Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
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Authors | Title | Published | Journal | PubMed Link |
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Wang L et al. | Puerarin Enhances Ca2+ Reuptake and Ca2+ Content of Sarcoplasmic Reticulum in Murine Embryonic Stem Cell-Derived Cardiomyocytes via Upregulation of SERCA2a. | 2017 | Cell. Physiol. Biochem. | pmid:29179218 |
Li Y et al. | Effect of puerarin on collagen metabolism of fibroblasts in pelvic tissue of women with pelvic organ prolapse. | 2018 | Mol Med Rep | pmid:29207080 |
Yang B et al. | Influence of paeoniflorin and menthol on puerarin transport across MDCK and MDCK-MDR1 cells as blood-brain barrier in vitro model. | 2018 | J. Pharm. Pharmacol. | pmid:29238980 |
Wang HQ et al. | Puerarin Up-regulates Methyl-CpG Binding Protein 2 Phosphorylation in Hippocampus of Vascular Dementia Rats. | 2018 | Chin J Integr Med | pmid:29327124 |
Fu C et al. | Puerarin protects endothelial progenitor cells from damage of angiotensin II via activation of ERK1/2‑Nrf2 signaling pathway. | 2018 | Mol Med Rep | pmid:29359784 |
Zeng X et al. | Puerarin inhibits TRPM3/miR-204 to promote MC3T3-E1 cells proliferation, differentiation and mineralization. | 2018 | Phytother Res | pmid:29368357 |
Hu Y et al. | Puerarin inhibits non-small cell lung cancer cell growth via the induction of apoptosis. | 2018 | Oncol. Rep. | pmid:29393465 |
Liu X et al. | Puerarin Inhibits Proliferation and Induces Apoptosis by Upregulation of miR-16 in Bladder Cancer Cell Line T24. | 2018 | Oncol. Res. | pmid:29422113 |
Chen G et al. | Puerarin attenuates angiotensin II-induced cardiac fibroblast proliferation via the promotion of catalase activity and the inhibition of hydrogen peroxide-dependent Rac-1 activation. | 2018 | Chin J Nat Med | pmid:29425589 |
Liu B et al. | Puerarin protects against heart failure induced by pressure overload through mitigation of ferroptosis. | 2018 | Biochem. Biophys. Res. Commun. | pmid:29427658 |
Ling C et al. | Synergistic Effects of Salvianolic Acid B and Puerarin on Cerebral Ischemia Reperfusion Injury. | 2018 | Molecules | pmid:29498696 |
Wu JY et al. | A microemulsion of puerarin-phospholipid complex for improving bioavailability: preparation, in vitro and in vivo evaluations. | 2018 | Drug Dev Ind Pharm | pmid:29513046 |
Meng GR | [Factors influencing the quality of a Chinese herbal medicine decoction]. | 1986 | Zhong Yao Tong Bao | pmid:2952321 |
Lee JH et al. | The suppressive effect of puerarin on atopic dermatitis-like skin lesions through regulation of inflammatory mediators in vitro and in vivo. | 2018 | Biochem. Biophys. Res. Commun. | pmid:29524423 |
Wang T et al. | Puerarin promotes MIN6 cell survival by reducing cellular reactive oxygen species. | 2018 | Mol Med Rep | pmid:29568901 |
Guo BQ et al. | Puerarin reduces ischemia/reperfusion-induced myocardial injury in diabetic rats via upregulation of vascular endothelial growth factor A/angiotensin-1 and suppression of apoptosis. | 2018 | Mol Med Rep | pmid:29568939 |
Wang X et al. | Puerarin prevents LPS-induced acute lung injury via inhibiting inflammatory response. | 2018 | Microb. Pathog. | pmid:29571724 |
Li W et al. | Puerarin-loaded PEG-PE micelles with enhanced anti-apoptotic effect and better pharmacokinetic profile. | 2018 | Drug Deliv | pmid:29587545 |
Wang S et al. | Optimization of ionic liquids-based microwave-assisted hydrolysis of puerarin and daidzein derivatives from Radix Puerariae Lobatae extract. | 2018 | Food Chem | pmid:29606431 |
Wei HY et al. | Puerarin regulates neovascular glaucoma through pigment epithelium‑derived growth factor‑induced NF‑κB signaling pathway. | 2018 | Mol Med Rep | pmid:29620183 |
Liu Q et al. | Puerarin improves methotrexate-induced renal damage by up-regulating renal expression of Oat1 and Oat3 in vivo and in vitro. | 2018 | Biomed. Pharmacother. | pmid:29710508 |
Deng Y et al. | ERK5/KLF2 activation is involved in the reducing effects of puerarin on monocyte adhesion to endothelial cells and atherosclerotic lesion in apolipoprotein E-deficient mice. | 2018 | Biochim. Biophys. Acta | pmid:29723698 |
Wan Q et al. | Puerarin inhibits vascular smooth muscle cells proliferation induced by fine particulate matter via suppressing of the p38 MAPK signaling pathway. | 2018 | BMC Complement Altern Med | pmid:29728095 |
Loutchanwoot P and Vortherms T | Effects of puerarin on estrogen-regulated gene expression in gonadotropin-releasing hormone pulse generator of ovariectomized rats. | 2018 | Steroids | pmid:29733861 |
Deng HF et al. | Puerarin prevents vascular endothelial injury through suppression of NF-κB activation in LPS-challenged human umbilical vein endothelial cells. | 2018 | Biomed. Pharmacother. | pmid:29775893 |
Chen X et al. | Puerarin attenuates palmitate-induced mitochondrial dysfunction, impaired mitophagy and inflammation in L6 myotubes. | 2018 | Life Sci. | pmid:29802940 |
Ullah MZ et al. | Attenuation of inflammatory pain by puerarin in animal model of inflammation through inhibition of pro-inflammatory mediators. | 2018 | Int. Immunopharmacol. | pmid:29909234 |
Wang L et al. | Puerarin Attenuates Osteoarthritis via Upregulating AMP-Activated Protein Kinase/Proliferator-Activated Receptor-γ Coactivator-1 Signaling Pathway in Osteoarthritis Rats. | 2018 | Pharmacology | pmid:29961054 |
Krittanai S et al. | Development of a colloidal gold nanoparticle-based immunochromatographic strip for the one-step detection of miroestrol and puerarin. | 2018 | Biomed. Chromatogr. | pmid:29972702 |
Pang Z et al. | Gel formation of puerarin and mechanistic study during its cooling process. | 2018 | Int J Pharm | pmid:30016673 |
Slámová K et al. | "Sweet Flavonoids": Glycosidase-Catalyzed Modifications. | 2018 | Int J Mol Sci | pmid:30037103 |
Hou B et al. | Puerarin Mitigates Diabetic Hepatic Steatosis and Fibrosis by Inhibiting TGF- Signaling Pathway Activation in Type 2 Diabetic Rats. | 2018 | Oxid Med Cell Longev | pmid:30057680 |
Shiying L et al. | Puerarin promoted proliferation and differentiation of dopamine-producing cells in Parkinson's animal models. | 2018 | Biomed. Pharmacother. | pmid:30119192 |
Wang Y et al. | Support Vector Regression Approach to Predict the Design Space for the Extraction Process of . | 2018 | Molecules | pmid:30241281 |
Zhong Y et al. | Puerarin alleviate radicular pain from lumbar disc herniation by inhibiting ERK-dependent spinal microglia activation. | 2018 | Neuropeptides | pmid:30466510 |
Song XP et al. | [Effects of puerarin on blood pressure and plasma renin activity in spontaneously hypertensive rats]. | 1988 | Zhongguo Yao Li Xue Bao | pmid:3055814 |
Xu LX et al. | [Differential pulse polarographic determination of flavonoids in Pueraria lobata]. | 1987 | Yao Xue Xue Bao | pmid:3661208 |
Fan LL et al. | [The antidysrhythmic effect of puerariae isoflavones]. | 1985 | Yao Xue Xue Bao | pmid:3834744 |
Shen ZF and Xie MZ | [Hypoglycemic effect of the combined use of puerarin and aspirin in mice]. | 1985 | Yao Xue Xue Bao | pmid:3835796 |
Fan LL et al. | Pharmacologic studies on radix puerariae: effect of puerarin on regional myocardial blood flow and cardiac hemodynamics in dogs with acute myocardial ischemia. | 1985 | Chin. Med. J. | pmid:3938713 |
Zhao SP and Zhang YZ | [Quantitative TLC-densitometry of isoflavones in Pueraria lobata (Willd.) Ohwi]. | 1985 | Yao Xue Xue Bao | pmid:4072688 |
Li XY et al. | [The effect of intravenous puerarin on acute myocardial infarction]. | 1985 | Zhonghua Xin Xue Guan Bing Za Zhi | pmid:4092596 |
Feng YP et al. | [Effect of puerarin and analogues of daidzein on adrenoceptors]. | 1984 | Zhongguo Yao Li Xue Bao | pmid:6242213 |
Yin ZZ and Zeng GY | [Pharmacology of puerarin. V. Effects of puerarin on platelet aggregation and release of 5-HT from platelets]. | 1981 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:6459876 |
Hsiang CS et al. | [Pharmacokinetics of puerarin - determination of its plasma concentration by spectrofluorometry]. | 1981 | Zhongguo Yi Xue Ke Xue Yuan Xue Bao | pmid:6459877 |
Fan LL et al. | [Effect of puerarin on regional myocardial blood flow and cardiac hemodynamics in dogs with acute myocardial ischemia]. | 1984 | Yao Xue Xue Bao | pmid:6544546 |
Fang QN et al. | [Separation and determination of puerarin by high performance liquid chromatography]. | 1983 | Yao Xue Xue Bao | pmid:6677057 |
Hayakawa J et al. | [Studies on physical and chemical quality evaluation of crude drug preparations. I. Analysis of Pueraria Radix and species Puerariae]. | 1984 | Yakugaku Zasshi | pmid:6737221 |
Zhang L et al. | [Determination of puerarin in various kinds of radix Puerariae from different places]. | 1995 | Zhongguo Zhong Yao Za Zhi | pmid:7576135 |
Yasuda T et al. | Urinary and biliary metabolites of puerarin in rats. | 1995 | Biol. Pharm. Bull. | pmid:7742802 |