SCHEMBL105486
Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with SCHEMBL105486?
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
PubChem Associated disorders and diseases
What pathways are associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with SCHEMBL105486?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
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What functions are associated with SCHEMBL105486?
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What lipids are associated with SCHEMBL105486?
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What genes are associated with SCHEMBL105486?
Related references are published most in these journals:
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What common seen animal models are associated with SCHEMBL105486?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
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NCBI Entrez Crosslinks
All references with SCHEMBL105486
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kim YS et al. | Biotransformation of ginsenoside Rb1, crocin, amygdalin, geniposide, puerarin, ginsenoside Re, hesperidin, poncirin, glycyrrhizin, and baicalin by human fecal microflora and its relation to cytotoxicity against tumor cells. | 2008 | J. Microbiol. Biotechnol. | pmid:18600055 |
| Chen JW et al. | [Molecular mechanism of reversing multi-drug resistance of K562/AO2 by puerarin]. | 2008 | Zhong Nan Da Xue Xue Bao Yi Xue Ban | pmid:18382055 |
| Wong RW and Rabie AB | Effect of quercetin on preosteoblasts and bone defects. | 2008 | Open Orthop J | pmid:19461927 |
| Mukherjee B et al. | Preparation, characterization and in-vitro evaluation of sustained release protein-loaded nanoparticles based on biodegradable polymers. | 2008 | Int J Nanomedicine | pmid:19337417 |
| Yang B et al. | [Mitochondrial mechanism of cardioprotective effect of puerarin against H202-stress in rats]. | 2008 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21158136 |
| Wang Y et al. | [Effect of puerarin and ligustrazine on cultured hippocampal neurons injury induced by Abeta25-35]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:18533503 |
| Zhang YB et al. | [Protective effects of 3'-methoxy-puerarin on rat brain suffering from ischemia]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:18536378 |
| Li JW et al. | [Inhibition of puerarin on pulmonary hypertension in rats with hypoxia and hypercapnia]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:18536380 |
| Yu CQ | [Treatment of endometriosis by puerarin]. | 2008 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:19213335 |
| Yang ZD et al. | [Chemical constituents in root of Hemerocallis fulva]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:18536463 |
| Wu GL et al. | [Effect of puerarin on levels of TGF-beta1 and alpha-SMA in rats with alcoholic injury liver]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:19166018 |
| Jing L and Gao ZY | [Retrospective analysis on Chinese medicinal treatment on 302 chronic heart failure patients of coronary heart disease and diabetes]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:19166020 |
| Zhang HY et al. | Puerarin protects PC12 cells against beta-amyloid-induced cell injury. | 2008 | Cell Biol. Int. | pmid:18675923 |
| Hao LN et al. | [The effect of puerarin on prevention of oxidative damage of cultured lens capsule epithelial cells]. | 2008 | Zhonghua Yan Ke Za Zhi | pmid:18683704 |
| Reppert A et al. | Isolation of radiolabeled isoflavones from kudzu (Pueraria lobata) root cultures. | 2008 | J. Agric. Food Chem. | pmid:18690681 |
| Wan H et al. | Protective effect of chuanxiongzine-puerarin in a rat model of transient middle cerebral artery occlusion-induced focal cerebral ischemia. | 2008 | Nucl Med Commun | pmid:18987534 |
| Hwang YP and Jeong HG | Mechanism of phytoestrogen puerarin-mediated cytoprotection following oxidative injury: estrogen receptor-dependent up-regulation of PI3K/Akt and HO-1. | 2008 | Toxicol. Appl. Pharmacol. | pmid:18845176 |
| Wang YG et al. | [High-performance capillary electrophoresis for determining the chemical compositions of Gegen and Fenge extracts]. | 2008 | Nan Fang Yi Ke Da Xue Xue Bao | pmid:18753072 |
| Li YW et al. | Regulation of aromatase P450 expression by puerarin in endometrial cell line RL95-2. | 2008 | Zhong Xi Yi Jie He Xue Bao | pmid:18847535 |
| Yu C et al. | Decreased expression of aromatase in the Ishikawa and RL95-2 cells by the isoflavone, puerarin, is associated with inhibition of c-jun expression and AP-1 activity. | 2008 | Food Chem. Toxicol. | pmid:18848966 |
| Jiang JR et al. | Conversion of puerarin into its 7-O-glycoside derivatives by Microbacterium oxydans (CGMCC 1788) to improve its water solubility and pharmacokinetic properties. | 2008 | Appl. Microbiol. Biotechnol. | pmid:18795283 |
| Zhang H et al. | Simultaneous determination of 12 chemical constituents in the traditional Chinese Medicinal Prescription Xiao-Yao-San-Jia-Wei by HPLC coupled with photodiode array detection. | 2008 | J Pharm Biomed Anal | pmid:18977108 |
| Pan HP and Li G | Protecting mechanism of puerarin on the brain neurocyte of rat in acute local ischemia brain injury and local cerebral ischemia-reperfusion injury. | 2008 | Yakugaku Zasshi | pmid:18981705 |
| Ye XY et al. | [Effect of puerarin injection on the mRNA expressions of AT1 and ACE2 in spontaneous hypertension rats]. | 2008 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:19065898 |
| Zou GX et al. | [New method of multi-components quantitation by one marker new method for quality evaluation of Guanmaikang capsula]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:19007008 |
| Huang J et al. | Selective adsorption of tannin from flavonoids by organically modified attapulgite clay. | 2008 | J. Hazard. Mater. | pmid:18433994 |
| Cherdshewasart W and Sutjit W | Correlation of antioxidant activity and major isoflavonoid contents of the phytoestrogen-rich Pueraria mirifica and Pueraria lobata tubers. | 2008 | Phytomedicine | pmid:17890070 |
| He Y et al. | Binding of puerarin to human serum albumin: a spectroscopic analysis and molecular docking. | 2008 | J Fluoresc | pmid:18058205 |
| Tian YX et al. | Radical dynamics of puerarin as revealed by laser flash photolysis and spin density analysis. | 2008 | J Phys Chem B | pmid:18232684 |
| Cherdshewasart W et al. | Determination of the estrogenic activity of wild phytoestrogen-rich Pueraria mirifica by MCF-7 proliferation assay. | 2008 | J. Reprod. Dev. | pmid:18160771 |
| Chung MJ et al. | Antioxidative and hypocholesterolemic activities of water-soluble puerarin glycosides in HepG2 cells and in C57 BL/6J mice. | 2008 | Eur. J. Pharmacol. | pmid:17976573 |
| Wang Q et al. | Quantification of puerarin in plasma by on-line solid-phase extraction column switching liquid chromatography-tandem mass spectrometry and its applications to a pharmacokinetic study. | 2008 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:18242154 |
| Tan Y et al. | Puerarin for acute ischaemic stroke. | 2008 | Cochrane Database Syst Rev | pmid:18254067 |
| Wang Z et al. | Study on the interaction of puerarin with lysozyme by spectroscopic methods. | 2008 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:18262462 |
| Yue PF et al. | The study to reduce the hemolysis side effect of puerarin by a submicron emulsion delivery system. | 2008 | Biol. Pharm. Bull. | pmid:18175940 |
| Li Y et al. | Comparative physicochemical characterization of phospholipids complex of puerarin formulated by conventional and supercritical methods. | 2008 | Pharm. Res. | pmid:17828444 |
| Tang X et al. | Phytoestrogens induce differential estrogen receptor beta-mediated responses in transfected MG-63 cells. | 2008 Aug-Dec | Endocrine | pmid:18937077 |
| Zhu J et al. | Puerarin reduces endothelial progenitor cells senescence through augmentation of telomerase activity. | 2008 Aug-Sep | Vascul. Pharmacol. | pmid:18692596 |
| Yue PF et al. | Preparation, characterization, and pharmacokinetic evaluation of puerarin submicron emulsion. | 2008 Jan-Feb | PDA J Pharm Sci Technol | pmid:18402366 |
| Zhang SY et al. | The effect of puerarin on serum nitric oxide concentration and myocardial eNOS expression in rats with myocardial infarction. | 2008 Mar-Apr | J Asian Nat Prod Res | pmid:18348063 |
| Park SJ et al. | Effects of mixed herbal extracts from parched Puerariae radix, gingered Magnoliae cortex, Glycyrrhizae radix and Euphorbiae radix (KIOM-79) on cardiac ion channels and action potentials. | 2009 | J. Korean Med. Sci. | pmid:19543501 |
| Chang Y et al. | Neuroprotective mechanisms of puerarin in middle cerebral artery occlusion-induced brain infarction in rats. | 2009 | J. Biomed. Sci. | pmid:19272172 |
| Lau CC et al. | Rapid analysis of Radix puerariae by near-infrared spectroscopy. | 2009 | J Chromatogr A | pmid:19185872 |
| Zhang H and Yang X | Profiling and quantification of isoflavone-C-glycosides impurities in puerarin injection by liquid chromatography coupled to ESI-ion trap mass spectrometry. | 2009 | J Pharm Biomed Anal | pmid:19186018 |
| Yan LP et al. | Analysis of the mechanisms underlying the endothelium-dependent antivasoconstriction of puerarin in rat aorta. | 2009 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:19190894 |
| Liu XJ et al. | [Study on absorption mechanism of puerarin and its nanoparticles across Caco-2 cell model]. | 2009 | Zhong Yao Cai | pmid:19960950 |
| Wang L et al. | [The pathway of absorption and conveying of puerarin microemulsion-in-oil]. | 2009 | Yao Xue Xue Bao | pmid:19806923 |
| Lu N et al. | Nitrite-glucose-glucose oxidase system directly induces rat heart homogenate oxidation and tyrosine nitration: effects of some flavonoids. | 2009 | Toxicol In Vitro | pmid:19286453 |
| Derda M et al. | Plant extracts as natural amoebicidal agents. | 2009 | Parasitol. Res. | pmid:19050923 |
| Tian J and Qin W | Quick and sensitive determination of flavonoids by capillary electrophoresis-potential gradient detection. | 2009 | Anal Sci | pmid:19745540 |