| MeSH term | MeSH ID | Detail |
|---|---|---|
| Brain Infarction | D020520 | 17 associated lipids |
| Stroke | D020521 | 32 associated lipids |
| Chemical and Drug Induced Liver Injury | D056486 | 39 associated lipids |
SCHEMBL105486
Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with SCHEMBL105486?
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
PubChem Associated disorders and diseases
What pathways are associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with SCHEMBL105486?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with SCHEMBL105486?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with SCHEMBL105486?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with SCHEMBL105486?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with SCHEMBL105486?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
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NCBI Entrez Crosslinks
All references with SCHEMBL105486
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Liu S et al. | Puerarin alleviates aggravated sympathoexcitatory response induced by myocardial ischemia via regulating P2X3 receptor in rat superior cervical ganglia. | 2014 | Neurochem. Int. | pmid:24657446 |
| Zhu G et al. | Involvement of activation of PI3K/Akt pathway in the protective effects of puerarin against MPP+-induced human neuroblastoma SH-SY5Y cell death. | 2012 | Neurochem. Int. | pmid:22265823 |
| Liang S et al. | P2X receptors and modulation of pain transmission: focus on effects of drugs and compounds used in traditional Chinese medicine. | 2010 | Neurochem. Int. | pmid:20863868 |
| Yan LP et al. | Analysis of the mechanisms underlying the endothelium-dependent antivasoconstriction of puerarin in rat aorta. | 2009 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:19190894 |
| Tao HQ et al. | HP-β-CD-PLGA nanoparticles improve the penetration and bioavailability of puerarin and enhance the therapeutic effects on brain ischemia-reperfusion injury in rats. | 2013 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:23192284 |
| Li Q et al. | Effect of puerarin on the expression of extracellular matrix in rats with streptozotocin-induced diabetic nephropathy. | 2009 Jan-Feb | Natl Med J India | pmid:19761151 |
| Maji AK et al. | Pueraria tuberosa: a review on its phytochemical and therapeutic potential. | 2014 | Nat. Prod. Res. | pmid:24980468 |
| Xu J et al. | A new flavonoid glycoside from the rhizomes and roots of Smilax scobinicaulis. | 2014 | Nat. Prod. Res. | pmid:24483603 |
| Wang YG et al. | [High-performance capillary electrophoresis for determining the chemical compositions of Gegen and Fenge extracts]. | 2008 | Nan Fang Yi Ke Da Xue Xue Bao | pmid:18753072 |
| Cui SQ | [Effect of puerarin in myocardial protection in rats with acute and chronic alcoholism]. | 2011 | Nan Fang Yi Ke Da Xue Xue Bao | pmid:22200707 |
| Zhang R et al. | [Protective effect of puerarin against calcium overload after focal cerebral ischemia injury in rats]. | 2010 | Nan Fang Yi Ke Da Xue Xue Bao | pmid:20584654 |
| Liao ZG et al. | Improvement of Transmembrane Transport Mechanism Study of Imperatorin on P-Glycoprotein-Mediated Drug Transport. | 2016 | Molecules | pmid:27886150 |
| Su B et al. | Relevance of the Pharmacokinetic and Pharmacodynamic Profiles of Puerariae lobatae Radix to Aggregation of Multi-Component Molecules in Aqueous Decoctions. | 2016 | Molecules | pmid:27367654 |
| Wu S et al. | Study of the Biotransformation of Tongmai Formula by Human Intestinal Flora and Its Intestinal Permeability across the Caco-2 Cell Monolayer. | 2015 | Molecules | pmid:26501241 |
| Shao J et al. | Spectroscopic and molecular docking studies of the in vitro interaction between puerarin and cytochrome P450. | 2014 | Molecules | pmid:24743933 |
| Wang Y et al. | Support Vector Regression Approach to Predict the Design Space for the Extraction Process of . | 2018 | Molecules | pmid:30241281 |
| Ling C et al. | Synergistic Effects of Salvianolic Acid B and Puerarin on Cerebral Ischemia Reperfusion Injury. | 2018 | Molecules | pmid:29498696 |
| Kong H et al. | Pharmacokinetics and Tissue Distribution Kinetics of Puerarin in Rats Using Indirect Competitive ELISA. | 2017 | Molecules | pmid:28587251 |
| Xu R et al. | Two new flavones from Tridax procumbens Linn. | 2010 | Molecules | pmid:20877227 |
| Zhu X et al. | The effect of puerarin against IL-1β-mediated leukostasis and apoptosis in retinal capillary endothelial cells (TR-iBRB2). | 2014 | Mol. Vis. | pmid:25593509 |
| Zhao J et al. | Plant Natural Product Puerarin Ameliorates Depressive Behaviors and Chronic Pain in Mice with Spared Nerve Injury (SNI). | 2017 | Mol. Neurobiol. | pmid:27013468 |
| Zhao J et al. | Botanical Drug Puerarin Attenuates 6-Hydroxydopamine (6-OHDA)-Induced Neurotoxicity via Upregulating Mitochondrial Enzyme Arginase-2. | 2016 | Mol. Neurobiol. | pmid:25952544 |
| Yang L et al. | Puerarin Protects Pancreatic β-Cells in Obese Diabetic Mice via Activation of GLP-1R Signaling. | 2016 | Mol. Endocrinol. | pmid:26789107 |
| Wei S et al. | Effect of puerarin on transcriptome of astrocyte during oxygen-glucose deprivation/reoxygenation injury. | 2017 | Mol. Cell. Biochem. | pmid:27844252 |
| Zhang H et al. | Puerarin: a novel antagonist to inward rectifier potassium channel (IK1). | 2011 | Mol. Cell. Biochem. | pmid:21327545 |
| Teng Y et al. | Protective effect of puerarin on diabetic retinopathy in rats. | 2009 | Mol. Biol. Rep. | pmid:18587665 |
| Shen JG et al. | Effects of puerarin on receptor for advanced glycation end products in nephridial tissue of streptozotocin-induced diabetic rats. | 2009 | Mol. Biol. Rep. | pmid:19125353 |
| Jun M et al. | Suppression of arachidonic acid metabolism and nitric oxide formation by kudzu isoflavones in murine macrophages. | 2005 | Mol Nutr Food Res | pmid:16254887 |
| Hien TT et al. | Molecular mechanism of suppression of MDR1 by puerarin from Pueraria lobata via NF-kappaB pathway and cAMP-responsive element transcriptional activity-dependent up-regulation of AMP-activated protein kinase in breast cancer MCF-7/adr cells. | 2010 | Mol Nutr Food Res | pmid:20077420 |
| Wang C et al. | Puerarin attenuates inflammation and oxidation in mice with collagen antibody-induced arthritis via TLR4/NF-κB signaling. | 2016 | Mol Med Rep | pmid:27278131 |
| Guo XF et al. | Synergistic antitumor effect of puerarin combined with 5-fluorouracil on gastric carcinoma. | 2015 | Mol Med Rep | pmid:25434307 |
| Lv H et al. | Puerarin enhances proliferation and osteoblastic differentiation of human bone marrow stromal cells via a nitric oxide/cyclic guanosine monophosphate signaling pathway. | 2015 | Mol Med Rep | pmid:25892538 |
| Wang J et al. | Synergistic effects of puerarin combined with 5-fluorouracil on esophageal cancer. | 2014 | Mol Med Rep | pmid:25189132 |
| Zhang WG et al. | Puerarin inhibits growth and induces apoptosis in SMMC-7721 hepatocellular carcinoma cells. | 2014 | Mol Med Rep | pmid:25175767 |
| Liang J et al. | Puerarin inhibits caspase-3 expression in osteoblasts of diabetic rats. | 2012 | Mol Med Rep | pmid:22470138 |
| Fu C et al. | Puerarin protects endothelial progenitor cells from damage of angiotensin II via activation of ERK1/2‑Nrf2 signaling pathway. | 2018 | Mol Med Rep | pmid:29359784 |
| Li Y et al. | Effect of puerarin on collagen metabolism of fibroblasts in pelvic tissue of women with pelvic organ prolapse. | 2018 | Mol Med Rep | pmid:29207080 |
| Yao Y et al. | Puerarin inhibits β‑amyloid peptide 1‑42‑induced tau hyperphosphorylation via the Wnt/β‑catenin signaling pathway. | 2017 | Mol Med Rep | pmid:28990074 |
| Zhan XQ et al. | Puerarin promotes the viability and differentiation of MC3T3‑E1 cells by miR‑204‑regulated Runx2 upregulation. | 2017 | Mol Med Rep | pmid:28901520 |
| Wei HY et al. | Puerarin regulates neovascular glaucoma through pigment epithelium‑derived growth factor‑induced NF‑κB signaling pathway. | 2018 | Mol Med Rep | pmid:29620183 |
| Guo BQ et al. | Puerarin reduces ischemia/reperfusion-induced myocardial injury in diabetic rats via upregulation of vascular endothelial growth factor A/angiotensin-1 and suppression of apoptosis. | 2018 | Mol Med Rep | pmid:29568939 |
| Wang T et al. | Puerarin promotes MIN6 cell survival by reducing cellular reactive oxygen species. | 2018 | Mol Med Rep | pmid:29568901 |
| Tang H et al. | Puerarin attenuates myocardial hypoxia/reoxygenation injury by inhibiting autophagy via the Akt signaling pathway. | 2017 | Mol Med Rep | pmid:28393209 |
| Liu G et al. | Recent Advances in Methods of Puerarin Biotransformation. | 2016 | Mini Rev Med Chem | pmid:27145856 |
| Wang X et al. | Puerarin prevents LPS-induced acute lung injury via inhibiting inflammatory response. | 2018 | Microb. Pathog. | pmid:29571724 |
| Tang F et al. | Puerarin protects against Staphylococcus aureus-induced injury of human alveolar epithelial A549 cells via downregulating alpha-hemolysin secretion. | 2014 | Microb. Drug Resist. | pmid:24372183 |
| Zhang XP et al. | Protective effects of ligustrazine, kakonein and Panax notoginsenosides on multiple organs in rats with severe acute pancreatitis. | 2010 | Methods Find Exp Clin Pharmacol | pmid:21225014 |
| Liu X et al. | Puerarin ameliorates cognitive deficits in streptozotocin-induced diabetic rats. | 2016 | Metab Brain Dis | pmid:26686502 |
| Zheng QH et al. | Efficacy and safety of puerarin injection in curing acute ischemic stroke: A meta-analysis of randomized controlled trials. | 2017 | Medicine (Baltimore) | pmid:28072733 |
| Gruber JV and Holtz R | Examining the genomic influence of skin antioxidants in vitro. | 2010 | Mediators Inflamm. | pmid:20706672 |