| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cataract | D002386 | 34 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Arthritis | D001168 | 41 associated lipids |
| Heart Failure | D006333 | 36 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Chemical and Drug Induced Liver Injury | D056486 | 39 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Endometriosis | D004715 | 29 associated lipids |
SCHEMBL105486
Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with SCHEMBL105486?
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
PubChem Associated disorders and diseases
What pathways are associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with SCHEMBL105486?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with SCHEMBL105486?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with SCHEMBL105486?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with SCHEMBL105486?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with SCHEMBL105486?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with SCHEMBL105486
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Bae HS et al. | Hepatoprotective activity of reduohanxiao-tang (yuldahanso-tang) is related to the inhibition of beta-glucuronidase. | 2003 | Am. J. Chin. Med. | pmid:12723760 |
| Liu R et al. | Pharmacokinetics of puerarin and ginsenoside Rg1 of CBN injection and the relation with platelet aggregation in rats. | 2006 | Am. J. Chin. Med. | pmid:17163592 |
| Zheng P et al. | Therapeutic effect of puerarin on non-alcoholic rat fatty liver by improving leptin signal transduction through JAK2/STAT3 pathways. | 2009 | Am. J. Chin. Med. | pmid:19222113 |
| Zhao M et al. | Protective effect of puerarin on acute alcoholic liver injury. | 2010 | Am. J. Chin. Med. | pmid:20387222 |
| Hsiang SW et al. | Puerarin accelerates peripheral nerve regeneration. | 2011 | Am. J. Chin. Med. | pmid:22083991 |
| Lu Q et al. | Puerarin attenuates calcification of vascular smooth muscle cells. | 2014 | Am. J. Chin. Med. | pmid:24707866 |
| Lin RC and Li TK | Effects of isoflavones on alcohol pharmacokinetics and alcohol-drinking behavior in rats. | 1998 | Am. J. Clin. Nutr. | pmid:9848526 |
| Wang J et al. | Detection of flavonoids and assay for their antioxidant activity based on enlargement of gold nanoparticles. | 2007 | Anal Bioanal Chem | pmid:17479255 |
| Baranowska I and Magiera S | Analysis of isoflavones and flavonoids in human urine by UHPLC. | 2011 | Anal Bioanal Chem | pmid:20936271 |
| Tian J and Qin W | Quick and sensitive determination of flavonoids by capillary electrophoresis-potential gradient detection. | 2009 | Anal Sci | pmid:19745540 |