Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
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Authors | Title | Published | Journal | PubMed Link |
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Liu S et al. | [A study on processing of the root of Pueraria lobata (Willd.) ohwi by HPLC]. | 1998 | Zhongguo Zhong Yao Za Zhi | pmid:12242820 |
Kim DH et al. | Metabolism of puerarin and daidzin by human intestinal bacteria and their relation to in vitro cytotoxicity. | 1998 | Biol. Pharm. Bull. | pmid:9657051 |
Keung WM and Vallee BL | Daidzin and its antidipsotropic analogs inhibit serotonin and dopamine metabolism in isolated mitochondria. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9482862 |
Lin RC and Li TK | Effects of isoflavones on alcohol pharmacokinetics and alcohol-drinking behavior in rats. | 1998 | Am. J. Clin. Nutr. | pmid:9848526 |
Dong LP and Wang TY | Effects of puerarin against glutamate excitotoxicity on cultured mouse cerebral cortical neurons. | 1998 | Zhongguo Yao Li Xue Bao | pmid:10375780 |
Wang CY et al. | Analysis of Puerariae radix and its medicinal preparations by capillary electrophoresis. | 1998 | J Chromatogr A | pmid:9588018 |
Zhu H et al. | [Application and characteristics of macroreticular resin in purification study of different effective ingredients in Chinese medicines]. | 1998 | Zhongguo Zhong Yao Za Zhi | pmid:11599359 |
Zhao Z et al. | [Clinical study of puerarin in treatment of patients with unstable angina]. | 1998 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:11477926 |
Fan S et al. | [Effects of both puerarin and gypsum on the firing of pyrogen-treated thermosensitive neurons in the region POAH of anesthetized cats]. | 1997 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:10074325 |
Li SM et al. | [Effect of puerarin on plasma endothelin, renin activity and angiotensin II in patients with acute myocardial infarction]. | 1997 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:9863126 |