| MeSH term | MeSH ID | Detail |
|---|---|---|
| Brain Infarction | D020520 | 17 associated lipids |
| Stroke | D020521 | 32 associated lipids |
| Chemical and Drug Induced Liver Injury | D056486 | 39 associated lipids |
SCHEMBL105486
Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with SCHEMBL105486?
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
PubChem Associated disorders and diseases
What pathways are associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with SCHEMBL105486?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with SCHEMBL105486?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with SCHEMBL105486?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with SCHEMBL105486?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with SCHEMBL105486?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with SCHEMBL105486
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Liu CM et al. | Puerarin protects the rat liver against oxidative stress-mediated DNA damage and apoptosis induced by lead. | 2012 | Exp. Toxicol. Pathol. | pmid:21146379 |
| Fan R et al. | Ethnopharmacokinetic- and activity-guided isolation of a new antidepressive compound from fructus aurantii found in the traditional chinese medicine chaihu-shugan-san: a new approach and its application. | 2012 | Evid Based Complement Alternat Med | pmid:22454671 |
| Zhu G et al. | Involvement of activation of PI3K/Akt pathway in the protective effects of puerarin against MPP+-induced human neuroblastoma SH-SY5Y cell death. | 2012 | Neurochem. Int. | pmid:22265823 |
| Zheng GM et al. | Puerarin suppresses production of nitric oxide and inducible nitric oxide synthase in lipopolysaccharide-induced N9 microglial cells through regulating MAPK phosphorylation, O-GlcNAcylation and NF-κB translocation. | 2012 | Int. J. Oncol. | pmid:22246431 |
| Lin F et al. | Protective effect of Puerarin on β-amyloid-induced neurotoxicity in rat hippocampal neurons. | 2012 | Arzneimittelforschung | pmid:22278629 |
| Tang XL et al. | Dynamic oxidative stress and DNA damage induced by oestrogen deficiency and protective effects of puerarin and 17β-oestradiol in ovariectomized rats. | 2012 | Basic Clin. Pharmacol. Toxicol. | pmid:22333267 |
| Huang F et al. | Puerarin attenuates endothelial insulin resistance through inhibition of inflammatory response in an IKKβ/IRS-1-dependent manner. | 2012 | Biochimie | pmid:22314193 |
| Coghlan ML et al. | Deep sequencing of plant and animal DNA contained within traditional Chinese medicines reveals legality issues and health safety concerns. | 2012 | PLoS Genet. | pmid:22511890 |
| Yang F et al. | Osteoblast response to puerarin-loaded porous titanium surfaces: an in vitro study. | 2012 | J Biomed Mater Res A | pmid:22374837 |
| Zhang H et al. | Insight into the structural deformations of beta-cyclodextrin caused by alcohol cosolvents and guest molecules. | 2012 | J Phys Chem B | pmid:22376204 |
| Hou Q et al. | [Puerarin combined with avandia for diabetic nephropathy]. | 2012 | Zhong Nan Da Xue Xue Bao Yi Xue Ban | pmid:22349389 |
| Liu L et al. | Determination of puerarin in pharmaceutical and biological samples by capillary zone electrophoresis with UV detection. | 2012 | Talanta | pmid:22365684 |
| Zhang Y et al. | Characterization and evaluation of self-microemulsifying sustained-release pellet formulation of puerarin for oral delivery. | 2012 | Int J Pharm | pmid:22366381 |
| Deng L et al. | [Effect of catalpol and puerarin freeze-dried powder on coagulability, hemorheology and no in rats with Qi-deficiency and blood-stasis syndrome]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:22860464 |
| Liang X et al. | [Intestinal absorption effect of Angelica dahurica extract on puerarin of puerariae Lobatae Radix]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:22860465 |
| Xue C et al. | [Determination of five components in Pueraria labta decoction with reference extraction method]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:23234135 |
| Sun XY et al. | [Optimal extraction of puerarin from Pueraria lobata based on central composite design and response surface methodology]. | 2012 | Zhong Yao Cai | pmid:23236837 |
| Chen YY et al. | Puerarin protects human umbilical vein endothelial cells against high glucose-induced apoptosis by upregulating heme oxygenase-1 and inhibiting calpain activation. | 2012 | Fundam Clin Pharmacol | pmid:21352351 |
| Hu JJ et al. | [Effect of pretreatment with puerarin on activation of LPS-induced RAW264. 7 cells]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:23311164 |
| Liu XY et al. | [Stability of PEGylated puerarin under different storage conditions]. | 2012 | Zhongguo Zhong Yao Za Zhi | pmid:23373208 |
| Luo J and Xu H | Outcome measures of chinese herbal medicine for coronary heart disease: an overview of systematic reviews. | 2012 | Evid Based Complement Alternat Med | pmid:22606207 |
| Yan F et al. | Effects of some antihypertensive drugs on the metabolism and pharmacokinetics of indapamide in rats. | 2012 | J Pharm Pharm Sci | pmid:22579001 |
| Wang J and Xiong X | Current situation and perspectives of clinical study in integrative medicine in china. | 2012 | Evid Based Complement Alternat Med | pmid:22550539 |
| Jiang H et al. | Natural product nitric oxide chemistry: new activity of old medicines. | 2012 | Evid Based Complement Alternat Med | pmid:22548122 |
| Qiu Y et al. | Traditional chinese herbal products for coronary heart disease: an overview of cochrane reviews. | 2012 | Evid Based Complement Alternat Med | pmid:22536282 |
| Yang R et al. | Determination of puerarin in biological samples and its application to a pharmacokinetic study by flow-injection chemiluminescence. | 2011 Sep-Oct | Luminescence | pmid:21547999 |
| Zhao C et al. | Rapid simultaneous determination of major isoflavones of Pueraria lobata and discriminative analysis of its geographical origins by principal component analysis. | 2011 Nov-Dec | Phytochem Anal | pmid:21495105 |
| Chauhan NS et al. | Spectrofluorimetric estimation of puerarin in Pueraria tuberosa. | 2011 May-Jun | Acta Pol Pharm | pmid:21648202 |
| Qin P et al. | Characterization and selectivity studies of molecular imprinted membranes of Puerarin using scanning electron microscopy. | 2011 Jan-Feb | Scanning | pmid:21246571 |
| Liu IM and Cheng JT | Mediation of Endogenous β-Endorphin in the Plasma Glucose-Lowering Action of Herbal Products Observed in Type 1-Like Diabetic Rats. | 2011 | Evid Based Complement Alternat Med | pmid:19095661 |
| Xing G et al. | Neuroprotective effects of puerarin against beta-amyloid-induced neurotoxicity in PC12 cells via a PI3K-dependent signaling pathway. | 2011 | Brain Res. Bull. | pmid:21473901 |
| Hou SZ et al. | Role of the interaction between puerarin and the erythrocyte membrane in puerarin-induced hemolysis. | 2011 | Chem. Biol. Interact. | pmid:21453687 |
| Luo CF et al. | Determination of puerarin in rat plasma by rapid resolution liquid chromatography tandem mass spectrometry in positive ionization mode. | 2011 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:21511546 |
| Yu A et al. | Formulation optimization and bioavailability after oral and nasal administration in rabbits of puerarin-loaded microemulsion. | 2011 | J Pharm Sci | pmid:20862776 |
| Zhang H et al. | Puerarin protects Alzheimer's disease neuronal cybrids from oxidant-stress induced apoptosis by inhibiting pro-death signaling pathways. | 2011 | Exp. Gerontol. | pmid:20933077 |
| Zhang L et al. | Intestinal absorbability of three Radix Puerariae isoflavones including daidzein, daidzin and puerarin. | 2011 | Chin Med | pmid:22108408 |
| Cui SQ | [Effect of puerarin in myocardial protection in rats with acute and chronic alcoholism]. | 2011 | Nan Fang Yi Ke Da Xue Xue Bao | pmid:22200707 |
| Zhang XP et al. | Protective effects of Ligustrazine, Kakonein and Panax Notoginsenoside on the small intestine and immune organs of rats with severe acute pancreatitis. | 2011 | HBPD INT | pmid:22146628 |
| Zhang H et al. | Puerarin: a novel antagonist to inward rectifier potassium channel (IK1). | 2011 | Mol. Cell. Biochem. | pmid:21327545 |
| Yao C et al. | [Ocular pharmacokinetics of puerarin in anesthetic rabbits by microdialysis]. | 2011 | Zhongguo Zhong Yao Za Zhi | pmid:22097338 |
| Zhang X et al. | [Puerarin induced apoptosis of pulmonary artery smooth muscle cell by mitochondrial pathway]. | 2011 | Zhongguo Zhong Yao Za Zhi | pmid:22097342 |
| Chen X et al. | [Study on pharmacokinetics of puerarin in rats following different methods of administration of Tongqiao Sanyu prescription]. | 2011 | Zhongguo Zhong Yao Za Zhi | pmid:22121800 |
| Hsiang SW et al. | Puerarin accelerates peripheral nerve regeneration. | 2011 | Am. J. Chin. Med. | pmid:22083991 |
| Chen L et al. | [Flavonoids of puerarin versus tanshinone II A for ischemic stroke: a randomized controlled trial]. | 2011 | Zhong Xi Yi Jie He Xue Bao | pmid:22088587 |
| Lipovac M et al. | Effect of Red Clover Isoflavones over Skin, Appendages, and Mucosal Status in Postmenopausal Women. | 2011 | Obstet Gynecol Int | pmid:22135679 |
| Li X et al. | Puerarin alleviates burn-related procedural pain mediated by P2X(3) receptors. | 2011 | Purinergic Signal. | pmid:21833698 |
| Kalani M and Yunus R | Application of supercritical antisolvent method in drug encapsulation: a review. | 2011 | Int J Nanomedicine | pmid:21796245 |
| Pan SY et al. | New perspectives on chinese herbal medicine (zhong-yao) research and development. | 2011 | Evid Based Complement Alternat Med | pmid:21785622 |
| Kim Y et al. | Novel PI3K/Akt inhibitors screened by the cytoprotective function of human immunodeficiency virus type 1 Tat. | 2011 | PLoS ONE | pmid:21765914 |
| Su SY and Hsieh CL | Anti-inflammatory effects of Chinese medicinal herbs on cerebral ischemia. | 2011 | Chin Med | pmid:21740583 |