| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetic Nephropathies | D003928 | 39 associated lipids |
| Chemical and Drug Induced Liver Injury | D056486 | 39 associated lipids |
| Heart Failure | D006333 | 36 associated lipids |
| Fever | D005334 | 35 associated lipids |
| Infarction, Middle Cerebral Artery | D020244 | 35 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Neurotoxicity Syndromes | D020258 | 34 associated lipids |
| Memory Disorders | D008569 | 33 associated lipids |
| Stroke | D020521 | 32 associated lipids |
| Endometriosis | D004715 | 29 associated lipids |
| Ventricular Remodeling | D020257 | 28 associated lipids |
| Angina Pectoris | D000787 | 27 associated lipids |
| Brain Infarction | D020520 | 17 associated lipids |
| Angina, Unstable | D000789 | 14 associated lipids |
| Glucose Intolerance | D018149 | 13 associated lipids |
| Amnesia | D000647 | 12 associated lipids |
| Hypertension, Renovascular | D006978 | 10 associated lipids |
| Dyspepsia | D004415 | 5 associated lipids |
| Hepatitis, Alcoholic | D006519 | 5 associated lipids |
SCHEMBL105486
Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with SCHEMBL105486?
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
PubChem Associated disorders and diseases
What pathways are associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with SCHEMBL105486?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with SCHEMBL105486?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with SCHEMBL105486?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with SCHEMBL105486?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with SCHEMBL105486?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with SCHEMBL105486
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Liu IM and Cheng JT | Mediation of Endogenous β-Endorphin in the Plasma Glucose-Lowering Action of Herbal Products Observed in Type 1-Like Diabetic Rats. | 2011 | Evid Based Complement Alternat Med | pmid:19095661 |
| Xiao C et al. | Anti-oxidative and TNF-α suppressive activities of puerarin derivative (4AC) in RAW264.7 cells and collagen-induced arthritic rats. | 2011 | Eur. J. Pharmacol. | pmid:21651907 |
| Su B et al. | [Rapid determination of puerarin in Xiaoke pill powder by near-infrared spectroscopy]. | 2011 | Zhongguo Zhong Yao Za Zhi | pmid:21710725 |
| Chen Y et al. | Endometriotic implants regress in rat models treated with puerarin by decreasing estradiol level. | 2011 | Reprod Sci | pmid:21673282 |
| Luo CF et al. | Pharmacokinetics, tissue distribution and relative bioavailability of puerarin solid lipid nanoparticles following oral administration. | 2011 | Int J Pharm | pmid:21392565 |
| Xu HX et al. | [Mechanism of advanced glycation end-products in the inducement of apoptosis of human gingival fibroblast and related effect of puerarin in the process]. | 2011 | Zhonghua Kou Qiang Yi Xue Za Zhi | pmid:21418943 |
| Xing G et al. | Neuroprotective effects of puerarin against beta-amyloid-induced neurotoxicity in PC12 cells via a PI3K-dependent signaling pathway. | 2011 | Brain Res. Bull. | pmid:21473901 |
| Hou SZ et al. | Role of the interaction between puerarin and the erythrocyte membrane in puerarin-induced hemolysis. | 2011 | Chem. Biol. Interact. | pmid:21453687 |
| Luo CF et al. | Determination of puerarin in rat plasma by rapid resolution liquid chromatography tandem mass spectrometry in positive ionization mode. | 2011 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:21511546 |
| Yu A et al. | Formulation optimization and bioavailability after oral and nasal administration in rabbits of puerarin-loaded microemulsion. | 2011 | J Pharm Sci | pmid:20862776 |
| Zhang H et al. | Puerarin protects Alzheimer's disease neuronal cybrids from oxidant-stress induced apoptosis by inhibiting pro-death signaling pathways. | 2011 | Exp. Gerontol. | pmid:20933077 |
| Wang G et al. | Implication of the c-Jun-NH2-terminal kinase pathway in the neuroprotective effect of puerarin against 1-methyl-4-phenylpyridinium (MPP+)-induced apoptosis in PC-12 cells. | 2011 | Neurosci. Lett. | pmid:20934486 |
| Tian F et al. | The optimal therapeutic timing and mechanism of puerarin treatment of spinal cord ischemia-reperfusion injury in rats. | 2011 | J Ethnopharmacol | pmid:21296138 |
| He X et al. | A genomic approach to isoflavone biosynthesis in kudzu (Pueraria lobata). | 2011 | Planta | pmid:21221632 |
| Hao LN et al. | [Protective effects of puerarin on lens epithelial cells in rat diabetic cataract]. | 2011 | Zhonghua Yan Ke Za Zhi | pmid:21612681 |
| Zhu YM et al. | [Effect and mechanism of puerarin on high glucose-induced hypo-responses in vascular contraction]. | 2011 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21560344 |
| Braune A and Blaut M | Deglycosylation of puerarin and other aromatic C-glucosides by a newly isolated human intestinal bacterium. | 2011 | Environ. Microbiol. | pmid:20946528 |
| Lv Y et al. | Preparation of monomeric and polymeric β-cyclodextrin functionalized monoliths for rapid isolation and purification of puerarin from Radix puerariae. | 2011 | J Sep Sci | pmid:21766485 |
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| Pan ZJ et al. | [Effects of puerarin on blood pressure, blood lipid and renal structure of cold-induced hypertensive mice]. | 2011 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:22295519 |
| Zhang L et al. | Intestinal absorbability of three Radix Puerariae isoflavones including daidzein, daidzin and puerarin. | 2011 | Chin Med | pmid:22108408 |
| Cui SQ | [Effect of puerarin in myocardial protection in rats with acute and chronic alcoholism]. | 2011 | Nan Fang Yi Ke Da Xue Xue Bao | pmid:22200707 |
| Zhang XP et al. | Protective effects of Ligustrazine, Kakonein and Panax Notoginsenoside on the small intestine and immune organs of rats with severe acute pancreatitis. | 2011 | HBPD INT | pmid:22146628 |
| Pongkitwitoon B et al. | Development of an enzyme-linked immunosorbent assay to determine puerarin and its aglycone daidzein. | 2011 | J Nat Med | pmid:20658197 |
| Zhang R et al. | [Effect of puerarin on the expression of NMDA receptor in the hippocampus CA1 region after focal cerebral ischemia in rats]. | 2011 | Sichuan Da Xue Xue Bao Yi Xue Ban | pmid:21355301 |
| Zhang H et al. | Puerarin: a novel antagonist to inward rectifier potassium channel (IK1). | 2011 | Mol. Cell. Biochem. | pmid:21327545 |
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| Zhang X et al. | [Puerarin induced apoptosis of pulmonary artery smooth muscle cell by mitochondrial pathway]. | 2011 | Zhongguo Zhong Yao Za Zhi | pmid:22097342 |
| Chen X et al. | [Study on pharmacokinetics of puerarin in rats following different methods of administration of Tongqiao Sanyu prescription]. | 2011 | Zhongguo Zhong Yao Za Zhi | pmid:22121800 |
| Hsiang SW et al. | Puerarin accelerates peripheral nerve regeneration. | 2011 | Am. J. Chin. Med. | pmid:22083991 |
| Chen L et al. | [Flavonoids of puerarin versus tanshinone II A for ischemic stroke: a randomized controlled trial]. | 2011 | Zhong Xi Yi Jie He Xue Bao | pmid:22088587 |
| Hu W et al. | Puerarin inhibits iNOS, COX-2 and CRP expression via suppression of NF-κB activation in LPS-induced RAW264.7 macrophage cells. | 2011 | Pharmacol Rep | pmid:21857089 |
| Han RM et al. | Phenol acidity and ease of oxidation in isoflavonoid/β-carotene antioxidant synergism. | 2011 | J. Agric. Food Chem. | pmid:21863887 |
| Zhao R et al. | NMR studies on puerarin and its interaction with beta-cyclodextrin. | 2011 | J Biol Phys | pmid:22942483 |
| Lipovac M et al. | Effect of Red Clover Isoflavones over Skin, Appendages, and Mucosal Status in Postmenopausal Women. | 2011 | Obstet Gynecol Int | pmid:22135679 |
| Li X et al. | Puerarin alleviates burn-related procedural pain mediated by P2X(3) receptors. | 2011 | Purinergic Signal. | pmid:21833698 |
| Kalani M and Yunus R | Application of supercritical antisolvent method in drug encapsulation: a review. | 2011 | Int J Nanomedicine | pmid:21796245 |
| Pan SY et al. | New perspectives on chinese herbal medicine (zhong-yao) research and development. | 2011 | Evid Based Complement Alternat Med | pmid:21785622 |
| Kim Y et al. | Novel PI3K/Akt inhibitors screened by the cytoprotective function of human immunodeficiency virus type 1 Tat. | 2011 | PLoS ONE | pmid:21765914 |
| Su SY and Hsieh CL | Anti-inflammatory effects of Chinese medicinal herbs on cerebral ischemia. | 2011 | Chin Med | pmid:21740583 |
| Qin P et al. | Characterization and selectivity studies of molecular imprinted membranes of Puerarin using scanning electron microscopy. | 2011 Jan-Feb | Scanning | pmid:21246571 |
| Chauhan NS et al. | Spectrofluorimetric estimation of puerarin in Pueraria tuberosa. | 2011 May-Jun | Acta Pol Pharm | pmid:21648202 |
| Zhao C et al. | Rapid simultaneous determination of major isoflavones of Pueraria lobata and discriminative analysis of its geographical origins by principal component analysis. | 2011 Nov-Dec | Phytochem Anal | pmid:21495105 |
| Yang R et al. | Determination of puerarin in biological samples and its application to a pharmacokinetic study by flow-injection chemiluminescence. | 2011 Sep-Oct | Luminescence | pmid:21547999 |
| Severino P et al. | Current State-of-Art and New Trends on Lipid Nanoparticles (SLN and NLC) for Oral Drug Delivery. | 2012 | J Drug Deliv | pmid:22175030 |
| Liu CM et al. | Puerarin protects the rat liver against oxidative stress-mediated DNA damage and apoptosis induced by lead. | 2012 | Exp. Toxicol. Pathol. | pmid:21146379 |
| Fan R et al. | Ethnopharmacokinetic- and activity-guided isolation of a new antidepressive compound from fructus aurantii found in the traditional chinese medicine chaihu-shugan-san: a new approach and its application. | 2012 | Evid Based Complement Alternat Med | pmid:22454671 |
| Penetar DM et al. | The isoflavone puerarin reduces alcohol intake in heavy drinkers: a pilot study. | 2012 | Drug Alcohol Depend | pmid:22578529 |
| Kim J et al. | Puerarin inhibits the retinal pericyte apoptosis induced by advanced glycation end products in vitro and in vivo by inhibiting NADPH oxidase-related oxidative stress. | 2012 | Free Radic. Biol. Med. | pmid:22609359 |
| Luo J et al. | Molecularly imprinted layer-coated monodisperse spherical silica microparticles toward affinity-enrichment of isoflavonoid glycosides from Radix puerariae. | 2012 | Analyst | pmid:22553769 |
| Sun L et al. | Involvement of abscisic acid in ozone-induced puerarin production of Pueraria thomsnii Benth. suspension cell cultures. | 2012 | Plant Cell Rep. | pmid:21947422 |
| Zhu G et al. | Involvement of activation of PI3K/Akt pathway in the protective effects of puerarin against MPP+-induced human neuroblastoma SH-SY5Y cell death. | 2012 | Neurochem. Int. | pmid:22265823 |
| Zheng GM et al. | Puerarin suppresses production of nitric oxide and inducible nitric oxide synthase in lipopolysaccharide-induced N9 microglial cells through regulating MAPK phosphorylation, O-GlcNAcylation and NF-κB translocation. | 2012 | Int. J. Oncol. | pmid:22246431 |
| Lin F et al. | Protective effect of Puerarin on β-amyloid-induced neurotoxicity in rat hippocampal neurons. | 2012 | Arzneimittelforschung | pmid:22278629 |
| Tang XL et al. | Dynamic oxidative stress and DNA damage induced by oestrogen deficiency and protective effects of puerarin and 17β-oestradiol in ovariectomized rats. | 2012 | Basic Clin. Pharmacol. Toxicol. | pmid:22333267 |
| Huang F et al. | Puerarin attenuates endothelial insulin resistance through inhibition of inflammatory response in an IKKβ/IRS-1-dependent manner. | 2012 | Biochimie | pmid:22314193 |
| Wang Q et al. | [Distribution of puerarin contained in Zige freeze-dried powder injection in rat liver and kidney]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:22994007 |
| Wang Y et al. | Formulation and pharmacokinetics evaluation of puerarin nanocrystals for intravenous delivery. | 2012 | J Nanosci Nanotechnol | pmid:22962724 |
| Coghlan ML et al. | Deep sequencing of plant and animal DNA contained within traditional Chinese medicines reveals legality issues and health safety concerns. | 2012 | PLoS Genet. | pmid:22511890 |
| Han J et al. | [Study on 3'-methoxy puerarin to dynamic changes of amino acids in rat brain ischemia-reperfusion]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:22792810 |
| Liang J et al. | Puerarin inhibits caspase-3 expression in osteoblasts of diabetic rats. | 2012 | Mol Med Rep | pmid:22470138 |
| Cho HJ et al. | Acute effect of high-dose isoflavones from Pueraria lobata (Willd.) Ohwi on lipid and bone metabolism in ovariectomized mice. | 2012 | Phytother Res | pmid:22422661 |
| Zhang MY et al. | In vitro and in vivo effects of puerarin on promotion of osteoblast bone formation. | 2012 | Chin J Integr Med | pmid:22457138 |
| Pang W et al. | Effect of puerarin on the release of interleukin-8 in co-culture of human bronchial epithelial cells and neutrophils. | 2012 | Chin J Integr Med | pmid:22457139 |
| Zhao Y and Zhou Y | Puerarin improve insulin resistance of adipocyte through activating Cb1 binding protein path. | 2012 | Chin J Integr Med | pmid:22457141 |
| Chen C et al. | Puerarin induces mitochondria-dependent apoptosis in hypoxic human pulmonary arterial smooth muscle cells. | 2012 | PLoS ONE | pmid:22457823 |
| Hao LN et al. | Puerarin decreases apoptosis of retinal pigment epithelial cells in diabetic rats by reducing peroxynitrite level and iNOS expression. | 2012 | Sheng Li Xue Bao | pmid:22513471 |
| Yao XJ et al. | Puerarin exerts antipyretic effect on lipopolysaccharide-induced fever in rats involving inhibition of pyrogen production from macrophages. | 2012 | J Ethnopharmacol | pmid:22401764 |
| Yu N et al. | The effects of sperminated pullulans on cornea permeability to puerarin and the toxicity. | 2012 | J Ocul Pharmacol Ther | pmid:22690870 |
| Wang R et al. | [Protective effects of puerarin on 60Co-gamma-induced acute injury of sertoli cells of testis in mice]. | 2012 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:22686089 |
| Luo CF et al. | UDP-glucuronosyltransferase 1A1 is the principal enzyme responsible for puerarin metabolism in human liver microsomes. | 2012 | Arch. Toxicol. | pmid:22648071 |
| Yang F et al. | Osteoblast response to puerarin-loaded porous titanium surfaces: an in vitro study. | 2012 | J Biomed Mater Res A | pmid:22374837 |
| Zhang H et al. | Insight into the structural deformations of beta-cyclodextrin caused by alcohol cosolvents and guest molecules. | 2012 | J Phys Chem B | pmid:22376204 |
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| Liu L et al. | Determination of puerarin in pharmaceutical and biological samples by capillary zone electrophoresis with UV detection. | 2012 | Talanta | pmid:22365684 |
| Zhang Y et al. | Characterization and evaluation of self-microemulsifying sustained-release pellet formulation of puerarin for oral delivery. | 2012 | Int J Pharm | pmid:22366381 |
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| Zeng X et al. | Enhanced adsorption of puerarin onto a novel hydrophilic and polar modified post-crosslinked resin from aqueous solution. | 2012 | J Colloid Interface Sci | pmid:22878002 |
| Liu B et al. | Physicochemical [corrected] properties of the inclusion complex of puerarin and glucosyl-β-cyclodextrin. | 2012 | J. Agric. Food Chem. | pmid:23215052 |
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| Sun XY et al. | [Optimal extraction of puerarin from Pueraria lobata based on central composite design and response surface methodology]. | 2012 | Zhong Yao Cai | pmid:23236837 |
| Chen YY et al. | Puerarin protects human umbilical vein endothelial cells against high glucose-induced apoptosis by upregulating heme oxygenase-1 and inhibiting calpain activation. | 2012 | Fundam Clin Pharmacol | pmid:21352351 |
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| Chen F et al. | Puerarin enhances superoxide dismutase activity and inhibits RAGE and VEGF expression in retinas of STZ-induced early diabetic rats. | 2012 | Asian Pac J Trop Med | pmid:23146804 |
| Prasain JK et al. | The Chinese Pueraria root extract (Pueraria lobata) ameliorates impaired glucose and lipid metabolism in obese mice. | 2012 | Phytomedicine | pmid:23123226 |
| Song JX et al. | Anti-Parkinsonian drug discovery from herbal medicines: what have we got from neurotoxic models? | 2012 | J Ethnopharmacol | pmid:22212501 |
| Deng Y et al. | Mechanisms of the cerebral vasodilator actions of isoflavonoids of Gegen on rat isolated basilar artery. | 2012 | J Ethnopharmacol | pmid:22120017 |
| Yu L et al. | Biotransformation of puerarin into puerarin-6″-O-phosphate by Bacillus cereus. | 2012 | J. Ind. Microbiol. Biotechnol. | pmid:21882014 |
| Wang X et al. | Identification and assay of 3'-O-methyltaxifolin by UPLC-MS in rat plasma. | 2012 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:23217303 |
| Wen Y et al. | Simultaneous determination of lidamycin enediyne chromophore (LDC) and its aromatized derivative (LDCA) using puerarin as internal standard in rat plasma by LC-MS/MS. | 2012 | Biomed. Chromatogr. | pmid:21830226 |
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| Yan F et al. | Effects of some antihypertensive drugs on the metabolism and pharmacokinetics of indapamide in rats. | 2012 | J Pharm Pharm Sci | pmid:22579001 |
| Wang J and Xiong X | Current situation and perspectives of clinical study in integrative medicine in china. | 2012 | Evid Based Complement Alternat Med | pmid:22550539 |
| Jiang H et al. | Natural product nitric oxide chemistry: new activity of old medicines. | 2012 | Evid Based Complement Alternat Med | pmid:22548122 |
| Qiu Y et al. | Traditional chinese herbal products for coronary heart disease: an overview of cochrane reviews. | 2012 | Evid Based Complement Alternat Med | pmid:22536282 |
| Zheng GH et al. | Systematic Review of Chinese Herbal Medicines for Preventing in-Stent Coronary Restenosis after Percutaneous Coronary Intervention. | 2012 | Evid Based Complement Alternat Med | pmid:22454659 |