Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Chen L et al. | [Effect of puerarin on cerebral blood flow in dogs]. | 1995 | Zhongguo Zhong Yao Za Zhi | pmid:8679097 |
Liu Q et al. | [Effect of puerarin on coronary collateral circulation in dogs with experimental acute myocardial infarction]. | 1999 | Zhongguo Zhong Yao Za Zhi | pmid:12205891 |
Wu GL et al. | [Effect of puerarin on levels of TGF-beta1 and alpha-SMA in rats with alcoholic injury liver]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:19166018 |
Jing L and Gao ZY | [Retrospective analysis on Chinese medicinal treatment on 302 chronic heart failure patients of coronary heart disease and diabetes]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:19166020 |
Han J et al. | [Protective effect of 3'-methoxy puerarin on cerebral ischemic injury/ reperfusion in rats]. | 2009 | Zhongguo Zhong Yao Za Zhi | pmid:19771877 |
Yang H et al. | [Studies on effect of microemulsion in enhancing solubility of baicalin and puerarin]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:18161289 |
Liu R et al. | [Inhibitory effect of quercetin, rutin and puerarin on LDL oxidation induced by Cu2+]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:18161305 |
Feng CG et al. | [Progress in research of aldose reductase inhibitors in traditional medicinal herbs]. | 2005 | Zhongguo Zhong Yao Za Zhi | pmid:16335816 |
Zhao Y et al. | [Experimental study of protective effect of pueraria compound on the cerebral ischemic injury]. | 2005 | Zhongguo Zhong Yao Za Zhi | pmid:16011106 |
Wang FW et al. | [Protective effect of puerarin on stress-induced gastric mucosal injury in rats]. | 2006 | Zhongguo Zhong Yao Za Zhi | pmid:16722386 |