Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
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Authors | Title | Published | Journal | PubMed Link |
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Wang C and Song Z | In vitro monitoring of nanogram levels of puerarin in human urine using flow injection chemiluminescence. | 2004 | Bioorg. Med. Chem. Lett. | pmid:15261255 |
Kato E and Kawabata J | Glucose uptake enhancing activity of puerarin and the role of C-glucoside suggested from activity of related compounds. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20605096 |
Ge B et al. | Puerarin offsets the anticoagulation effect of warfarin in rats by inducing rCyps, upregulating vitamin K epoxide reductase and inhibiting thrombomodulin. | 2017 | Biopharm Drug Dispos | pmid:27925234 |
Cherdshewasart W and Sriwatcharakul S | Major isoflavonoid contents of the 1-year-cultivated phytoestrogen-rich herb, Pueraria mirifica. | 2007 | Biosci. Biotechnol. Biochem. | pmid:17928711 |
Qu H et al. | Rapid lateral-flow immunoassay for the quantum dot-based detection of puerarin. | 2016 | Biosens Bioelectron | pmid:26991602 |
Kintzios S et al. | Scale-up production of puerarin from hairy roots of Pueraria phaseoloides in an airlift bioreactor. | 2004 | Biotechnol. Lett. | pmid:15218379 |
Efferth T et al. | Activity of drugs from traditional Chinese medicine toward sensitive and MDR1- or MRP1-overexpressing multidrug-resistant human CCRF-CEM leukemia cells. | Blood Cells Mol. Dis. | pmid:12064912 | |
Chang BY et al. | Protective activity of kudzu (Pueraria thunbergiana) vine on chemically-induced hepatotoxicity: in vitro and in vivo studies. | 2016 | BMC Complement Altern Med | pmid:26825303 |
Lee JS et al. | The effect of Puerariae radix on lipoprotein metabolism in liver and intestinal cells. | 2002 | BMC Complement Altern Med | pmid:12485466 |
Wan Q et al. | Puerarin inhibits vascular smooth muscle cells proliferation induced by fine particulate matter via suppressing of the p38 MAPK signaling pathway. | 2018 | BMC Complement Altern Med | pmid:29728095 |
Wang MS et al. | Curcumin reduces alpha-synuclein induced cytotoxicity in Parkinson's disease cell model. | 2010 | BMC Neurosci | pmid:20433710 |
Li L et al. | Puerarin suppression of Aβ-induced primary cortical neuron death is largely dependent on ERβ. | 2017 | Brain Res. | pmid:27923632 |
Li R et al. | Puerarin attenuates neuronal degeneration and blocks oxidative stress to elicit a neuroprotective effect on substantia nigra injury in 6-OHDA-lesioned rats. | 2013 | Brain Res. | pmid:23603411 |
Li R et al. | Puerarin attenuates neuronal degeneration in the substantia nigra of 6-OHDA-lesioned rats through regulating BDNF expression and activating the Nrf2/ARE signaling pathway. | 2013 | Brain Res. | pmid:23747813 |
Xing G et al. | Neuroprotective effects of puerarin against beta-amyloid-induced neurotoxicity in PC12 cells via a PI3K-dependent signaling pathway. | 2011 | Brain Res. Bull. | pmid:21473901 |
Xu C et al. | Effect of puerarin on P2X3 receptor involved in hyperalgesia after burn injury in the rat. | 2009 | Brain Res. Bull. | pmid:19744545 |
Xu C et al. | Role of puerarin in the signalling of neuropathic pain mediated by P2X3 receptor of dorsal root ganglion neurons. | 2012 | Brain Res. Bull. | pmid:22044944 |
Liu S et al. | Puerarin blocks the signaling transmission mediated by P2X3 in SG and DRG to relieve myocardial ischemic damage. | 2014 | Brain Res. Bull. | pmid:24447636 |
Cui SQ et al. | Puerarin protects against damage to spatial learning and memory ability in mice with chronic alcohol poisoning. | 2015 | Braz. J. Med. Biol. Res. | pmid:25831201 |
Boonchird C et al. | Differential binding with ERalpha and ERbeta of the phytoestrogen-rich plant Pueraria mirifica. | 2010 | Braz. J. Med. Biol. Res. | pmid:20027484 |
Liu S et al. | Puerarin attenuates severe burn-induced acute myocardial injury in rats. | 2015 | Burns | pmid:26514700 |
Zhang J et al. | Effects of puerarin on the inflammatory role of burn-related procedural pain mediated by P2X(7) receptors. | 2013 | Burns | pmid:23044342 |
Bao MH et al. | Puerarin protects endothelial cells from oxidized low density lipoprotein induced injuries via the suppression of LOX-1 and induction of eNOS. | 2014 | Can. J. Physiol. Pharmacol. | pmid:24708212 |
Mahdy HM et al. | The anti-apoptotic and anti-inflammatory properties of puerarin attenuate 3-nitropropionic-acid induced neurotoxicity in rats. | 2014 | Can. J. Physiol. Pharmacol. | pmid:24593790 |
Yu Z and Li W | Induction of apoptosis by puerarin in colon cancer HT-29 cells. | 2006 | Cancer Lett. | pmid:16055262 |
Li D et al. | In vitro enzymatic modification of puerarin to puerarin glycosides by maltogenic amylase. | 2004 | Carbohydr. Res. | pmid:15542087 |
Gan M and Yin X | Puerarin induced in mantle cell lymphoma apoptosis and its possible mechanisms involving multi-signaling pathway. | 2015 | Cell Biochem. Biophys. | pmid:25173778 |
Tang L et al. | The protective effects of puerarin in cardiomyocytes from anoxia/reoxygenation injury are mediated by PKCε. | 2014 | Cell Biochem. Funct. | pmid:24496955 |
Jiang B et al. | Hydrogen peroxide-induced apoptosis in pc12 cells and the protective effect of puerarin. | 2003 | Cell Biol. Int. | pmid:14642535 |
Zhang HY et al. | Puerarin protects PC12 cells against beta-amyloid-induced cell injury. | 2008 | Cell Biol. Int. | pmid:18675923 |
Zhang Q et al. | Puerarin protects differentiated PC12 cells from Hâ‚‚Oâ‚‚-induced apoptosis through the PI3K/Akt signalling pathway. | 2012 | Cell Biol. Int. | pmid:22126839 |
Xie N et al. | Puerarin protects hippocampal neurons against cell death in pilocarpine-induced seizures through antioxidant and anti-apoptotic mechanisms. | 2014 | Cell. Mol. Neurobiol. | pmid:25151533 |
Zhang D et al. | The Neuroprotective Effect of Puerarin in Acute Spinal Cord Injury Rats. | 2016 | Cell. Physiol. Biochem. | pmid:27576607 |
Luo X et al. | Puerarin Exerts a Delayed Inhibitory Effect on the Proliferation of Cardiomyocytes Derived from Murine ES Cells via Slowing Progression through G2/M Phase. | 2016 | Cell. Physiol. Biochem. | pmid:27008508 |
Yin M et al. | Puerarin Suppresses the Self-Renewal of Murine Embryonic Stem Cells by Inhibition of REST-MiR-21 Regulatory Pathway. | 2015 | Cell. Physiol. Biochem. | pmid:26330232 |
Wang L et al. | Puerarin facilitates T-tubule development of murine embryonic stem cell-derived cardiomyocytes. | 2014 | Cell. Physiol. Biochem. | pmid:25059232 |
Cheng Y et al. | Effects of puerarin on cardiac differentiation and ventricular specialization of murine embryonic stem cells. | 2013 | Cell. Physiol. Biochem. | pmid:24080853 |
Wang L et al. | Puerarin Enhances Ca2+ Reuptake and Ca2+ Content of Sarcoplasmic Reticulum in Murine Embryonic Stem Cell-Derived Cardiomyocytes via Upregulation of SERCA2a. | 2017 | Cell. Physiol. Biochem. | pmid:29179218 |
Song XB et al. | Puerarin protects against cadmium-induced proximal tubular cell apoptosis by restoring mitochondrial function. | 2016 | Chem. Biol. Interact. | pmid:27717697 |
Liu CM et al. | Puerarin protects mouse liver against nickel-induced oxidative stress and inflammation associated with the TLR4/p38/CREB pathway. | 2016 | Chem. Biol. Interact. | pmid:26607348 |
Hou SZ et al. | Role of the interaction between puerarin and the erythrocyte membrane in puerarin-induced hemolysis. | 2011 | Chem. Biol. Interact. | pmid:21453687 |
Qi H et al. | Optimization and physicochemical characterization of thermosensitive poloxamer gel containing puerarin for ophthalmic use. | 2006 | Chem. Pharm. Bull. | pmid:17077546 |
Yu Z et al. | Simultaneous determination of components in preparation Naodesheng injection by high performance liquid chromatograph-atmospheric pressure chemical ionization mass spectrometry (HPLC-MS/APCI). | 2006 | Chem. Pharm. Bull. | pmid:16595973 |
Nakamura K et al. | The C-glucosyl bond of puerarin was cleaved hydrolytically by a human intestinal bacterium strain PUE to yield its aglycone daidzein and an intact glucose. | 2011 | Chem. Pharm. Bull. | pmid:21212542 |
Yue PF et al. | Development and optimization of intravenous puerarin emulsions formation by a novel complex-phase inversion-homogenization technology. | 2007 | Chem. Pharm. Bull. | pmid:17978512 |
Quan DQ et al. | Studies on preparation and absolute bioavailability of a self-emulsifying system containing puerarin. | 2007 | Chem. Pharm. Bull. | pmid:17473473 |
Zhang CL et al. | Comparative study of Puerariae lobatae and Puerariae thomsonii by HPLC-diode array detection-flow injection-chemiluminescence coupled with HPLC-electrospray ionization-MS. | 2011 | Chem. Pharm. Bull. | pmid:21532189 |
Zhang MY et al. | In vitro and in vivo effects of puerarin on promotion of osteoblast bone formation. | 2012 | Chin J Integr Med | pmid:22457138 |
Pang W et al. | Effect of puerarin on the release of interleukin-8 in co-culture of human bronchial epithelial cells and neutrophils. | 2012 | Chin J Integr Med | pmid:22457139 |
Zhao Y and Zhou Y | Puerarin improve insulin resistance of adipocyte through activating Cb1 binding protein path. | 2012 | Chin J Integr Med | pmid:22457141 |