| MeSH term | MeSH ID | Detail |
|---|---|---|
| Fever | D005334 | 35 associated lipids |
| Heart Failure | D006333 | 36 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Hepatitis, Alcoholic | D006519 | 5 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Hypertension, Renovascular | D006978 | 10 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
| Lead Poisoning | D007855 | 4 associated lipids |
| Liver Cirrhosis | D008103 | 67 associated lipids |
| Memory Disorders | D008569 | 33 associated lipids |
| Parkinson Disease | D010300 | 53 associated lipids |
| Urinary Incontinence | D014549 | 4 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Glucose Intolerance | D018149 | 13 associated lipids |
| Alcohol-Related Disorders | D019973 | 3 associated lipids |
| Infarction, Middle Cerebral Artery | D020244 | 35 associated lipids |
| Ventricular Remodeling | D020257 | 28 associated lipids |
| Neurotoxicity Syndromes | D020258 | 34 associated lipids |
SCHEMBL105486
Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with SCHEMBL105486?
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
PubChem Associated disorders and diseases
What pathways are associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with SCHEMBL105486?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with SCHEMBL105486?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with SCHEMBL105486?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with SCHEMBL105486?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with SCHEMBL105486?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with SCHEMBL105486
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chen Y et al. | [Effect of puerarin on action potential and inward rectifier potassium current in rat myocardium]. | 2010 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:20684293 |
| Liu X et al. | A HPLC-UV method for the determination of puerarin in rat plasma after intravenous administration of PEGylated puerarin conjugate. | 2010 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:21056017 |
| Yang L and Tan T | An enhanced adsorption in puerarin retention on oligo-beta-cyclodextrin grafted poly(glycidyl methacrylate) media. | 2010 | Appl. Biochem. Biotechnol. | pmid:19067245 |
| Bebrevska L et al. | In vivo antioxidative activity of a quantified Pueraria lobata root extract. | 2010 | J Ethnopharmacol | pmid:19799984 |
| Mun JG et al. | Tracking deposition of a 14C-radiolabeled kudzu hairy root-derived isoflavone-rich fraction into bone. | 2010 | Exp. Biol. Med. (Maywood) | pmid:20851832 |
| Yu C et al. | Permeabilization of Microbacterium oxylans shifts the conversion of puerarin from puerarin-7-O-glucoside to puerarin-7-O-fructoside. | 2010 | Appl. Microbiol. Biotechnol. | pmid:19943046 |
| Liao XH et al. | [Effect of major components of maijunan tablets on the transport of hydrochlorothiazide in Caco-2 cell monolayer model]. | 2010 | Yao Xue Xue Bao | pmid:21351458 |
| Guo D et al. | [Study on pharmacokinetics and biodistribution of pur derivative nanopaticles in mice]. | 2010 | Zhongguo Zhong Yao Za Zhi | pmid:21355276 |
| Sun C et al. | On-line HPLC method for screening of antioxidants against superoxide anion radical from complex mixtures. | 2010 | J Sep Sci | pmid:20183820 |
| Liu J et al. | An improved LC-MS/MS method for simultaneous determination of 1,5-dicaffeoylquinic acid and its active metabolites in human plasma and its application to a pharmacokinetic study in patients. | 2010 | Biomed. Chromatogr. | pmid:20058327 |
| Hanhineva K et al. | Impact of dietary polyphenols on carbohydrate metabolism. | 2010 | Int J Mol Sci | pmid:20480025 |
| Han RM et al. | Fast regeneration of carotenoids from radical cations by isoflavonoid dianions: importance of the carotenoid keto group for electron transfer. | 2010 | J Phys Chem A | pmid:19957978 |
| Hirota K et al. | Effect of genistein and daidzein on the proliferation and differentiation of human preadipocyte cell line. | 2010 | J. Agric. Food Chem. | pmid:20397699 |
| Branco DM et al. | Cross-talk between mitochondria and proteasome in Parkinson's disease pathogenesis. | 2010 | Front Aging Neurosci | pmid:20577640 |
| Wong RW and Rabie AB | Effect of bio-oss collagen and collagen matrix on bone formation. | 2010 | Open Biomed Eng J | pmid:20461225 |
| Wang MS et al. | Curcumin reduces alpha-synuclein induced cytotoxicity in Parkinson's disease cell model. | 2010 | BMC Neurosci | pmid:20433710 |
| Yao M et al. | Quantitative analysis of two isoflavones in Pueraria lobata flowers from eleven Chinese provinces using high performance liquid chromatography. | 2010 | Chin Med | pmid:20416072 |
| Lee OH et al. | Puerarin enhances adipocyte differentiation, adiponectin expression, and antioxidant response in 3T3-L1 cells. | 2010 Nov-Dec | Biofactors | pmid:20806284 |
| Liu IM and Cheng JT | Mediation of Endogenous β-Endorphin in the Plasma Glucose-Lowering Action of Herbal Products Observed in Type 1-Like Diabetic Rats. | 2011 | Evid Based Complement Alternat Med | pmid:19095661 |
| Su B et al. | [Rapid determination of puerarin in Xiaoke pill powder by near-infrared spectroscopy]. | 2011 | Zhongguo Zhong Yao Za Zhi | pmid:21710725 |
| Chen Y et al. | Endometriotic implants regress in rat models treated with puerarin by decreasing estradiol level. | 2011 | Reprod Sci | pmid:21673282 |
| Luo CF et al. | Pharmacokinetics, tissue distribution and relative bioavailability of puerarin solid lipid nanoparticles following oral administration. | 2011 | Int J Pharm | pmid:21392565 |
| Xu HX et al. | [Mechanism of advanced glycation end-products in the inducement of apoptosis of human gingival fibroblast and related effect of puerarin in the process]. | 2011 | Zhonghua Kou Qiang Yi Xue Za Zhi | pmid:21418943 |
| Xing G et al. | Neuroprotective effects of puerarin against beta-amyloid-induced neurotoxicity in PC12 cells via a PI3K-dependent signaling pathway. | 2011 | Brain Res. Bull. | pmid:21473901 |
| Hou SZ et al. | Role of the interaction between puerarin and the erythrocyte membrane in puerarin-induced hemolysis. | 2011 | Chem. Biol. Interact. | pmid:21453687 |
| Luo CF et al. | Determination of puerarin in rat plasma by rapid resolution liquid chromatography tandem mass spectrometry in positive ionization mode. | 2011 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:21511546 |
| Yu A et al. | Formulation optimization and bioavailability after oral and nasal administration in rabbits of puerarin-loaded microemulsion. | 2011 | J Pharm Sci | pmid:20862776 |
| Zhang H et al. | Puerarin protects Alzheimer's disease neuronal cybrids from oxidant-stress induced apoptosis by inhibiting pro-death signaling pathways. | 2011 | Exp. Gerontol. | pmid:20933077 |
| Zhu YM et al. | [Effect and mechanism of puerarin on high glucose-induced hypo-responses in vascular contraction]. | 2011 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21560344 |
| Braune A and Blaut M | Deglycosylation of puerarin and other aromatic C-glucosides by a newly isolated human intestinal bacterium. | 2011 | Environ. Microbiol. | pmid:20946528 |
| Lv Y et al. | Preparation of monomeric and polymeric β-cyclodextrin functionalized monoliths for rapid isolation and purification of puerarin from Radix puerariae. | 2011 | J Sep Sci | pmid:21766485 |
| Zhang L et al. | Intestinal absorbability of three Radix Puerariae isoflavones including daidzein, daidzin and puerarin. | 2011 | Chin Med | pmid:22108408 |
| Cui SQ | [Effect of puerarin in myocardial protection in rats with acute and chronic alcoholism]. | 2011 | Nan Fang Yi Ke Da Xue Xue Bao | pmid:22200707 |
| Zhang XP et al. | Protective effects of Ligustrazine, Kakonein and Panax Notoginsenoside on the small intestine and immune organs of rats with severe acute pancreatitis. | 2011 | HBPD INT | pmid:22146628 |
| Pongkitwitoon B et al. | Development of an enzyme-linked immunosorbent assay to determine puerarin and its aglycone daidzein. | 2011 | J Nat Med | pmid:20658197 |
| Zhang R et al. | [Effect of puerarin on the expression of NMDA receptor in the hippocampus CA1 region after focal cerebral ischemia in rats]. | 2011 | Sichuan Da Xue Xue Bao Yi Xue Ban | pmid:21355301 |
| Zhang H et al. | Puerarin: a novel antagonist to inward rectifier potassium channel (IK1). | 2011 | Mol. Cell. Biochem. | pmid:21327545 |
| Yao C et al. | [Ocular pharmacokinetics of puerarin in anesthetic rabbits by microdialysis]. | 2011 | Zhongguo Zhong Yao Za Zhi | pmid:22097338 |
| Zhang X et al. | [Puerarin induced apoptosis of pulmonary artery smooth muscle cell by mitochondrial pathway]. | 2011 | Zhongguo Zhong Yao Za Zhi | pmid:22097342 |
| Chen X et al. | [Study on pharmacokinetics of puerarin in rats following different methods of administration of Tongqiao Sanyu prescription]. | 2011 | Zhongguo Zhong Yao Za Zhi | pmid:22121800 |
| Hsiang SW et al. | Puerarin accelerates peripheral nerve regeneration. | 2011 | Am. J. Chin. Med. | pmid:22083991 |
| Chen L et al. | [Flavonoids of puerarin versus tanshinone II A for ischemic stroke: a randomized controlled trial]. | 2011 | Zhong Xi Yi Jie He Xue Bao | pmid:22088587 |
| Hu W et al. | Puerarin inhibits iNOS, COX-2 and CRP expression via suppression of NF-κB activation in LPS-induced RAW264.7 macrophage cells. | 2011 | Pharmacol Rep | pmid:21857089 |
| Han RM et al. | Phenol acidity and ease of oxidation in isoflavonoid/β-carotene antioxidant synergism. | 2011 | J. Agric. Food Chem. | pmid:21863887 |
| Lipovac M et al. | Effect of Red Clover Isoflavones over Skin, Appendages, and Mucosal Status in Postmenopausal Women. | 2011 | Obstet Gynecol Int | pmid:22135679 |
| Li X et al. | Puerarin alleviates burn-related procedural pain mediated by P2X(3) receptors. | 2011 | Purinergic Signal. | pmid:21833698 |
| Kalani M and Yunus R | Application of supercritical antisolvent method in drug encapsulation: a review. | 2011 | Int J Nanomedicine | pmid:21796245 |
| Pan SY et al. | New perspectives on chinese herbal medicine (zhong-yao) research and development. | 2011 | Evid Based Complement Alternat Med | pmid:21785622 |
| Kim Y et al. | Novel PI3K/Akt inhibitors screened by the cytoprotective function of human immunodeficiency virus type 1 Tat. | 2011 | PLoS ONE | pmid:21765914 |
| Su SY and Hsieh CL | Anti-inflammatory effects of Chinese medicinal herbs on cerebral ischemia. | 2011 | Chin Med | pmid:21740583 |