Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Luo ZR and Zheng B | [Effect of Puerarin on platelet activating factors CD63 and CD62P, plasminogen activator inhibitor and C-reactive protein in patients with unstable angia pectoris]. | 2001 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:12577374 |
Peng XY et al. | [Study on the differentiation and apoptosis of HL-60 cell line induced by Puerarin]. | 2001 | Hunan Yi Ke Da Xue Xue Bao | pmid:12536642 |
Vera JC et al. | Direct inhibition of the hexose transporter GLUT1 by tyrosine kinase inhibitors. | 2001 | Biochemistry | pmid:11170395 |
Dong LP et al. | [The protective effect of puerarin on cultured rat cerebral cortical astrocytes]. | 2001 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21171401 |
Chen G et al. | Determination of puerarin, daidzein and rutin in Pueraria lobata (Wild.) Ohwi by capillary electrophoresis with electrochemical detection. | 2001 | J Chromatogr A | pmid:11510548 |
Zhang GQ et al. | Puerarin blocks transient outward K+ current and delayed rectifier K+ current in mice hippocampal CA1 neurons. | 2001 | Acta Pharmacol. Sin. | pmid:11742573 |
Wang YJ et al. | [Determination of beberine hydrochloride and puerarin in tangwei capsules by RP-HPLC of gradient elution method]. | 2000 | Se Pu | pmid:12541715 |
Ma YS et al. | [Studies permeation of puerarin and its phospholipid complex through mouse skin in vitro]. | 2000 | Zhongguo Zhong Yao Za Zhi | pmid:12512448 |
Liu Q et al. | Restrictive effect of puerarin on myocardial infarct area in dogs and its possible mechanism. | 2000 | J. Tongji Med. Univ. | pmid:12845754 |
Guerra MC et al. | Comparison between chinese medical herb Pueraria lobata crude extract and its main isoflavone puerarin antioxidant properties and effects on rat liver CYP-catalysed drug metabolism. | 2000 | Life Sci. | pmid:11133012 |