Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
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Authors | Title | Published | Journal | PubMed Link |
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Li X et al. | Experimental study on the protective effect of puerarin to Parkinson disease. | 2003 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:12973933 |
Jin XL and Zhu XY | [Pharmacokinetics of puerarin in rats, rabbits, and dogs]. | 1992 | Zhongguo Yao Li Xue Bao | pmid:1442117 |
Fan LL et al. | Protective effect of puerarin against myocardial reperfusion injury. Myocardial metabolism and ultrastructure. | 1992 | Chin. Med. J. | pmid:1451545 |
Matkowski A et al. | Flavonoids of Pueraria lobata: chromatographic analysis of leaves and roots of cultivated plants. | 2003 | Pharmazie | pmid:14531473 |
Jiang B et al. | Hydrogen peroxide-induced apoptosis in pc12 cells and the protective effect of puerarin. | 2003 | Cell Biol. Int. | pmid:14642535 |
Zhang GQ et al. | Puerarin blocks Na+ current in rat ventricular myocytes. | 2003 | Acta Pharmacol. Sin. | pmid:14653946 |
Xie RQ et al. | [Myocardial protection and mechanism of Puerarin Injection on patients of coronary heart disease with ischemia/reperfusion]. | 2003 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:14714357 |
Shi HP et al. | [Culture of hairy roots in Pueraria phaseoloides and its puerarin production]. | 2003 | Shi Yan Sheng Wu Xue Bao | pmid:14724930 |
He X et al. | Separation and purification of puerarin using beta-cyclodextrin-coupled agarose gel media. | 2004 | J Chromatogr A | pmid:14753773 |
Wang B et al. | [Clinical analysis of 5 cases with acute intravascular hemolysis caused by puerarin]. | 2004 | Beijing Da Xue Xue Bao | pmid:14970887 |