Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
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Authors | Title | Published | Journal | PubMed Link |
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Li R et al. | Puerarin exerts the protective effect against chemical induced dysmetabolism in rats. | 2016 | Gene | pmid:27677221 |
Loutchanwoot P et al. | Evaluation of in vivo estrogenic potency of natural estrogen-active chemical, puerarin, on pituitary function in gonadectomized female rats. | 2016 | Life Sci. | pmid:27615593 |
Gao Y et al. | An isoflavonoid-enriched extract from Pueraria lobata (kudzu) root protects human umbilical vein endothelial cells against oxidative stress induced apoptosis. | 2016 | J Ethnopharmacol | pmid:27717903 |
Song XB et al. | Puerarin protects against cadmium-induced proximal tubular cell apoptosis by restoring mitochondrial function. | 2016 | Chem. Biol. Interact. | pmid:27717697 |
Zhang Y et al. | Puerarin Prevents LPS-Induced Osteoclast Formation and Bone Loss via Inhibition of Akt Activation. | 2016 | Biol. Pharm. Bull. | pmid:27904045 |
Liao ZG et al. | Improvement of Transmembrane Transport Mechanism Study of Imperatorin on P-Glycoprotein-Mediated Drug Transport. | 2016 | Molecules | pmid:27886150 |
Ji Y et al. | Anticerebral Ischemia-Reperfusion Injury Activity of Synthesized Puerarin Derivatives. | 2016 | Biomed Res Int | pmid:27807543 |
Zhang D et al. | The Neuroprotective Effect of Puerarin in Acute Spinal Cord Injury Rats. | 2016 | Cell. Physiol. Biochem. | pmid:27576607 |
Zhang L et al. | Puerarin transport across a Calu-3 cell monolayer - an in vitro model of nasal mucosa permeability and the influence of paeoniflorin and menthol. | 2016 | Drug Des Devel Ther | pmid:27468226 |
Wang K et al. | Neuroprotective Effect of Puerarin on Glutamate-Induced Cytotoxicity in Differentiated Y-79 Cells via Inhibition of ROS Generation and Ca(2+) Influx. | 2016 | Int J Mol Sci | pmid:27409614 |
Chen J et al. | Puerarin affects bone biomarkers in the serum of rats with intrauterine growth restriction. | 2016 | J Tradit Chin Med | pmid:27400476 |
Su B et al. | Relevance of the Pharmacokinetic and Pharmacodynamic Profiles of Puerariae lobatae Radix to Aggregation of Multi-Component Molecules in Aqueous Decoctions. | 2016 | Molecules | pmid:27367654 |
Zhang X et al. | Puerarin Attenuates Cardiac Hypertrophy Partly Through Increasing Mir-15b/195 Expression and Suppressing Non-Canonical Transforming Growth Factor Beta (Tgfβ) Signal Pathway. | 2016 | Med. Sci. Monit. | pmid:27145790 |
Xiong N et al. | hVMAT2: A Target of Individualized Medication for Parkinson's Disease. | 2016 | Neurotherapeutics | pmid:27137201 |
Cheng Y et al. | Protective Effect of Puerarin Against Oxidative Stress Injury of Neural Cells and Related Mechanisms. | 2016 | Med. Sci. Monit. | pmid:27074962 |
Saraswat G et al. | Molecular cues to the anti-implantation effect of nano-puerarin in rats. | 2016 | Reproduction | pmid:27026713 |
Xue Q et al. | Lyophilized Powder of Catalpol and Puerarin Protects Neurovascular Unit from Stroke. | 2016 | Int. J. Biol. Sci. | pmid:27019622 |
Wang ZK et al. | Alleviation of Lead-Induced Apoptosis by Puerarin via Inhibiting Mitochondrial Permeability Transition Pore Opening in Primary Cultures of Rat Proximal Tubular Cells. | 2016 | Biol Trace Elem Res | pmid:27116952 |
Ma Y et al. | Puerarin Attenuates Anoxia/Reoxygenation Injury Through Enhancing Bcl-2 Associated Athanogene 3 Expression, a Modulator of Apoptosis and Autophagy. | 2016 | Med. Sci. Monit. | pmid:27011313 |
Luo X et al. | Puerarin Exerts a Delayed Inhibitory Effect on the Proliferation of Cardiomyocytes Derived from Murine ES Cells via Slowing Progression through G2/M Phase. | 2016 | Cell. Physiol. Biochem. | pmid:27008508 |
Hu Y et al. | Inhibitory effect of puerarin on vascular smooth muscle cells proliferation induced by oxidised low-density lipoprotein via suppressing ERK 1/2 phosphorylation and PCNA expression. | 2016 | Pharmazie | pmid:27004373 |
Jiang QD and Li XP | Effect of puerarin on the expression of NMU, NPY, and POMC genes in the hypothalamus. | 2016 | Genet. Mol. Res. | pmid:26985919 |
Yuan SY et al. | Puerarin prevents bone loss in ovariectomized mice and inhibits osteoclast formation in vitro. | 2016 | Chin J Nat Med | pmid:27114313 |
Qu H et al. | Rapid lateral-flow immunoassay for the quantum dot-based detection of puerarin. | 2016 | Biosens Bioelectron | pmid:26991602 |
Liu B et al. | Puerarin for ischaemic stroke. | 2016 | Cochrane Database Syst Rev | pmid:26891451 |
Hong XP et al. | Puerarin Ameliorates D-Galactose Induced Enhanced Hippocampal Neurogenesis and Tau Hyperphosphorylation in Rat Brain. | 2016 | J. Alzheimers Dis. | pmid:26890737 |
Suthon S et al. | Anti-osteoporotic effects of Pueraria candollei var. mirifica on bone mineral density and histomorphometry in estrogen-deficient rats. | 2016 | J Nat Med | pmid:26815435 |
Qiao L et al. | A HPLC-MS/MS method for determination of 6'''-feruloylspinosin in rat plasma and tissues: Pharmacokinetics and tissue distribution study. | 2016 | J Pharm Biomed Anal | pmid:26780157 |
Zhao YZ et al. | Using PG-Liposome-Based System to Enhance Puerarin Liver-Targeted Therapy for Alcohol-Induced Liver Disease. | 2016 | AAPS PharmSciTech | pmid:26753818 |
Huang FJ and Chan WH | Apoptotic effects on maturation of mouse oocytes, fertilization and fetal development by puerarin. | 2016 | Drug Chem Toxicol | pmid:26712108 |
Cheng G et al. | Preparation and In Vitro/In Vivo Evaluation of Puerarin Solid Self-Microemulsifying Drug Delivery System by Spherical Crystallization Technique. | 2016 | AAPS PharmSciTech | pmid:26694058 |
Liu X et al. | Puerarin ameliorates cognitive deficits in streptozotocin-induced diabetic rats. | 2016 | Metab Brain Dis | pmid:26686502 |
Liu CM et al. | Puerarin protects mouse liver against nickel-induced oxidative stress and inflammation associated with the TLR4/p38/CREB pathway. | 2016 | Chem. Biol. Interact. | pmid:26607348 |
Yi T et al. | Enhancing both oral bioavailability and brain penetration of puerarin using borneol in combination with preparation technologies. | 2017 | Drug Deliv | pmid:28165806 |
Kang H et al. | Puerarin inhibits M2 polarization and metastasis of tumor-associated macrophages from NSCLC xenograft model via inactivating MEK/ERK 1/2 pathway. | 2017 | Int. J. Oncol. | pmid:28101568 |
Li X et al. | Puerarin protects against endothelial dysfunction and end-organ damage in Ang II-induced hypertension. | 2017 | Clin. Exp. Hypertens. | pmid:28060542 |
Ge B et al. | Puerarin offsets the anticoagulation effect of warfarin in rats by inducing rCyps, upregulating vitamin K epoxide reductase and inhibiting thrombomodulin. | 2017 | Biopharm Drug Dispos | pmid:27925234 |
Li L et al. | Puerarin suppression of Aβ-induced primary cortical neuron death is largely dependent on ERβ. | 2017 | Brain Res. | pmid:27923632 |
Türer ÇC et al. | The Local Effect of Puerarin on Critical-Sized Calvarial Defects. | 2017 | J Craniofac Surg | pmid:27922959 |
Wei S et al. | Effect of puerarin on transcriptome of astrocyte during oxygen-glucose deprivation/reoxygenation injury. | 2017 | Mol. Cell. Biochem. | pmid:27844252 |
Cheng YF et al. | GPR30 Activation Contributes to the Puerarin-Mediated Neuroprotection in MPP-Induced SH-SY5Y Cell Death. | 2017 | J. Mol. Neurosci. | pmid:27796870 |
Cong X et al. | Puerarin ameliorates heat stress-induced oxidative damage and apoptosis in bovine Sertoli cells by suppressing ROS production and upregulating Hsp72 expression. | 2017 | Theriogenology | pmid:27771118 |
Song X et al. | Restoration of autophagy by puerarin in lead-exposed primary rat proximal tubular cells via regulating AMPK-mTOR signaling. | 2017 | J. Biochem. Mol. Toxicol. | pmid:27762461 |
Liu Y et al. | Lyophilized Powder of Catalpol and Puerarin Protected Cerebral Vessels from Ischemia by Its Anti-apoptosis on Endothelial Cells. | 2017 | Int. J. Biol. Sci. | pmid:28367097 |
Sun H et al. | Simultaneous determination of epalrestat and puerarin in rat plasma by UHPLC-MS/MS: Application to their pharmacokinetic interaction study. | 2017 | Biomed. Chromatogr. | pmid:27650591 |
Ma X et al. | Puerarin attenuates cisplatin-induced rat nephrotoxicity: The involvement of TLR4/NF-κB signaling pathway. | 2017 | PLoS ONE | pmid:28182789 |
Zheng QH et al. | Efficacy and safety of puerarin injection in curing acute ischemic stroke: A meta-analysis of randomized controlled trials. | 2017 | Medicine (Baltimore) | pmid:28072733 |
Jung HW et al. | The Root Extract of Pueraria lobata and Its Main Compound, Puerarin, Prevent Obesity by Increasing the Energy Metabolism in Skeletal Muscle. | 2017 | Nutrients | pmid:28054981 |
Bacanlı M et al. | The antioxidant, cytotoxic, and antigenotoxic effects of galangin, puerarin, and ursolic acid in mammalian cells. | 2017 | Drug Chem Toxicol | pmid:27461151 |
Wu L et al. | Protective Effects of Puerarin against Aβ 1-42-Induced Learning and Memory Impairments in Mice. | 2017 | Planta Med. | pmid:27420352 |
KopeÄná-Zapletalová M et al. | Interaction of isoflavonoids with human liver microsomal cytochromes P450: inhibition of CYP enzyme activities. | 2017 | Xenobiotica | pmid:27312150 |
Zhao J et al. | Plant Natural Product Puerarin Ameliorates Depressive Behaviors and Chronic Pain in Mice with Spared Nerve Injury (SNI). | 2017 | Mol. Neurobiol. | pmid:27013468 |
Dong Z et al. | RGD modified and PEGylated lipid nanoparticles loaded with puerarin: Formulation, characterization and protective effects on acute myocardial ischemia model. | 2017 | Biomed. Pharmacother. | pmid:28236703 |
Li CH et al. | Puerarin promotes ABCA1-mediated cholesterol efflux and decreases cellular lipid accumulation in THP-1 macrophages. | 2017 | Eur. J. Pharmacol. | pmid:28576406 |
Li W et al. | Puerarin attenuates the daunorubicin-induced apoptosis of H9c2 cells by activating the PI3K/Akt signaling pathway via the inhibition of Ca2+ influx. | 2017 | Int. J. Mol. Med. | pmid:29039532 |
Yao Y et al. | Puerarin inhibits β‑amyloid peptide 1‑42‑induced tau hyperphosphorylation via the Wnt/β‑catenin signaling pathway. | 2017 | Mol Med Rep | pmid:28990074 |
Tu YM et al. | A high concentration of fatty acids induces TNF-α as well as NO release mediated by the P2X4 receptor, and the protective effects of puerarin in RAW264.7 cells. | 2017 | Food Funct | pmid:28937704 |
Zhang L et al. | Puerarin transport across rat nasal epithelial cells and the influence of compatibility with peoniflorin and menthol. | 2017 | Drug Des Devel Ther | pmid:28919709 |
Zhan XQ et al. | Puerarin promotes the viability and differentiation of MC3T3‑E1 cells by miR‑204‑regulated Runx2 upregulation. | 2017 | Mol Med Rep | pmid:28901520 |
Li X et al. | Puerarin and Amlodipine Improvement of D-Galactose-Induced Impairments of Behaviour and Neurogenesis in Mouse Dentate Gyrus: Correlation with Glucocorticoid Receptor Expression. | 2017 | Neurochem. Res. | pmid:28831640 |
Bhuiyan MMH et al. | Radix Puerariae modulates glutamatergic synaptic architecture and potentiates functional synaptic plasticity in primary hippocampal neurons. | 2017 | J Ethnopharmacol | pmid:28734961 |
Kim Y et al. | Pharmacokinetics and Safety of DW1029M, a Botanical Drug for the Treatment of Diabetic Nephropathy, Following Single Doses in Healthy Subjects. | 2017 | Clin Pharmacol Drug Dev | pmid:28301092 |
Li P et al. | In Vivo Pharmacokinetics of Puerarin via Different Drug Administration Routes Based on Middle Cerebral Artery Occlusion Model. | 2017 | Eur J Drug Metab Pharmacokinet | pmid:27928655 |
Jing S et al. | A novel electrochemical sensor based on WO nanorods-decorated poly(sodium 4-styrenesulfonate) functionalized graphene nanocomposite modified electrode for detecting of puerarin. | 2017 | Talanta | pmid:28738611 |
Wang L et al. | Puerarin Enhances Ca2+ Reuptake and Ca2+ Content of Sarcoplasmic Reticulum in Murine Embryonic Stem Cell-Derived Cardiomyocytes via Upregulation of SERCA2a. | 2017 | Cell. Physiol. Biochem. | pmid:29179218 |
Wang J et al. | Novel cationic lipid nanoparticles as an ophthalmic delivery system for multicomponent drugs: development, characterization, in vitro permeation, in vivo pharmacokinetic, and molecular dynamics studies. | 2017 | Int J Nanomedicine | pmid:29158673 |
Lin L et al. | The Effects and Possible Mechanisms of Puerarin to Treat Uterine Fibrosis Induced by Ischemia-Reperfusion Injury in Rats. | 2017 | Med. Sci. Monit. | pmid:28704345 |
Kong H et al. | Pharmacokinetics and Tissue Distribution Kinetics of Puerarin in Rats Using Indirect Competitive ELISA. | 2017 | Molecules | pmid:28587251 |
Liu X et al. | Puerarin suppresses LPS-induced breast cancer cell migration, invasion and adhesion by blockage NF-κB and Erk pathway. | 2017 | Biomed. Pharmacother. | pmid:28558356 |
Tang H et al. | Puerarin attenuates myocardial hypoxia/reoxygenation injury by inhibiting autophagy via the Akt signaling pathway. | 2017 | Mol Med Rep | pmid:28393209 |
Liu H et al. | Puerarin and zinc additively prevent mandibular bone loss through inhibiting osteoclastogenesis in ovariectomized rats. | 2017 | Histol. Histopathol. | pmid:27966208 |
Shang Z et al. | Rapid profiling and identification of puerarin metabolites in rat urine and plasma after oral administration by UHPLC-LTQ-Orbitrap mass spectrometer. | 2017 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:29073480 |
Deng HF et al. | Puerarin inhibits expression of tissue factor induced by oxidative low-density lipoprotein through activating the PI3K/Akt/eNOS pathway and inhibiting activation of ERK1/2 and NF-κB. | 2017 | Life Sci. | pmid:29037842 |
Tan C et al. | Puerarin Improves Vascular Insulin Resistance and Cardiovascular Remodeling in Salt-Sensitive Hypertension. | 2017 | Am. J. Chin. Med. | pmid:28830209 |
Zhang WG et al. | Puerarin Induces Hepatocellular Carcinoma Cell Apoptosis Modulated by MAPK Signaling Pathways in a Dose-dependent Manner. | 2017 | Anticancer Res. | pmid:28739736 |
Wang K et al. | Puerarin inhibits amyloid β-induced NLRP3 inflammasome activation in retinal pigment epithelial cells via suppressing ROS-dependent oxidative and endoplasmic reticulum stresses. | 2017 | Exp. Cell Res. | pmid:28583762 |
Cheng HH et al. | Effects of puerarin on intracellular Ca and cell viability of MDCK renal tubular cells. | 2017 | Environ. Toxicol. Pharmacol. | pmid:28384516 |
Zhou X et al. | Puerarin attenuates renal fibrosis by reducing oxidative stress induced-epithelial cell apoptosis via MAPK signal pathways in vivo and in vitro. | 2017 | Ren Fail | pmid:28335679 |
Wang X et al. | Molecular characterization of the C-glucosylation for puerarin biosynthesis in Pueraria lobata. | 2017 | Plant J. | pmid:28207970 |
Hongyun H et al. | Puerarin provides a neuroprotection against transient cerebral ischemia by attenuating autophagy at the ischemic penumbra in neurons but not in astrocytes. | 2017 | Neurosci. Lett. | pmid:28192195 |
Xue B et al. | Puerarin may protect against Schwann cell damage induced by glucose fluctuation. | 2017 | J Nat Med | pmid:28181078 |
Chen X et al. | Puerarin attenuates palmitate-induced mitochondrial dysfunction, impaired mitophagy and inflammation in L6 myotubes. | 2018 | Life Sci. | pmid:29802940 |
Wan Q et al. | Puerarin inhibits vascular smooth muscle cells proliferation induced by fine particulate matter via suppressing of the p38 MAPK signaling pathway. | 2018 | BMC Complement Altern Med | pmid:29728095 |
Deng Y et al. | ERK5/KLF2 activation is involved in the reducing effects of puerarin on monocyte adhesion to endothelial cells and atherosclerotic lesion in apolipoprotein E-deficient mice. | 2018 | Biochim. Biophys. Acta | pmid:29723698 |
Lee JH et al. | The suppressive effect of puerarin on atopic dermatitis-like skin lesions through regulation of inflammatory mediators in vitro and in vivo. | 2018 | Biochem. Biophys. Res. Commun. | pmid:29524423 |
Zhong Y et al. | Puerarin alleviate radicular pain from lumbar disc herniation by inhibiting ERK-dependent spinal microglia activation. | 2018 | Neuropeptides | pmid:30466510 |
Wang Y et al. | Support Vector Regression Approach to Predict the Design Space for the Extraction Process of . | 2018 | Molecules | pmid:30241281 |
Shiying L et al. | Puerarin promoted proliferation and differentiation of dopamine-producing cells in Parkinson's animal models. | 2018 | Biomed. Pharmacother. | pmid:30119192 |
Hou B et al. | Puerarin Mitigates Diabetic Hepatic Steatosis and Fibrosis by Inhibiting TGF- Signaling Pathway Activation in Type 2 Diabetic Rats. | 2018 | Oxid Med Cell Longev | pmid:30057680 |
Pang Z et al. | Gel formation of puerarin and mechanistic study during its cooling process. | 2018 | Int J Pharm | pmid:30016673 |
Krittanai S et al. | Development of a colloidal gold nanoparticle-based immunochromatographic strip for the one-step detection of miroestrol and puerarin. | 2018 | Biomed. Chromatogr. | pmid:29972702 |
Wang L et al. | Puerarin Attenuates Osteoarthritis via Upregulating AMP-Activated Protein Kinase/Proliferator-Activated Receptor-γ Coactivator-1 Signaling Pathway in Osteoarthritis Rats. | 2018 | Pharmacology | pmid:29961054 |
Ullah MZ et al. | Attenuation of inflammatory pain by puerarin in animal model of inflammation through inhibition of pro-inflammatory mediators. | 2018 | Int. Immunopharmacol. | pmid:29909234 |
Deng HF et al. | Puerarin prevents vascular endothelial injury through suppression of NF-κB activation in LPS-challenged human umbilical vein endothelial cells. | 2018 | Biomed. Pharmacother. | pmid:29775893 |
Loutchanwoot P and Vortherms T | Effects of puerarin on estrogen-regulated gene expression in gonadotropin-releasing hormone pulse generator of ovariectomized rats. | 2018 | Steroids | pmid:29733861 |
Liu Q et al. | Puerarin improves methotrexate-induced renal damage by up-regulating renal expression of Oat1 and Oat3 in vivo and in vitro. | 2018 | Biomed. Pharmacother. | pmid:29710508 |
Wei HY et al. | Puerarin regulates neovascular glaucoma through pigment epithelium‑derived growth factor‑induced NF‑κB signaling pathway. | 2018 | Mol Med Rep | pmid:29620183 |
Liu B et al. | Puerarin protects against heart failure induced by pressure overload through mitigation of ferroptosis. | 2018 | Biochem. Biophys. Res. Commun. | pmid:29427658 |
Wang C et al. | Mechanism of aquaporin 4 (AQP 4) up-regulation in rat cerebral edema under hypobaric hypoxia and the preventative effect of puerarin. | 2018 | Life Sci. | pmid:29054452 |
Slámová K et al. | "Sweet Flavonoids": Glycosidase-Catalyzed Modifications. | 2018 | Int J Mol Sci | pmid:30037103 |