SCHEMBL105486
Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with SCHEMBL105486?
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
PubChem Associated disorders and diseases
What pathways are associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with SCHEMBL105486?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
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What functions are associated with SCHEMBL105486?
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What lipids are associated with SCHEMBL105486?
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What genes are associated with SCHEMBL105486?
Related references are published most in these journals:
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What common seen animal models are associated with SCHEMBL105486?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
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NCBI Entrez Crosslinks
All references with SCHEMBL105486
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wong KH et al. | Differentiation of Pueraria lobata and Pueraria thomsonii using partial least square discriminant analysis (PLS-DA). | 2013 | J Pharm Biomed Anal | pmid:23777642 |
| Liu X et al. | Pharmacokinetic comparisons of puerarin, daidzin and the glucuronide metabolite of puerarin after administration of total flavonoid from Gegen alone and total flavonoid from Gegen combined with total saponin from Sanqi in rats under different physiological states. | 2013 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:23774247 |
| Xia DZ et al. | Hepatoprotective activity of puerarin against carbon tetrachloride-induced injuries in rats: a randomized controlled trial. | 2013 | Food Chem. Toxicol. | pmid:23764356 |
| Li R et al. | Puerarin, isolated from Kudzu root (Willd.), attenuates hepatocellular cytotoxicity and regulates the GSK-3β/NF-κB pathway for exerting the hepatoprotection against chronic alcohol-induced liver injury in rats. | 2013 | Int. Immunopharmacol. | pmid:23751897 |
| Li R et al. | Puerarin attenuates neuronal degeneration in the substantia nigra of 6-OHDA-lesioned rats through regulating BDNF expression and activating the Nrf2/ARE signaling pathway. | 2013 | Brain Res. | pmid:23747813 |
| Chen YG et al. | Metabolic differentiations of Pueraria lobata and Pueraria thomsonii using ¹H NMR spectroscopy and multivariate statistical analysis. | 2014 | J Pharm Biomed Anal | pmid:23746990 |
| Ji O et al. | [Effect of flavonoids of puerarin on the proliferation and apoptosis of retinoic acid resistant acute promyelocytic leukemia cell line NB4-R1 cells]. | 2013 | Zhonghua Xue Ye Xue Za Zhi | pmid:23688762 |
| Chen X et al. | Puerarin improves metabolic function leading to hepatoprotective effects in chronic alcohol-induced liver injury in rats. | 2013 | Phytomedicine | pmid:23669266 |
| Zhang Y et al. | Effects of puerarin on cholinergic enzymes in the brain of ovariectomized guinea pigs. | 2013 | Int. J. Neurosci. | pmid:23668913 |
| Huang ZG et al. | [Effect of puerarin combined with felodipine on mRNA and protein expression of apelin and APJ in renovascular hypertensive rat]. | 2013 | Zhongguo Zhong Yao Za Zhi | pmid:23668014 |
| Cao WL et al. | [Effect of puerarin on hemorheology and pulmonary pressure in rat pneumo-cardiac disease]. | 2013 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:23662397 |
| Chen F et al. | Puerarin-induced immune hemolytic anemia. | 2013 | Int. J. Hematol. | pmid:23661032 |
| Wang Y et al. | Puerarin stimulates proliferation and differentiation and protects against cell death in human osteoblastic MG-63 cells via ER-dependent MEK/ERK and PI3K/Akt activation. | 2013 | Phytomedicine | pmid:23639192 |
| Li R et al. | Puerarin attenuates neuronal degeneration and blocks oxidative stress to elicit a neuroprotective effect on substantia nigra injury in 6-OHDA-lesioned rats. | 2013 | Brain Res. | pmid:23603411 |
| Li N et al. | Determination of glibenclamide and puerarin in rat plasma by UPLC-MS/MS: application to their pharmacokinetic interaction study. | 2013 | Talanta | pmid:23597896 |
| Zhang E et al. | [Formulation optimization and drug release in vitro of membrane controlled tablets of puerarin inclusion compound]. | 2013 | Zhongguo Zhong Yao Za Zhi | pmid:23596875 |
| Tian F et al. | The neuroprotective mechanism of puerarin treatment of acute spinal cord injury in rats. | 2013 | Neurosci. Lett. | pmid:23570727 |
| Bai S et al. | Effects of felodipine combined with puerarin on ACE2-Ang (1-7)-Mas axis in renovascular hypertensive rat. | 2013 | Regul. Pept. | pmid:23523569 |
| Zhu G et al. | Neuroprotective effects of puerarin on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine induced Parkinson's disease model in mice. | 2014 | Phytother Res | pmid:23512787 |
| Liu CM et al. | Protective effect of puerarin on lead-induced mouse cognitive impairment via altering activities of acetyl cholinesterase, monoamine oxidase and nitric oxide synthase. | 2013 | Environ. Toxicol. Pharmacol. | pmid:23501611 |
| Guo C et al. | Anti-fibrotic effects of puerarin on CCl4-induced hepatic fibrosis in rats possibly through the regulation of PPAR-γ expression and inhibition of PI3K/Akt pathway. | 2013 | Food Chem. Toxicol. | pmid:23500774 |
| Cao L et al. | Pharmacokinetics of puerarin in pregnant rats at different stages of gestation after oral administration. | 2013 | Fitoterapia | pmid:23500385 |
| Luo CF et al. | Metabolic profile of puerarin in rats after intragastric administration of puerarin solid lipid nanoparticles. | 2013 | Int J Nanomedicine | pmid:23486407 |
| An R et al. | [Intestinal absorption of different combinations of active compounds from Gegenqinlian decoction by rat single pass intestinal perfusion in situ]. | 2012 | Yao Xue Xue Bao | pmid:23460978 |
| Zhang BS et al. | [Cellular absorption of the active ingredients in different compatibilities of gegenqinlian decoction in human intestinal Caco-2 cells]. | 2012 | Zhong Yao Cai | pmid:23451503 |
| Liu XY et al. | [Stability of PEGylated puerarin under different storage conditions]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:23373208 |
| Nakamura K et al. | Enzymatic cleavage of the C-glucosidic bond of puerarin by three proteins, Mn(2+), and oxidized form of nicotinamide adenine dinucleotide. | 2013 | Biol. Pharm. Bull. | pmid:23328408 |
| Wang L et al. | Protective effects of puerarin on experimental chronic lead nephrotoxicity in immature female rats. | 2013 | Hum Exp Toxicol | pmid:23315276 |
| Jiang L et al. | Simultaneous determination of gastrodin and puerarin in rat plasma by HPLC and the application to their interaction on pharmacokinetics. | 2013 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:23314488 |
| Hu JJ et al. | [Effect of pretreatment with puerarin on activation of LPS-induced RAW264. 7 cells]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:23311164 |
| Peng JH et al. | Puerarin ameliorates experimental alcoholic liver injury by inhibition of endotoxin gut leakage, Kupffer cell activation, and endotoxin receptors expression. | 2013 | J. Pharmacol. Exp. Ther. | pmid:23277536 |
| Deng Y et al. | [Effect of phenformin hydrochloride on pharmacokinetics of puerarin in rats]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:23270242 |
| Wang Q et al. | Magnetic solid-phase extraction and determination of puerarin in rat plasma using C(18)-functionalized magnetic silica nanoparticles by high performance liquid chromatography. | 2013 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:23246846 |
| Sun XY et al. | [Optimal extraction of puerarin from Pueraria lobata based on central composite design and response surface methodology]. | 2012 | Zhong Yao Cai | pmid:23236837 |
| Xue C et al. | [Determination of five components in Pueraria labta decoction with reference extraction method]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:23234135 |
| Wang X et al. | Identification and assay of 3'-O-methyltaxifolin by UPLC-MS in rat plasma. | 2012 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:23217303 |
| Liu B et al. | Physicochemical [corrected] properties of the inclusion complex of puerarin and glucosyl-β-cyclodextrin. | 2012 | J. Agric. Food Chem. | pmid:23215052 |
| Tao HQ et al. | HP-β-CD-PLGA nanoparticles improve the penetration and bioavailability of puerarin and enhance the therapeutic effects on brain ischemia-reperfusion injury in rats. | 2013 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:23192284 |
| Han JQ et al. | [Effects of puerarin on the neurocyte apoptosis and p-Akt (Ser473) expressions in rats with cerebral ischemia/reperfusion injury]. | 2012 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:23173255 |
| Chen F et al. | Puerarin enhances superoxide dismutase activity and inhibits RAGE and VEGF expression in retinas of STZ-induced early diabetic rats. | 2012 | Asian Pac J Trop Med | pmid:23146804 |
| Li R et al. | Puerarin mediates hepatoprotection against CCl4-induced hepatic fibrosis rats through attenuation of inflammation response and amelioration of metabolic function. | 2013 | Food Chem. Toxicol. | pmid:23146695 |
| Yin R et al. | UFLC-MS/MS method for simultaneous determination of luteolin-7-O-gentiobioside, luteolin-7-O-β-D-glucoside and luteolin-7-O-β-D-glucuronide in beagle dog plasma and its application to a pharmacokinetic study after administration of traditional Chinese medicinal preparation: Kudiezi injection. | 2013 | J Pharm Biomed Anal | pmid:23146236 |
| Prasain JK et al. | The Chinese Pueraria root extract (Pueraria lobata) ameliorates impaired glucose and lipid metabolism in obese mice. | 2012 | Phytomedicine | pmid:23123226 |
| Wang Y et al. | In vitro and in vivo anticancer activity of a novel puerarin nanosuspension against colon cancer, with high efficacy and low toxicity. | 2013 | Int J Pharm | pmid:23089583 |
| Zou Y et al. | Protective effect of puerarin against beta-amyloid-induced oxidative stress in neuronal cultures from rat hippocampus: involvement of the GSK-3β/Nrf2 signaling pathway. | 2013 | Free Radic. Res. | pmid:23088308 |
| Liang XL et al. | Transport properties of puerarin and effect of Radix Angelicae Dahuricae extract on the transport of puerarin in Caco-2 cell model. | 2012 | J Ethnopharmacol | pmid:23085309 |
| Sheu SY et al. | Stimulatory effect of puerarin on bone formation through co-activation of nitric oxide and bone morphogenetic protein-2/mitogen-activated protein kinases pathways in mice. | 2012 | Chin. Med. J. | pmid:23075718 |
| Zhang J et al. | Effects of puerarin on the inflammatory role of burn-related procedural pain mediated by P2X(7) receptors. | 2013 | Burns | pmid:23044342 |
| Cheng W et al. | Puerarin suppresses proliferation of endometriotic stromal cells partly via the MAPK signaling pathway induced by 17ß-estradiol-BSA. | 2012 | PLoS ONE | pmid:23029074 |
| Wang Q et al. | [Distribution of puerarin contained in Zige freeze-dried powder injection in rat liver and kidney]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:22994007 |