Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
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Authors | Title | Published | Journal | PubMed Link |
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Chang Q et al. | Simultaneous determination of ten active components in traditional Chinese medicinal products containing both Gegen (Pueraria lobata) and Danshen (Salvia miltiorrhiza) by high-performance liquid chromatography. | Phytochem Anal | pmid:18438756 | |
Wang Y et al. | Puerarin concurrently stimulates osteoprotegerin and inhibits receptor activator of NF-κB ligand (RANKL) and interleukin-6 production in human osteoblastic MG-63 cells. | Phytomedicine | pmid:24854571 | |
Li C et al. | Puerarin induces the upregulation of glutathione levels and nuclear translocation of Nrf2 through PI3K/Akt/GSK-3β signaling events in PC12 cells exposed to lead. | Neurotoxicol Teratol | pmid:25195717 | |
Li H et al. | Comparison of two approaches of intestinal absorption by puerarin. | J Pharmacol Toxicol Methods | pmid:24674709 | |
pmid: | ||||
Nguyen VD et al. | Identification of a naturally-occurring 8-[alpha-D-glucopyranosyl-(1-->6)-beta-D-glucopyranosyl]daidzein from cultivated kudzu root. | Phytochem Anal | pmid:19609885 | |
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Yin ZZ and Zeng GY | [Pharmacology of puerarin. V. Effects of puerarin on platelet aggregation and release of 5-HT from platelets]. | 1981 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:6459876 |
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Fan LL et al. | Pharmacologic studies on radix puerariae: effect of puerarin on regional myocardial blood flow and cardiac hemodynamics in dogs with acute myocardial ischemia. | 1985 | Chin. Med. J. | pmid:3938713 |
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Lu XR et al. | Puerarin beta-adrenergic receptor blocking effect. | 1987 | Chin. Med. J. | pmid:2885157 |
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Song XP et al. | [Effects of puerarin on blood pressure and plasma renin activity in spontaneously hypertensive rats]. | 1988 | Zhongguo Yao Li Xue Bao | pmid:3055814 |
Zhang JQ and Zhou YP | [Inhibition of aldose reductase from rat lens by some Chinese herbs and their components]. | 1989 | Zhongguo Zhong Yao Za Zhi | pmid:2511877 |
Jiang XL and Xu LN | [Beneficial effect of puerarin on experimental microcirculatory disturbance in mice]. | 1989 | Yao Xue Xue Bao | pmid:2816384 |
Xu LX et al. | Determination of 4'-methoxy-puerarin in puerarin by reversed phase HPLC. | 1991 | Yao Xue Xue Bao | pmid:1789117 |
Fan LL et al. | The protective effect of puerarin against myocardial reperfusion injury. Study on cardiac function. | 1992 | Chin. Med. J. | pmid:1576864 |
Yu S et al. | [Comparison of constituents in Pueraria thomsonii Benth before and after processing]. | 1992 | Zhongguo Zhong Yao Za Zhi | pmid:1292491 |
Fan LL et al. | Protective effect of puerarin against myocardial reperfusion injury. Myocardial metabolism and ultrastructure. | 1992 | Chin. Med. J. | pmid:1451545 |
Jin XL and Zhu XY | [Pharmacokinetics of puerarin in rats, rabbits, and dogs]. | 1992 | Zhongguo Yao Li Xue Bao | pmid:1442117 |
Kang RX | [The intraocular pressure depressive effect of puerarin]. | 1993 | Zhonghua Yan Ke Za Zhi | pmid:7912669 |
Yasuda T et al. | [A simultaneous determination of daidzin and puerarin and determination of daidzein in Oriental pharmaceutical decoctions containing puerariae radix by ion-pair high-performance liquid chromatography]. | 1993 | Yakugaku Zasshi | pmid:8301541 |
Keung WM and Vallee BL | Therapeutic lessons from traditional Oriental medicine to contemporary Occidental pharmacology. | 1994 | EXS | pmid:8032168 |
Wang LY et al. | [Effects of puerarin on cat vascular smooth muscle in vitro]. | 1994 | Zhongguo Yao Li Xue Bao | pmid:8010117 |
Yasuda T et al. | Urinary and biliary metabolites of puerarin in rats. | 1995 | Biol. Pharm. Bull. | pmid:7742802 |
Zhou Y et al. | [Comparative study on pharmacological effects of various species of Pueraria]. | 1995 | Zhongguo Zhong Yao Za Zhi | pmid:8679082 |
Chen L et al. | [Effect of puerarin on cerebral blood flow in dogs]. | 1995 | Zhongguo Zhong Yao Za Zhi | pmid:8679097 |
Zhang X et al. | [Determination of puerarin in radix Puerariae and yufengningxin tablets by HPLC]. | 1995 | Zhongguo Zhong Yao Za Zhi | pmid:8561884 |
Zhang L et al. | [Determination of puerarin in various kinds of radix Puerariae from different places]. | 1995 | Zhongguo Zhong Yao Za Zhi | pmid:7576135 |
Lin RC et al. | Isoflavonoid compounds extracted from Pueraria lobata suppress alcohol preference in a pharmacogenetic rat model of alcoholism. | 1996 | Alcohol. Clin. Exp. Res. | pmid:8800381 |
Shen XL et al. | Inhibition of [3H] flunitrazepam binding to rat brain membranes in vitro by puerarin and daidzein. | 1996 | Yao Xue Xue Bao | pmid:8762462 |
Overstreet DH et al. | Suppression of alcohol intake after administration of the Chinese herbal medicine, NPI-028, and its derivatives. | 1996 | Alcohol. Clin. Exp. Res. | pmid:8730211 |
Yue HW and Hu XQ | [Pharmacologic value of radix Puerariae and puerarine on cardiovascular system]. | 1996 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:9387770 |
Tan S et al. | [Determination of puerarin in gegen ginlian tablets by RP-HPLC]. | 1996 | Zhongguo Zhong Yao Za Zhi | pmid:9812678 |
Ji HL and Wang TY | Puerarin inhibits tetrodotoxin-resistant sodium current in rat dorsal root ganglion neurons. | 1996 | Zhongguo Yao Li Xue Bao | pmid:9772657 |
Ning Y et al. | [Effects of purerarin on blood superoxide dismutase activities and plasma malondialdehyde levels in patients with angina pectoris]. | 1997 | Hunan Yi Ke Da Xue Xue Bao | pmid:9868043 |
Fan S et al. | [Effects of both puerarin and gypsum on the firing of pyrogen-treated thermosensitive neurons in the region POAH of anesthetized cats]. | 1997 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:10074325 |
Li SM et al. | [Effect of puerarin on plasma endothelin, renin activity and angiotensin II in patients with acute myocardial infarction]. | 1997 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:9863126 |
Wang L et al. | [Protective effect of puerarin on acute cerebral ischemia in rats]. | 1997 | Zhongguo Zhong Yao Za Zhi | pmid:11243176 |
Jin XL et al. | [Determination of puerarin in plasma by high performance liquid chromatography]. | 1997 | Yao Xue Xue Bao | pmid:11596224 |
Liu S et al. | [A study on processing of the root of Pueraria lobata (Willd.) ohwi by HPLC]. | 1998 | Zhongguo Zhong Yao Za Zhi | pmid:12242820 |
Kim DH et al. | Metabolism of puerarin and daidzin by human intestinal bacteria and their relation to in vitro cytotoxicity. | 1998 | Biol. Pharm. Bull. | pmid:9657051 |
Keung WM and Vallee BL | Daidzin and its antidipsotropic analogs inhibit serotonin and dopamine metabolism in isolated mitochondria. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9482862 |
Lin RC and Li TK | Effects of isoflavones on alcohol pharmacokinetics and alcohol-drinking behavior in rats. | 1998 | Am. J. Clin. Nutr. | pmid:9848526 |
Dong LP and Wang TY | Effects of puerarin against glutamate excitotoxicity on cultured mouse cerebral cortical neurons. | 1998 | Zhongguo Yao Li Xue Bao | pmid:10375780 |
Wang CY et al. | Analysis of Puerariae radix and its medicinal preparations by capillary electrophoresis. | 1998 | J Chromatogr A | pmid:9588018 |
Zhu H et al. | [Application and characteristics of macroreticular resin in purification study of different effective ingredients in Chinese medicines]. | 1998 | Zhongguo Zhong Yao Za Zhi | pmid:11599359 |
Zhao Z et al. | [Clinical study of puerarin in treatment of patients with unstable angina]. | 1998 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:11477926 |
Fu C et al. | [The study of ethanol-water used as reversed-phase high performance liquid chromatographic mobile phase]. | 1999 | Se Pu | pmid:12552885 |
Okamura N et al. | Simultaneous high-performance liquid chromatographic determination of puerarin, daidzin, paeoniflorin, liquiritin, cinnamic acid, cinnamaldehyde and glycyrrhizin in Kampo medicines. | 1999 | J Pharm Biomed Anal | pmid:10704126 |
Xuan B et al. | Improvement of ocular blood flow and retinal functions with puerarin analogs. | 1999 | J Ocul Pharmacol Ther | pmid:10385129 |
Qian Y et al. | Blocking effect of puerarin on calcium channel in isolated guinea pig ventricular myocytes. | 1999 | Chin. Med. J. | pmid:11717945 |
Meng P et al. | [Clinical observation of the treatment of infantile viral myocarditis with puerarin]. | 1999 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:11783152 |
Chen J et al. | [Effect of puerarin on fibrinolytic activity and lipid peroxide in patients with coronary heart disease]. | 1999 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:11783153 |
Liu Q et al. | [Effect of puerarin on coronary collateral circulation in dogs with experimental acute myocardial infarction]. | 1999 | Zhongguo Zhong Yao Za Zhi | pmid:12205891 |
Wang YJ et al. | [Determination of beberine hydrochloride and puerarin in tangwei capsules by RP-HPLC of gradient elution method]. | 2000 | Se Pu | pmid:12541715 |
Ma YS et al. | [Studies permeation of puerarin and its phospholipid complex through mouse skin in vitro]. | 2000 | Zhongguo Zhong Yao Za Zhi | pmid:12512448 |
Liu Q et al. | Restrictive effect of puerarin on myocardial infarct area in dogs and its possible mechanism. | 2000 | J. Tongji Med. Univ. | pmid:12845754 |
Guerra MC et al. | Comparison between chinese medical herb Pueraria lobata crude extract and its main isoflavone puerarin antioxidant properties and effects on rat liver CYP-catalysed drug metabolism. | 2000 | Life Sci. | pmid:11133012 |
Ren P et al. | [Observation on efficacy of puerarin in treating diabetic retinopathy]. | 2000 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:11789184 |
Jiang B et al. | [Stable life prediction for a complex injection of Chinese materia medica by initial average rate stability test]. | 2000 | Zhongguo Zhong Yao Za Zhi | pmid:12212078 |
Duan S et al. | [Effect of puerarin on heart function and serum oxidized-LDL in the patients with chronic cardiac failure]. | 2000 | Hunan Yi Ke Da Xue Xue Bao | pmid:12212215 |
Zhu ZT et al. | [Inhibitive effect of puerarin on increased NO production by neonatal cardiomyocytes during hypoxia/reoxygenation injury]. | 2001 | Zhongguo Zhong Yao Za Zhi | pmid:12776339 |
Huang YF et al. | [Determination of puerarin in xinmaitong oral liquid by HPLC]. | 2001 | Zhongguo Zhong Yao Za Zhi | pmid:12776346 |
Tian J et al. | [Determination of puerarin in three traditional Chinese patent medicines by high performance liquid chromatography]. | 2001 | Se Pu | pmid:12545446 |
Wu P et al. | [Study on effect of Puerarin on nitric oxide system in rats' tissue and its mechanism]. | 2001 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:12577337 |
Luo ZR and Zheng B | [Effect of Puerarin on platelet activating factors CD63 and CD62P, plasminogen activator inhibitor and C-reactive protein in patients with unstable angia pectoris]. | 2001 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:12577374 |
Peng XY et al. | [Study on the differentiation and apoptosis of HL-60 cell line induced by Puerarin]. | 2001 | Hunan Yi Ke Da Xue Xue Bao | pmid:12536642 |
Vera JC et al. | Direct inhibition of the hexose transporter GLUT1 by tyrosine kinase inhibitors. | 2001 | Biochemistry | pmid:11170395 |
Dong LP et al. | [The protective effect of puerarin on cultured rat cerebral cortical astrocytes]. | 2001 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21171401 |
Chen G et al. | Determination of puerarin, daidzein and rutin in Pueraria lobata (Wild.) Ohwi by capillary electrophoresis with electrochemical detection. | 2001 | J Chromatogr A | pmid:11510548 |
Zhang GQ et al. | Puerarin blocks transient outward K+ current and delayed rectifier K+ current in mice hippocampal CA1 neurons. | 2001 | Acta Pharmacol. Sin. | pmid:11742573 |
Qi BL and Qi BM | [Effect of the purariae-isofiavones on estrogen level in normal and ovariectomized rats]. | 2002 | Zhongguo Zhong Yao Za Zhi | pmid:12776591 |
Wei GL et al. | Endotoxin removal in some medicines and human serum albumin solution by affinity membranes. | 2002 | Se Pu | pmid:12541963 |
Shi WG et al. | [Study on interventing effect of puerarin on insulin resistance in patients with coronary heart disease]. | 2002 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:12585165 |
Hsu HH et al. | Stimulatory effect of puerarin on alpha1A-adrenoceptor to increase glucose uptake into cultured C2C12 cells of mice. | 2002 | Planta Med. | pmid:12451490 |
Liu JM et al. | [Therapeutic effect of puerarin therapy on sudden deafness]. | 2002 | Di Yi Jun Yi Da Xue Xue Bao | pmid:12433647 |
Chen B et al. | [The rapid analysis of functional components of P. Lobata by near infrared spectrum]. | 2002 | Guang Pu Xue Yu Guang Pu Fen Xi | pmid:12914179 |
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Miao WN et al. | [Effect of Puerarin on K+ channel of isolated ventricular myocyte in guinea pig]. | 2002 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21179804 |
Lee JS et al. | The effect of Puerariae radix on lipoprotein metabolism in liver and intestinal cells. | 2002 | BMC Complement Altern Med | pmid:12485466 |
Cervellati R et al. | Evaluation of antioxidant activity of some natural polyphenolic compounds using the Briggs-Rauscher reaction method. | 2002 | J. Agric. Food Chem. | pmid:12475261 |
Xu XH and Zhao TQ | Effects of puerarin on D-galactose-induced memory deficits in mice. | 2002 | Acta Pharmacol. Sin. | pmid:12100749 |
Benlhabib E et al. | Composition, red blood cell uptake, and serum protein binding of phytoestrogens extracted from commercial kudzu-root and soy preparations. | 2002 | J Med Food | pmid:12495583 |
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Keyler DE et al. | Toxicity study of an antidipsotropic Chinese herbal mixture in rats: NPI-028. | 2002 | J Altern Complement Med | pmid:12006125 |
Yu BS et al. | RP-HPLC determination of puerarin in Chinese traditional medicinal preparations containing pueraria. | 2002 | J Pharm Biomed Anal | pmid:12367710 |
Hsieh MT et al. | Effects of puerarin on scopolamine-, mecamylamine-, p-chloroamphetamine- and dizocilpine-induced inhibitory avoidance performance impairment in rats. | 2002 | Planta Med. | pmid:12391553 |
Choo MK et al. | Antithrombotic and antiallergic activities of daidzein, a metabolite of puerarin and daidzin produced by human intestinal microflora. | 2002 | Biol. Pharm. Bull. | pmid:12392089 |