Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
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Authors | Title | Published | Journal | PubMed Link |
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Lee JS et al. | The effect of Puerariae radix on lipoprotein metabolism in liver and intestinal cells. | 2002 | BMC Complement Altern Med | pmid:12485466 |
Hsu FL et al. | Antihyperglycemic effect of puerarin in streptozotocin-induced diabetic rats. | 2003 | J. Nat. Prod. | pmid:12828463 |
Jin WS et al. | [Determination of puerarin, daidzin and daidzein in root of Pueraria lobata of different origin by HPLC]. | 2003 | Zhongguo Zhong Yao Za Zhi | pmid:15015267 |
Overstreet DH et al. | NPI-031G (puerarin) reduces anxiogenic effects of alcohol withdrawal or benzodiazepine inverse or 5-HT2C agonists. | 2003 | Pharmacol. Biochem. Behav. | pmid:12895679 |
Li B and Yu S | [Effect of puerarin on the bone metabolism in vitro]. | 2003 | Beijing Da Xue Xue Bao | pmid:12920814 |
Jiang B et al. | Hydrogen peroxide-induced apoptosis in pc12 cells and the protective effect of puerarin. | 2003 | Cell Biol. Int. | pmid:14642535 |
Zhang GQ et al. | Puerarin blocks Na+ current in rat ventricular myocytes. | 2003 | Acta Pharmacol. Sin. | pmid:14653946 |
Matkowski A et al. | Flavonoids of Pueraria lobata: chromatographic analysis of leaves and roots of cultivated plants. | 2003 | Pharmazie | pmid:14531473 |
Rezvani AH et al. | Plant derivatives in the treatment of alcohol dependency. | 2003 | Pharmacol. Biochem. Behav. | pmid:12895677 |
Prasain JK et al. | Profiling and quantification of isoflavonoids in kudzu dietary supplements by high-performance liquid chromatography and electrospray ionization tandem mass spectrometry. | 2003 | J. Agric. Food Chem. | pmid:12848487 |