| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
SCHEMBL105486
Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with SCHEMBL105486?
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
PubChem Associated disorders and diseases
What pathways are associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with SCHEMBL105486?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with SCHEMBL105486?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with SCHEMBL105486?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with SCHEMBL105486?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with SCHEMBL105486?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with SCHEMBL105486
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Li QX et al. | [Effect of compound Puerarin on the collage IV in streptozotocin-induced diabetic nephropathy rats]. | 2008 | Zhonghua Yu Fang Yi Xue Za Zhi | pmid:18763636 |
| Han P et al. | [Effect of pueraria crude extreact and puerarin on ethanol-induced expression of heat shock protein 70 in embryonic mouse hippocampal cultures]. | 2005 | Zhonghua Yi Xue Za Zhi | pmid:16324368 |
| Xu YZ et al. | [Effects of puerarin on proliferation of vascular smooth muscle cells induced by thrombin]. | 2006 | Zhonghua Yi Xue Za Zhi | pmid:16677576 |
| Hao LN et al. | [Peroxynitrite-induced formation of diabetic cataract and its prevention by puerarin in rat]. | 2004 | Zhonghua Yan Ke Za Zhi | pmid:15312625 |
| Hao LN et al. | [Protective effects of puerarin on lens epithelial cells in rat diabetic cataract]. | 2011 | Zhonghua Yan Ke Za Zhi | pmid:21612681 |
| Hao LN et al. | [The effect of puerarin on prevention of oxidative damage of cultured lens capsule epithelial cells]. | 2008 | Zhonghua Yan Ke Za Zhi | pmid:18683704 |
| Kang RX | [The intraocular pressure depressive effect of puerarin]. | 1993 | Zhonghua Yan Ke Za Zhi | pmid:7912669 |
| Ji O et al. | [Effect of flavonoids of puerarin on the proliferation and apoptosis of retinoic acid resistant acute promyelocytic leukemia cell line NB4-R1 cells]. | 2013 | Zhonghua Xue Ye Xue Za Zhi | pmid:23688762 |
| Li XY et al. | [The effect of intravenous puerarin on acute myocardial infarction]. | 1985 | Zhonghua Xin Xue Guan Bing Za Zhi | pmid:4092596 |
| Han P et al. | [Potential antiviral drug Pueraria crude extract and puerarin protect against ethanol-induced cytotoxicity in embryonic mouse hippocampal cultures]. | 2005 | Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi | pmid:16261207 |
| Luo ZK et al. | [A clinical efficacy and safety study on coronary heart disease and angina treatment with Puerarin Injection]. | 2012 | Zhonghua Liu Xing Bing Xue Za Zhi | pmid:22883272 |
| Chen C et al. | [Effects of puerarin on proliferation, apoptosis and Kv1.5 gene expression of pulmonary artery smooth muscle cells induced by hypoxia]. | 2011 | Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi | pmid:22357486 |
| Xu HX et al. | [Mechanism of advanced glycation end-products in the inducement of apoptosis of human gingival fibroblast and related effect of puerarin in the process]. | 2011 | Zhonghua Kou Qiang Yi Xue Za Zhi | pmid:21418943 |
| Wang C et al. | [Therapeutic effect of puerarin on rats with pre-eclampsia]. | 2006 | Zhonghua Fu Chan Ke Za Zhi | pmid:16640862 |
| Pan HP et al. | [Protection of puerarin on the cerebral injury in the rats with acute local ischemia]. | 2005 | Zhongguo Zhong Yao Za Zhi | pmid:15810455 |
| Dong K et al. | [Endothelium-independent vasorelaxant effect of puerarin on rat thoracic aorta]. | 2004 | Zhongguo Zhong Yao Za Zhi | pmid:15631089 |
| Pan HP et al. | [Experimental study of puerarin injection on the hemorheology in acute blood-stasis model rats]. | 2003 | Zhongguo Zhong Yao Za Zhi | pmid:15617506 |
| Feng CG et al. | [Progress in research of aldose reductase inhibitors in traditional medicinal herbs]. | 2005 | Zhongguo Zhong Yao Za Zhi | pmid:16335816 |
| Ma YS et al. | [Studies permeation of puerarin and its phospholipid complex through mouse skin in vitro]. | 2000 | Zhongguo Zhong Yao Za Zhi | pmid:12512448 |
| Liu S et al. | [A study on processing of the root of Pueraria lobata (Willd.) ohwi by HPLC]. | 1998 | Zhongguo Zhong Yao Za Zhi | pmid:12242820 |
| Song CY and Bi HM | [Effects of puerarin on plasma membrane GLUT4 content in skeletal muscle from insulin-resistant Sprague-Dawley rats under insulin stimulation]. | 2004 | Zhongguo Zhong Yao Za Zhi | pmid:15719689 |
| Guo XG et al. | [Effect of puerarin on L-type calcium channel in isolated rat ventricular myocytes]. | 2004 | Zhongguo Zhong Yao Za Zhi | pmid:15706853 |
| Han J et al. | [Effect of puerarin and daidzein on proliferating vascular smooth muscle cells]. | 2004 | Zhongguo Zhong Yao Za Zhi | pmid:15706898 |
| Pan HP et al. | [Effect of puerarin on the expression of Hsp70 in the rats with cerebral injury induced by acute local ischemia]. | 2005 | Zhongguo Zhong Yao Za Zhi | pmid:16011103 |
| Zhao Y et al. | [Experimental study of protective effect of pueraria compound on the cerebral ischemic injury]. | 2005 | Zhongguo Zhong Yao Za Zhi | pmid:16011106 |
| Su B et al. | [Rapid determination of puerarin in Xiaoke pill powder by near-infrared spectroscopy]. | 2011 | Zhongguo Zhong Yao Za Zhi | pmid:21710725 |
| Li J et al. | [Permeability of blood-brain barrier oxygen-glucose deprivation induced by tetramethylpyrazine-puerarin in vitro]. | 2010 | Zhongguo Zhong Yao Za Zhi | pmid:21246832 |
| Xu YZ et al. | [Puerarin suppresses the proliferation of vscular smooth muscule cells and c-fos and bcl-2 protein expression]. | 2006 | Zhongguo Zhong Yao Za Zhi | pmid:16722382 |
| Wang FW et al. | [Protective effect of puerarin on stress-induced gastric mucosal injury in rats]. | 2006 | Zhongguo Zhong Yao Za Zhi | pmid:16722386 |
| Wu GL et al. | [Effect of puerarin on levels of TGF-beta1 and alpha-SMA in rats with alcoholic injury liver]. | 2008 | Zhongguo Zhong Yao Za Zhi | pmid:19166018 |
| Han J et al. | [Protective effect of 3'-methoxy puerarin on cerebral ischemic injury/ reperfusion in rats]. | 2009 | Zhongguo Zhong Yao Za Zhi | pmid:19771877 |
| Chen R et al. | [Simultaneous quantification of five impurities in puerarin and its injections by HPLC method with correction factor]. | 2011 | Zhongguo Zhong Yao Za Zhi | pmid:22032137 |
| Liu Y et al. | [Corneal penetration of PAMAM dendrimers-coated puerarin liposomes]. | 2010 | Zhongguo Zhong Yao Za Zhi | pmid:20349711 |
| Zhang D et al. | [Isoflavones from vines of Pueraria lobata]. | 2009 | Zhongguo Zhong Yao Za Zhi | pmid:20353004 |
| Han J et al. | [Study on 3'-methoxy puerarin to dynamic changes of amino acids in rat brain ischemia-reperfusion]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:22792810 |
| Jin G et al. | [Effects of puerarin on expression of apelin and its receptor of 2K1C renal hypertension rats]. | 2009 | Zhongguo Zhong Yao Za Zhi | pmid:20353015 |
| Zhang E et al. | [Formulation optimization and drug release in vitro of membrane controlled tablets of puerarin inclusion compound]. | 2013 | Zhongguo Zhong Yao Za Zhi | pmid:23596875 |
| Huang ZG et al. | [Effect of puerarin combined with felodipine on mRNA and protein expression of apelin and APJ in renovascular hypertensive rat]. | 2013 | Zhongguo Zhong Yao Za Zhi | pmid:23668014 |
| Deng Y et al. | [Preparation and lacrimal pharmacokinetics of eye drops of puerarin liposomes in rabbit tears]. | 2010 | Zhongguo Zhong Yao Za Zhi | pmid:20422993 |
| Wang Q and Xu X | [Progresses in research of hemolysis induced by puerarin injection]. | 2011 | Zhongguo Zhong Yao Za Zhi | pmid:21837990 |
| Cheng Y et al. | [Protective effects of puerarin against 1-methyl-4-phenylpyridinium-induced mitochondrial apoptotic death in differentiated SH-SY5Y cells]. | 2011 | Zhongguo Zhong Yao Za Zhi | pmid:21842654 |
| Yu S et al. | [Comparison of constituents in Pueraria thomsonii Benth before and after processing]. | 1992 | Zhongguo Zhong Yao Za Zhi | pmid:1292491 |
| Zhou HY et al. | [Separation and determination of puerarin, daidzin and daidzein in stems and leaves of Pueraria thomsonii by RP-HPLC]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:17655152 |
| Wang XC et al. | [Effect of chaperone-mediated autophagy in MPP(+) -induced SH-SY5Y cells and interventional effect of puerarin]. | 2014 | Zhongguo Zhong Yao Za Zhi | pmid:24754178 |
| Xu XH | [Effects of puerarin on fatty superoxide in aged mice induced by D-galactose]. | 2003 | Zhongguo Zhong Yao Za Zhi | pmid:15015271 |
| Wang L et al. | [Protective effect of puerarin on acute cerebral ischemia in rats]. | 1997 | Zhongguo Zhong Yao Za Zhi | pmid:11243176 |
| Yang H et al. | [Studies on effect of microemulsion in enhancing solubility of baicalin and puerarin]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:18161289 |
| Liu R et al. | [Inhibitory effect of quercetin, rutin and puerarin on LDL oxidation induced by Cu2+]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:18161305 |
| Lv JH et al. | [Improvement effects of puerarin on glycated brain damages in rats induced by D-galactose]. | 2006 | Zhongguo Zhong Yao Za Zhi | pmid:17048591 |
| Zhu H et al. | [Application and characteristics of macroreticular resin in purification study of different effective ingredients in Chinese medicines]. | 1998 | Zhongguo Zhong Yao Za Zhi | pmid:11599359 |