Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
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Authors | Title | Published | Journal | PubMed Link |
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Ji Y et al. | Anticerebral Ischemia-Reperfusion Injury Activity of Synthesized Puerarin Derivatives. | 2016 | Biomed Res Int | pmid:27807543 |
Zhang H et al. | Puerarin Inhibits oxLDL-Induced Macrophage Activation and Foam Cell Formation in Human THP1 Macrophage. | 2015 | Biomed Res Int | pmid:26576421 |
Cui S et al. | Study on the bioavailability of puerarin from Pueraria lobata isoflavone self-microemulsifying drug-delivery systems and tablets in rabbits by liquid chromatography-mass spectrometry. | 2005 | Biomed. Chromatogr. | pmid:15627278 |
Li C et al. | Non-aqueous capillary electrophoresis for simultaneous separation and determination of three major active components in traditional medicinal preparations. | 2005 | Biomed. Chromatogr. | pmid:15627280 |
Prasain JK et al. | Pharmacokinetic study of puerarin in rat serum by liquid chromatography tandem mass spectrometry. | 2007 | Biomed. Chromatogr. | pmid:17221935 |
Zhu S et al. | Preparation of a super-long two column chromatography system and its application in separating glycosylated puerarin. | 2009 | Biomed. Chromatogr. | pmid:19603387 |
Krittanai S et al. | Development of a colloidal gold nanoparticle-based immunochromatographic strip for the one-step detection of miroestrol and puerarin. | 2018 | Biomed. Chromatogr. | pmid:29972702 |
Li Y et al. | Comparative pharmacokinetics of prim-O-glucosylcimifugin and cimifugin by liquid chromatography-mass spectrometry after oral administration of Radix Saposhnikoviae extract, cimifugin monomer solution and prim-O-glucosylcimifugin monomer solution to rats. | 2012 | Biomed. Chromatogr. | pmid:22253022 |
Wen Y et al. | Simultaneous determination of lidamycin enediyne chromophore (LDC) and its aromatized derivative (LDCA) using puerarin as internal standard in rat plasma by LC-MS/MS. | 2012 | Biomed. Chromatogr. | pmid:21830226 |
Wang Y et al. | Simultaneous determination of four components in Baige capsule by HPLC: application to pharmacokinetics and tissue distribution of normal and middle cerebral artery occlusion rats. | 2014 | Biomed. Chromatogr. | pmid:24122939 |