| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
| Liver Cirrhosis | D008103 | 67 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Parkinson Disease | D010300 | 53 associated lipids |
| Fatty Liver | D005234 | 48 associated lipids |
| Ischemic Attack, Transient | D002546 | 42 associated lipids |
| Arthritis | D001168 | 41 associated lipids |
SCHEMBL105486
Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with SCHEMBL105486?
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
PubChem Associated disorders and diseases
What pathways are associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with SCHEMBL105486?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with SCHEMBL105486?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with SCHEMBL105486?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with SCHEMBL105486?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with SCHEMBL105486?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with SCHEMBL105486
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Liu CM et al. | Puerarin protects mouse liver against nickel-induced oxidative stress and inflammation associated with the TLR4/p38/CREB pathway. | 2016 | Chem. Biol. Interact. | pmid:26607348 |
| Qi H et al. | Optimization and physicochemical characterization of thermosensitive poloxamer gel containing puerarin for ophthalmic use. | 2006 | Chem. Pharm. Bull. | pmid:17077546 |
| Yu Z et al. | Simultaneous determination of components in preparation Naodesheng injection by high performance liquid chromatograph-atmospheric pressure chemical ionization mass spectrometry (HPLC-MS/APCI). | 2006 | Chem. Pharm. Bull. | pmid:16595973 |
| Nakamura K et al. | The C-glucosyl bond of puerarin was cleaved hydrolytically by a human intestinal bacterium strain PUE to yield its aglycone daidzein and an intact glucose. | 2011 | Chem. Pharm. Bull. | pmid:21212542 |
| Yue PF et al. | Development and optimization of intravenous puerarin emulsions formation by a novel complex-phase inversion-homogenization technology. | 2007 | Chem. Pharm. Bull. | pmid:17978512 |
| Quan DQ et al. | Studies on preparation and absolute bioavailability of a self-emulsifying system containing puerarin. | 2007 | Chem. Pharm. Bull. | pmid:17473473 |
| Zhang CL et al. | Comparative study of Puerariae lobatae and Puerariae thomsonii by HPLC-diode array detection-flow injection-chemiluminescence coupled with HPLC-electrospray ionization-MS. | 2011 | Chem. Pharm. Bull. | pmid:21532189 |
| Wu HQ et al. | Protective effects and mechanism of puerarin on learning-memory disorder after global cerebral ischemia-reperfusion injury in rats. | 2009 | Chin J Integr Med | pmid:19271171 |
| Liu Y et al. | Induction of adhesion molecule expression in co-culture of human bronchial epithelial cells and neutrophils suppressed by puerarin via down-regulating p38 mitogen-activated protein kinase and nuclear factor κB pathways. | 2014 | Chin J Integr Med | pmid:24122632 |
| Zhang MY et al. | In vitro and in vivo effects of puerarin on promotion of osteoblast bone formation. | 2012 | Chin J Integr Med | pmid:22457138 |