Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Yu CQ | [Treatment of endometriosis by puerarin]. | 2008 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:19213335 |
Zheng P et al. | Therapeutic effect of puerarin on non-alcoholic rat fatty liver by improving leptin signal transduction through JAK2/STAT3 pathways. | 2009 | Am. J. Chin. Med. | pmid:19222113 |
Hu HT et al. | [Effects of puerarin with aspirin on the markers of damaged vascular endothelial cells in patients with acute cerebral infarction]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:19260323 |
Wen BY et al. | [Metabolic kinetic of puerarin in beagle liver microsomal by HPLC-ESI-MS]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:19260325 |
Wu HQ et al. | Protective effects and mechanism of puerarin on learning-memory disorder after global cerebral ischemia-reperfusion injury in rats. | 2009 | Chin J Integr Med | pmid:19271171 |
Chang Y et al. | Neuroprotective mechanisms of puerarin in middle cerebral artery occlusion-induced brain infarction in rats. | 2009 | J. Biomed. Sci. | pmid:19272172 |
Lu N et al. | Nitrite-glucose-glucose oxidase system directly induces rat heart homogenate oxidation and tyrosine nitration: effects of some flavonoids. | 2009 | Toxicol In Vitro | pmid:19286453 |
Mukherjee B et al. | Preparation, characterization and in-vitro evaluation of sustained release protein-loaded nanoparticles based on biodegradable polymers. | 2008 | Int J Nanomedicine | pmid:19337417 |
Han S | Determination of puerarin by capillary electrophoresis with chemiluminescence detection. | 2009 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:19342316 |
Yue PF et al. | The study on the entrapment efficiency and in vitro release of puerarin submicron emulsion. | 2009 | AAPS PharmSciTech | pmid:19381837 |
Retraction. Cardioprotective effects of the combined use of puerarin and danshensu on acute ischemic myocardial injury in rats. | 2009 | Phytother Res | pmid:19391124 | |
Retraction. The correlation between angiogenesis and abnormal expression of SERCA2a, phospholamban and the endothelin pathway in heart failure, and improvement by puerarin. | 2009 | Phytother Res | pmid:19391125 | |
Wong RW and Rabie AB | Effect of quercetin on preosteoblasts and bone defects. | 2008 | Open Orthop J | pmid:19461927 |
Chen AZ et al. | Microencapsulation of puerarin nanoparticles by poly(l-lactide) in a supercritical CO(2) process. | 2009 | Acta Biomater | pmid:19463980 |
Wang Y et al. | Simultaneous determination of puerarin, daidzein, baicalin, wogonoside and liquiritin of GegenQinlian decoction in rat plasma by ultra-performance liquid chromatography-mass spectrometry. | 2009 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:19493706 |
Gao L et al. | Puerarin protects against ischemic brain injury in a rat model of transient focal ischemia. | 2009 | Neurol. Res. | pmid:19508827 |
Li X et al. | Evaluation of Pharmasolve corneal permeability enhancement and its irritation on rabbit eyes. | 2009 | Drug Deliv | pmid:19514982 |
Pan ZY et al. | The myocardial protective effects of puerarin on STZ-induced diabetic rats. | 2009 | Fen Zi Xi Bao Sheng Wu Xue Bao | pmid:19537197 |
Park SJ et al. | Effects of mixed herbal extracts from parched Puerariae radix, gingered Magnoliae cortex, Glycyrrhizae radix and Euphorbiae radix (KIOM-79) on cardiac ion channels and action potentials. | 2009 | J. Korean Med. Sci. | pmid:19543501 |
Zhu S et al. | Preparation of a super-long two column chromatography system and its application in separating glycosylated puerarin. | 2009 | Biomed. Chromatogr. | pmid:19603387 |
Nguyen VD et al. | Identification of a naturally-occurring 8-[alpha-D-glucopyranosyl-(1-->6)-beta-D-glucopyranosyl]daidzein from cultivated kudzu root. | Phytochem Anal | pmid:19609885 | |
Xu J et al. | Cyclodextrin-containing hydrogels for contact lenses as a platform for drug incorporation and release. | 2010 | Acta Biomater | pmid:19619677 |
Chen CC and Chan WH | Impact effects of puerarin on mouse embryonic development. | 2009 | Reprod. Toxicol. | pmid:19646524 |
Xiao J et al. | Glycosylation of dietary flavonoids decreases the affinities for plasma protein. | 2009 | J. Agric. Food Chem. | pmid:19722570 |
Xu C et al. | Effect of puerarin on P2X3 receptor involved in hyperalgesia after burn injury in the rat. | 2009 | Brain Res. Bull. | pmid:19744545 |
Tian J and Qin W | Quick and sensitive determination of flavonoids by capillary electrophoresis-potential gradient detection. | 2009 | Anal Sci | pmid:19745540 |
Li Q et al. | Effect of puerarin on the expression of extracellular matrix in rats with streptozotocin-induced diabetic nephropathy. | 2009 Jan-Feb | Natl Med J India | pmid:19761151 |
Zhu CQ et al. | [Preparation technology of Zhangyanming dispersible tablet and determination of puerarin by HPLC]. | 2009 | Zhong Yao Cai | pmid:19771855 |
Han J et al. | [Protective effect of 3'-methoxy puerarin on cerebral ischemic injury/ reperfusion in rats]. | 2009 | Zhongguo Zhong Yao Za Zhi | pmid:19771877 |
Han MX et al. | [Identification of three-step IR spectra of radix Puerariae from different habitats]. | 2009 | Guang Pu Xue Yu Guang Pu Fen Xi | pmid:19798956 |
Bebrevska L et al. | In vivo antioxidative activity of a quantified Pueraria lobata root extract. | 2010 | J Ethnopharmacol | pmid:19799984 |
Wang L et al. | [The pathway of absorption and conveying of puerarin microemulsion-in-oil]. | 2009 | Yao Xue Xue Bao | pmid:19806923 |
Yang S et al. | [Effect of puerarin on liver injury in KKAy mice with type 2 diabetes mellitus]. | 2009 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:19848202 |
Gao L et al. | [Of berberine and puerarin on dexamethasone-induced insulin resistance in porcine ovarian thecal cells]. | 2009 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:19852296 |
Han J et al. | [Inhibitory effects of puerarin on invasion and metastasis of oophoroma cells HO-8910]. | 2009 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:19852298 |
Zhu LH et al. | Puerarin attenuates high-glucose-and diabetes-induced vascular smooth muscle cell proliferation by blocking PKCbeta2/Rac1-dependent signaling. | 2010 | Free Radic. Biol. Med. | pmid:19854265 |
Thielemann A et al. | Comparison of urodynamic effects of phytoestrogens equol, puerarin and genistein with these of estradiol 17beta in ovariectomized rats. | 2010 | Exp. Gerontol. | pmid:19903517 |
Gu L et al. | Puerarin inhibits acid-sensing ion channels and protects against neuron death induced by acidosis. | 2010 | Planta Med. | pmid:19918715 |
Yu C et al. | Permeabilization of Microbacterium oxylans shifts the conversion of puerarin from puerarin-7-O-glucoside to puerarin-7-O-fructoside. | 2010 | Appl. Microbiol. Biotechnol. | pmid:19943046 |
Han RM et al. | Fast regeneration of carotenoids from radical cations by isoflavonoid dianions: importance of the carotenoid keto group for electron transfer. | 2010 | J Phys Chem A | pmid:19957978 |
Liu XJ et al. | [Study on absorption mechanism of puerarin and its nanoparticles across Caco-2 cell model]. | 2009 | Zhong Yao Cai | pmid:19960950 |
Luo CF et al. | Metabolites of puerarin identified by liquid chromatography tandem mass spectrometry: similar metabolic profiles in liver and intestine of rats. | 2010 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:20006564 |
Hu W et al. | Puerarin inhibits adhesion molecule expression in tnf-alpha-stimulated human endothelial cells via modulation of the nuclear factor kappaB pathway. | 2010 | Pharmacology | pmid:20016245 |
Boonchird C et al. | Differential binding with ERalpha and ERbeta of the phytoestrogen-rich plant Pueraria mirifica. | 2010 | Braz. J. Med. Biol. Res. | pmid:20027484 |
Pongkitwitoon B et al. | Enzyme-linked immunosorbent assay for total isoflavonoids in Pueraria candollei using anti-puerarin and anti-daidzin polyclonal antibodies. | 2010 | Planta Med. | pmid:20033865 |
Zhang X et al. | [Pharmacokinetics of puerarin and hydrochlorothiazide from maijunan tablets in rats]. | 2009 | Yao Xue Xue Bao | pmid:20055185 |
Liu J et al. | An improved LC-MS/MS method for simultaneous determination of 1,5-dicaffeoylquinic acid and its active metabolites in human plasma and its application to a pharmacokinetic study in patients. | 2010 | Biomed. Chromatogr. | pmid:20058327 |
Kim KM et al. | Puerarin suppresses AGEs-induced inflammation in mouse mesangial cells: a possible pathway through the induction of heme oxygenase-1 expression. | 2010 | Toxicol. Appl. Pharmacol. | pmid:20060010 |
Hien TT et al. | Molecular mechanism of suppression of MDR1 by puerarin from Pueraria lobata via NF-kappaB pathway and cAMP-responsive element transcriptional activity-dependent up-regulation of AMP-activated protein kinase in breast cancer MCF-7/adr cells. | 2010 | Mol Nutr Food Res | pmid:20077420 |
Gokara M et al. | Molecular interaction studies of trimethoxy flavone with human serum albumin. | 2010 | PLoS ONE | pmid:20098677 |