Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
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Authors | Title | Published | Journal | PubMed Link |
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Yan LP et al. | Puerarin decreases serum total cholesterol and enhances thoracic aorta endothelial nitric oxide synthase expression in diet-induced hypercholesterolemic rats. | 2006 | Life Sci. | pmid:16472823 |
Zang HM et al. | [Experimental study of the effects of puerarin on biological characters of osteoblasts in vitro]. | 2005 | Zhongguo Zhong Yao Za Zhi | pmid:16494032 |
Yu Z et al. | Simultaneous determination of components in preparation Naodesheng injection by high performance liquid chromatograph-atmospheric pressure chemical ionization mass spectrometry (HPLC-MS/APCI). | 2006 | Chem. Pharm. Bull. | pmid:16595973 |
Wu XP et al. | [Protective effects of puerarin against myocardial injury in patients with hypertension during perioperational period]. | 2006 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:16613276 |
Li Y et al. | Pharmacokinetic, tissue distribution, and excretion of puerarin and puerarin-phospholipid complex in rats. | 2006 | Drug Dev Ind Pharm | pmid:16638679 |
Wang C et al. | [Therapeutic effect of puerarin on rats with pre-eclampsia]. | 2006 | Zhonghua Fu Chan Ke Za Zhi | pmid:16640862 |
Zhang S et al. | Puerarin induces angiogenesis in myocardium of rat with myocardial infarction. | 2006 | Biol. Pharm. Bull. | pmid:16651724 |
Zhang B et al. | [Protective effects of hydroxyethylpuerarin against brain astrocytes injury induced by hydrogen peroxide]. | 2006 | Yao Xue Xue Bao | pmid:16671550 |
Xu YZ et al. | [Effects of puerarin on proliferation of vascular smooth muscle cells induced by thrombin]. | 2006 | Zhonghua Yi Xue Za Zhi | pmid:16677576 |
Chen SB et al. | High-performance thin-layer chromatographic fingerprints of isoflavonoids for distinguishing between Radix Puerariae Lobate and Radix Puerariae Thomsonii. | 2006 | J Chromatogr A | pmid:16714027 |
Xu YZ et al. | [Puerarin suppresses the proliferation of vscular smooth muscule cells and c-fos and bcl-2 protein expression]. | 2006 | Zhongguo Zhong Yao Za Zhi | pmid:16722382 |
Wang FW et al. | [Protective effect of puerarin on stress-induced gastric mucosal injury in rats]. | 2006 | Zhongguo Zhong Yao Za Zhi | pmid:16722386 |
Yu Z et al. | Determination of safflor yellow A, puerarin, ferulic acid, ginsenoside Rg1, and Rb1 in the Traditional Chinese Medicinal preparation Naodesheng injection by high-performance liquid chromatography. | 2006 May-Jun | J Chromatogr Sci | pmid:16774713 |
Kirakosyan A et al. | Regulation of isoflavone production in hydroponically grown Pueraria montana (kudzu) by cork pieces, XAD-4, and methyl jasmonate. | 2006 | Plant Cell Rep. | pmid:16841218 |
Zhang SP et al. | [The experimental study of Radix Puerariae inhibiting glycation in rats induced by D-galactose]. | 2006 | Zhong Yao Cai | pmid:16850728 |
Li L and Zhang CR | Production of puerarin and isoflavones in cell suspension cultures of Pueraria lobata (Willd.): effects of medium supplementation with casein hydrolysate and coconut milk. | 2006 | J Environ Biol | pmid:16850870 |
Wang Q et al. | Puerarin injection for unstable angina pectoris. | 2006 | Cochrane Database Syst Rev | pmid:16856037 |
Gao R et al. | Gradient high-performance liquid chromatography for the simultaneous determination of chlorogenic acid and baicalin in plasma and its application in the study of pharmacokinetics in rats. | 2007 | J Pharm Biomed Anal | pmid:16859859 |
Derda M et al. | [Amebicidal plants extracts]. | 2004 | Wiad Parazytol | pmid:16862806 |
Penetar DM et al. | Pharmacokinetic profile of the isoflavone puerarin after acute and repeated administration of a novel kudzu extract to human volunteers. | 2006 Jul-Aug | J Altern Complement Med | pmid:16884345 |