid:17076244 |
| Qi H et al. | Optimization and physicochemical characterization of thermosensitive poloxamer gel containing puerarin for ophthalmic use. | 2006 | Chem. Pharm. Bull. | pmid:17077546 |
| Wu CJ et al. | Promoting effect of borneol on the permeability of puerarin eye drops and timolol maleate eye drops through the cornea in vitro. | 2006 | Pharmazie | pmid:17020156 |
| Yeung DK et al. | Puerarin, an isoflavonoid derived from Radix puerariae, potentiates endothelium-independent relaxation via the cyclic AMP pathway in porcine coronary artery. | 2006 | Eur. J. Pharmacol. | pmid:17027964 |
| Chen L et al. | Simultaneous analysis of nine active components in Gegen Qinlian preparations by high-performance liquid chromatography with diode array detection. | 2006 | J Sep Sci | pmid:17069251 |
| Kim JM et al. | Constituents of the roots of Pueraria lobata inhibit formation of advanced glycation end products (AGEs). | 2006 | Arch. Pharm. Res. | pmid:17121174 |
| Park EK et al. | Intestinal bacteria activate estrogenic effect of main constituents puerarin and daidzin of Pueraria thunbergiana. | 2006 | Biol. Pharm. Bull. | pmid:17142977 |
| Liu R et al. | Pharmacokinetics of puerarin and ginsenoside Rg1 of CBN injection and the relation with platelet aggregation in rats. | 2006 | Am. J. Chin. Med. | pmid:17163592 |
| Pan J et al. | [Isolation and purification of puerarin from puerarin extractive by chelate complex chromatography]. | 2006 | Se Pu | pmid:17165543 |
| Chen M et al. | [Determination of puerarin in Kangshen granule by reversed-phase high performance liquid chromatography]. | 2006 | Se Pu | pmid:17165545 |
| Ren F et al. | Quantitative determination of puerarin in dog plasma by HPLC and study on the relative bioavailability of sustained release tablets. | 2006 | J Pharm Biomed Anal | pmid:16413737 |
| Zhang S et al. | Puerarin induces angiogenesis in myocardium of rat with myocardial infarction. | 2006 | Biol. Pharm. Bull. | pmid:16651724 |
| Li Y et al. | Pharmacokinetic, tissue distribution, and excretion of puerarin and puerarin-phospholipid complex in rats. | 2006 | Drug Dev Ind Pharm | pmid:16638679 |
| Wang C et al. | [Therapeutic effect of puerarin on rats with pre-eclampsia]. | 2006 | Zhonghua Fu Chan Ke Za Zhi | pmid:16640862 |
| Yu Z et al. | Simultaneous determination of components in preparation Naodesheng injection by high performance liquid chromatograph-atmospheric pressure chemical ionization mass spectrometry (HPLC-MS/APCI). | 2006 | Chem. Pharm. Bull. | pmid:16595973 |
| Wu XP et al. | [Protective effects of puerarin against myocardial injury in patients with hypertension during perioperational period]. | 2006 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:16613276 |
| Zhang B et al. | [Protective effects of hydroxyethylpuerarin against brain astrocytes injury induced by hydrogen peroxide]. | 2006 | Yao Xue Xue Bao | pmid:16671550 |
| Xu YZ et al. | [Effects of puerarin on proliferation of vascular smooth muscle cells induced by thrombin]. | 2006 | Zhonghua Yi Xue Za Zhi | pmid:16677576 |
| Xu YZ et al. | [Puerarin suppresses the proliferation of vscular smooth muscule cells and c-fos and bcl-2 protein expression]. | 2006 | Zhongguo Zhong Yao Za Zhi | pmid:16722382 |
| Deng X et al. | [Pharmacokinetics of puerarin in the aqueous humor and vitreous of rabbit eye following systemic administration]. | 2006 | Yan Ke Xue Bao | pmid:17378162 |
| Li DZ et al. | [Protective effect of puerarin on endothelial dysfunction of heat shock protein 60 induced specific immunity in apolipoprotein E-null mice]. | 2006 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:17569333 |
| Tian H et al. | Liquid chromatography-mass spectrometric analysis of puerarin and its metabolite in human urine. | 2006 | J Sep Sci | pmid:17313111 |
| Zhang SP et al. | [The experimental study of Radix Puerariae inhibiting glycation in rats induced by D-galactose]. | 2006 | Zhong Yao Cai | pmid:16850728 |
| Penetar DM et al. | Pharmacokinetic profile of the isoflavone puerarin after acute and repeated administration of a novel kudzu extract to human volunteers. | 2006 Jul-Aug | J Altern Complement Med | pmid:16884345 |
| Yu Z et al. | Determination of safflor yellow A, puerarin, ferulic acid, ginsenoside Rg1, and Rb1 in the Traditional Chinese Medicinal preparation Naodesheng injection by high-performance liquid chromatography. | 2006 May-Jun | J Chromatogr Sci | pmid:16774713 |
| Yan H et al. | Treating senile dementia with traditional Chinese medicine. | 2007 | Clin Interv Aging | pmid:18044136 |
| Mo SF et al. | Hypouricemic action of selected flavonoids in mice: structure-activity relationships. | 2007 | Biol. Pharm. Bull. | pmid:17666819 |
| Song J et al. | Simultaneous determination of multiple marker constituents in concentrated Gegen Tang granule by high performance liquid chromatography. | 2007 | Chin Med | pmid:17578586 |
| Wu B et al. | Meta-analysis of traditional Chinese patent medicine for ischemic stroke. | 2007 | Stroke | pmid:17463317 |
| Cherdshewasart W et al. | Major isoflavonoid contents of the phytoestrogen rich-herb Pueraria mirifica in comparison with Pueraria lobata. | 2007 | J Pharm Biomed Anal | pmid:16930918 |
| Xi J and Guo R | Acid-base equilibrium of puerarin in CTAB micelles. | 2007 | J Pharm Biomed Anal | pmid:16935449 |
| Liang JQ et al. | [The protective function of puerarin to the injury of the lung and its mechanisms during diabetes]. | 2007 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21162284 |
| Prasain JK et al. | Pharmacokinetic study of puerarin in rat serum by liquid chromatography tandem mass spectrometry. | 2007 | Biomed. Chromatogr. | pmid:17221935 |
| Wu C et al. | Preparation and evaluation of a Carbopol/HPMC-based in situ gelling ophthalmic system for puerarin. | 2007 | Yakugaku Zasshi | pmid:17202799 |
| Yang GJ et al. | The simultaneous separation and determination of six flavonoids and troxerutin in rat urine and chicken plasma by reversed-phase high-performance liquid chromatography with ultraviolet-visible detection. | 2007 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:17588830 |
| Li DY et al. | [Clinical significance of matrix metalloproteinase-9 and tissue factors secreted by cultured monocyte-derived macrophage of patients with coronary heart disease in vitro and the intervenient effect of puerarin on them]. | 2007 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:17879530 |
| Li Q et al. | [Study of regulation of Puerarin on blood P-selectin and the expression of aorta VCAM mRNA in diabetes]. | 2007 | Wei Sheng Yan Jiu | pmid:18095572 |
| Kim YS et al. | The role of intestinal microflora on daidzein excretion in urine in humans treated with Chungpesagantang. | 2007 | Arch. Pharm. Res. | pmid:17489365 |
| Rachoń D et al. | Dietary daidzein and puerarin do not affect pituitary LH expression but exert uterotropic effects in ovariectomized rats. | 2007 | Maturitas | pmid:17258874 |
| Singh AK et al. | Herbal mixtures consisting of puerarin and either polyenylphosphatidylcholine or curcumin provide comprehensive protection against alcohol-related disorders in P rats receiving free choice water and 15% ethanol in pure water. | 2007 | J Med Food | pmid:17887948 |
| Xu XH et al. | Inhibition of excitatory amino acid efflux contributes to protective effects of puerarin against cerebral ischemia in rats. | 2007 | Biomed. Environ. Sci. | pmid:17948770 |
| Cherdshewasart W and Sriwatcharakul S | Major isoflavonoid contents of the 1-year-cultivated phytoestrogen-rich herb, Pueraria mirifica. | 2007 | Biosci. Biotechnol. Biochem. | pmid:17928711 |
| Yue PF et al. | Development and optimization of intravenous puerarin emulsions formation by a novel complex-phase inversion-homogenization technology. | 2007 | Chem. Pharm. Bull. | pmid:17978512 |
| Xiao J et al. | Analysis of binding interaction between puerarin and bovine serum albumin by multi-spectroscopic method. | 2007 | J Pharm Biomed Anal | pmid:17942262 |
| Quan DQ and Xu GX | Formulation optimization of self-emulsifying preparations of puerarin through self-emulsifying performances evaluation in vitro and pharmacokinetic studies in vivo. | 2007 | Yao Xue Xue Bao | pmid:17944241 |
| Qi H et al. | Development of a poloxamer analogs/carbopol-based in situ gelling and mucoadhesive ophthalmic delivery system for puerarin. | 2007 | Int J Pharm | pmid:17254725 |
| Wong R and Rabie B | Effect of puerarin on bone formation. | 2007 | Osteoarthr. Cartil. | pmid:17379543 |
| Han RM et al. | Puerarin and conjugate bases as radical scavengers and antioxidants: molecular mechanism and synergism with beta-carotene. | 2007 | J. Agric. Food Chem. | pmid:17300199 |
| Yu Z et al. | HPLC determination of safflor yellow A and three active isoflavones from TCM Naodesheng in rat plasma and tissues and its application to pharmacokinetic studies. | 2007 | Biomed. Chromatogr. | pmid:17385809 |
| Zhao T et al. | The mechanism of 3-methoxy puerarin on decreasing the cerebral ischemia-reperfusion injury in rats. | 2007 | Asia Pac J Clin Nutr | pmid:17392123 |
| Wang HG et al. | [Preparation and characterization of chitosan coated puerarin liposomes]. | 2007 | Zhong Yao Cai | pmid:17539312 |
| Xu YC et al. | Structure-activity relationships of flavonoids for vascular relaxation in porcine coronary artery. | 2007 | Phytochemistry | pmid:17395220 |
| Yu Z et al. | Simultaneous determination of safflor yellow A, puerarin, daidzein, ginsenosides (Rg(1), Rb(1), Rd), and notoginsenoside R(1) in rat plasma by liquid chromatography-mass spectrometry. | 2007 | J Pharm Biomed Anal | pmid:17590558 |
| Xu X and Zhang Z | Effects of puerarin on synaptic structural modification in hippocampus of ovariectomized mice. | 2007 | Planta Med. | pmid:17628835 |
| Zhang Y et al. | Stimulatory effect of puerarin on bone formation through activation of PI3K/Akt pathway in rat calvaria osteoblasts. | 2007 | Planta Med. | pmid:17443435 |
| Wang J et al. | Detection of flavonoids and assay for their antioxidant activity based on enlargement of gold nanoparticles. | 2007 | Anal Bioanal Chem | pmid:17479255 |
| Wu L et al. | Cardioprotective effects of the combined use of puerarin and Danshensu on acute ischemic myocardial injury in rats. | 2007 | Phytother Res | pmid:17450507 |
| Quan DQ et al. | Studies on preparation and absolute bioavailability of a self-emulsifying system containing puerarin. | 2007 | Chem. Pharm. Bull. | pmid:17473473 |
| Gao R et al. | Gradient high-performance liquid chromatography for the simultaneous determination of chlorogenic acid and baicalin in plasma and its application in the study of pharmacokinetics in rats. | 2007 | J Pharm Biomed Anal | pmid:16859859 |
| Zhou HY et al. | [Separation and determination of puerarin, daidzin and daidzein in stems and leaves of Pueraria thomsonii by RP-HPLC]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:17655152 |
| Li H et al. | Fragmentation study of a 8-C-glycosyl isoflavone, puerarin, using electrospray ion trap time-of-flight mass spectrometry at high resolution. | 2007 | Rapid Commun. Mass Spectrom. | pmid:17610215 |
| Lin F et al. | Puerarin facilitates Ca(2+)-induced Ca(2+) release triggered by KCl-depolarization in primary cultured rat hippocampal neurons. | 2007 | Eur. J. Pharmacol. | pmid:17610871 |
| Sun XH et al. | Activation of large-conductance calcium-activated potassium channels by puerarin: the underlying mechanism of puerarin-mediated vasodilation. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17652634 |
| Gu YZ et al. | [Preparation of puerarin liposome and its oral absorption in rat]. | 2007 | Zhong Yao Cai | pmid:18074848 |
| Zhang GW et al. | [Studies on the interaction between puerarin and bovine serum albumin]. | 2007 | Guang Pu Xue Yu Guang Pu Fen Xi | pmid:18051529 |
| Hwang YP et al. | Protective effects of puerarin on carbon tetrachloride-induced hepatotoxicity. | 2007 | Arch. Pharm. Res. | pmid:18038910 |
| Yang H et al. | [Studies on effect of microemulsion in enhancing solubility of baicalin and puerarin]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:18161289 |
| Liu R et al. | [Inhibitory effect of quercetin, rutin and puerarin on LDL oxidation induced by Cu2+]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:18161305 |
| Lu Y et al. | [Pharmacokinetics of pueraria for intranasal on spray in rabbits]. | 2007 | Zhong Yao Cai | pmid:18236755 |
| Wu L et al. | Protective roles of puerarin and Danshensu on acute ischemic myocardial injury in rats. | 2007 | Phytomedicine | pmid:17870452 |
| Xu X and Zheng X | Potential involvement of calcium and nitric oxide in protective effects of puerarin on oxygen-glucose deprivation in cultured hippocampal neurons. | 2007 | J Ethnopharmacol | pmid:17698307 |
| Yue PF et al. | [Preparation and characterization of the puerarin submicron emulsion]. | 2007 | Yao Xue Xue Bao | pmid:17702404 |
| Gao Q et al. | Opening the calcium-activated potassium channel participates in the cardioprotective effect of puerarin. | 2007 | Eur. J. Pharmacol. | pmid:17692311 |
| Ding MP et al. | [Effects of puerarin on expression of nuclear factor kappaB after cerebral ischemia/reperfusion in rats]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:18330247 |
| Guo Y et al. | [Study on effect of different combinations of traditional Chinese medicine preparation active parts on metabolism of puerarin in plasma of rats]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:18330251 |
| Dong-Qin Q et al. | Formulation development and pharmacokinetics of puerarin self-emulsifying drug delivery systems. | 2007 Jan-Feb | PDA J Pharm Sci Technol | pmid:17390702 |
| Yang B et al. | [Mitochondrial mechanism of cardioprotective effect of puerarin against H202-stress in rats]. | 2008 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21158136 |
| Wang Y et al. | [Effect of puerarin and ligustrazine on cultured hippocampal neurons injury induced by Abeta25-35]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:18533503 |
| Zhang YB et al. | [Protective effects of 3'-methoxy-puerarin on rat brain suffering from ischemia]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:18536378 |
| Li JW et al. | [Inhibition of puerarin on pulmonary hypertension in rats with hypoxia and hypercapnia]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:18536380 |
| Yu CQ | [Treatment of endometriosis by puerarin]. | 2008 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:19213335 |
| Yang ZD et al. | [Chemical constituents in root of Hemerocallis fulva]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:18536463 |
| Zhang HY et al. | Puerarin protects PC12 cells against beta-amyloid-induced cell injury. | 2008 | Cell Biol. Int. | pmid:18675923 |
| Hao LN et al. | [The effect of puerarin on prevention of oxidative damage of cultured lens capsule epithelial cells]. | 2008 | Zhonghua Yan Ke Za Zhi | pmid:18683704 |
| Reppert A et al. | Isolation of radiolabeled isoflavones from kudzu (Pueraria lobata) root cultures. | 2008 | J. Agric. Food Chem. | pmid:18690681 |
| Ye XY et al. | [Effect of puerarin injection on the mRNA expressions of AT1 and ACE2 in spontaneous hypertension rats]. | 2008 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:19065898 |
| Zou GX et al. | [New method of multi-components quantitation by one marker new method for quality evaluation of Guanmaikang capsula]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:19007008 |
| Cui JH et al. | [Preparation and in vitro evaluation of gastroretentive dosage form containing puerarin-HP-beta-CD inclusion complex]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:19086628 |
| Sun W et al. | [Effects of puerarin on ADRP gene expression in fatty tissue of type 2 diabetes mellitus rats]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:19086646 |
| Cherdshewasart W et al. | Determination of the estrogenic activity of wild phytoestrogen-rich Pueraria mirifica by MCF-7 proliferation assay. | 2008 | J. Reprod. Dev. | pmid:18160771 |
| Wang Q et al. | Quantification of puerarin in plasma by on-line solid-phase extraction column switching liquid chromatography-tandem mass spectrometry and its applications to a pharmacokinetic study. | 2008 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:18242154 |
| Tan Y et al. | Puerarin for acute ischaemic stroke. | 2008 | Cochrane Database Syst Rev | pmid:18254067 |
| Wang Z et al. | Study on the interaction of puerarin with lysozyme by spectroscopic methods. | 2008 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:18262462 |
| Yue PF et al. | The study to reduce the hemolysis side effect of puerarin by a submicron emulsion delivery system. | 2008 | Biol. Pharm. Bull. | pmid:18175940 |
| Li Y et al. | Comparative physicochemical characterization of phospholipids complex of puerarin formulated by conventional and supercritical methods. | 2008 | Pharm. Res. | pmid:17828444 |
| Wang Y et al. | Preventive effects of puerarin on alcohol-induced osteonecrosis. | 2008 | Clin. Orthop. Relat. Res. | pmid:18350350 |