Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
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Authors | Title | Published | Journal | PubMed Link |
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Park SJ et al. | Effects of mixed herbal extracts from parched Puerariae radix, gingered Magnoliae cortex, Glycyrrhizae radix and Euphorbiae radix (KIOM-79) on cardiac ion channels and action potentials. | 2009 | J. Korean Med. Sci. | pmid:19543501 |
Pan ZY et al. | The myocardial protective effects of puerarin on STZ-induced diabetic rats. | 2009 | Fen Zi Xi Bao Sheng Wu Xue Bao | pmid:19537197 |
Li X et al. | Evaluation of Pharmasolve corneal permeability enhancement and its irritation on rabbit eyes. | 2009 | Drug Deliv | pmid:19514982 |
Gao L et al. | Puerarin protects against ischemic brain injury in a rat model of transient focal ischemia. | 2009 | Neurol. Res. | pmid:19508827 |
Wang Y et al. | Simultaneous determination of puerarin, daidzein, baicalin, wogonoside and liquiritin of GegenQinlian decoction in rat plasma by ultra-performance liquid chromatography-mass spectrometry. | 2009 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:19493706 |
Chen AZ et al. | Microencapsulation of puerarin nanoparticles by poly(l-lactide) in a supercritical CO(2) process. | 2009 | Acta Biomater | pmid:19463980 |
Wong RW and Rabie AB | Effect of quercetin on preosteoblasts and bone defects. | 2008 | Open Orthop J | pmid:19461927 |
Retraction. The correlation between angiogenesis and abnormal expression of SERCA2a, phospholamban and the endothelin pathway in heart failure, and improvement by puerarin. | 2009 | Phytother Res | pmid:19391125 | |
Retraction. Cardioprotective effects of the combined use of puerarin and danshensu on acute ischemic myocardial injury in rats. | 2009 | Phytother Res | pmid:19391124 | |
Yue PF et al. | The study on the entrapment efficiency and in vitro release of puerarin submicron emulsion. | 2009 | AAPS PharmSciTech | pmid:19381837 |
Han S | Determination of puerarin by capillary electrophoresis with chemiluminescence detection. | 2009 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:19342316 |
Mukherjee B et al. | Preparation, characterization and in-vitro evaluation of sustained release protein-loaded nanoparticles based on biodegradable polymers. | 2008 | Int J Nanomedicine | pmid:19337417 |
Lu N et al. | Nitrite-glucose-glucose oxidase system directly induces rat heart homogenate oxidation and tyrosine nitration: effects of some flavonoids. | 2009 | Toxicol In Vitro | pmid:19286453 |
Chang Y et al. | Neuroprotective mechanisms of puerarin in middle cerebral artery occlusion-induced brain infarction in rats. | 2009 | J. Biomed. Sci. | pmid:19272172 |
Wu HQ et al. | Protective effects and mechanism of puerarin on learning-memory disorder after global cerebral ischemia-reperfusion injury in rats. | 2009 | Chin J Integr Med | pmid:19271171 |
Wen BY et al. | [Metabolic kinetic of puerarin in beagle liver microsomal by HPLC-ESI-MS]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:19260325 |
Hu HT et al. | [Effects of puerarin with aspirin on the markers of damaged vascular endothelial cells in patients with acute cerebral infarction]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:19260323 |
Zheng P et al. | Therapeutic effect of puerarin on non-alcoholic rat fatty liver by improving leptin signal transduction through JAK2/STAT3 pathways. | 2009 | Am. J. Chin. Med. | pmid:19222113 |
Yu CQ | [Treatment of endometriosis by puerarin]. | 2008 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:19213335 |
Yan LP et al. | Analysis of the mechanisms underlying the endothelium-dependent antivasoconstriction of puerarin in rat aorta. | 2009 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:19190894 |
Zhang H and Yang X | Profiling and quantification of isoflavone-C-glycosides impurities in puerarin injection by liquid chromatography coupled to ESI-ion trap mass spectrometry. | 2009 | J Pharm Biomed Anal | pmid:19186018 |
Lau CC et al. | Rapid analysis of Radix puerariae by near-infrared spectroscopy. | 2009 | J Chromatogr A | pmid:19185872 |
Jing L and Gao ZY | [Retrospective analysis on Chinese medicinal treatment on 302 chronic heart failure patients of coronary heart disease and diabetes]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:19166020 |
Wu GL et al. | [Effect of puerarin on levels of TGF-beta1 and alpha-SMA in rats with alcoholic injury liver]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:19166018 |
Yu CQ et al. | [Regulatory mechanism of malignant behavior of endometriosis mediated by puerarin]. | 2009 | Zhong Xi Yi Jie He Xue Bao | pmid:19134456 |
Qin F et al. | Pharmacokinetic comparison of puerarin after oral administration of Jiawei-Xiaoyao-San to healthy volunteers and patients with functional dyspepsia: influence of disease state. | 2009 | J. Pharm. Pharmacol. | pmid:19126307 |
Shen JG et al. | Effects of puerarin on receptor for advanced glycation end products in nephridial tissue of streptozotocin-induced diabetic rats. | 2009 | Mol. Biol. Rep. | pmid:19125353 |
Liu IM and Cheng JT | Mediation of Endogenous β-Endorphin in the Plasma Glucose-Lowering Action of Herbal Products Observed in Type 1-Like Diabetic Rats. | 2011 | Evid Based Complement Alternat Med | pmid:19095661 |
Cui SM and Ma YB | [Effect of verapamil on pharmacokinetics of puerarin in rats]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:19086648 |
Sun W et al. | [Effects of puerarin on ADRP gene expression in fatty tissue of type 2 diabetes mellitus rats]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:19086646 |
Cui JH et al. | [Preparation and in vitro evaluation of gastroretentive dosage form containing puerarin-HP-beta-CD inclusion complex]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:19086628 |
Meng XH et al. | Puerarin protects against high glucose-induced acute vascular dysfunction: role of heme oxygenase-1 in rat thoracic aorta. | 2009 Mar-Apr | Vascul. Pharmacol. | pmid:19073281 |
Yang L and Tan T | An enhanced adsorption in puerarin retention on oligo-beta-cyclodextrin grafted poly(glycidyl methacrylate) media. | 2010 | Appl. Biochem. Biotechnol. | pmid:19067245 |
Ye XY et al. | [Effect of puerarin injection on the mRNA expressions of AT1 and ACE2 in spontaneous hypertension rats]. | 2008 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:19065898 |
Derda M et al. | Plant extracts as natural amoebicidal agents. | 2009 | Parasitol. Res. | pmid:19050923 |
Wu H et al. | Enhanced oral bioavailability of puerarin using microemulsion vehicle. | 2009 | Drug Dev Ind Pharm | pmid:19040180 |
Prasain JK et al. | Tissue distribution of puerarin and its conjugated metabolites in rats assessed by liquid chromatography-tandem mass spectrometry. | 2009 | Phytomedicine | pmid:19027277 |
Cheng YF et al. | Involvement of ubiquitin proteasome system in protective mechanisms of Puerarin to MPP(+)-elicited apoptosis. | 2009 | Neurosci. Res. | pmid:19022306 |
Lin YJ et al. | Puerariae radix isoflavones and their metabolites inhibit growth and induce apoptosis in breast cancer cells. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19013426 |
Zou GX et al. | [New method of multi-components quantitation by one marker new method for quality evaluation of Guanmaikang capsula]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:19007008 |
Wan H et al. | Protective effect of chuanxiongzine-puerarin in a rat model of transient middle cerebral artery occlusion-induced focal cerebral ischemia. | 2008 | Nucl Med Commun | pmid:18987534 |
Pan HP and Li G | Protecting mechanism of puerarin on the brain neurocyte of rat in acute local ischemia brain injury and local cerebral ischemia-reperfusion injury. | 2008 | Yakugaku Zasshi | pmid:18981705 |
Zhang H et al. | Simultaneous determination of 12 chemical constituents in the traditional Chinese Medicinal Prescription Xiao-Yao-San-Jia-Wei by HPLC coupled with photodiode array detection. | 2008 | J Pharm Biomed Anal | pmid:18977108 |
He JT et al. | Biotin-avidin amplified enzyme-linked immunosorbent assay for determination of isoflavone daidzein. | 2005 | Talanta | pmid:18969844 |
Wen A et al. | A rapid and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the determination of hydroxysafflor yellow A in human plasma: application to a pharmacokinetic study. | 2008 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:18964371 |
Tang X et al. | Phytoestrogens induce differential estrogen receptor beta-mediated responses in transfected MG-63 cells. | 2008 Aug-Dec | Endocrine | pmid:18937077 |
Hou HG et al. | [Puerarin in the treatment of poisoning of acute organophosphorous compound with toxic myocarditis]. | 2008 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:18928024 |
Yu C et al. | Decreased expression of aromatase in the Ishikawa and RL95-2 cells by the isoflavone, puerarin, is associated with inhibition of c-jun expression and AP-1 activity. | 2008 | Food Chem. Toxicol. | pmid:18848966 |
Li YW et al. | Regulation of aromatase P450 expression by puerarin in endometrial cell line RL95-2. | 2008 | Zhong Xi Yi Jie He Xue Bao | pmid:18847535 |
Hwang YP and Jeong HG | Mechanism of phytoestrogen puerarin-mediated cytoprotection following oxidative injury: estrogen receptor-dependent up-regulation of PI3K/Akt and HO-1. | 2008 | Toxicol. Appl. Pharmacol. | pmid:18845176 |
Jiang JR et al. | Conversion of puerarin into its 7-O-glycoside derivatives by Microbacterium oxydans (CGMCC 1788) to improve its water solubility and pharmacokinetic properties. | 2008 | Appl. Microbiol. Biotechnol. | pmid:18795283 |
Zhang MY et al. | [Effects of different doses of puerarin on vascular endothelial cell proliferation in vitro]. | 2008 | Zhong Xi Yi Jie He Xue Bao | pmid:18782539 |
Zheng PY et al. | [Effects of puerarin on expressions of leptin receptor mRNA, phosphorylated Janus kinase 2/phosphorylated signal transducers and activators of transcription 3 proteins in the liver of rats with non-alcoholic fatty liver]. | 2008 | Zhong Xi Yi Jie He Xue Bao | pmid:18782535 |
Li QX et al. | [Effect of compound Puerarin on the collage IV in streptozotocin-induced diabetic nephropathy rats]. | 2008 | Zhonghua Yu Fang Yi Xue Za Zhi | pmid:18763636 |
Wang YG et al. | [High-performance capillary electrophoresis for determining the chemical compositions of Gegen and Fenge extracts]. | 2008 | Nan Fang Yi Ke Da Xue Xue Bao | pmid:18753072 |
Zhu J et al. | Puerarin reduces endothelial progenitor cells senescence through augmentation of telomerase activity. | 2008 Aug-Sep | Vascul. Pharmacol. | pmid:18692596 |
Reppert A et al. | Isolation of radiolabeled isoflavones from kudzu (Pueraria lobata) root cultures. | 2008 | J. Agric. Food Chem. | pmid:18690681 |
Hao LN et al. | [The effect of puerarin on prevention of oxidative damage of cultured lens capsule epithelial cells]. | 2008 | Zhonghua Yan Ke Za Zhi | pmid:18683704 |
Zhang HY et al. | Puerarin protects PC12 cells against beta-amyloid-induced cell injury. | 2008 | Cell Biol. Int. | pmid:18675923 |
Jin JS et al. | Biotransformation of C-glucosylisoflavone puerarin to estrogenic (3S)-equol in co-culture of two human intestinal bacteria. | 2008 | Biol. Pharm. Bull. | pmid:18670101 |
Zhang HY et al. | [Effect of puerarin on PC12 cells apoptosis induced by Abeta25-35 in vitro]. | 2008 | Zhong Yao Cai | pmid:18661826 |
Lv YQ et al. | One-step rapid determination and purification of puerarin from Radix puerariae by n-octylamine-modified poly(methacrylate-co-ethylene dimethacrylate) monolith. | 2008 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:18639505 |
Kim YS et al. | Biotransformation of ginsenoside Rb1, crocin, amygdalin, geniposide, puerarin, ginsenoside Re, hesperidin, poncirin, glycyrrhizin, and baicalin by human fecal microflora and its relation to cytotoxicity against tumor cells. | 2008 | J. Microbiol. Biotechnol. | pmid:18600055 |
Teng Y et al. | Protective effect of puerarin on diabetic retinopathy in rats. | 2009 | Mol. Biol. Rep. | pmid:18587665 |
Yang ZD et al. | [Chemical constituents in root of Hemerocallis fulva]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:18536463 |
Li JW et al. | [Inhibition of puerarin on pulmonary hypertension in rats with hypoxia and hypercapnia]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:18536380 |
Zhang YB et al. | [Protective effects of 3'-methoxy-puerarin on rat brain suffering from ischemia]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:18536378 |
Wang Y et al. | [Effect of puerarin and ligustrazine on cultured hippocampal neurons injury induced by Abeta25-35]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:18533503 |
Dai J et al. | A sensitive liquid chromatography-mass spectrometry method for simultaneous determination of two active chromones from Saposhnikovia root in rat plasma and urine. | 2008 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:18485839 |
Clarke DB et al. | Determination of phytoestrogens in dietary supplements by LC-MS/MS. | 2008 | Food Addit Contam Part A Chem Anal Control Expo Risk Assess | pmid:18478479 |
Li Y et al. | Process parameters and morphology in puerarin, phospholipids and their complex microparticles generation by supercritical antisolvent precipitation. | 2008 | Int J Pharm | pmid:18440736 |
Chang Q et al. | Simultaneous determination of ten active components in traditional Chinese medicinal products containing both Gegen (Pueraria lobata) and Danshen (Salvia miltiorrhiza) by high-performance liquid chromatography. | Phytochem Anal | pmid:18438756 | |
Huang J et al. | Selective adsorption of tannin from flavonoids by organically modified attapulgite clay. | 2008 | J. Hazard. Mater. | pmid:18433994 |
Yue PF et al. | Preparation, characterization, and pharmacokinetic evaluation of puerarin submicron emulsion. | 2008 Jan-Feb | PDA J Pharm Sci Technol | pmid:18402366 |
He H et al. | The correlation between angiogenesis and abnormal expression of SERCA2a, phospholamban and the endothelin pathway in heart failure, and improvement by puerarin. | 2008 | Phytother Res | pmid:18389490 |
Chen JW et al. | [Molecular mechanism of reversing multi-drug resistance of K562/AO2 by puerarin]. | 2008 | Zhong Nan Da Xue Xue Bao Yi Xue Ban | pmid:18382055 |
Wang Y et al. | Preventive effects of puerarin on alcohol-induced osteonecrosis. | 2008 | Clin. Orthop. Relat. Res. | pmid:18350350 |
Zhang SY et al. | The effect of puerarin on serum nitric oxide concentration and myocardial eNOS expression in rats with myocardial infarction. | 2008 Mar-Apr | J Asian Nat Prod Res | pmid:18348063 |
Guo Y et al. | [Study on effect of different combinations of traditional Chinese medicine preparation active parts on metabolism of puerarin in plasma of rats]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:18330251 |
Ding MP et al. | [Effects of puerarin on expression of nuclear factor kappaB after cerebral ischemia/reperfusion in rats]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:18330247 |
Cherdshewasart W and Sriwatcharakul S | Metabolic activation promotes estrogenic activity of the phytoestrogen-rich plant. | 2008 | Maturitas | pmid:18313242 |
Zhu Z et al. | Effects of puerarin on pulmonary vascular remodeling and protein kinase C-alpha in chronic cigarette smoke exposure smoke-exposed rats. | 2008 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:18278451 |
Wang Z et al. | Study on the interaction of puerarin with lysozyme by spectroscopic methods. | 2008 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:18262462 |
Tan Y et al. | Puerarin for acute ischaemic stroke. | 2008 | Cochrane Database Syst Rev | pmid:18254067 |
Wang Q et al. | Quantification of puerarin in plasma by on-line solid-phase extraction column switching liquid chromatography-tandem mass spectrometry and its applications to a pharmacokinetic study. | 2008 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:18242154 |
Lu Y et al. | [Pharmacokinetics of pueraria for intranasal on spray in rabbits]. | 2007 | Zhong Yao Cai | pmid:18236755 |
Tian YX et al. | Radical dynamics of puerarin as revealed by laser flash photolysis and spin density analysis. | 2008 | J Phys Chem B | pmid:18232684 |
Yue PF et al. | The study to reduce the hemolysis side effect of puerarin by a submicron emulsion delivery system. | 2008 | Biol. Pharm. Bull. | pmid:18175940 |
Liu R et al. | [Inhibitory effect of quercetin, rutin and puerarin on LDL oxidation induced by Cu2+]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:18161305 |
Yang H et al. | [Studies on effect of microemulsion in enhancing solubility of baicalin and puerarin]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:18161289 |
Cherdshewasart W et al. | Determination of the estrogenic activity of wild phytoestrogen-rich Pueraria mirifica by MCF-7 proliferation assay. | 2008 | J. Reprod. Dev. | pmid:18160771 |
Li Q et al. | [Study of regulation of Puerarin on blood P-selectin and the expression of aorta VCAM mRNA in diabetes]. | 2007 | Wei Sheng Yan Jiu | pmid:18095572 |
Gu YZ et al. | [Preparation of puerarin liposome and its oral absorption in rat]. | 2007 | Zhong Yao Cai | pmid:18074848 |
He Y et al. | Binding of puerarin to human serum albumin: a spectroscopic analysis and molecular docking. | 2008 | J Fluoresc | pmid:18058205 |
Zhang GW et al. | [Studies on the interaction between puerarin and bovine serum albumin]. | 2007 | Guang Pu Xue Yu Guang Pu Fen Xi | pmid:18051529 |
Yan H et al. | Treating senile dementia with traditional Chinese medicine. | 2007 | Clin Interv Aging | pmid:18044136 |
Hwang YP et al. | Protective effects of puerarin on carbon tetrachloride-induced hepatotoxicity. | 2007 | Arch. Pharm. Res. | pmid:18038910 |
Yue PF et al. | Development and optimization of intravenous puerarin emulsions formation by a novel complex-phase inversion-homogenization technology. | 2007 | Chem. Pharm. Bull. | pmid:17978512 |
Chung MJ et al. | Antioxidative and hypocholesterolemic activities of water-soluble puerarin glycosides in HepG2 cells and in C57 BL/6J mice. | 2008 | Eur. J. Pharmacol. | pmid:17976573 |
Xu XH et al. | Inhibition of excitatory amino acid efflux contributes to protective effects of puerarin against cerebral ischemia in rats. | 2007 | Biomed. Environ. Sci. | pmid:17948770 |