| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetic Nephropathies | D003928 | 39 associated lipids |
| Chemical and Drug Induced Liver Injury | D056486 | 39 associated lipids |
| Heart Failure | D006333 | 36 associated lipids |
| Fever | D005334 | 35 associated lipids |
| Infarction, Middle Cerebral Artery | D020244 | 35 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Neurotoxicity Syndromes | D020258 | 34 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Memory Disorders | D008569 | 33 associated lipids |
| Stroke | D020521 | 32 associated lipids |
| Endometriosis | D004715 | 29 associated lipids |
| Ventricular Remodeling | D020257 | 28 associated lipids |
| Angina Pectoris | D000787 | 27 associated lipids |
| Brain Infarction | D020520 | 17 associated lipids |
| Angina, Unstable | D000789 | 14 associated lipids |
| Glucose Intolerance | D018149 | 13 associated lipids |
| Amnesia | D000647 | 12 associated lipids |
| Hypertension, Renovascular | D006978 | 10 associated lipids |
| Hepatitis, Alcoholic | D006519 | 5 associated lipids |
| Dyspepsia | D004415 | 5 associated lipids |
SCHEMBL105486
Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with SCHEMBL105486?
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
PubChem Associated disorders and diseases
What pathways are associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with SCHEMBL105486?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with SCHEMBL105486?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with SCHEMBL105486?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with SCHEMBL105486?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with SCHEMBL105486?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with SCHEMBL105486
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Tanaka T et al. | Kudzu (Pueraria lobata) vine ethanol extracts improve ovariectomy-induced bone loss in female mice. | 2011 | J. Agric. Food Chem. | pmid:22053809 |
| Chen J et al. | Puerarin affects bone biomarkers in the serum of rats with intrauterine growth restriction. | 2016 | J Tradit Chin Med | pmid:27400476 |
| Xu X et al. | Puerarin reduces apoptosis in rat hippocampal neurons culturea in high glucose medium by modulating the p38 mitogen activated protein kinase and c-Jun N-terminal kinase signaling pathways. | 2016 | J Tradit Chin Med | pmid:26946623 |
| Wu J et al. | Efficacy and safety of puerarin injection in treatment of diabetic peripheral neuropathy: a systematic review and meta-analysis of randomized controlled trials. | 2014 | J Tradit Chin Med | pmid:25185357 |
| Zhu H et al. | Effect of puerarin on matrix metalloproteinase-2 in human fetal scleral fibroblasts treated with low frequency electromagnetic fields. | 2013 | J Tradit Chin Med | pmid:24660593 |
| Chen L et al. | Simultaneous analysis of nine active components in Gegen Qinlian preparations by high-performance liquid chromatography with diode array detection. | 2006 | J Sep Sci | pmid:17069251 |
| Lv Y et al. | Preparation of monomeric and polymeric β-cyclodextrin functionalized monoliths for rapid isolation and purification of puerarin from Radix puerariae. | 2011 | J Sep Sci | pmid:21766485 |
| Zhao X et al. | Simultaneous determination of six isoflavonoids in rat plasma after administration of total flavonoid from Gegen by ultra-HPLC-MS/MS. | 2012 | J Sep Sci | pmid:22589159 |
| Sun C et al. | On-line HPLC method for screening of antioxidants against superoxide anion radical from complex mixtures. | 2010 | J Sep Sci | pmid:20183820 |
| Tian H et al. | Liquid chromatography-mass spectrometric analysis of puerarin and its metabolite in human urine. | 2006 | J Sep Sci | pmid:17313111 |
| Zhang H et al. | Insight into the structural deformations of beta-cyclodextrin caused by alcohol cosolvents and guest molecules. | 2012 | J Phys Chem B | pmid:22376204 |
| Zhang H et al. | Investigation of the inclusions of puerarin and daidzin with beta-cyclodextrin by molecular dynamics simulation. | 2010 | J Phys Chem B | pmid:20297792 |
| Tian YX et al. | Radical dynamics of puerarin as revealed by laser flash photolysis and spin density analysis. | 2008 | J Phys Chem B | pmid:18232684 |
| Han RM et al. | Fast regeneration of carotenoids from radical cations by isoflavonoid dianions: importance of the carotenoid keto group for electron transfer. | 2010 | J Phys Chem A | pmid:19957978 |
| Li H et al. | Comparison of two approaches of intestinal absorption by puerarin. | J Pharmacol Toxicol Methods | pmid:24674709 | |
| Yu A et al. | Formulation optimization and bioavailability after oral and nasal administration in rabbits of puerarin-loaded microemulsion. | 2011 | J Pharm Sci | pmid:20862776 |
| Liu R et al. | Gelucire44/14 as a novel absorption enhancer for drugs with different hydrophilicities: in vitro and in vivo improvement on transcorneal permeation. | 2011 | J Pharm Sci | pmid:21416467 |
| Gang C et al. | Puerarin Suppresses Angiotensin II-Induced Cardiac Hypertrophy by Inhibiting NADPH Oxidase Activation and Oxidative Stress-Triggered AP-1 Signaling Pathways. | 2015 | J Pharm Pharm Sci | pmid:26158288 |
| Yan F et al. | Effects of some antihypertensive drugs on the metabolism and pharmacokinetics of indapamide in rats. | 2012 | J Pharm Pharm Sci | pmid:22579001 |
| Zhang Q et al. | Flow injection-chemiluminescence determination of puerarin in pharmaceutical preparations. | 2004 | J Pharm Biomed Anal | pmid:15522534 |
| Okamura N et al. | Simultaneous high-performance liquid chromatographic determination of puerarin, daidzin, paeoniflorin, liquiritin, cinnamic acid, cinnamaldehyde and glycyrrhizin in Kampo medicines. | 1999 | J Pharm Biomed Anal | pmid:10704126 |
| Li C et al. | Separation and simultaneous determination of rutin, puerarin, daidzein, esculin and esculetin in medicinal preparations by non-aqueous capillary. | 2005 | J Pharm Biomed Anal | pmid:15894450 |
| Qiao L et al. | A HPLC-MS/MS method for determination of 6'''-feruloylspinosin in rat plasma and tissues: Pharmacokinetics and tissue distribution study. | 2016 | J Pharm Biomed Anal | pmid:26780157 |
| Cherdshewasart W et al. | Major isoflavonoid contents of the phytoestrogen rich-herb Pueraria mirifica in comparison with Pueraria lobata. | 2007 | J Pharm Biomed Anal | pmid:16930918 |
| Xi J and Guo R | Acid-base equilibrium of puerarin in CTAB micelles. | 2007 | J Pharm Biomed Anal | pmid:16935449 |
| Ren F et al. | Quantitative determination of puerarin in dog plasma by HPLC and study on the relative bioavailability of sustained release tablets. | 2006 | J Pharm Biomed Anal | pmid:16413737 |
| Yan Y et al. | Simultaneous determination of puerarin, daidzin, daidzein, paeoniflorin, albiflorin, liquiritin and liquiritigenin in rat plasma and its application to a pharmacokinetic study of Ge-Gen Decoction by a liquid chromatography-electrospray ionization-tandem mass spectrometry. | 2014 | J Pharm Biomed Anal | pmid:24637051 |
| Zhang H and Yang X | Profiling and quantification of isoflavone-C-glycosides impurities in puerarin injection by liquid chromatography coupled to ESI-ion trap mass spectrometry. | 2009 | J Pharm Biomed Anal | pmid:19186018 |
| Zhang H et al. | Simultaneous determination of 12 chemical constituents in the traditional Chinese Medicinal Prescription Xiao-Yao-San-Jia-Wei by HPLC coupled with photodiode array detection. | 2008 | J Pharm Biomed Anal | pmid:18977108 |
| Chen YG et al. | Metabolic differentiations of Pueraria lobata and Pueraria thomsonii using ¹H NMR spectroscopy and multivariate statistical analysis. | 2014 | J Pharm Biomed Anal | pmid:23746990 |
| Yin R et al. | UFLC-MS/MS method for simultaneous determination of luteolin-7-O-gentiobioside, luteolin-7-O-β-D-glucoside and luteolin-7-O-β-D-glucuronide in beagle dog plasma and its application to a pharmacokinetic study after administration of traditional Chinese medicinal preparation: Kudiezi injection. | 2013 | J Pharm Biomed Anal | pmid:23146236 |
| Wong KH et al. | Differentiation of Pueraria lobata and Pueraria thomsonii using partial least square discriminant analysis (PLS-DA). | 2013 | J Pharm Biomed Anal | pmid:23777642 |
| Wang WY et al. | Determination of puerarin in rabbit aqueous humor by liquid chromatography tandem mass spectrometry using microdialysis sampling after topical administration of puerarin PAMAM dendrimer complex. | 2011 | J Pharm Biomed Anal | pmid:21831555 |
| Xiao J et al. | Analysis of binding interaction between puerarin and bovine serum albumin by multi-spectroscopic method. | 2007 | J Pharm Biomed Anal | pmid:17942262 |
| Yu Z et al. | Simultaneous determination of safflor yellow A, puerarin, daidzein, ginsenosides (Rg(1), Rb(1), Rd), and notoginsenoside R(1) in rat plasma by liquid chromatography-mass spectrometry. | 2007 | J Pharm Biomed Anal | pmid:17590558 |
| Gao R et al. | Gradient high-performance liquid chromatography for the simultaneous determination of chlorogenic acid and baicalin in plasma and its application in the study of pharmacokinetics in rats. | 2007 | J Pharm Biomed Anal | pmid:16859859 |
| Yan B et al. | HPLC method for the determination and pharmacokinetic studies on puerarin in cerebral ischemia reperfusion rat plasma after intravenous administration of puerariae radix isoflavone. | 2005 | J Pharm Biomed Anal | pmid:15708670 |
| Yu BS et al. | RP-HPLC determination of puerarin in Chinese traditional medicinal preparations containing pueraria. | 2002 | J Pharm Biomed Anal | pmid:12367710 |
| Yu N et al. | The effects of sperminated pullulans on cornea permeability to puerarin and the toxicity. | 2012 | J Ocul Pharmacol Ther | pmid:22690870 |
| Yao C et al. | Effects of poly(amidoamine) dendrimers on ocular absorption of puerarin using microdialysis. | 2011 | J Ocul Pharmacol Ther | pmid:21895496 |
| Xuan B et al. | Improvement of ocular blood flow and retinal functions with puerarin analogs. | 1999 | J Ocul Pharmacol Ther | pmid:10385129 |
| Suthon S et al. | Anti-osteoporotic effects of Pueraria candollei var. mirifica on bone mineral density and histomorphometry in estrogen-deficient rats. | 2016 | J Nat Med | pmid:26815435 |
| Pongkitwitoon B et al. | Development of an enzyme-linked immunosorbent assay to determine puerarin and its aglycone daidzein. | 2011 | J Nat Med | pmid:20658197 |
| Xue B et al. | Puerarin may protect against Schwann cell damage induced by glucose fluctuation. | 2017 | J Nat Med | pmid:28181078 |
| Zhai Y et al. | Preparation and Characterization of Puerarin-Loaded Lipid Nanocapsules. | 2015 | J Nanosci Nanotechnol | pmid:26353476 |
| Wang Y et al. | Formulation and pharmacokinetics evaluation of puerarin nanocrystals for intravenous delivery. | 2012 | J Nanosci Nanotechnol | pmid:22962724 |
| Zhang H et al. | A model for the shuttle motions of puerarin and daidzin inside the cavity of β-cyclodextrin in aqueous acetic acid: insights from molecular dynamics simulations. | 2012 | J Mol Model | pmid:21523551 |
| Benlhabib E et al. | Effects of purified puerarin on voluntary alcohol intake and alcohol withdrawal symptoms in P rats receiving free access to water and alcohol. | 2004 | J Med Food | pmid:15298765 |
| Singh AK et al. | Herbal mixtures consisting of puerarin and either polyenylphosphatidylcholine or curcumin provide comprehensive protection against alcohol-related disorders in P rats receiving free choice water and 15% ethanol in pure water. | 2007 | J Med Food | pmid:17887948 |
| Singh AK et al. | Anti-inflammatory potency of nano-formulated puerarin and curcumin in rats subjected to the lipopolysaccharide-induced inflammation. | 2013 | J Med Food | pmid:24138167 |
| Benlhabib E et al. | Kudzu root extract suppresses voluntary alcohol intake and alcohol withdrawal symptoms in P rats receiving free access to water and alcohol. | 2004 | J Med Food | pmid:15298764 |
| Benlhabib E et al. | Composition, red blood cell uptake, and serum protein binding of phytoestrogens extracted from commercial kudzu-root and soy preparations. | 2002 | J Med Food | pmid:12495583 |
| He Y et al. | Binding of puerarin to human serum albumin: a spectroscopic analysis and molecular docking. | 2008 | J Fluoresc | pmid:18058205 |
| Gao Y et al. | An isoflavonoid-enriched extract from Pueraria lobata (kudzu) root protects human umbilical vein endothelial cells against oxidative stress induced apoptosis. | 2016 | J Ethnopharmacol | pmid:27717903 |
| Wang D et al. | Evaluation of kudzu root extract-induced hepatotoxicity. | 2015 | J Ethnopharmacol | pmid:26545459 |
| Zhou J et al. | Puerarin attenuates glutamate-induced neurofilament axonal transport impairment. | 2010 | J Ethnopharmacol | pmid:20727960 |
| Haque Bhuiyan MM et al. | The neuritogenic and synaptogenic effects of the ethanolic extract of radix Puerariae in cultured rat hippocampal neurons. | 2015 | J Ethnopharmacol | pmid:26196403 |
| Tian F et al. | The optimal therapeutic timing and mechanism of puerarin treatment of spinal cord ischemia-reperfusion injury in rats. | 2011 | J Ethnopharmacol | pmid:21296138 |
| Zhang NB et al. | Effects of puerarin on expression of cardiac Smad3 and Smad7 mRNA in spontaneously hypertensive rat. | 2011 | J Ethnopharmacol | pmid:22027447 |
| Yao XJ et al. | Puerarin exerts antipyretic effect on lipopolysaccharide-induced fever in rats involving inhibition of pyrogen production from macrophages. | 2012 | J Ethnopharmacol | pmid:22401764 |
| Bebrevska L et al. | In vivo antioxidative activity of a quantified Pueraria lobata root extract. | 2010 | J Ethnopharmacol | pmid:19799984 |
| Liang XL et al. | Transport properties of puerarin and effect of Radix Angelicae Dahuricae extract on the transport of puerarin in Caco-2 cell model. | 2012 | J Ethnopharmacol | pmid:23085309 |
| Ho FM et al. | Anti-atherosclerotic action of Ger-Gen-Chyn-Lian-Tang and AMPK-dependent lipid lowering effect in hepatocytes. | 2012 | J Ethnopharmacol | pmid:22543166 |
| Song JX et al. | Anti-Parkinsonian drug discovery from herbal medicines: what have we got from neurotoxic models? | 2012 | J Ethnopharmacol | pmid:22212501 |
| Deng Y et al. | Mechanisms of the cerebral vasodilator actions of isoflavonoids of Gegen on rat isolated basilar artery. | 2012 | J Ethnopharmacol | pmid:22120017 |
| Bhuiyan MMH et al. | Radix Puerariae modulates glutamatergic synaptic architecture and potentiates functional synaptic plasticity in primary hippocampal neurons. | 2017 | J Ethnopharmacol | pmid:28734961 |
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| Xu X and Zheng X | Potential involvement of calcium and nitric oxide in protective effects of puerarin on oxygen-glucose deprivation in cultured hippocampal neurons. | 2007 | J Ethnopharmacol | pmid:17698307 |
| Li L and Zhang CR | Production of puerarin and isoflavones in cell suspension cultures of Pueraria lobata (Willd.): effects of medium supplementation with casein hydrolysate and coconut milk. | 2006 | J Environ Biol | pmid:16850870 |
| Severino P et al. | Current State-of-Art and New Trends on Lipid Nanoparticles (SLN and NLC) for Oral Drug Delivery. | 2012 | J Drug Deliv | pmid:22175030 |
| Li W et al. | Puerarin Improves Diabetic Aorta Injury by Inhibiting NADPH Oxidase-Derived Oxidative Stress in STZ-Induced Diabetic Rats. | 2016 | J Diabetes Res | pmid:26881260 |
| Türer ÇC et al. | The Local Effect of Puerarin on Critical-Sized Calvarial Defects. | 2017 | J Craniofac Surg | pmid:27922959 |
| Zeng X et al. | Enhanced adsorption of puerarin onto a novel hydrophilic and polar modified post-crosslinked resin from aqueous solution. | 2012 | J Colloid Interface Sci | pmid:22878002 |
| Yu Z et al. | Determination of safflor yellow A, puerarin, ferulic acid, ginsenoside Rg1, and Rb1 in the Traditional Chinese Medicinal preparation Naodesheng injection by high-performance liquid chromatography. | 2006 May-Jun | J Chromatogr Sci | pmid:16774713 |
| He X et al. | Purification of the isoflavonoid puerarin by adsorption chromatography on cross-linked 12% agarose. | 2004 | J Chromatogr A | pmid:15584227 |
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| Wang PP et al. | Puerarin stimulates osteoblasts differentiation and bone formation through estrogen receptor, p38 MAPK, and Wnt/β-catenin pathways. | 2012 | J Asian Nat Prod Res | pmid:22917468 |
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| Zhang Y et al. | Effects of puerarin on cholinergic enzymes in the brain of ovariectomized guinea pigs. | 2013 | Int. J. Neurosci. | pmid:23668913 |
| Zhou Y et al. | Puerarin alleviates cognitive impairment and oxidative stress in APP/PS1 transgenic mice. | 2014 | Int. J. Neuropsychopharmacol. | pmid:24345484 |
| Yu D et al. | Puerarin attenuates glucocorticoid-induced apoptosis of hFOB1.19 cells through the JNK- and Akt-mediated mitochondrial apoptotic pathways. | 2015 | Int. J. Mol. Med. | pmid:26101183 |
| Li W et al. | Puerarin attenuates the daunorubicin-induced apoptosis of H9c2 cells by activating the PI3K/Akt signaling pathway via the inhibition of Ca2+ influx. | 2017 | Int. J. Mol. Med. | pmid:29039532 |
| Kang OH et al. | Puerarin ameliorates hepatic steatosis by activating the PPARα and AMPK signaling pathways in hepatocytes. | 2015 | Int. J. Mol. Med. | pmid:25605057 |
| Chen F et al. | Puerarin-induced immune hemolytic anemia. | 2013 | Int. J. Hematol. | pmid:23661032 |