Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Zhou Y et al. | [Comparative study on pharmacological effects of various species of Pueraria]. | 1995 | Zhongguo Zhong Yao Za Zhi | pmid:8679082 |
Chen L et al. | [Effect of puerarin on cerebral blood flow in dogs]. | 1995 | Zhongguo Zhong Yao Za Zhi | pmid:8679097 |
Zhang X et al. | [Determination of puerarin in radix Puerariae and yufengningxin tablets by HPLC]. | 1995 | Zhongguo Zhong Yao Za Zhi | pmid:8561884 |
Zhang L et al. | [Determination of puerarin in various kinds of radix Puerariae from different places]. | 1995 | Zhongguo Zhong Yao Za Zhi | pmid:7576135 |
Keung WM and Vallee BL | Therapeutic lessons from traditional Oriental medicine to contemporary Occidental pharmacology. | 1994 | EXS | pmid:8032168 |
Wang LY et al. | [Effects of puerarin on cat vascular smooth muscle in vitro]. | 1994 | Zhongguo Yao Li Xue Bao | pmid:8010117 |
Kang RX | [The intraocular pressure depressive effect of puerarin]. | 1993 | Zhonghua Yan Ke Za Zhi | pmid:7912669 |
Yasuda T et al. | [A simultaneous determination of daidzin and puerarin and determination of daidzein in Oriental pharmaceutical decoctions containing puerariae radix by ion-pair high-performance liquid chromatography]. | 1993 | Yakugaku Zasshi | pmid:8301541 |
Fan LL et al. | The protective effect of puerarin against myocardial reperfusion injury. Study on cardiac function. | 1992 | Chin. Med. J. | pmid:1576864 |
Yu S et al. | [Comparison of constituents in Pueraria thomsonii Benth before and after processing]. | 1992 | Zhongguo Zhong Yao Za Zhi | pmid:1292491 |
Fan LL et al. | Protective effect of puerarin against myocardial reperfusion injury. Myocardial metabolism and ultrastructure. | 1992 | Chin. Med. J. | pmid:1451545 |
Jin XL and Zhu XY | [Pharmacokinetics of puerarin in rats, rabbits, and dogs]. | 1992 | Zhongguo Yao Li Xue Bao | pmid:1442117 |
Xu LX et al. | Determination of 4'-methoxy-puerarin in puerarin by reversed phase HPLC. | 1991 | Yao Xue Xue Bao | pmid:1789117 |
Zhang JQ and Zhou YP | [Inhibition of aldose reductase from rat lens by some Chinese herbs and their components]. | 1989 | Zhongguo Zhong Yao Za Zhi | pmid:2511877 |
Jiang XL and Xu LN | [Beneficial effect of puerarin on experimental microcirculatory disturbance in mice]. | 1989 | Yao Xue Xue Bao | pmid:2816384 |
Song XP et al. | [Effects of puerarin on blood pressure and plasma renin activity in spontaneously hypertensive rats]. | 1988 | Zhongguo Yao Li Xue Bao | pmid:3055814 |
Lu XR et al. | Puerarin beta-adrenergic receptor blocking effect. | 1987 | Chin. Med. J. | pmid:2885157 |
Xu LX et al. | [Differential pulse polarographic determination of flavonoids in Pueraria lobata]. | 1987 | Yao Xue Xue Bao | pmid:3661208 |
Lu XR et al. | [Blocking effect of puerarin on beta-adrenoceptors of isolated organs and the whole animal]. | 1986 | Zhongguo Yao Li Xue Bao | pmid:2886005 |
Meng GR | [Factors influencing the quality of a Chinese herbal medicine decoction]. | 1986 | Zhong Yao Tong Bao | pmid:2952321 |