Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
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Authors | Title | Published | Journal | PubMed Link |
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Zhou PQ et al. | [Clinical observation of puerarin in treating patients with vertebral artery insufficiency due to cervical spondylosis: a report of 123 cases]. | 2006 | Zhong Xi Yi Jie He Xue Bao | pmid:16409979 |
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Yeung DK et al. | Puerarin, an isoflavonoid derived from Radix puerariae, potentiates endothelium-independent relaxation via the cyclic AMP pathway in porcine coronary artery. | 2006 | Eur. J. Pharmacol. | pmid:17027964 |
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Kim JM et al. | Constituents of the roots of Pueraria lobata inhibit formation of advanced glycation end products (AGEs). | 2006 | Arch. Pharm. Res. | pmid:17121174 |
Park EK et al. | Intestinal bacteria activate estrogenic effect of main constituents puerarin and daidzin of Pueraria thunbergiana. | 2006 | Biol. Pharm. Bull. | pmid:17142977 |
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Chen M et al. | [Determination of puerarin in Kangshen granule by reversed-phase high performance liquid chromatography]. | 2006 | Se Pu | pmid:17165545 |
Ren F et al. | Quantitative determination of puerarin in dog plasma by HPLC and study on the relative bioavailability of sustained release tablets. | 2006 | J Pharm Biomed Anal | pmid:16413737 |
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Xu YZ et al. | [Puerarin suppresses the proliferation of vscular smooth muscule cells and c-fos and bcl-2 protein expression]. | 2006 | Zhongguo Zhong Yao Za Zhi | pmid:16722382 |
Wang FW et al. | [Protective effect of puerarin on stress-induced gastric mucosal injury in rats]. | 2006 | Zhongguo Zhong Yao Za Zhi | pmid:16722386 |
Hao LN et al. | Puerarin decreases lens epithelium cell apoptosis induced partly by peroxynitrite in diabetic rats. | 2006 | Sheng Li Xue Bao | pmid:17173194 |
Kirakosyan A et al. | Regulation of isoflavone production in hydroponically grown Pueraria montana (kudzu) by cork pieces, XAD-4, and methyl jasmonate. | 2006 | Plant Cell Rep. | pmid:16841218 |
Deng X et al. | [Pharmacokinetics of puerarin in the aqueous humor and vitreous of rabbit eye following systemic administration]. | 2006 | Yan Ke Xue Bao | pmid:17378162 |
Li DZ et al. | [Protective effect of puerarin on endothelial dysfunction of heat shock protein 60 induced specific immunity in apolipoprotein E-null mice]. | 2006 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:17569333 |
Tian H et al. | Liquid chromatography-mass spectrometric analysis of puerarin and its metabolite in human urine. | 2006 | J Sep Sci | pmid:17313111 |
Chen SB et al. | High-performance thin-layer chromatographic fingerprints of isoflavonoids for distinguishing between Radix Puerariae Lobate and Radix Puerariae Thomsonii. | 2006 | J Chromatogr A | pmid:16714027 |
Zhang SP et al. | [The experimental study of Radix Puerariae inhibiting glycation in rats induced by D-galactose]. | 2006 | Zhong Yao Cai | pmid:16850728 |
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Pan HP et al. | [Protection of puerarin on the cerebral injury in the rats with acute local ischemia]. | 2005 | Zhongguo Zhong Yao Za Zhi | pmid:15810455 |
Cui S et al. | Study on the bioavailability of puerarin from Pueraria lobata isoflavone self-microemulsifying drug-delivery systems and tablets in rabbits by liquid chromatography-mass spectrometry. | 2005 | Biomed. Chromatogr. | pmid:15627278 |
Li C et al. | Non-aqueous capillary electrophoresis for simultaneous separation and determination of three major active components in traditional medicinal preparations. | 2005 | Biomed. Chromatogr. | pmid:15627280 |
Jin LH et al. | [Protective effects of puerarin on radiation injury of experimental rats]. | 2005 | Zhong Xi Yi Jie He Xue Bao | pmid:15644160 |
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Han P et al. | [Effect of pueraria crude extreact and puerarin on ethanol-induced expression of heat shock protein 70 in embryonic mouse hippocampal cultures]. | 2005 | Zhonghua Yi Xue Za Zhi | pmid:16324368 |
Tian H et al. | [Separation and identification of isoflavonoids in Pueraria lobata extracts and its preparations by reversed-phase capillary liquid chromatography coupled with electrospray ionization quadrupole time of flight mass spectrometry]. | 2005 | Se Pu | pmid:16350789 |
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Meezan E et al. | Contrasting effects of puerarin and daidzin on glucose homeostasis in mice. | 2005 | J. Agric. Food Chem. | pmid:16248582 |
Han P et al. | [Potential antiviral drug Pueraria crude extract and puerarin protect against ethanol-induced cytotoxicity in embryonic mouse hippocampal cultures]. | 2005 | Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi | pmid:16261207 |
Bo J et al. | Protection by puerarin against MPP+-induced neurotoxicity in PC12 cells mediated by inhibiting mitochondrial dysfunction and caspase-3-like activation. | 2005 | Neurosci. Res. | pmid:16112764 |
Cui S et al. | Self-microemulsifying drug delivery systems (SMEDDS) for improving in vitro dissolution and oral absorption of Pueraria lobata isoflavone. | 2005 | Drug Dev Ind Pharm | pmid:16093200 |
Mao CP and Gu ZL | Puerarin reduces increased c-fos, c-jun, and type IV collagen expression caused by high glucose in glomerular mesangial cells. | 2005 | Acta Pharmacol. Sin. | pmid:16038632 |
Xu X et al. | The Neuroprotection of puerarin against cerebral ischemia is associated with the prevention of apoptosis in rats. | 2005 | Planta Med. | pmid:16041641 |
Li C et al. | Separation and simultaneous determination of rutin, puerarin, daidzein, esculin and esculetin in medicinal preparations by non-aqueous capillary. | 2005 | J Pharm Biomed Anal | pmid:15894450 |
Xiao LZ et al. | [Comparative study on effects of puerarin and granulocyte colony-stimulating factor in treating acute myocardial infarction]. | 2005 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:15842138 |
Xu ME et al. | The study of anti-metabolic syndrome effect of puerarin in vitro. | 2005 | Life Sci. | pmid:16005472 |
Ma Z et al. | Determination of puerarin in human plasma by high performance liquid chromatography. | 2005 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:16009605 |
Pan HP et al. | [Effect of puerarin on the expression of Hsp70 in the rats with cerebral injury induced by acute local ischemia]. | 2005 | Zhongguo Zhong Yao Za Zhi | pmid:16011103 |
Zhao Y et al. | [Experimental study of protective effect of pueraria compound on the cerebral ischemic injury]. | 2005 | Zhongguo Zhong Yao Za Zhi | pmid:16011106 |
He HJ et al. | [Effects of sucrose and light on the growth and production of secondary metabolites in Pueraria phaseoloides hairy roots]. | 2005 | Sheng Wu Gong Cheng Xue Bao | pmid:16468362 |
Gao Q et al. | Improvement of ventricular mechanical properties by puerarin involves mitochondrial permeability transition in isolated rat heart during ischemia and reperfusion. | 2005 | Conf Proc IEEE Eng Med Biol Soc | pmid:17281523 |
Zang HM et al. | [Experimental study of the effects of puerarin on biological characters of osteoblasts in vitro]. | 2005 | Zhongguo Zhong Yao Za Zhi | pmid:16494032 |
Wang YL et al. | [Myocardial protective effect of puerarin injection in children with severe pneumonia]. | 2005 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:16025962 |
Mercer LD et al. | Dietary polyphenols protect dopamine neurons from oxidative insults and apoptosis: investigations in primary rat mesencephalic cultures. | 2005 | Biochem. Pharmacol. | pmid:15627486 |
Jun M et al. | Suppression of arachidonic acid metabolism and nitric oxide formation by kudzu isoflavones in murine macrophages. | 2005 | Mol Nutr Food Res | pmid:16254887 |
Plontke S | Therapy of hearing disorders - conservative procedures. | 2005 | GMS Curr Top Otorhinolaryngol Head Neck Surg | pmid:22073049 |
Romero MR et al. | Effect of artemisinin/artesunate as inhibitors of hepatitis B virus production in an "in vitro" replicative system. | 2005 | Antiviral Res. | pmid:16122816 |
He JT et al. | Biotin-avidin amplified enzyme-linked immunosorbent assay for determination of isoflavone daidzein. | 2005 | Talanta | pmid:18969844 |
Zhang S et al. | Application of microdialysis technique in the traditional chinese medicine. | 2005 | Conf Proc IEEE Eng Med Biol Soc | pmid:17282072 |
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Zhang Y et al. | Analysis of the estrogenic components in kudzu root by bioassay and high performance liquid chromatography. | 2005 | J. Steroid Biochem. Mol. Biol. | pmid:15857757 |
Yan B et al. | HPLC method for the determination and pharmacokinetic studies on puerarin in cerebral ischemia reperfusion rat plasma after intravenous administration of puerariae radix isoflavone. | 2005 | J Pharm Biomed Anal | pmid:15708670 |
Jiang RW et al. | A comparative study on aqueous root extracts of Pueraria thomsonii and Pueraria lobata by antioxidant assay and HPLC fingerprint analysis. | 2005 | J Ethnopharmacol | pmid:15588661 |
Dong K et al. | [Endothelium-independent vasorelaxant effect of puerarin on rat thoracic aorta]. | 2004 | Zhongguo Zhong Yao Za Zhi | pmid:15631089 |
Chauhan SK et al. | Determination of puerarin from pueraria tuberosa dc by HPLC. | 2004 | Anc Sci Life | pmid:22557128 |
Chueh FS et al. | Puerarin acts through brain serotonergic mechanisms to induce thermal effects. | 2004 | J. Pharmacol. Sci. | pmid:15599109 |
Chen WC et al. | Mediation of beta-endorphin by the isoflavone puerarin to lower plasma glucose in streptozotocin-induced diabetic rats. | 2004 | Planta Med. | pmid:14994187 |
Wang B et al. | [Clinical analysis of 5 cases with acute intravascular hemolysis caused by puerarin]. | 2004 | Beijing Da Xue Xue Bao | pmid:14970887 |
Zhang FR et al. | [Effects of puerarin on number and activity of endothelial progenitor cells from peripheral blood]. | 2004 | Zhongguo Zhong Yao Za Zhi | pmid:15506293 |
Zhang Q et al. | Flow injection-chemiluminescence determination of puerarin in pharmaceutical preparations. | 2004 | J Pharm Biomed Anal | pmid:15522534 |
Duan HJ et al. | [Effects of puerarin on renal function, expressions of MMP-2 and TIMP-2 in diabetic rats]. | 2004 | Yao Xue Xue Bao | pmid:15493832 |
Xiao LZ et al. | [Study on the effect and mechanism of puerarin on the size of infarction in patients with acute myocardial infarction]. | 2004 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:15495821 |
Prasain JK et al. | Identification of puerarin and its metabolites in rats by liquid chromatography-tandem mass spectrometry. | 2004 | J. Agric. Food Chem. | pmid:15186086 |
Sang HF et al. | Effect of puerarin on neural function and histopathological damages after transient spinal cord ischemia in rabbits. | 2004 | Chin. J. Traumatol. | pmid:15294110 |
Song CY and Bi HM | [Effects of puerarin on plasma membrane GLUT4 content in skeletal muscle from insulin-resistant Sprague-Dawley rats under insulin stimulation]. | 2004 | Zhongguo Zhong Yao Za Zhi | pmid:15719689 |
Benlhabib E et al. | Effects of purified puerarin on voluntary alcohol intake and alcohol withdrawal symptoms in P rats receiving free access to water and alcohol. | 2004 | J Med Food | pmid:15298765 |
Guo XG et al. | [Effect of puerarin on L-type calcium channel in isolated rat ventricular myocytes]. | 2004 | Zhongguo Zhong Yao Za Zhi | pmid:15706853 |
Hao LN et al. | [Peroxynitrite-induced formation of diabetic cataract and its prevention by puerarin in rat]. | 2004 | Zhonghua Yan Ke Za Zhi | pmid:15312625 |
Han J et al. | [Effect of puerarin and daidzein on proliferating vascular smooth muscle cells]. | 2004 | Zhongguo Zhong Yao Za Zhi | pmid:15706898 |
Zhu JH et al. | Effects of puerarin on number and activity of endothelial progenitor cells from peripheral blood. | 2004 | Acta Pharmacol. Sin. | pmid:15301738 |
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Kintzios S et al. | Scale-up production of puerarin from hairy roots of Pueraria phaseoloides in an airlift bioreactor. | 2004 | Biotechnol. Lett. | pmid:15218379 |
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Benlhabib E et al. | Kudzu root extract suppresses voluntary alcohol intake and alcohol withdrawal symptoms in P rats receiving free access to water and alcohol. | 2004 | J Med Food | pmid:15298764 |
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