SCHEMBL105486
Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
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Introduction
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with SCHEMBL105486?
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
PubChem Associated disorders and diseases
What pathways are associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with SCHEMBL105486?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
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What functions are associated with SCHEMBL105486?
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What lipids are associated with SCHEMBL105486?
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What genes are associated with SCHEMBL105486?
Related references are published most in these journals:
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What common seen animal models are associated with SCHEMBL105486?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
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NCBI Entrez Crosslinks
All references with SCHEMBL105486
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Yao WJ et al. | Effect of poly(amidoamine) dendrimers on corneal penetration of puerarin. | 2010 | Biol. Pharm. Bull. | pmid:20686234 |
| Liu YK et al. | On-line solid-phase extraction-HPLC-fluorescence detection for simultaneous determination of puerarin and daidzein in human serum. | 2010 | Talanta | pmid:20801320 |
| Feng ZQ et al. | The synthesis of puerarin derivatives and their protective effect on the myocardial ischemia and reperfusion injury. | 2010 | J Asian Nat Prod Res | pmid:20924897 |
| Li J et al. | Puerarin attenuates amyloid-beta-induced cognitive impairment through suppression of apoptosis in rat hippocampus in vivo. | 2010 | Eur. J. Pharmacol. | pmid:20868658 |
| Zhang W et al. | Puerarin improves insulin resistance and modulates adipokine expression in rats fed a high-fat diet. | 2010 | Eur. J. Pharmacol. | pmid:20869961 |
| Zhang HY et al. | [The protective effect of puerarin on Abeta(25-35)-induced PC12 cell injury]. | 2010 | Zhong Yao Cai | pmid:20873562 |
| Zhang XP et al. | Protective effects of ligustrazine, kakonein and Panax notoginsenosides on multiple organs in rats with severe acute pancreatitis. | 2010 | Methods Find Exp Clin Pharmacol | pmid:21225014 |
| Wang L and Zhao Y | [Effect of decoction method on pharmacokinetics of puerarin in dogs]. | 2010 | Zhong Yao Cai | pmid:21243776 |
| Pan E et al. | [Absorption transport mechanism of puerarin oil-in-oil nanoemulsion]. | 2010 | Zhongguo Zhong Yao Za Zhi | pmid:21246816 |
| Li J et al. | [Permeability of blood-brain barrier oxygen-glucose deprivation induced by tetramethylpyrazine-puerarin in vitro]. | 2010 | Zhongguo Zhong Yao Za Zhi | pmid:21246832 |
| Rudra A et al. | Doxorubicin-loaded phosphatidylethanolamine-conjugated nanoliposomes: in vitro characterization and their accumulation in liver, kidneys, and lungs in rats. | 2010 | Int J Nanomedicine | pmid:21042545 |
| Zhu L et al. | [Molecular mechanism of protective effect of puerarin solid lipid nanoparticle on cerebral ischemia-reperfusion injury in gerbils]. | 2010 | Zhong Yao Cai | pmid:21548369 |
| Boonchird C et al. | Differential binding with ERalpha and ERbeta of the phytoestrogen-rich plant Pueraria mirifica. | 2010 | Braz. J. Med. Biol. Res. | pmid:20027484 |
| Yang L and Tan T | An enhanced adsorption in puerarin retention on oligo-beta-cyclodextrin grafted poly(glycidyl methacrylate) media. | 2010 | Appl. Biochem. Biotechnol. | pmid:19067245 |
| Kim SJ et al. | Peroxyl radical scavenging capacity of extracts and isolated components from selected medicinal plants. | 2010 | Arch. Pharm. Res. | pmid:20607491 |
| Yang X et al. | Puerarin inhibits C-reactive protein expression via suppression of nuclear factor kappaB activation in lipopolysaccharide-induced peripheral blood mononuclear cells of patients with stable angina pectoris. | 2010 | Basic Clin. Pharmacol. Toxicol. | pmid:20346059 |
| Liu Y et al. | [Corneal penetration of PAMAM dendrimers-coated puerarin liposomes]. | 2010 | Zhongguo Zhong Yao Za Zhi | pmid:20349711 |
| Liu XJ et al. | The effects of genistein and puerarin on the activation of nuclear factor-kappaB and the production of tumor necrosis factor-alpha in asthma patients. | 2010 | Pharmazie | pmid:20225658 |
| Thielemann A et al. | Comparison of urodynamic effects of phytoestrogens equol, puerarin and genistein with these of estradiol 17beta in ovariectomized rats. | 2010 | Exp. Gerontol. | pmid:19903517 |
| Bebrevska L et al. | In vivo antioxidative activity of a quantified Pueraria lobata root extract. | 2010 | J Ethnopharmacol | pmid:19799984 |
| Zhu LH et al. | Puerarin attenuates high-glucose-and diabetes-induced vascular smooth muscle cell proliferation by blocking PKCbeta2/Rac1-dependent signaling. | 2010 | Free Radic. Biol. Med. | pmid:19854265 |
| Gu L et al. | Puerarin inhibits acid-sensing ion channels and protects against neuron death induced by acidosis. | 2010 | Planta Med. | pmid:19918715 |
| Luo CF et al. | Metabolites of puerarin identified by liquid chromatography tandem mass spectrometry: similar metabolic profiles in liver and intestine of rats. | 2010 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:20006564 |
| Hu W et al. | Puerarin inhibits adhesion molecule expression in tnf-alpha-stimulated human endothelial cells via modulation of the nuclear factor kappaB pathway. | 2010 | Pharmacology | pmid:20016245 |
| Shao HM et al. | [Inhibitory effect of flavonoids of puerarin on proliferation of different human acute myeloid leukemia cell lines in vitro]. | 2010 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:20416155 |
| Semalty A et al. | Development and evaluation of pharmacosomes of aceclofenac. | 2010 | Indian J Pharm Sci | pmid:21694988 |
| Tang YH et al. | [Apoptosis of NB4 cells induced by flavonoids of puerarin in vitro]. | 2010 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:20416161 |
| Gao C et al. | Pharmacokinetic interaction between puerarin and edaravone, and effect of borneol on the brain distribution kinetics of puerarin in rats. | 2010 | J. Pharm. Pharmacol. | pmid:20487220 |
| Zhang H et al. | Investigation of the inclusions of puerarin and daidzin with beta-cyclodextrin by molecular dynamics simulation. | 2010 | J Phys Chem B | pmid:20297792 |
| Kato E and Kawabata J | Glucose uptake enhancing activity of puerarin and the role of C-glucoside suggested from activity of related compounds. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20605096 |
| Liu X et al. | A validated stability-indicating HPLC method for the determination of PEGylated puerarin in aqueous solutions. | 2010 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:20580327 |
| Zhang R et al. | [Protective effect of puerarin against calcium overload after focal cerebral ischemia injury in rats]. | 2010 | Nan Fang Yi Ke Da Xue Xue Bao | pmid:20584654 |
| Yao W et al. | Preparation and characterization of puerarin-dendrimer complexes as an ocular drug delivery system. | 2010 | Drug Dev Ind Pharm | pmid:20545508 |
| Xu J et al. | PVA hydrogels containing beta-cyclodextrin for enhanced loading and sustained release of ocular therapeutics. | 2010 | J Biomater Sci Polym Ed | pmid:20507706 |
| Zhu G et al. | Puerarin protects dopaminergic neurons against 6-hydroxydopamine neurotoxicity via inhibiting apoptosis and upregulating glial cell line-derived neurotrophic factor in a rat model of Parkinson's disease. | 2010 | Planta Med. | pmid:20509103 |
| Malaivijitnond S et al. | Puerarin exhibits weak estrogenic activity in female rats. | 2010 | Fitoterapia | pmid:20117180 |
| Zheng J et al. | The effects of puerarin on CYP2D6 and CYP1A2 activities in vivo. | 2010 | Arch. Pharm. Res. | pmid:20195825 |
| Xu J et al. | Preparation and evaluation of a contact lens vehicle for puerarin delivery. | 2010 | J Biomater Sci Polym Ed | pmid:20178685 |
| Hien TT et al. | Molecular mechanism of suppression of MDR1 by puerarin from Pueraria lobata via NF-kappaB pathway and cAMP-responsive element transcriptional activity-dependent up-regulation of AMP-activated protein kinase in breast cancer MCF-7/adr cells. | 2010 | Mol Nutr Food Res | pmid:20077420 |
| He D et al. | [Improvement of solubility of puerarin through deoxycholate/phospholipid mixed micelle preparing technology]. | 2010 | Zhongguo Zhong Yao Za Zhi | pmid:20822006 |
| Mun JG et al. | Tracking deposition of a 14C-radiolabeled kudzu hairy root-derived isoflavone-rich fraction into bone. | 2010 | Exp. Biol. Med. (Maywood) | pmid:20851832 |
| Yu C et al. | Permeabilization of Microbacterium oxylans shifts the conversion of puerarin from puerarin-7-O-glucoside to puerarin-7-O-fructoside. | 2010 | Appl. Microbiol. Biotechnol. | pmid:19943046 |
| Liao XH et al. | [Effect of major components of maijunan tablets on the transport of hydrochlorothiazide in Caco-2 cell monolayer model]. | 2010 | Yao Xue Xue Bao | pmid:21351458 |
| Guo D et al. | [Study on pharmacokinetics and biodistribution of pur derivative nanopaticles in mice]. | 2010 | Zhongguo Zhong Yao Za Zhi | pmid:21355276 |
| Li BJ et al. | [Fingerprints of Tongmai Keli by HPLC-DAD-MS]. | 2010 | Yao Xue Xue Bao | pmid:21361041 |
| Yao H et al. | [The role of mitochondrial K+ channels in the cardioprotection of puerarin against hypoxia/reoxygenation injury in rats]. | 2010 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21328988 |
| Chen TR et al. | Evaluation of quality of Radix Puerariae herbal medicine by isoflavonoids. | 2010 | J. Pharm. Pharmacol. | pmid:20609068 |
| Sun C et al. | On-line HPLC method for screening of antioxidants against superoxide anion radical from complex mixtures. | 2010 | J Sep Sci | pmid:20183820 |
| Liu J et al. | An improved LC-MS/MS method for simultaneous determination of 1,5-dicaffeoylquinic acid and its active metabolites in human plasma and its application to a pharmacokinetic study in patients. | 2010 | Biomed. Chromatogr. | pmid:20058327 |
| Hanhineva K et al. | Impact of dietary polyphenols on carbohydrate metabolism. | 2010 | Int J Mol Sci | pmid:20480025 |
| Han RM et al. | Fast regeneration of carotenoids from radical cations by isoflavonoid dianions: importance of the carotenoid keto group for electron transfer. | 2010 | J Phys Chem A | pmid:19957978 |
| Xu J et al. | Cyclodextrin-containing hydrogels for contact lenses as a platform for drug incorporation and release. | 2010 | Acta Biomater | pmid:19619677 |
| Hirota K et al. | Effect of genistein and daidzein on the proliferation and differentiation of human preadipocyte cell line. | 2010 | J. Agric. Food Chem. | pmid:20397699 |
| Fan X et al. | Pharmacological neuroprotection after perinatal hypoxic-ischemic brain injury. | 2010 | Curr Neuropharmacol | pmid:21629441 |
| Chen CC et al. | Hazardous effects of curcumin on mouse embryonic development through a mitochondria-dependent apoptotic signaling pathway. | 2010 | Int J Mol Sci | pmid:21152277 |
| Li Q et al. | Neuroprotective properties of picroside II in a rat model of focal cerebral ischemia. | 2010 | Int J Mol Sci | pmid:21151457 |
| Xu R et al. | Two new flavones from Tridax procumbens Linn. | 2010 | Molecules | pmid:20877227 |
| Branco DM et al. | Cross-talk between mitochondria and proteasome in Parkinson's disease pathogenesis. | 2010 | Front Aging Neurosci | pmid:20577640 |
| Wong RW and Rabie AB | Effect of bio-oss collagen and collagen matrix on bone formation. | 2010 | Open Biomed Eng J | pmid:20461225 |
| Wang MS et al. | Curcumin reduces alpha-synuclein induced cytotoxicity in Parkinson's disease cell model. | 2010 | BMC Neurosci | pmid:20433710 |
| Gruber JV and Holtz R | Examining the genomic influence of skin antioxidants in vitro. | 2010 | Mediators Inflamm. | pmid:20706672 |
| Yao M et al. | Quantitative analysis of two isoflavones in Pueraria lobata flowers from eleven Chinese provinces using high performance liquid chromatography. | 2010 | Chin Med | pmid:20416072 |
| Gokara M et al. | Molecular interaction studies of trimethoxy flavone with human serum albumin. | 2010 | PLoS ONE | pmid:20098677 |
| Hao LN et al. | Effect of puerarin on retinal pigment epithelial cells apoptosis induced partly by peroxynitrite via Fas/FasL pathway. | 2010 | Int J Ophthalmol | pmid:22553574 |
| Lee IK et al. | Compound K, a metabolite of ginseng saponin, induces mitochondria-dependent and caspase-dependent apoptosis via the generation of reactive oxygen species in human colon cancer cells. | 2010 | Int J Mol Sci | pmid:21614182 |
| O'Brien KA | Alternative perspectives: how chinese medicine understands hypercholesterolemia. | 2010 | Cholesterol | pmid:21490916 |
| Patel RP and Barnes S | Isoflavones and PPAR Signaling: A Critical Target in Cardiovascular, Metastatic, and Metabolic Disease. | 2010 | PPAR Res | pmid:21461045 |
| Lee OH et al. | Puerarin enhances adipocyte differentiation, adiponectin expression, and antioxidant response in 3T3-L1 cells. | 2010 Nov-Dec | Biofactors | pmid:20806284 |
| Xiao C et al. | Anti-oxidative and TNF-α suppressive activities of puerarin derivative (4AC) in RAW264.7 cells and collagen-induced arthritic rats. | 2011 | Eur. J. Pharmacol. | pmid:21651907 |
| Su B et al. | [Rapid determination of puerarin in Xiaoke pill powder by near-infrared spectroscopy]. | 2011 | Zhongguo Zhong Yao Za Zhi | pmid:21710725 |
| Chen Y et al. | Endometriotic implants regress in rat models treated with puerarin by decreasing estradiol level. | 2011 | Reprod Sci | pmid:21673282 |
| Luo CF et al. | Pharmacokinetics, tissue distribution and relative bioavailability of puerarin solid lipid nanoparticles following oral administration. | 2011 | Int J Pharm | pmid:21392565 |
| Xu HX et al. | [Mechanism of advanced glycation end-products in the inducement of apoptosis of human gingival fibroblast and related effect of puerarin in the process]. | 2011 | Zhonghua Kou Qiang Yi Xue Za Zhi | pmid:21418943 |
| Xing G et al. | Neuroprotective effects of puerarin against beta-amyloid-induced neurotoxicity in PC12 cells via a PI3K-dependent signaling pathway. | 2011 | Brain Res. Bull. | pmid:21473901 |
| Hou SZ et al. | Role of the interaction between puerarin and the erythrocyte membrane in puerarin-induced hemolysis. | 2011 | Chem. Biol. Interact. | pmid:21453687 |
| Luo CF et al. | Determination of puerarin in rat plasma by rapid resolution liquid chromatography tandem mass spectrometry in positive ionization mode. | 2011 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:21511546 |
| Yu A et al. | Formulation optimization and bioavailability after oral and nasal administration in rabbits of puerarin-loaded microemulsion. | 2011 | J Pharm Sci | pmid:20862776 |
| Nakamura K et al. | The C-glucosyl bond of puerarin was cleaved hydrolytically by a human intestinal bacterium strain PUE to yield its aglycone daidzein and an intact glucose. | 2011 | Chem. Pharm. Bull. | pmid:21212542 |
| Wu H et al. | Examination of lymphatic transport of puerarin in unconscious lymph duct-cannulated rats after administration in microemulsion drug delivery systems. | 2011 | Eur J Pharm Sci | pmid:21216284 |
| Hao LN et al. | [Protective effects of puerarin on lens epithelial cells in rat diabetic cataract]. | 2011 | Zhonghua Yan Ke Za Zhi | pmid:21612681 |
| Zhu YM et al. | [Effect and mechanism of puerarin on high glucose-induced hypo-responses in vascular contraction]. | 2011 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21560344 |
| Braune A and Blaut M | Deglycosylation of puerarin and other aromatic C-glucosides by a newly isolated human intestinal bacterium. | 2011 | Environ. Microbiol. | pmid:20946528 |
| Wang D et al. | Puerarin suppresses invasion and vascularization of endometriosis tissue stimulated by 17β-estradiol. | 2011 | PLoS ONE | pmid:21949833 |
| Zhang NB et al. | Effects of puerarin on expression of cardiac Smad3 and Smad7 mRNA in spontaneously hypertensive rat. | 2011 | J Ethnopharmacol | pmid:22027447 |
| Chen R et al. | [Simultaneous quantification of five impurities in puerarin and its injections by HPLC method with correction factor]. | 2011 | Zhongguo Zhong Yao Za Zhi | pmid:22032137 |
| Chen XX et al. | [Pharmacokinetics and bioavailability of Puerarin self-microemulsion in Beagle dogs]. | 2011 | Zhong Yao Cai | pmid:21954564 |
| Pan ZJ et al. | [Effects of puerarin on blood pressure, blood lipid and renal structure of cold-induced hypertensive mice]. | 2011 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:22295519 |
| Zhang L et al. | Intestinal absorbability of three Radix Puerariae isoflavones including daidzein, daidzin and puerarin. | 2011 | Chin Med | pmid:22108408 |
| Chen C et al. | [Effects of puerarin on proliferation, apoptosis and Kv1.5 gene expression of pulmonary artery smooth muscle cells induced by hypoxia]. | 2011 | Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi | pmid:22357486 |
| Zhang R et al. | [Effect of puerarin on the expression of NMDA receptor in the hippocampus CA1 region after focal cerebral ischemia in rats]. | 2011 | Sichuan Da Xue Xue Bao Yi Xue Ban | pmid:21355301 |
| Zhang H et al. | Puerarin: a novel antagonist to inward rectifier potassium channel (IK1). | 2011 | Mol. Cell. Biochem. | pmid:21327545 |
| Yao C et al. | [Ocular pharmacokinetics of puerarin in anesthetic rabbits by microdialysis]. | 2011 | Zhongguo Zhong Yao Za Zhi | pmid:22097338 |
| Zhang X et al. | [Puerarin induced apoptosis of pulmonary artery smooth muscle cell by mitochondrial pathway]. | 2011 | Zhongguo Zhong Yao Za Zhi | pmid:22097342 |
| Hao LN et al. | Inducible nitric oxide synthase and Fas/FasL with C3 expression of mouse retinal pigment epithelial cells in response to stimulation by peroxynitrite and antagonism of puerarin. | 2011 | Chin. Med. J. | pmid:21933599 |
| Wang WY et al. | Determination of puerarin in rabbit aqueous humor by liquid chromatography tandem mass spectrometry using microdialysis sampling after topical administration of puerarin PAMAM dendrimer complex. | 2011 | J Pharm Biomed Anal | pmid:21831555 |
| Zhao R et al. | NMR studies on puerarin and its interaction with beta-cyclodextrin. | 2011 | J Biol Phys | pmid:22942483 |
| Lipovac M et al. | Effect of Red Clover Isoflavones over Skin, Appendages, and Mucosal Status in Postmenopausal Women. | 2011 | Obstet Gynecol Int | pmid:22135679 |
| Kim J et al. | KIOM-79 Prevents Lens Epithelial Cell Apoptosis and Lens Opacification in Zucker Diabetic Fatty Rats. | 2011 | Evid Based Complement Alternat Med | pmid:20953387 |
| Baranowska I and Magiera S | Analysis of isoflavones and flavonoids in human urine by UHPLC. | 2011 | Anal Bioanal Chem | pmid:20936271 |
| Xie W and Du L | Diabetes is an inflammatory disease: evidence from traditional Chinese medicines. | 2011 | Diabetes Obes Metab | pmid:21205111 |