SCHEMBL105486
Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with SCHEMBL105486?
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
PubChem Associated disorders and diseases
What pathways are associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with SCHEMBL105486?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with SCHEMBL105486?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with SCHEMBL105486?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with SCHEMBL105486?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with SCHEMBL105486?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with SCHEMBL105486
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Xiao C et al. | Anti-oxidative and TNF-α suppressive activities of puerarin derivative (4AC) in RAW264.7 cells and collagen-induced arthritic rats. | 2011 | Eur. J. Pharmacol. | pmid:21651907 |
| Tian F et al. | The optimal therapeutic timing and mechanism of puerarin treatment of spinal cord ischemia-reperfusion injury in rats. | 2011 | J Ethnopharmacol | pmid:21296138 |
| He X et al. | A genomic approach to isoflavone biosynthesis in kudzu (Pueraria lobata). | 2011 | Planta | pmid:21221632 |
| Nakamura K et al. | The C-glucosyl bond of puerarin was cleaved hydrolytically by a human intestinal bacterium strain PUE to yield its aglycone daidzein and an intact glucose. | 2011 | Chem. Pharm. Bull. | pmid:21212542 |
| Wu H et al. | Examination of lymphatic transport of puerarin in unconscious lymph duct-cannulated rats after administration in microemulsion drug delivery systems. | 2011 | Eur J Pharm Sci | pmid:21216284 |
| Hao LN et al. | [Protective effects of puerarin on lens epithelial cells in rat diabetic cataract]. | 2011 | Zhonghua Yan Ke Za Zhi | pmid:21612681 |
| Zhao J et al. | MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula. | 2011 | Plant Cell | pmid:21467581 |
| Noh BK et al. | Restoration of autophagy by puerarin in ethanol-treated hepatocytes via the activation of AMP-activated protein kinase. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21964292 |
| Liu CM et al. | Protective role of puerarin on lead-induced alterations of the hepatic glutathione antioxidant system and hyperlipidemia in rats. | 2011 | Food Chem. Toxicol. | pmid:22001170 |
| Yu M et al. | Analysis of binding interaction between pegylated puerarin and bovine serum albumin by spectroscopic methods and dynamic light scattering. | 2011 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:21945127 |
| Wang D et al. | Puerarin suppresses invasion and vascularization of endometriosis tissue stimulated by 17β-estradiol. | 2011 | PLoS ONE | pmid:21949833 |
| Zhang NB et al. | Effects of puerarin on expression of cardiac Smad3 and Smad7 mRNA in spontaneously hypertensive rat. | 2011 | J Ethnopharmacol | pmid:22027447 |
| Chen R et al. | [Simultaneous quantification of five impurities in puerarin and its injections by HPLC method with correction factor]. | 2011 | Zhongguo Zhong Yao Za Zhi | pmid:22032137 |
| Chen XX et al. | [Pharmacokinetics and bioavailability of Puerarin self-microemulsion in Beagle dogs]. | 2011 | Zhong Yao Cai | pmid:21954564 |
| Mazzio EA et al. | The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's disease. | 2011 | Int J Mol Sci | pmid:21340000 |
| Chen C et al. | [Effects of puerarin on proliferation, apoptosis and Kv1.5 gene expression of pulmonary artery smooth muscle cells induced by hypoxia]. | 2011 | Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi | pmid:22357486 |
| Pongkitwitoon B et al. | Development of an enzyme-linked immunosorbent assay to determine puerarin and its aglycone daidzein. | 2011 | J Nat Med | pmid:20658197 |
| Han RM et al. | Phenol acidity and ease of oxidation in isoflavonoid/β-carotene antioxidant synergism. | 2011 | J. Agric. Food Chem. | pmid:21863887 |
| Barnes S et al. | The metabolism and analysis of isoflavones and other dietary polyphenols in foods and biological systems. | 2011 | Food Funct | pmid:21779561 |
| Cai X et al. | [Detection of drug-human serum albumin binding ratios of two Chinese medicinal ingredients by high performance affinity chromatography]. | 2011 | Se Pu | pmid:21770248 |
| Wang Q and Xu X | [Progresses in research of hemolysis induced by puerarin injection]. | 2011 | Zhongguo Zhong Yao Za Zhi | pmid:21837990 |
| Cheng Y et al. | [Protective effects of puerarin against 1-methyl-4-phenylpyridinium-induced mitochondrial apoptotic death in differentiated SH-SY5Y cells]. | 2011 | Zhongguo Zhong Yao Za Zhi | pmid:21842654 |
| Tanaka T et al. | Kudzu (Pueraria lobata) vine ethanol extracts improve ovariectomy-induced bone loss in female mice. | 2011 | J. Agric. Food Chem. | pmid:22053809 |
| Cai H et al. | [Effects of puerarin on proliferation and differentiation of umbilical cord mesenchymal stem cells into osteoblasts in vitro]. | 2011 | Yao Xue Xue Bao | pmid:21882538 |
| Liu G et al. | Hydroxylation modification and free radical scavenging activity of puerarin-7-O-fructoside. | 2011 | Folia Microbiol. (Praha) | pmid:21818614 |
| Hwang YP et al. | Puerarin activates endothelial nitric oxide synthase through estrogen receptor-dependent PI3-kinase and calcium-dependent AMP-activated protein kinase. | 2011 | Toxicol. Appl. Pharmacol. | pmid:21884717 |
| Liu R et al. | Gelucire44/14 as a novel absorption enhancer for drugs with different hydrophilicities: in vitro and in vivo improvement on transcorneal permeation. | 2011 | J Pharm Sci | pmid:21416467 |
| Yao C et al. | Effects of poly(amidoamine) dendrimers on ocular absorption of puerarin using microdialysis. | 2011 | J Ocul Pharmacol Ther | pmid:21895496 |
| Gasser P et al. | Glycation induction and antiglycation activity of skin care ingredients on living human skin explants. | 2011 | Int J Cosmet Sci | pmid:21401648 |
| Hao LN et al. | Inducible nitric oxide synthase and Fas/FasL with C3 expression of mouse retinal pigment epithelial cells in response to stimulation by peroxynitrite and antagonism of puerarin. | 2011 | Chin. Med. J. | pmid:21933599 |
| Baranowska I et al. | UHPLC method for the simultaneous determination of β-blockers, isoflavones and their metabolites in human urine. | 2011 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:21345747 |
| Wong KH et al. | Kudzu root: traditional uses and potential medicinal benefits in diabetes and cardiovascular diseases. | 2011 | J Ethnopharmacol | pmid:21315814 |
| Wang WY et al. | Determination of puerarin in rabbit aqueous humor by liquid chromatography tandem mass spectrometry using microdialysis sampling after topical administration of puerarin PAMAM dendrimer complex. | 2011 | J Pharm Biomed Anal | pmid:21831555 |
| Zhao R et al. | NMR studies on puerarin and its interaction with beta-cyclodextrin. | 2011 | J Biol Phys | pmid:22942483 |
| Zhang CL et al. | Comparative study of Puerariae lobatae and Puerariae thomsonii by HPLC-diode array detection-flow injection-chemiluminescence coupled with HPLC-electrospray ionization-MS. | 2011 | Chem. Pharm. Bull. | pmid:21532189 |
| Wong SM et al. | Myocardial post-conditioning with Danshen-Gegen decoction protects against isoproterenol-induced myocardial injury via a PKCε/mKATP-mediated pathway in rats. | 2011 | Chin Med | pmid:21320349 |
| Hao LN et al. | Toxicity of endogenous peroxynitrite and effects of puerarin on transplanted retinal pigment epithelial sheets in the subretinal space in mice. | 2011 | Int J Ophthalmol | pmid:22553655 |
| Kim J et al. | KIOM-79 Prevents Lens Epithelial Cell Apoptosis and Lens Opacification in Zucker Diabetic Fatty Rats. | 2011 | Evid Based Complement Alternat Med | pmid:20953387 |
| Baranowska I and Magiera S | Analysis of isoflavones and flavonoids in human urine by UHPLC. | 2011 | Anal Bioanal Chem | pmid:20936271 |
| Xie W and Du L | Diabetes is an inflammatory disease: evidence from traditional Chinese medicines. | 2011 | Diabetes Obes Metab | pmid:21205111 |
| Qin P et al. | Characterization and selectivity studies of molecular imprinted membranes of Puerarin using scanning electron microscopy. | 2011 Jan-Feb | Scanning | pmid:21246571 |
| Chauhan NS et al. | Spectrofluorimetric estimation of puerarin in Pueraria tuberosa. | 2011 May-Jun | Acta Pol Pharm | pmid:21648202 |
| Zhao C et al. | Rapid simultaneous determination of major isoflavones of Pueraria lobata and discriminative analysis of its geographical origins by principal component analysis. | 2011 Nov-Dec | Phytochem Anal | pmid:21495105 |
| Yang R et al. | Determination of puerarin in biological samples and its application to a pharmacokinetic study by flow-injection chemiluminescence. | 2011 Sep-Oct | Luminescence | pmid:21547999 |
| Severino P et al. | Current State-of-Art and New Trends on Lipid Nanoparticles (SLN and NLC) for Oral Drug Delivery. | 2012 | J Drug Deliv | pmid:22175030 |
| Zhang H et al. | A model for the shuttle motions of puerarin and daidzin inside the cavity of β-cyclodextrin in aqueous acetic acid: insights from molecular dynamics simulations. | 2012 | J Mol Model | pmid:21523551 |
| Fan R et al. | Ethnopharmacokinetic- and activity-guided isolation of a new antidepressive compound from fructus aurantii found in the traditional chinese medicine chaihu-shugan-san: a new approach and its application. | 2012 | Evid Based Complement Alternat Med | pmid:22454671 |
| Penetar DM et al. | The isoflavone puerarin reduces alcohol intake in heavy drinkers: a pilot study. | 2012 | Drug Alcohol Depend | pmid:22578529 |
| Lin F et al. | Protective effect of Puerarin on β-amyloid-induced neurotoxicity in rat hippocampal neurons. | 2012 | Arzneimittelforschung | pmid:22278629 |
| Tang XL et al. | Dynamic oxidative stress and DNA damage induced by oestrogen deficiency and protective effects of puerarin and 17β-oestradiol in ovariectomized rats. | 2012 | Basic Clin. Pharmacol. Toxicol. | pmid:22333267 |
| Huang F et al. | Puerarin attenuates endothelial insulin resistance through inhibition of inflammatory response in an IKKβ/IRS-1-dependent manner. | 2012 | Biochimie | pmid:22314193 |
| Wang Q et al. | [Distribution of puerarin contained in Zige freeze-dried powder injection in rat liver and kidney]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:22994007 |
| Wang Y et al. | Formulation and pharmacokinetics evaluation of puerarin nanocrystals for intravenous delivery. | 2012 | J Nanosci Nanotechnol | pmid:22962724 |
| Tiyasatkulkovit W et al. | Upregulation of osteoblastic differentiation marker mRNA expression in osteoblast-like UMR106 cells by puerarin and phytoestrogens from Pueraria mirifica. | 2012 | Phytomedicine | pmid:22951392 |
| Coghlan ML et al. | Deep sequencing of plant and animal DNA contained within traditional Chinese medicines reveals legality issues and health safety concerns. | 2012 | PLoS Genet. | pmid:22511890 |
| Wang PP et al. | Puerarin stimulates osteoblasts differentiation and bone formation through estrogen receptor, p38 MAPK, and Wnt/β-catenin pathways. | 2012 | J Asian Nat Prod Res | pmid:22917468 |
| Saha P et al. | Puerarin, a selective oestrogen receptor modulator, disrupts pregnancy in rats at pre-implantation stage. | 2012 | Reproduction | pmid:22919047 |
| Fan JP et al. | Optimization of ionic liquid based ultrasonic assisted extraction of puerarin from Radix Puerariae Lobatae by response surface methodology. | 2012 | Food Chem | pmid:22980805 |
| Liu CM et al. | Puerarin protects rat kidney from lead-induced apoptosis by modulating the PI3K/Akt/eNOS pathway. | 2012 | Toxicol. Appl. Pharmacol. | pmid:22172631 |
| Zeng A et al. | Simultaneous analysis and retention behavior of major isoflavonoids in Radix Puerariae lobatae and Radix Puerariae thomsonii by high performance liquid chromatography with cyclodextrins as a mobile phase modifier. | 2012 | Anal. Chim. Acta | pmid:22177078 |
| Huang MQ et al. | [Puerarin inhibits DNA damage of HaCaT cells induced by UVB via ceramide pathway]. | 2012 | Yao Xue Xue Bao | pmid:22812004 |
| Ko JA et al. | Enzymatic synthesis of puerarin glucosides using Leuconostoc dextransucrase. | 2012 | J. Microbiol. Biotechnol. | pmid:22814496 |
| Han J et al. | [Study on 3'-methoxy puerarin to dynamic changes of amino acids in rat brain ischemia-reperfusion]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:22792810 |
| Zhang H et al. | Insight into the structural deformations of beta-cyclodextrin caused by alcohol cosolvents and guest molecules. | 2012 | J Phys Chem B | pmid:22376204 |
| Hou Q et al. | [Puerarin combined with avandia for diabetic nephropathy]. | 2012 | Zhong Nan Da Xue Xue Bao Yi Xue Ban | pmid:22349389 |
| Liu L et al. | Determination of puerarin in pharmaceutical and biological samples by capillary zone electrophoresis with UV detection. | 2012 | Talanta | pmid:22365684 |
| Zhang Y et al. | Characterization and evaluation of self-microemulsifying sustained-release pellet formulation of puerarin for oral delivery. | 2012 | Int J Pharm | pmid:22366381 |
| Deng L et al. | [Effect of catalpol and puerarin freeze-dried powder on coagulability, hemorheology and no in rats with Qi-deficiency and blood-stasis syndrome]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:22860464 |
| Liang X et al. | [Intestinal absorption effect of Angelica dahurica extract on puerarin of puerariae Lobatae Radix]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:22860465 |
| Luo ZK et al. | [A clinical efficacy and safety study on coronary heart disease and angina treatment with Puerarin Injection]. | 2012 | Zhonghua Liu Xing Bing Xue Za Zhi | pmid:22883272 |
| Zeng X et al. | Enhanced adsorption of puerarin onto a novel hydrophilic and polar modified post-crosslinked resin from aqueous solution. | 2012 | J Colloid Interface Sci | pmid:22878002 |
| Michihara S et al. | Puerarin exerted anti-osteoporotic action independent of estrogen receptor-mediated pathway. | 2012 | J. Nutr. Sci. Vitaminol. | pmid:22878391 |
| Zhang BS et al. | [Cellular absorption of the active ingredients in different compatibilities of gegenqinlian decoction in human intestinal Caco-2 cells]. | 2012 | Zhong Yao Cai | pmid:23451503 |
| An R et al. | [Intestinal absorption of different combinations of active compounds from Gegenqinlian decoction by rat single pass intestinal perfusion in situ]. | 2012 | Yao Xue Xue Bao | pmid:23460978 |
| Sun XY et al. | [Optimal extraction of puerarin from Pueraria lobata based on central composite design and response surface methodology]. | 2012 | Zhong Yao Cai | pmid:23236837 |
| Chen YY et al. | Puerarin protects human umbilical vein endothelial cells against high glucose-induced apoptosis by upregulating heme oxygenase-1 and inhibiting calpain activation. | 2012 | Fundam Clin Pharmacol | pmid:21352351 |
| Hu JJ et al. | [Effect of pretreatment with puerarin on activation of LPS-induced RAW264. 7 cells]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:23311164 |
| Liu XY et al. | [Stability of PEGylated puerarin under different storage conditions]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:23373208 |
| Chen F et al. | Puerarin enhances superoxide dismutase activity and inhibits RAGE and VEGF expression in retinas of STZ-induced early diabetic rats. | 2012 | Asian Pac J Trop Med | pmid:23146804 |
| Prasain JK et al. | The Chinese Pueraria root extract (Pueraria lobata) ameliorates impaired glucose and lipid metabolism in obese mice. | 2012 | Phytomedicine | pmid:23123226 |
| Chen R et al. | Puerarin prevents isoprenaline-induced myocardial fibrosis in mice by reduction of myocardial TGF-β1 expression. | 2012 | J. Nutr. Biochem. | pmid:22079205 |
| Han JQ et al. | [Effects of puerarin on the neurocyte apoptosis and p-Akt (Ser473) expressions in rats with cerebral ischemia/reperfusion injury]. | 2012 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:23173255 |
| Liang XL et al. | Transport properties of puerarin and effect of Radix Angelicae Dahuricae extract on the transport of puerarin in Caco-2 cell model. | 2012 | J Ethnopharmacol | pmid:23085309 |
| Zhang Q et al. | Puerarin protects differentiated PC12 cells from Hâ‚‚Oâ‚‚-induced apoptosis through the PI3K/Akt signalling pathway. | 2012 | Cell Biol. Int. | pmid:22126839 |
| Ford AP | In pursuit of P2X3 antagonists: novel therapeutics for chronic pain and afferent sensitization. | 2012 | Purinergic Signal. | pmid:22095157 |
| Xu C et al. | Role of puerarin in the signalling of neuropathic pain mediated by P2X3 receptor of dorsal root ganglion neurons. | 2012 | Brain Res. Bull. | pmid:22044944 |
| Jin SE et al. | Anti-inflammatory and antioxidant activities of constituents isolated from Pueraria lobata roots. | 2012 | Arch. Pharm. Res. | pmid:22644850 |
| Cheng W et al. | Puerarin suppresses proliferation of endometriotic stromal cells partly via the MAPK signaling pathway induced by 17ß-estradiol-BSA. | 2012 | PLoS ONE | pmid:23029074 |
| Zhao X et al. | Simultaneous determination of six isoflavonoids in rat plasma after administration of total flavonoid from Gegen by ultra-HPLC-MS/MS. | 2012 | J Sep Sci | pmid:22589159 |
| Sheu SY et al. | Stimulatory effect of puerarin on bone formation through co-activation of nitric oxide and bone morphogenetic protein-2/mitogen-activated protein kinases pathways in mice. | 2012 | Chin. Med. J. | pmid:23075718 |
| Ho FM et al. | Anti-atherosclerotic action of Ger-Gen-Chyn-Lian-Tang and AMPK-dependent lipid lowering effect in hepatocytes. | 2012 | J Ethnopharmacol | pmid:22543166 |
| Gomuttapong S et al. | Testing of the estrogenic activity and toxicity of Stephania venosa herb in ovariectomized rats. | 2012 | Toxicol. Mech. Methods | pmid:22394346 |
| Li Y et al. | Comparative pharmacokinetics of prim-O-glucosylcimifugin and cimifugin by liquid chromatography-mass spectrometry after oral administration of Radix Saposhnikoviae extract, cimifugin monomer solution and prim-O-glucosylcimifugin monomer solution to rats. | 2012 | Biomed. Chromatogr. | pmid:22253022 |
| Song JX et al. | Anti-Parkinsonian drug discovery from herbal medicines: what have we got from neurotoxic models? | 2012 | J Ethnopharmacol | pmid:22212501 |
| Deng Y et al. | [Effect of phenformin hydrochloride on pharmacokinetics of puerarin in rats]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:23270242 |
| Yan F et al. | Effects of some antihypertensive drugs on the metabolism and pharmacokinetics of indapamide in rats. | 2012 | J Pharm Pharm Sci | pmid:22579001 |
| Wang J and Xiong X | Current situation and perspectives of clinical study in integrative medicine in china. | 2012 | Evid Based Complement Alternat Med | pmid:22550539 |
| Jiang H et al. | Natural product nitric oxide chemistry: new activity of old medicines. | 2012 | Evid Based Complement Alternat Med | pmid:22548122 |
| Qiu Y et al. | Traditional chinese herbal products for coronary heart disease: an overview of cochrane reviews. | 2012 | Evid Based Complement Alternat Med | pmid:22536282 |
| Zheng GH et al. | Systematic Review of Chinese Herbal Medicines for Preventing in-Stent Coronary Restenosis after Percutaneous Coronary Intervention. | 2012 | Evid Based Complement Alternat Med | pmid:22454659 |