SCHEMBL105486
Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with SCHEMBL105486?
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
PubChem Associated disorders and diseases
What pathways are associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with SCHEMBL105486?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
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What functions are associated with SCHEMBL105486?
Related references are published most in these journals:
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What lipids are associated with SCHEMBL105486?
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What genes are associated with SCHEMBL105486?
Related references are published most in these journals:
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What common seen animal models are associated with SCHEMBL105486?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
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NCBI Entrez Crosslinks
All references with SCHEMBL105486
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Li QX et al. | [Effect of compound Puerarin on the collage IV in streptozotocin-induced diabetic nephropathy rats]. | 2008 | Zhonghua Yu Fang Yi Xue Za Zhi | pmid:18763636 |
| Han P et al. | [Effect of pueraria crude extreact and puerarin on ethanol-induced expression of heat shock protein 70 in embryonic mouse hippocampal cultures]. | 2005 | Zhonghua Yi Xue Za Zhi | pmid:16324368 |
| Xu YZ et al. | [Effects of puerarin on proliferation of vascular smooth muscle cells induced by thrombin]. | 2006 | Zhonghua Yi Xue Za Zhi | pmid:16677576 |
| Hao LN et al. | [Peroxynitrite-induced formation of diabetic cataract and its prevention by puerarin in rat]. | 2004 | Zhonghua Yan Ke Za Zhi | pmid:15312625 |
| Hao LN et al. | [Protective effects of puerarin on lens epithelial cells in rat diabetic cataract]. | 2011 | Zhonghua Yan Ke Za Zhi | pmid:21612681 |
| Hao LN et al. | [The effect of puerarin on prevention of oxidative damage of cultured lens capsule epithelial cells]. | 2008 | Zhonghua Yan Ke Za Zhi | pmid:18683704 |
| Kang RX | [The intraocular pressure depressive effect of puerarin]. | 1993 | Zhonghua Yan Ke Za Zhi | pmid:7912669 |
| Ji O et al. | [Effect of flavonoids of puerarin on the proliferation and apoptosis of retinoic acid resistant acute promyelocytic leukemia cell line NB4-R1 cells]. | 2013 | Zhonghua Xue Ye Xue Za Zhi | pmid:23688762 |
| Li XY et al. | [The effect of intravenous puerarin on acute myocardial infarction]. | 1985 | Zhonghua Xin Xue Guan Bing Za Zhi | pmid:4092596 |
| Han P et al. | [Potential antiviral drug Pueraria crude extract and puerarin protect against ethanol-induced cytotoxicity in embryonic mouse hippocampal cultures]. | 2005 | Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi | pmid:16261207 |
| Luo ZK et al. | [A clinical efficacy and safety study on coronary heart disease and angina treatment with Puerarin Injection]. | 2012 | Zhonghua Liu Xing Bing Xue Za Zhi | pmid:22883272 |
| Chen C et al. | [Effects of puerarin on proliferation, apoptosis and Kv1.5 gene expression of pulmonary artery smooth muscle cells induced by hypoxia]. | 2011 | Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi | pmid:22357486 |
| Xu HX et al. | [Mechanism of advanced glycation end-products in the inducement of apoptosis of human gingival fibroblast and related effect of puerarin in the process]. | 2011 | Zhonghua Kou Qiang Yi Xue Za Zhi | pmid:21418943 |
| Wang C et al. | [Therapeutic effect of puerarin on rats with pre-eclampsia]. | 2006 | Zhonghua Fu Chan Ke Za Zhi | pmid:16640862 |
| Jin WS et al. | [Determination of puerarin, daidzin and daidzein in root of Pueraria lobata of different origin by HPLC]. | 2003 | Zhongguo Zhong Yao Za Zhi | pmid:15015267 |
| Zhang FR et al. | [Effects of puerarin on number and activity of endothelial progenitor cells from peripheral blood]. | 2004 | Zhongguo Zhong Yao Za Zhi | pmid:15506293 |
| Liu S et al. | [A study on processing of the root of Pueraria lobata (Willd.) ohwi by HPLC]. | 1998 | Zhongguo Zhong Yao Za Zhi | pmid:12242820 |
| Su B et al. | [Rapid determination of puerarin in Xiaoke pill powder by near-infrared spectroscopy]. | 2011 | Zhongguo Zhong Yao Za Zhi | pmid:21710725 |
| Zang HM et al. | [Experimental study of the effects of puerarin on biological characters of osteoblasts in vitro]. | 2005 | Zhongguo Zhong Yao Za Zhi | pmid:16494032 |
| Wang Y et al. | [Effect of puerarin and ligustrazine on cultured hippocampal neurons injury induced by Abeta25-35]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:18533503 |
| Zhang YB et al. | [Protective effects of 3'-methoxy-puerarin on rat brain suffering from ischemia]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:18536378 |
| Li JW et al. | [Inhibition of puerarin on pulmonary hypertension in rats with hypoxia and hypercapnia]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:18536380 |
| Yang ZD et al. | [Chemical constituents in root of Hemerocallis fulva]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:18536463 |
| Wu GL et al. | [Effect of puerarin on levels of TGF-beta1 and alpha-SMA in rats with alcoholic injury liver]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:19166018 |
| Jing L and Gao ZY | [Retrospective analysis on Chinese medicinal treatment on 302 chronic heart failure patients of coronary heart disease and diabetes]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:19166020 |
| Hu HT et al. | [Effects of puerarin with aspirin on the markers of damaged vascular endothelial cells in patients with acute cerebral infarction]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:19260323 |
| Wen BY et al. | [Metabolic kinetic of puerarin in beagle liver microsomal by HPLC-ESI-MS]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:19260325 |
| Zou GX et al. | [New method of multi-components quantitation by one marker new method for quality evaluation of Guanmaikang capsula]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:19007008 |
| Cui JH et al. | [Preparation and in vitro evaluation of gastroretentive dosage form containing puerarin-HP-beta-CD inclusion complex]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:19086628 |
| Sun W et al. | [Effects of puerarin on ADRP gene expression in fatty tissue of type 2 diabetes mellitus rats]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:19086646 |
| Cui SM and Ma YB | [Effect of verapamil on pharmacokinetics of puerarin in rats]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:19086648 |
| Wang Q et al. | [Distribution of puerarin contained in Zige freeze-dried powder injection in rat liver and kidney]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:22994007 |
| Deng L et al. | [Effect of catalpol and puerarin freeze-dried powder on coagulability, hemorheology and no in rats with Qi-deficiency and blood-stasis syndrome]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:22860464 |
| Liang X et al. | [Intestinal absorption effect of Angelica dahurica extract on puerarin of puerariae Lobatae Radix]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:22860465 |
| He D et al. | [Improvement of solubility of puerarin through deoxycholate/phospholipid mixed micelle preparing technology]. | 2010 | Zhongguo Zhong Yao Za Zhi | pmid:20822006 |
| Xue C et al. | [Determination of five components in Pueraria labta decoction with reference extraction method]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:23234135 |
| Guo D et al. | [Study on pharmacokinetics and biodistribution of pur derivative nanopaticles in mice]. | 2010 | Zhongguo Zhong Yao Za Zhi | pmid:21355276 |
| Hu JJ et al. | [Effect of pretreatment with puerarin on activation of LPS-induced RAW264. 7 cells]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:23311164 |
| Liu XY et al. | [Stability of PEGylated puerarin under different storage conditions]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:23373208 |
| Yao C et al. | [Ocular pharmacokinetics of puerarin in anesthetic rabbits by microdialysis]. | 2011 | Zhongguo Zhong Yao Za Zhi | pmid:22097338 |
| Zhang X et al. | [Puerarin induced apoptosis of pulmonary artery smooth muscle cell by mitochondrial pathway]. | 2011 | Zhongguo Zhong Yao Za Zhi | pmid:22097342 |
| Zhou Y et al. | [Comparative study on pharmacological effects of various species of Pueraria]. | 1995 | Zhongguo Zhong Yao Za Zhi | pmid:8679082 |
| Chen L et al. | [Effect of puerarin on cerebral blood flow in dogs]. | 1995 | Zhongguo Zhong Yao Za Zhi | pmid:8679097 |
| Zhang X et al. | [Determination of puerarin in radix Puerariae and yufengningxin tablets by HPLC]. | 1995 | Zhongguo Zhong Yao Za Zhi | pmid:8561884 |
| Deng Y et al. | [Effect of phenformin hydrochloride on pharmacokinetics of puerarin in rats]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:23270242 |
| Zhang L et al. | [Determination of puerarin in various kinds of radix Puerariae from different places]. | 1995 | Zhongguo Zhong Yao Za Zhi | pmid:7576135 |
| Liu Q et al. | [Effect of puerarin on coronary collateral circulation in dogs with experimental acute myocardial infarction]. | 1999 | Zhongguo Zhong Yao Za Zhi | pmid:12205891 |
| Jiang B et al. | [Stable life prediction for a complex injection of Chinese materia medica by initial average rate stability test]. | 2000 | Zhongguo Zhong Yao Za Zhi | pmid:12212078 |
| Ding MP et al. | [Effects of puerarin on expression of nuclear factor kappaB after cerebral ischemia/reperfusion in rats]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:18330247 |
| Guo Y et al. | [Study on effect of different combinations of traditional Chinese medicine preparation active parts on metabolism of puerarin in plasma of rats]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:18330251 |