Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
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Zhu Z et al. | Effects of puerarin on pulmonary vascular remodeling and protein kinase C-alpha in chronic cigarette smoke exposure smoke-exposed rats. | 2008 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:18278451 |
Li Y et al. | Process parameters and morphology in puerarin, phospholipids and their complex microparticles generation by supercritical antisolvent precipitation. | 2008 | Int J Pharm | pmid:18440736 |
He H et al. | The correlation between angiogenesis and abnormal expression of SERCA2a, phospholamban and the endothelin pathway in heart failure, and improvement by puerarin. | 2008 | Phytother Res | pmid:18389490 |
Kim YS et al. | Biotransformation of ginsenoside Rb1, crocin, amygdalin, geniposide, puerarin, ginsenoside Re, hesperidin, poncirin, glycyrrhizin, and baicalin by human fecal microflora and its relation to cytotoxicity against tumor cells. | 2008 | J. Microbiol. Biotechnol. | pmid:18600055 |
Chen JW et al. | [Molecular mechanism of reversing multi-drug resistance of K562/AO2 by puerarin]. | 2008 | Zhong Nan Da Xue Xue Bao Yi Xue Ban | pmid:18382055 |
Wong RW and Rabie AB | Effect of quercetin on preosteoblasts and bone defects. | 2008 | Open Orthop J | pmid:19461927 |
Mukherjee B et al. | Preparation, characterization and in-vitro evaluation of sustained release protein-loaded nanoparticles based on biodegradable polymers. | 2008 | Int J Nanomedicine | pmid:19337417 |
Yu CQ | [Treatment of endometriosis by puerarin]. | 2008 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:19213335 |
Wu GL et al. | [Effect of puerarin on levels of TGF-beta1 and alpha-SMA in rats with alcoholic injury liver]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:19166018 |
Jing L and Gao ZY | [Retrospective analysis on Chinese medicinal treatment on 302 chronic heart failure patients of coronary heart disease and diabetes]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:19166020 |
Zheng PY et al. | [Effects of puerarin on expressions of leptin receptor mRNA, phosphorylated Janus kinase 2/phosphorylated signal transducers and activators of transcription 3 proteins in the liver of rats with non-alcoholic fatty liver]. | 2008 | Zhong Xi Yi Jie He Xue Bao | pmid:18782535 |
Hu HT et al. | [Effects of puerarin with aspirin on the markers of damaged vascular endothelial cells in patients with acute cerebral infarction]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:19260323 |
Zhang MY et al. | [Effects of different doses of puerarin on vascular endothelial cell proliferation in vitro]. | 2008 | Zhong Xi Yi Jie He Xue Bao | pmid:18782539 |
Wen BY et al. | [Metabolic kinetic of puerarin in beagle liver microsomal by HPLC-ESI-MS]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:19260325 |
Zhang HY et al. | [Effect of puerarin on PC12 cells apoptosis induced by Abeta25-35 in vitro]. | 2008 | Zhong Yao Cai | pmid:18661826 |
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Jin JS et al. | Biotransformation of C-glucosylisoflavone puerarin to estrogenic (3S)-equol in co-culture of two human intestinal bacteria. | 2008 | Biol. Pharm. Bull. | pmid:18670101 |
Wan H et al. | Protective effect of chuanxiongzine-puerarin in a rat model of transient middle cerebral artery occlusion-induced focal cerebral ischemia. | 2008 | Nucl Med Commun | pmid:18987534 |
Li QX et al. | [Effect of compound Puerarin on the collage IV in streptozotocin-induced diabetic nephropathy rats]. | 2008 | Zhonghua Yu Fang Yi Xue Za Zhi | pmid:18763636 |
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Wang YG et al. | [High-performance capillary electrophoresis for determining the chemical compositions of Gegen and Fenge extracts]. | 2008 | Nan Fang Yi Ke Da Xue Xue Bao | pmid:18753072 |
Li YW et al. | Regulation of aromatase P450 expression by puerarin in endometrial cell line RL95-2. | 2008 | Zhong Xi Yi Jie He Xue Bao | pmid:18847535 |
Yu C et al. | Decreased expression of aromatase in the Ishikawa and RL95-2 cells by the isoflavone, puerarin, is associated with inhibition of c-jun expression and AP-1 activity. | 2008 | Food Chem. Toxicol. | pmid:18848966 |
Jiang JR et al. | Conversion of puerarin into its 7-O-glycoside derivatives by Microbacterium oxydans (CGMCC 1788) to improve its water solubility and pharmacokinetic properties. | 2008 | Appl. Microbiol. Biotechnol. | pmid:18795283 |
Zhang H et al. | Simultaneous determination of 12 chemical constituents in the traditional Chinese Medicinal Prescription Xiao-Yao-San-Jia-Wei by HPLC coupled with photodiode array detection. | 2008 | J Pharm Biomed Anal | pmid:18977108 |
Pan HP and Li G | Protecting mechanism of puerarin on the brain neurocyte of rat in acute local ischemia brain injury and local cerebral ischemia-reperfusion injury. | 2008 | Yakugaku Zasshi | pmid:18981705 |
Sun W et al. | [Effects of puerarin on ADRP gene expression in fatty tissue of type 2 diabetes mellitus rats]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:19086646 |
Cui SM and Ma YB | [Effect of verapamil on pharmacokinetics of puerarin in rats]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:19086648 |
Dai J et al. | A sensitive liquid chromatography-mass spectrometry method for simultaneous determination of two active chromones from Saposhnikovia root in rat plasma and urine. | 2008 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:18485839 |
Wen A et al. | A rapid and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the determination of hydroxysafflor yellow A in human plasma: application to a pharmacokinetic study. | 2008 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:18964371 |
Clarke DB et al. | Determination of phytoestrogens in dietary supplements by LC-MS/MS. | 2008 | Food Addit Contam Part A Chem Anal Control Expo Risk Assess | pmid:18478479 |
Huang J et al. | Selective adsorption of tannin from flavonoids by organically modified attapulgite clay. | 2008 | J. Hazard. Mater. | pmid:18433994 |
Cherdshewasart W and Sutjit W | Correlation of antioxidant activity and major isoflavonoid contents of the phytoestrogen-rich Pueraria mirifica and Pueraria lobata tubers. | 2008 | Phytomedicine | pmid:17890070 |
He Y et al. | Binding of puerarin to human serum albumin: a spectroscopic analysis and molecular docking. | 2008 | J Fluoresc | pmid:18058205 |
Tian YX et al. | Radical dynamics of puerarin as revealed by laser flash photolysis and spin density analysis. | 2008 | J Phys Chem B | pmid:18232684 |
Cherdshewasart W et al. | Determination of the estrogenic activity of wild phytoestrogen-rich Pueraria mirifica by MCF-7 proliferation assay. | 2008 | J. Reprod. Dev. | pmid:18160771 |
Chung MJ et al. | Antioxidative and hypocholesterolemic activities of water-soluble puerarin glycosides in HepG2 cells and in C57 BL/6J mice. | 2008 | Eur. J. Pharmacol. | pmid:17976573 |
Wang Q et al. | Quantification of puerarin in plasma by on-line solid-phase extraction column switching liquid chromatography-tandem mass spectrometry and its applications to a pharmacokinetic study. | 2008 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:18242154 |
Cherdshewasart W and Sriwatcharakul S | Metabolic activation promotes estrogenic activity of the phytoestrogen-rich plant. | 2008 | Maturitas | pmid:18313242 |
Dong-Qin Q et al. | Formulation development and pharmacokinetics of puerarin self-emulsifying drug delivery systems. | 2007 Jan-Feb | PDA J Pharm Sci Technol | pmid:17390702 |
Yan H et al. | Treating senile dementia with traditional Chinese medicine. | 2007 | Clin Interv Aging | pmid:18044136 |
Mo SF et al. | Hypouricemic action of selected flavonoids in mice: structure-activity relationships. | 2007 | Biol. Pharm. Bull. | pmid:17666819 |
Song J et al. | Simultaneous determination of multiple marker constituents in concentrated Gegen Tang granule by high performance liquid chromatography. | 2007 | Chin Med | pmid:17578586 |
Wu B et al. | Meta-analysis of traditional Chinese patent medicine for ischemic stroke. | 2007 | Stroke | pmid:17463317 |
Cherdshewasart W et al. | Major isoflavonoid contents of the phytoestrogen rich-herb Pueraria mirifica in comparison with Pueraria lobata. | 2007 | J Pharm Biomed Anal | pmid:16930918 |
Xi J and Guo R | Acid-base equilibrium of puerarin in CTAB micelles. | 2007 | J Pharm Biomed Anal | pmid:16935449 |
Liang JQ et al. | [The protective function of puerarin to the injury of the lung and its mechanisms during diabetes]. | 2007 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21162284 |
Prasain JK et al. | Pharmacokinetic study of puerarin in rat serum by liquid chromatography tandem mass spectrometry. | 2007 | Biomed. Chromatogr. | pmid:17221935 |
Wu C et al. | Preparation and evaluation of a Carbopol/HPMC-based in situ gelling ophthalmic system for puerarin. | 2007 | Yakugaku Zasshi | pmid:17202799 |
Yang GJ et al. | The simultaneous separation and determination of six flavonoids and troxerutin in rat urine and chicken plasma by reversed-phase high-performance liquid chromatography with ultraviolet-visible detection. | 2007 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:17588830 |
Li DY et al. | [Clinical significance of matrix metalloproteinase-9 and tissue factors secreted by cultured monocyte-derived macrophage of patients with coronary heart disease in vitro and the intervenient effect of puerarin on them]. | 2007 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:17879530 |
Li Q et al. | [Study of regulation of Puerarin on blood P-selectin and the expression of aorta VCAM mRNA in diabetes]. | 2007 | Wei Sheng Yan Jiu | pmid:18095572 |
Kim YS et al. | The role of intestinal microflora on daidzein excretion in urine in humans treated with Chungpesagantang. | 2007 | Arch. Pharm. Res. | pmid:17489365 |
Rachoń D et al. | Dietary daidzein and puerarin do not affect pituitary LH expression but exert uterotropic effects in ovariectomized rats. | 2007 | Maturitas | pmid:17258874 |
Singh AK et al. | Herbal mixtures consisting of puerarin and either polyenylphosphatidylcholine or curcumin provide comprehensive protection against alcohol-related disorders in P rats receiving free choice water and 15% ethanol in pure water. | 2007 | J Med Food | pmid:17887948 |
Xu XH et al. | Inhibition of excitatory amino acid efflux contributes to protective effects of puerarin against cerebral ischemia in rats. | 2007 | Biomed. Environ. Sci. | pmid:17948770 |
Cherdshewasart W and Sriwatcharakul S | Major isoflavonoid contents of the 1-year-cultivated phytoestrogen-rich herb, Pueraria mirifica. | 2007 | Biosci. Biotechnol. Biochem. | pmid:17928711 |
Yue PF et al. | Development and optimization of intravenous puerarin emulsions formation by a novel complex-phase inversion-homogenization technology. | 2007 | Chem. Pharm. Bull. | pmid:17978512 |
Xiao J et al. | Analysis of binding interaction between puerarin and bovine serum albumin by multi-spectroscopic method. | 2007 | J Pharm Biomed Anal | pmid:17942262 |
Quan DQ and Xu GX | Formulation optimization of self-emulsifying preparations of puerarin through self-emulsifying performances evaluation in vitro and pharmacokinetic studies in vivo. | 2007 | Yao Xue Xue Bao | pmid:17944241 |
Qi H et al. | Development of a poloxamer analogs/carbopol-based in situ gelling and mucoadhesive ophthalmic delivery system for puerarin. | 2007 | Int J Pharm | pmid:17254725 |
Wong R and Rabie B | Effect of puerarin on bone formation. | 2007 | Osteoarthr. Cartil. | pmid:17379543 |
Han RM et al. | Puerarin and conjugate bases as radical scavengers and antioxidants: molecular mechanism and synergism with beta-carotene. | 2007 | J. Agric. Food Chem. | pmid:17300199 |
Yu Z et al. | HPLC determination of safflor yellow A and three active isoflavones from TCM Naodesheng in rat plasma and tissues and its application to pharmacokinetic studies. | 2007 | Biomed. Chromatogr. | pmid:17385809 |
Zhao T et al. | The mechanism of 3-methoxy puerarin on decreasing the cerebral ischemia-reperfusion injury in rats. | 2007 | Asia Pac J Clin Nutr | pmid:17392123 |
Wang HG et al. | [Preparation and characterization of chitosan coated puerarin liposomes]. | 2007 | Zhong Yao Cai | pmid:17539312 |
Xu YC et al. | Structure-activity relationships of flavonoids for vascular relaxation in porcine coronary artery. | 2007 | Phytochemistry | pmid:17395220 |
Yu Z et al. | Simultaneous determination of safflor yellow A, puerarin, daidzein, ginsenosides (Rg(1), Rb(1), Rd), and notoginsenoside R(1) in rat plasma by liquid chromatography-mass spectrometry. | 2007 | J Pharm Biomed Anal | pmid:17590558 |
Xu X and Zhang Z | Effects of puerarin on synaptic structural modification in hippocampus of ovariectomized mice. | 2007 | Planta Med. | pmid:17628835 |
Zhang Y et al. | Stimulatory effect of puerarin on bone formation through activation of PI3K/Akt pathway in rat calvaria osteoblasts. | 2007 | Planta Med. | pmid:17443435 |
Wang J et al. | Detection of flavonoids and assay for their antioxidant activity based on enlargement of gold nanoparticles. | 2007 | Anal Bioanal Chem | pmid:17479255 |
Wu L et al. | Cardioprotective effects of the combined use of puerarin and Danshensu on acute ischemic myocardial injury in rats. | 2007 | Phytother Res | pmid:17450507 |
Quan DQ et al. | Studies on preparation and absolute bioavailability of a self-emulsifying system containing puerarin. | 2007 | Chem. Pharm. Bull. | pmid:17473473 |
Gao R et al. | Gradient high-performance liquid chromatography for the simultaneous determination of chlorogenic acid and baicalin in plasma and its application in the study of pharmacokinetics in rats. | 2007 | J Pharm Biomed Anal | pmid:16859859 |
Zhou HY et al. | [Separation and determination of puerarin, daidzin and daidzein in stems and leaves of Pueraria thomsonii by RP-HPLC]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:17655152 |
Li H et al. | Fragmentation study of a 8-C-glycosyl isoflavone, puerarin, using electrospray ion trap time-of-flight mass spectrometry at high resolution. | 2007 | Rapid Commun. Mass Spectrom. | pmid:17610215 |
Lin F et al. | Puerarin facilitates Ca(2+)-induced Ca(2+) release triggered by KCl-depolarization in primary cultured rat hippocampal neurons. | 2007 | Eur. J. Pharmacol. | pmid:17610871 |
Sun XH et al. | Activation of large-conductance calcium-activated potassium channels by puerarin: the underlying mechanism of puerarin-mediated vasodilation. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17652634 |
Gu YZ et al. | [Preparation of puerarin liposome and its oral absorption in rat]. | 2007 | Zhong Yao Cai | pmid:18074848 |
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Wu L et al. | Protective roles of puerarin and Danshensu on acute ischemic myocardial injury in rats. | 2007 | Phytomedicine | pmid:17870452 |
Xu X and Zheng X | Potential involvement of calcium and nitric oxide in protective effects of puerarin on oxygen-glucose deprivation in cultured hippocampal neurons. | 2007 | J Ethnopharmacol | pmid:17698307 |
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Gao Q et al. | Opening the calcium-activated potassium channel participates in the cardioprotective effect of puerarin. | 2007 | Eur. J. Pharmacol. | pmid:17692311 |
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Penetar DM et al. | Pharmacokinetic profile of the isoflavone puerarin after acute and repeated administration of a novel kudzu extract to human volunteers. | 2006 Jul-Aug | J Altern Complement Med | pmid:16884345 |
Li L and Zhang CR | Production of puerarin and isoflavones in cell suspension cultures of Pueraria lobata (Willd.): effects of medium supplementation with casein hydrolysate and coconut milk. | 2006 | J Environ Biol | pmid:16850870 |
Wang Q et al. | Puerarin injection for unstable angina pectoris. | 2006 | Cochrane Database Syst Rev | pmid:16856037 |
Zhang S et al. | Reversal of chemical-induced liver fibrosis in Wistar rats by puerarin. | 2006 | J. Nutr. Biochem. | pmid:16426832 |
Weiping S et al. | Self-assembly of an amphiphilic derivative of chitosan and micellar solubilization of puerarin. | 2006 | Colloids Surf B Biointerfaces | pmid:16466908 |
Li JX et al. | [Effect of puerarin on ADMA-DDAH system in human umbilical vein endothelial cells cultured with oxidized free radical]. | 2006 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:17205823 |
Gao Q et al. | Atractyloside and 5-hydroxydecanoate block the protective effect of puerarin in isolated rat heart. | 2006 | Life Sci. | pmid:16458326 |
Delmonte P et al. | Determination of isoflavones in dietary supplements containing soy, Red Clover and kudzu: extraction followed by basic or acid hydrolysis. | 2006 | J Chromatogr A | pmid:16413562 |
Kirakosyan A et al. | Isoflavone levels in five soybean (Glycine max) genotypes are altered by phytochrome-mediated light treatments. | 2006 | J. Agric. Food Chem. | pmid:16390177 |