SCHEMBL105486
Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
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Introduction
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with SCHEMBL105486?
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
PubChem Associated disorders and diseases
What pathways are associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with SCHEMBL105486?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
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What functions are associated with SCHEMBL105486?
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What lipids are associated with SCHEMBL105486?
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What genes are associated with SCHEMBL105486?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with SCHEMBL105486?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
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NCBI Entrez Crosslinks
All references with SCHEMBL105486
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Severino P et al. | Current State-of-Art and New Trends on Lipid Nanoparticles (SLN and NLC) for Oral Drug Delivery. | 2012 | J Drug Deliv | pmid:22175030 |
| Zhang H et al. | A model for the shuttle motions of puerarin and daidzin inside the cavity of β-cyclodextrin in aqueous acetic acid: insights from molecular dynamics simulations. | 2012 | J Mol Model | pmid:21523551 |
| Fan R et al. | Ethnopharmacokinetic- and activity-guided isolation of a new antidepressive compound from fructus aurantii found in the traditional chinese medicine chaihu-shugan-san: a new approach and its application. | 2012 | Evid Based Complement Alternat Med | pmid:22454671 |
| Wang Q et al. | [Distribution of puerarin contained in Zige freeze-dried powder injection in rat liver and kidney]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:22994007 |
| Wang Y et al. | Formulation and pharmacokinetics evaluation of puerarin nanocrystals for intravenous delivery. | 2012 | J Nanosci Nanotechnol | pmid:22962724 |
| Tiyasatkulkovit W et al. | Upregulation of osteoblastic differentiation marker mRNA expression in osteoblast-like UMR106 cells by puerarin and phytoestrogens from Pueraria mirifica. | 2012 | Phytomedicine | pmid:22951392 |
| Wang PP et al. | Puerarin stimulates osteoblasts differentiation and bone formation through estrogen receptor, p38 MAPK, and Wnt/β-catenin pathways. | 2012 | J Asian Nat Prod Res | pmid:22917468 |
| Saha P et al. | Puerarin, a selective oestrogen receptor modulator, disrupts pregnancy in rats at pre-implantation stage. | 2012 | Reproduction | pmid:22919047 |
| Fan JP et al. | Optimization of ionic liquid based ultrasonic assisted extraction of puerarin from Radix Puerariae Lobatae by response surface methodology. | 2012 | Food Chem | pmid:22980805 |
| Liu CM et al. | Puerarin protects rat kidney from lead-induced apoptosis by modulating the PI3K/Akt/eNOS pathway. | 2012 | Toxicol. Appl. Pharmacol. | pmid:22172631 |
| Luo ZK et al. | [A clinical efficacy and safety study on coronary heart disease and angina treatment with Puerarin Injection]. | 2012 | Zhonghua Liu Xing Bing Xue Za Zhi | pmid:22883272 |
| Zeng X et al. | Enhanced adsorption of puerarin onto a novel hydrophilic and polar modified post-crosslinked resin from aqueous solution. | 2012 | J Colloid Interface Sci | pmid:22878002 |
| Michihara S et al. | Puerarin exerted anti-osteoporotic action independent of estrogen receptor-mediated pathway. | 2012 | J. Nutr. Sci. Vitaminol. | pmid:22878391 |
| Zhang BS et al. | [Cellular absorption of the active ingredients in different compatibilities of gegenqinlian decoction in human intestinal Caco-2 cells]. | 2012 | Zhong Yao Cai | pmid:23451503 |
| An R et al. | [Intestinal absorption of different combinations of active compounds from Gegenqinlian decoction by rat single pass intestinal perfusion in situ]. | 2012 | Yao Xue Xue Bao | pmid:23460978 |
| Chen F et al. | Puerarin enhances superoxide dismutase activity and inhibits RAGE and VEGF expression in retinas of STZ-induced early diabetic rats. | 2012 | Asian Pac J Trop Med | pmid:23146804 |
| Prasain JK et al. | The Chinese Pueraria root extract (Pueraria lobata) ameliorates impaired glucose and lipid metabolism in obese mice. | 2012 | Phytomedicine | pmid:23123226 |
| Chen R et al. | Puerarin prevents isoprenaline-induced myocardial fibrosis in mice by reduction of myocardial TGF-β1 expression. | 2012 | J. Nutr. Biochem. | pmid:22079205 |
| Han JQ et al. | [Effects of puerarin on the neurocyte apoptosis and p-Akt (Ser473) expressions in rats with cerebral ischemia/reperfusion injury]. | 2012 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:23173255 |
| Liang XL et al. | Transport properties of puerarin and effect of Radix Angelicae Dahuricae extract on the transport of puerarin in Caco-2 cell model. | 2012 | J Ethnopharmacol | pmid:23085309 |
| Zhang Q et al. | Puerarin protects differentiated PC12 cells from Hâ‚‚Oâ‚‚-induced apoptosis through the PI3K/Akt signalling pathway. | 2012 | Cell Biol. Int. | pmid:22126839 |
| Ford AP | In pursuit of P2X3 antagonists: novel therapeutics for chronic pain and afferent sensitization. | 2012 | Purinergic Signal. | pmid:22095157 |
| Jin SE et al. | Anti-inflammatory and antioxidant activities of constituents isolated from Pueraria lobata roots. | 2012 | Arch. Pharm. Res. | pmid:22644850 |
| Deng Y et al. | [Effect of phenformin hydrochloride on pharmacokinetics of puerarin in rats]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:23270242 |
| Zheng GH et al. | Systematic Review of Chinese Herbal Medicines for Preventing in-Stent Coronary Restenosis after Percutaneous Coronary Intervention. | 2012 | Evid Based Complement Alternat Med | pmid:22454659 |
| Wu Y et al. | Optimisation of ultrasound-assisted extraction of puerarin and total isoflavones from Puerariae Lobatae Radix (Pueraria lobata (Wild.) Ohwi) with response surface methodology. | 2012 Sep-Oct | Phytochem Anal | pmid:22259187 |
| Xie J et al. | Improvement in solubility and bioavailability of puerarin by mechanochemical preparation. | 2013 | Drug Dev Ind Pharm | pmid:22591175 |
| Luo CF et al. | Metabolic profile of puerarin in rats after intragastric administration of puerarin solid lipid nanoparticles. | 2013 | Int J Nanomedicine | pmid:23486407 |
| Cao L et al. | Pharmacokinetics of puerarin in pregnant rats at different stages of gestation after oral administration. | 2013 | Fitoterapia | pmid:23500385 |
| Guo C et al. | Anti-fibrotic effects of puerarin on CCl4-induced hepatic fibrosis in rats possibly through the regulation of PPAR-γ expression and inhibition of PI3K/Akt pathway. | 2013 | Food Chem. Toxicol. | pmid:23500774 |
| Liu CM et al. | Protective effect of puerarin on lead-induced mouse cognitive impairment via altering activities of acetyl cholinesterase, monoamine oxidase and nitric oxide synthase. | 2013 | Environ. Toxicol. Pharmacol. | pmid:23501611 |
| Cheng M et al. | Puerarin accelerates re-endothelialization in a carotid arterial injury model: impact on vasodilator concentration and vascular cell functions. | 2013 | J. Cardiovasc. Pharmacol. | pmid:23792702 |
| Xu L et al. | Puerarin, isolated from Pueraria lobata (Willd.), protects against hepatotoxicity via specific inhibition of the TGF-β1/Smad signaling pathway, thereby leading to anti-fibrotic effect. | 2013 | Phytomedicine | pmid:23856441 |
| Li R et al. | Puerarin attenuates neuronal degeneration and blocks oxidative stress to elicit a neuroprotective effect on substantia nigra injury in 6-OHDA-lesioned rats. | 2013 | Brain Res. | pmid:23603411 |
| Zhang E et al. | [Formulation optimization and drug release in vitro of membrane controlled tablets of puerarin inclusion compound]. | 2013 | Zhongguo Zhong Yao Za Zhi | pmid:23596875 |
| Li N et al. | Determination of glibenclamide and puerarin in rat plasma by UPLC-MS/MS: application to their pharmacokinetic interaction study. | 2013 | Talanta | pmid:23597896 |
| Wang Y et al. | Puerarin stimulates proliferation and differentiation and protects against cell death in human osteoblastic MG-63 cells via ER-dependent MEK/ERK and PI3K/Akt activation. | 2013 | Phytomedicine | pmid:23639192 |
| Chen F et al. | Puerarin-induced immune hemolytic anemia. | 2013 | Int. J. Hematol. | pmid:23661032 |
| Cao WL et al. | [Effect of puerarin on hemorheology and pulmonary pressure in rat pneumo-cardiac disease]. | 2013 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:23662397 |
| Huang ZG et al. | [Effect of puerarin combined with felodipine on mRNA and protein expression of apelin and APJ in renovascular hypertensive rat]. | 2013 | Zhongguo Zhong Yao Za Zhi | pmid:23668014 |
| Zhang Y et al. | Effects of puerarin on cholinergic enzymes in the brain of ovariectomized guinea pigs. | 2013 | Int. J. Neurosci. | pmid:23668913 |
| Chen X et al. | Puerarin improves metabolic function leading to hepatoprotective effects in chronic alcohol-induced liver injury in rats. | 2013 | Phytomedicine | pmid:23669266 |
| Wang Q et al. | Magnetic solid-phase extraction and determination of puerarin in rat plasma using C(18)-functionalized magnetic silica nanoparticles by high performance liquid chromatography. | 2013 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:23246846 |
| Peng JH et al. | Puerarin ameliorates experimental alcoholic liver injury by inhibition of endotoxin gut leakage, Kupffer cell activation, and endotoxin receptors expression. | 2013 | J. Pharmacol. Exp. Ther. | pmid:23277536 |
| Nakamura K et al. | Enzymatic cleavage of the C-glucosidic bond of puerarin by three proteins, Mn(2+), and oxidized form of nicotinamide adenine dinucleotide. | 2013 | Biol. Pharm. Bull. | pmid:23328408 |
| Tao HQ et al. | HP-β-CD-PLGA nanoparticles improve the penetration and bioavailability of puerarin and enhance the therapeutic effects on brain ischemia-reperfusion injury in rats. | 2013 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:23192284 |
| Yin R et al. | UFLC-MS/MS method for simultaneous determination of luteolin-7-O-gentiobioside, luteolin-7-O-β-D-glucoside and luteolin-7-O-β-D-glucuronide in beagle dog plasma and its application to a pharmacokinetic study after administration of traditional Chinese medicinal preparation: Kudiezi injection. | 2013 | J Pharm Biomed Anal | pmid:23146236 |
| Li R et al. | Puerarin mediates hepatoprotection against CCl4-induced hepatic fibrosis rats through attenuation of inflammation response and amelioration of metabolic function. | 2013 | Food Chem. Toxicol. | pmid:23146695 |
| Zou Y et al. | Protective effect of puerarin against beta-amyloid-induced oxidative stress in neuronal cultures from rat hippocampus: involvement of the GSK-3β/Nrf2 signaling pathway. | 2013 | Free Radic. Res. | pmid:23088308 |
| Wang Y et al. | In vitro and in vivo anticancer activity of a novel puerarin nanosuspension against colon cancer, with high efficacy and low toxicity. | 2013 | Int J Pharm | pmid:23089583 |
| Zhang J et al. | Effects of puerarin on the inflammatory role of burn-related procedural pain mediated by P2X(7) receptors. | 2013 | Burns | pmid:23044342 |
| Bai S et al. | Effects of felodipine combined with puerarin on ACE2-Ang (1-7)-Mas axis in renovascular hypertensive rat. | 2013 | Regul. Pept. | pmid:23523569 |
| Tian F et al. | The neuroprotective mechanism of puerarin treatment of acute spinal cord injury in rats. | 2013 | Neurosci. Lett. | pmid:23570727 |
| Li R et al. | Puerarin attenuates neuronal degeneration in the substantia nigra of 6-OHDA-lesioned rats through regulating BDNF expression and activating the Nrf2/ARE signaling pathway. | 2013 | Brain Res. | pmid:23747813 |
| Li R et al. | Puerarin, isolated from Kudzu root (Willd.), attenuates hepatocellular cytotoxicity and regulates the GSK-3β/NF-κB pathway for exerting the hepatoprotection against chronic alcohol-induced liver injury in rats. | 2013 | Int. Immunopharmacol. | pmid:23751897 |
| Liu X et al. | Pharmacokinetic comparisons of puerarin, daidzin and the glucuronide metabolite of puerarin after administration of total flavonoid from Gegen alone and total flavonoid from Gegen combined with total saponin from Sanqi in rats under different physiological states. | 2013 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:23774247 |
| Wong KH et al. | Differentiation of Pueraria lobata and Pueraria thomsonii using partial least square discriminant analysis (PLS-DA). | 2013 | J Pharm Biomed Anal | pmid:23777642 |
| Xia DZ et al. | Hepatoprotective activity of puerarin against carbon tetrachloride-induced injuries in rats: a randomized controlled trial. | 2013 | Food Chem. Toxicol. | pmid:23764356 |
| Wang L et al. | Protective effects of puerarin on experimental chronic lead nephrotoxicity in immature female rats. | 2013 | Hum Exp Toxicol | pmid:23315276 |
| Wu K et al. | Anti-diabetic effects of puerarin, isolated from Pueraria lobata (Willd.), on streptozotocin-diabetogenic mice through promoting insulin expression and ameliorating metabolic function. | 2013 | Food Chem. Toxicol. | pmid:23927877 |
| Wu X et al. | Isolation, identification and pharmacokinetic analysis of fructosyl puerarins from enzymatic glycosylation. | 2013 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:23948238 |
| Cheng Y et al. | Effects of puerarin on cardiac differentiation and ventricular specialization of murine embryonic stem cells. | 2013 | Cell. Physiol. Biochem. | pmid:24080853 |
| Zhao LX et al. | The permeability of puerarin loaded poly(butylcyanoacrylate) nanoparticles coated with polysorbate 80 on the blood-brain barrier and its protective effect against cerebral ischemia/reperfusion injury. | 2013 | Biol. Pharm. Bull. | pmid:23902970 |
| Ji M et al. | Puerarin suppresses proliferation of endometriotic stromal cells in part via differential recruitment of nuclear receptor coregulators to estrogen receptor-α. | 2013 | J. Steroid Biochem. Mol. Biol. | pmid:23907019 |
| Tu L et al. | Effects of particle size on the pharmacokinetics of puerarin nanocrystals and microcrystals after oral administration to rat. | 2013 | Int J Pharm | pmid:24120729 |
| Cui YH et al. | [Adsorption and isolation of macroporous resin for three isoflavonoids from puerariae lobatae radix]. | 2013 | Zhong Yao Cai | pmid:24134015 |
| Singh AK et al. | Anti-inflammatory potency of nano-formulated puerarin and curcumin in rats subjected to the lipopolysaccharide-induced inflammation. | 2013 | J Med Food | pmid:24138167 |
| Jiang L et al. | Simultaneous determination of gastrodin and puerarin in rat plasma by HPLC and the application to their interaction on pharmacokinetics. | 2013 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:23314488 |
| Liu AC et al. | LC-MS/MS method for the determination of a new puerarin derivative and its application in pharmacokinetic studies in rats. | 2013 | Chin J Nat Med | pmid:24359785 |
| Zhu H et al. | Effect of puerarin on matrix metalloproteinase-2 in human fetal scleral fibroblasts treated with low frequency electromagnetic fields. | 2013 | J Tradit Chin Med | pmid:24660593 |
| Tang TT et al. | Mechanisms of microemulsion enhancing the oral bioavailability of puerarin: comparison between oil-in-water and water-in-oil microemulsions using the single-pass intestinal perfusion method and a chylomicron flow blocking approach. | 2013 | Int J Nanomedicine | pmid:24277986 |
| Ji O et al. | [Effect of flavonoids of puerarin on the proliferation and apoptosis of retinoic acid resistant acute promyelocytic leukemia cell line NB4-R1 cells]. | 2013 | Zhonghua Xue Ye Xue Za Zhi | pmid:23688762 |
| Gu L et al. | Polyamidomine dendrimers: an excellent drug carrier for improving the solubility and bioavailability of puerarin. | 2013 Sep-Oct | Pharm Dev Technol | pmid:22303809 |
| Zhu X et al. | The effect of puerarin against IL-1β-mediated leukostasis and apoptosis in retinal capillary endothelial cells (TR-iBRB2). | 2014 | Mol. Vis. | pmid:25593509 |
| Fu R et al. | Digital gene expression analysis of the pathogenesis and therapeutic mechanisms of ligustrazine and puerarin in rat atherosclerosis. | 2014 | Gene | pmid:25218235 |
| Kim MH et al. | Mechanisms of action of phytochemicals from medicinal herbs in the treatment of Alzheimer's disease. | 2014 | Planta Med. | pmid:25210998 |
| Wang J et al. | Synergistic effects of puerarin combined with 5-fluorouracil on esophageal cancer. | 2014 | Mol Med Rep | pmid:25189132 |
| Zhang WG et al. | Puerarin inhibits growth and induces apoptosis in SMMC-7721 hepatocellular carcinoma cells. | 2014 | Mol Med Rep | pmid:25175767 |
| Wang C et al. | Puerarin protects against β-amyloid-induced microglia apoptosis via a PI3K-dependent signaling pathway. | 2014 | Neurochem. Res. | pmid:25173404 |
| Xie N et al. | Puerarin protects hippocampal neurons against cell death in pilocarpine-induced seizures through antioxidant and anti-apoptotic mechanisms. | 2014 | Cell. Mol. Neurobiol. | pmid:25151533 |
| Maji AK et al. | Pueraria tuberosa: a review on its phytochemical and therapeutic potential. | 2014 | Nat. Prod. Res. | pmid:24980468 |
| Ma JQ et al. | Puerarin ameliorates carbon tetrachloride-induced oxidative DNA damage and inflammation in mouse kidney through ERK/Nrf2/ARE pathway. | 2014 | Food Chem. Toxicol. | pmid:24975872 |
| Wang C et al. | The proliferation, differentiation, and mineralization effects of puerarin on osteoblasts in vitro. | 2014 | Chin J Nat Med | pmid:24969524 |
| Wei SY et al. | Progress on the pharmacological research of puerarin: a review. | 2014 | Chin J Nat Med | pmid:24969520 |
| Park WS et al. | Anti-graying effect of the extract of Pueraria thunbergiana via upregulation of cAMP/MITF-M signaling pathway. | 2014 | J. Dermatol. Sci. | pmid:24924521 |
| Yu P et al. | Determination of puerarin in rat plasma using PEGylated magnetic carbon nanotubes by high performance liquid chromatography. | 2014 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:24768919 |
| Kim SB et al. | In vitro and in vivo evaluation of the effect of puerarin on hepatic cytochrome p450-mediated drug metabolism. | 2014 | Planta Med. | pmid:24710899 |
| Liu Y et al. | Induction of adhesion molecule expression in co-culture of human bronchial epithelial cells and neutrophils suppressed by puerarin via down-regulating p38 mitogen-activated protein kinase and nuclear factor κB pathways. | 2014 | Chin J Integr Med | pmid:24122632 |
| Chen YG et al. | Metabolic differentiations of Pueraria lobata and Pueraria thomsonii using ¹H NMR spectroscopy and multivariate statistical analysis. | 2014 | J Pharm Biomed Anal | pmid:23746990 |
| Zhu G et al. | Neuroprotective effects of puerarin on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine induced Parkinson's disease model in mice. | 2014 | Phytother Res | pmid:23512787 |
| Zhou A et al. | Lymphatic transport of puerarin occurs after oral administration of different lipid-based formulations to unconscious lymph duct-cannulated rats. | 2014 | Pharm Dev Technol | pmid:23978005 |
| Wang JW et al. | Puerarin ameliorates oxidative stress in a rodent model of traumatic brain injury. | 2014 | J. Surg. Res. | pmid:24079811 |
| Zhong Y et al. | Puerarin attenuated early diabetic kidney injury through down-regulation of matrix metalloproteinase 9 in streptozotocin-induced diabetic rats. | 2014 | PLoS ONE | pmid:24454919 |
| Bao MH et al. | Puerarin protects endothelial cells from oxidized low density lipoprotein induced injuries via the suppression of LOX-1 and induction of eNOS. | 2014 | Can. J. Physiol. Pharmacol. | pmid:24708212 |
| Mahdy HM et al. | The anti-apoptotic and anti-inflammatory properties of puerarin attenuate 3-nitropropionic-acid induced neurotoxicity in rats. | 2014 | Can. J. Physiol. Pharmacol. | pmid:24593790 |
| Wang XC et al. | [Effect of chaperone-mediated autophagy in MPP(+) -induced SH-SY5Y cells and interventional effect of puerarin]. | 2014 | Zhongguo Zhong Yao Za Zhi | pmid:24754178 |
| Qu H et al. | Development of an enzyme-linked immunosorbent assay based on anti-puerarin monoclonal antibody and its applications. | 2014 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:24583873 |
| Liao ZG et al. | Transport properties of puerarin and effect of extract of Radix Angelicae dahuricae on puerarin intestinal absorption using in situ and in vitro models. | 2014 | Phytother Res | pmid:24756954 |
| Lu Q et al. | Puerarin attenuates calcification of vascular smooth muscle cells. | 2014 | Am. J. Chin. Med. | pmid:24707866 |
| Wang Y et al. | Simultaneous determination of four components in Baige capsule by HPLC: application to pharmacokinetics and tissue distribution of normal and middle cerebral artery occlusion rats. | 2014 | Biomed. Chromatogr. | pmid:24122939 |