SCHEMBL105486
Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with SCHEMBL105486?
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
PubChem Associated disorders and diseases
What pathways are associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with SCHEMBL105486?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
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What functions are associated with SCHEMBL105486?
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What lipids are associated with SCHEMBL105486?
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What genes are associated with SCHEMBL105486?
Related references are published most in these journals:
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What common seen animal models are associated with SCHEMBL105486?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
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NCBI Entrez Crosslinks
All references with SCHEMBL105486
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Yi T et al. | Enhancing both oral bioavailability and brain penetration of puerarin using borneol in combination with preparation technologies. | 2017 | Drug Deliv | pmid:28165806 |
| Kang H et al. | Puerarin inhibits M2 polarization and metastasis of tumor-associated macrophages from NSCLC xenograft model via inactivating MEK/ERK 1/2 pathway. | 2017 | Int. J. Oncol. | pmid:28101568 |
| Li X et al. | Puerarin protects against endothelial dysfunction and end-organ damage in Ang II-induced hypertension. | 2017 | Clin. Exp. Hypertens. | pmid:28060542 |
| Ge B et al. | Puerarin offsets the anticoagulation effect of warfarin in rats by inducing rCyps, upregulating vitamin K epoxide reductase and inhibiting thrombomodulin. | 2017 | Biopharm Drug Dispos | pmid:27925234 |
| Li L et al. | Puerarin suppression of Aβ-induced primary cortical neuron death is largely dependent on ERβ. | 2017 | Brain Res. | pmid:27923632 |
| Türer ÇC et al. | The Local Effect of Puerarin on Critical-Sized Calvarial Defects. | 2017 | J Craniofac Surg | pmid:27922959 |
| Wei S et al. | Effect of puerarin on transcriptome of astrocyte during oxygen-glucose deprivation/reoxygenation injury. | 2017 | Mol. Cell. Biochem. | pmid:27844252 |
| Cheng YF et al. | GPR30 Activation Contributes to the Puerarin-Mediated Neuroprotection in MPP-Induced SH-SY5Y Cell Death. | 2017 | J. Mol. Neurosci. | pmid:27796870 |
| Cong X et al. | Puerarin ameliorates heat stress-induced oxidative damage and apoptosis in bovine Sertoli cells by suppressing ROS production and upregulating Hsp72 expression. | 2017 | Theriogenology | pmid:27771118 |
| Song X et al. | Restoration of autophagy by puerarin in lead-exposed primary rat proximal tubular cells via regulating AMPK-mTOR signaling. | 2017 | J. Biochem. Mol. Toxicol. | pmid:27762461 |
| Sun H et al. | Simultaneous determination of epalrestat and puerarin in rat plasma by UHPLC-MS/MS: Application to their pharmacokinetic interaction study. | 2017 | Biomed. Chromatogr. | pmid:27650591 |
| Ma X et al. | Puerarin attenuates cisplatin-induced rat nephrotoxicity: The involvement of TLR4/NF-κB signaling pathway. | 2017 | PLoS ONE | pmid:28182789 |
| Zheng QH et al. | Efficacy and safety of puerarin injection in curing acute ischemic stroke: A meta-analysis of randomized controlled trials. | 2017 | Medicine (Baltimore) | pmid:28072733 |
| Jung HW et al. | The Root Extract of Pueraria lobata and Its Main Compound, Puerarin, Prevent Obesity by Increasing the Energy Metabolism in Skeletal Muscle. | 2017 | Nutrients | pmid:28054981 |
| KopeÄná-Zapletalová M et al. | Interaction of isoflavonoids with human liver microsomal cytochromes P450: inhibition of CYP enzyme activities. | 2017 | Xenobiotica | pmid:27312150 |
| Zhao J et al. | Plant Natural Product Puerarin Ameliorates Depressive Behaviors and Chronic Pain in Mice with Spared Nerve Injury (SNI). | 2017 | Mol. Neurobiol. | pmid:27013468 |
| Dong Z et al. | RGD modified and PEGylated lipid nanoparticles loaded with puerarin: Formulation, characterization and protective effects on acute myocardial ischemia model. | 2017 | Biomed. Pharmacother. | pmid:28236703 |
| Li CH et al. | Puerarin promotes ABCA1-mediated cholesterol efflux and decreases cellular lipid accumulation in THP-1 macrophages. | 2017 | Eur. J. Pharmacol. | pmid:28576406 |
| Li W et al. | Puerarin attenuates the daunorubicin-induced apoptosis of H9c2 cells by activating the PI3K/Akt signaling pathway via the inhibition of Ca2+ influx. | 2017 | Int. J. Mol. Med. | pmid:29039532 |
| Yao Y et al. | Puerarin inhibits β‑amyloid peptide 1‑42‑induced tau hyperphosphorylation via the Wnt/β‑catenin signaling pathway. | 2017 | Mol Med Rep | pmid:28990074 |
| Tu YM et al. | A high concentration of fatty acids induces TNF-α as well as NO release mediated by the P2X4 receptor, and the protective effects of puerarin in RAW264.7 cells. | 2017 | Food Funct | pmid:28937704 |
| Zhang L et al. | Puerarin transport across rat nasal epithelial cells and the influence of compatibility with peoniflorin and menthol. | 2017 | Drug Des Devel Ther | pmid:28919709 |
| Zhan XQ et al. | Puerarin promotes the viability and differentiation of MC3T3‑E1 cells by miR‑204‑regulated Runx2 upregulation. | 2017 | Mol Med Rep | pmid:28901520 |
| Li X et al. | Puerarin and Amlodipine Improvement of D-Galactose-Induced Impairments of Behaviour and Neurogenesis in Mouse Dentate Gyrus: Correlation with Glucocorticoid Receptor Expression. | 2017 | Neurochem. Res. | pmid:28831640 |
| Bhuiyan MMH et al. | Radix Puerariae modulates glutamatergic synaptic architecture and potentiates functional synaptic plasticity in primary hippocampal neurons. | 2017 | J Ethnopharmacol | pmid:28734961 |
| Kim Y et al. | Pharmacokinetics and Safety of DW1029M, a Botanical Drug for the Treatment of Diabetic Nephropathy, Following Single Doses in Healthy Subjects. | 2017 | Clin Pharmacol Drug Dev | pmid:28301092 |
| Jing S et al. | A novel electrochemical sensor based on WO nanorods-decorated poly(sodium 4-styrenesulfonate) functionalized graphene nanocomposite modified electrode for detecting of puerarin. | 2017 | Talanta | pmid:28738611 |
| Liu X et al. | Puerarin suppresses LPS-induced breast cancer cell migration, invasion and adhesion by blockage NF-κB and Erk pathway. | 2017 | Biomed. Pharmacother. | pmid:28558356 |
| Tang H et al. | Puerarin attenuates myocardial hypoxia/reoxygenation injury by inhibiting autophagy via the Akt signaling pathway. | 2017 | Mol Med Rep | pmid:28393209 |
| Liu H et al. | Puerarin and zinc additively prevent mandibular bone loss through inhibiting osteoclastogenesis in ovariectomized rats. | 2017 | Histol. Histopathol. | pmid:27966208 |
| Wang K et al. | Puerarin inhibits amyloid β-induced NLRP3 inflammasome activation in retinal pigment epithelial cells via suppressing ROS-dependent oxidative and endoplasmic reticulum stresses. | 2017 | Exp. Cell Res. | pmid:28583762 |
| Cheng HH et al. | Effects of puerarin on intracellular Ca and cell viability of MDCK renal tubular cells. | 2017 | Environ. Toxicol. Pharmacol. | pmid:28384516 |
| Zhou X et al. | Puerarin attenuates renal fibrosis by reducing oxidative stress induced-epithelial cell apoptosis via MAPK signal pathways in vivo and in vitro. | 2017 | Ren Fail | pmid:28335679 |
| Wang X et al. | Molecular characterization of the C-glucosylation for puerarin biosynthesis in Pueraria lobata. | 2017 | Plant J. | pmid:28207970 |
| Hongyun H et al. | Puerarin provides a neuroprotection against transient cerebral ischemia by attenuating autophagy at the ischemic penumbra in neurons but not in astrocytes. | 2017 | Neurosci. Lett. | pmid:28192195 |
| Xue B et al. | Puerarin may protect against Schwann cell damage induced by glucose fluctuation. | 2017 | J Nat Med | pmid:28181078 |
| Tanaka T et al. | Puerarin Suppresses Macrophage Activation via Antioxidant Mechanisms in a CaPO4-Induced Mouse Model of Aneurysm. | 2016 | J. Nutr. Sci. Vitaminol. | pmid:28202848 |
| Tanaka T et al. | Anti-Hyperglycemic Effect of a Kudzu (Pueraria lobata) Vine Extract in Ovariectomized Mice. | 2016 | J. Nutr. Sci. Vitaminol. | pmid:27928122 |
| Lv B et al. | Puerarin Attenuates N-Methyl-D-aspartic Acid-induced Apoptosis and Retinal Ganglion Cell Damage Through the JNK/p38 MAPK Pathway. | 2016 | J. Glaucoma | pmid:27552519 |
| Ji L et al. | Puerarin inhibits the inflammatory response in atherosclerosis via modulation of the NF-κB pathway in a rabbit model. | 2016 | Pharmacol Rep | pmid:27505855 |
| Wu H et al. | Puerarin Exerts an Antiinflammatory Effect by Inhibiting NF-kB and MAPK Activation in Staphylococcus aureus-Induced Mastitis. | 2016 | Phytother Res | pmid:27335240 |
| Wang S et al. | Puerarin protects against CCl4-induced liver fibrosis in mice: possible role of PARP-1 inhibition. | 2016 | Int. Immunopharmacol. | pmid:27318789 |
| Xu X et al. | Puerarin, isolated from Pueraria lobata (Willd.), protects against diabetic nephropathy by attenuating oxidative stress. | 2016 | Gene | pmid:27317894 |
| Wang C et al. | Puerarin attenuates inflammation and oxidation in mice with collagen antibody-induced arthritis via TLR4/NF-κB signaling. | 2016 | Mol Med Rep | pmid:27278131 |
| Liu G et al. | Recent Advances in Methods of Puerarin Biotransformation. | 2016 | Mini Rev Med Chem | pmid:27145856 |
| Wang Q et al. | WITHDRAWN: Puerarin injection for unstable angina pectoris. | 2016 | Cochrane Database Syst Rev | pmid:27136749 |
| Yang L et al. | Puerarin Protects Pancreatic β-Cells in Obese Diabetic Mice via Activation of GLP-1R Signaling. | 2016 | Mol. Endocrinol. | pmid:26789107 |
| Zhao J et al. | Botanical Drug Puerarin Attenuates 6-Hydroxydopamine (6-OHDA)-Induced Neurotoxicity via Upregulating Mitochondrial Enzyme Arginase-2. | 2016 | Mol. Neurobiol. | pmid:25952544 |
| Huang J et al. | Different Flavonoids Can Shape Unique Gut Microbiota Profile In Vitro. | 2016 | J. Food Sci. | pmid:27472307 |
| Xu H et al. | The Effects of Puerarin on Rat Ventricular Myocytes and the Potential Mechanism. | 2016 | Sci Rep | pmid:27762288 |