| MeSH term | MeSH ID | Detail |
|---|---|---|
| Liver Cirrhosis | D008103 | 67 associated lipids |
| Memory Disorders | D008569 | 33 associated lipids |
| Parkinson Disease | D010300 | 53 associated lipids |
| Urinary Incontinence | D014549 | 4 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Glucose Intolerance | D018149 | 13 associated lipids |
| Alcohol-Related Disorders | D019973 | 3 associated lipids |
| Infarction, Middle Cerebral Artery | D020244 | 35 associated lipids |
| Ventricular Remodeling | D020257 | 28 associated lipids |
| Neurotoxicity Syndromes | D020258 | 34 associated lipids |
SCHEMBL105486
Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with SCHEMBL105486?
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
PubChem Associated disorders and diseases
What pathways are associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with SCHEMBL105486?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with SCHEMBL105486?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with SCHEMBL105486?
Related references are published most in these journals:
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What genes are associated with SCHEMBL105486?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with SCHEMBL105486?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
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NCBI Entrez Crosslinks
All references with SCHEMBL105486
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Luo CF et al. | Pharmacokinetics, tissue distribution and relative bioavailability of puerarin solid lipid nanoparticles following oral administration. | 2011 | Int J Pharm | pmid:21392565 |
| Xu HX et al. | [Mechanism of advanced glycation end-products in the inducement of apoptosis of human gingival fibroblast and related effect of puerarin in the process]. | 2011 | Zhonghua Kou Qiang Yi Xue Za Zhi | pmid:21418943 |
| Xing G et al. | Neuroprotective effects of puerarin against beta-amyloid-induced neurotoxicity in PC12 cells via a PI3K-dependent signaling pathway. | 2011 | Brain Res. Bull. | pmid:21473901 |
| Hou SZ et al. | Role of the interaction between puerarin and the erythrocyte membrane in puerarin-induced hemolysis. | 2011 | Chem. Biol. Interact. | pmid:21453687 |
| Luo CF et al. | Determination of puerarin in rat plasma by rapid resolution liquid chromatography tandem mass spectrometry in positive ionization mode. | 2011 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:21511546 |
| Yu A et al. | Formulation optimization and bioavailability after oral and nasal administration in rabbits of puerarin-loaded microemulsion. | 2011 | J Pharm Sci | pmid:20862776 |
| Zhang H et al. | Puerarin protects Alzheimer's disease neuronal cybrids from oxidant-stress induced apoptosis by inhibiting pro-death signaling pathways. | 2011 | Exp. Gerontol. | pmid:20933077 |
| Wang G et al. | Implication of the c-Jun-NH2-terminal kinase pathway in the neuroprotective effect of puerarin against 1-methyl-4-phenylpyridinium (MPP+)-induced apoptosis in PC-12 cells. | 2011 | Neurosci. Lett. | pmid:20934486 |
| Tian F et al. | The optimal therapeutic timing and mechanism of puerarin treatment of spinal cord ischemia-reperfusion injury in rats. | 2011 | J Ethnopharmacol | pmid:21296138 |
| He X et al. | A genomic approach to isoflavone biosynthesis in kudzu (Pueraria lobata). | 2011 | Planta | pmid:21221632 |
| Zhao J et al. | MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula. | 2011 | Plant Cell | pmid:21467581 |
| Braune A and Blaut M | Deglycosylation of puerarin and other aromatic C-glucosides by a newly isolated human intestinal bacterium. | 2011 | Environ. Microbiol. | pmid:20946528 |
| Lv Y et al. | Preparation of monomeric and polymeric β-cyclodextrin functionalized monoliths for rapid isolation and purification of puerarin from Radix puerariae. | 2011 | J Sep Sci | pmid:21766485 |
| Noh BK et al. | Restoration of autophagy by puerarin in ethanol-treated hepatocytes via the activation of AMP-activated protein kinase. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21964292 |
| Liu CM et al. | Protective role of puerarin on lead-induced alterations of the hepatic glutathione antioxidant system and hyperlipidemia in rats. | 2011 | Food Chem. Toxicol. | pmid:22001170 |
| Yu M et al. | Analysis of binding interaction between pegylated puerarin and bovine serum albumin by spectroscopic methods and dynamic light scattering. | 2011 | Spectrochim Acta A Mol Biomol Spectrosc | pmid:21945127 |
| Wang D et al. | Puerarin suppresses invasion and vascularization of endometriosis tissue stimulated by 17β-estradiol. | 2011 | PLoS ONE | pmid:21949833 |
| Zhang NB et al. | Effects of puerarin on expression of cardiac Smad3 and Smad7 mRNA in spontaneously hypertensive rat. | 2011 | J Ethnopharmacol | pmid:22027447 |
| Chen R et al. | [Simultaneous quantification of five impurities in puerarin and its injections by HPLC method with correction factor]. | 2011 | Zhongguo Zhong Yao Za Zhi | pmid:22032137 |
| Chen XX et al. | [Pharmacokinetics and bioavailability of Puerarin self-microemulsion in Beagle dogs]. | 2011 | Zhong Yao Cai | pmid:21954564 |
| Pan ZJ et al. | [Effects of puerarin on blood pressure, blood lipid and renal structure of cold-induced hypertensive mice]. | 2011 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:22295519 |
| Mazzio EA et al. | The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's disease. | 2011 | Int J Mol Sci | pmid:21340000 |
| Chen C et al. | [Effects of puerarin on proliferation, apoptosis and Kv1.5 gene expression of pulmonary artery smooth muscle cells induced by hypoxia]. | 2011 | Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi | pmid:22357486 |
| Pongkitwitoon B et al. | Development of an enzyme-linked immunosorbent assay to determine puerarin and its aglycone daidzein. | 2011 | J Nat Med | pmid:20658197 |
| Zhang R et al. | [Effect of puerarin on the expression of NMDA receptor in the hippocampus CA1 region after focal cerebral ischemia in rats]. | 2011 | Sichuan Da Xue Xue Bao Yi Xue Ban | pmid:21355301 |
| Chen L et al. | [Flavonoids of puerarin versus tanshinone II A for ischemic stroke: a randomized controlled trial]. | 2011 | Zhong Xi Yi Jie He Xue Bao | pmid:22088587 |
| Hu W et al. | Puerarin inhibits iNOS, COX-2 and CRP expression via suppression of NF-κB activation in LPS-induced RAW264.7 macrophage cells. | 2011 | Pharmacol Rep | pmid:21857089 |
| Han RM et al. | Phenol acidity and ease of oxidation in isoflavonoid/β-carotene antioxidant synergism. | 2011 | J. Agric. Food Chem. | pmid:21863887 |
| Barnes S et al. | The metabolism and analysis of isoflavones and other dietary polyphenols in foods and biological systems. | 2011 | Food Funct | pmid:21779561 |
| Cai X et al. | [Detection of drug-human serum albumin binding ratios of two Chinese medicinal ingredients by high performance affinity chromatography]. | 2011 | Se Pu | pmid:21770248 |
| Wang Q and Xu X | [Progresses in research of hemolysis induced by puerarin injection]. | 2011 | Zhongguo Zhong Yao Za Zhi | pmid:21837990 |
| Cheng Y et al. | [Protective effects of puerarin against 1-methyl-4-phenylpyridinium-induced mitochondrial apoptotic death in differentiated SH-SY5Y cells]. | 2011 | Zhongguo Zhong Yao Za Zhi | pmid:21842654 |
| Tanaka T et al. | Kudzu (Pueraria lobata) vine ethanol extracts improve ovariectomy-induced bone loss in female mice. | 2011 | J. Agric. Food Chem. | pmid:22053809 |
| Cai H et al. | [Effects of puerarin on proliferation and differentiation of umbilical cord mesenchymal stem cells into osteoblasts in vitro]. | 2011 | Yao Xue Xue Bao | pmid:21882538 |
| Liu G et al. | Hydroxylation modification and free radical scavenging activity of puerarin-7-O-fructoside. | 2011 | Folia Microbiol. (Praha) | pmid:21818614 |
| Hwang YP et al. | Puerarin activates endothelial nitric oxide synthase through estrogen receptor-dependent PI3-kinase and calcium-dependent AMP-activated protein kinase. | 2011 | Toxicol. Appl. Pharmacol. | pmid:21884717 |
| Liu R et al. | Gelucire44/14 as a novel absorption enhancer for drugs with different hydrophilicities: in vitro and in vivo improvement on transcorneal permeation. | 2011 | J Pharm Sci | pmid:21416467 |
| Yao C et al. | Effects of poly(amidoamine) dendrimers on ocular absorption of puerarin using microdialysis. | 2011 | J Ocul Pharmacol Ther | pmid:21895496 |
| Gasser P et al. | Glycation induction and antiglycation activity of skin care ingredients on living human skin explants. | 2011 | Int J Cosmet Sci | pmid:21401648 |
| Hao LN et al. | Inducible nitric oxide synthase and Fas/FasL with C3 expression of mouse retinal pigment epithelial cells in response to stimulation by peroxynitrite and antagonism of puerarin. | 2011 | Chin. Med. J. | pmid:21933599 |
| Baranowska I et al. | UHPLC method for the simultaneous determination of β-blockers, isoflavones and their metabolites in human urine. | 2011 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:21345747 |
| Wong KH et al. | Kudzu root: traditional uses and potential medicinal benefits in diabetes and cardiovascular diseases. | 2011 | J Ethnopharmacol | pmid:21315814 |
| Wang WY et al. | Determination of puerarin in rabbit aqueous humor by liquid chromatography tandem mass spectrometry using microdialysis sampling after topical administration of puerarin PAMAM dendrimer complex. | 2011 | J Pharm Biomed Anal | pmid:21831555 |
| Zhao R et al. | NMR studies on puerarin and its interaction with beta-cyclodextrin. | 2011 | J Biol Phys | pmid:22942483 |
| Su SY and Hsieh CL | Anti-inflammatory effects of Chinese medicinal herbs on cerebral ischemia. | 2011 | Chin Med | pmid:21740583 |
| Zhang CL et al. | Comparative study of Puerariae lobatae and Puerariae thomsonii by HPLC-diode array detection-flow injection-chemiluminescence coupled with HPLC-electrospray ionization-MS. | 2011 | Chem. Pharm. Bull. | pmid:21532189 |
| Wong SM et al. | Myocardial post-conditioning with Danshen-Gegen decoction protects against isoproterenol-induced myocardial injury via a PKCε/mKATP-mediated pathway in rats. | 2011 | Chin Med | pmid:21320349 |
| Hao LN et al. | Toxicity of endogenous peroxynitrite and effects of puerarin on transplanted retinal pigment epithelial sheets in the subretinal space in mice. | 2011 | Int J Ophthalmol | pmid:22553655 |
| Kim J et al. | KIOM-79 Prevents Lens Epithelial Cell Apoptosis and Lens Opacification in Zucker Diabetic Fatty Rats. | 2011 | Evid Based Complement Alternat Med | pmid:20953387 |
| Baranowska I and Magiera S | Analysis of isoflavones and flavonoids in human urine by UHPLC. | 2011 | Anal Bioanal Chem | pmid:20936271 |
| Xie W and Du L | Diabetes is an inflammatory disease: evidence from traditional Chinese medicines. | 2011 | Diabetes Obes Metab | pmid:21205111 |
| Lee OH et al. | Puerarin enhances adipocyte differentiation, adiponectin expression, and antioxidant response in 3T3-L1 cells. | 2010 Nov-Dec | Biofactors | pmid:20806284 |
| Zhou J et al. | Puerarin attenuates glutamate-induced neurofilament axonal transport impairment. | 2010 | J Ethnopharmacol | pmid:20727960 |
| Chen Y et al. | [Effect of puerarin on action potential and inward rectifier potassium current in rat myocardium]. | 2010 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:20684293 |
| Liu X et al. | A HPLC-UV method for the determination of puerarin in rat plasma after intravenous administration of PEGylated puerarin conjugate. | 2010 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:21056017 |
| Feng ZQ et al. | The synthesis of puerarin derivatives and their protective effect on the myocardial ischemia and reperfusion injury. | 2010 | J Asian Nat Prod Res | pmid:20924897 |
| Li J et al. | Puerarin attenuates amyloid-beta-induced cognitive impairment through suppression of apoptosis in rat hippocampus in vivo. | 2010 | Eur. J. Pharmacol. | pmid:20868658 |
| Zhang W et al. | Puerarin improves insulin resistance and modulates adipokine expression in rats fed a high-fat diet. | 2010 | Eur. J. Pharmacol. | pmid:20869961 |
| Zhang HY et al. | [The protective effect of puerarin on Abeta(25-35)-induced PC12 cell injury]. | 2010 | Zhong Yao Cai | pmid:20873562 |
| Rudra A et al. | Doxorubicin-loaded phosphatidylethanolamine-conjugated nanoliposomes: in vitro characterization and their accumulation in liver, kidneys, and lungs in rats. | 2010 | Int J Nanomedicine | pmid:21042545 |
| Zhu L et al. | [Molecular mechanism of protective effect of puerarin solid lipid nanoparticle on cerebral ischemia-reperfusion injury in gerbils]. | 2010 | Zhong Yao Cai | pmid:21548369 |
| Boonchird C et al. | Differential binding with ERalpha and ERbeta of the phytoestrogen-rich plant Pueraria mirifica. | 2010 | Braz. J. Med. Biol. Res. | pmid:20027484 |
| Yang X et al. | Puerarin inhibits C-reactive protein expression via suppression of nuclear factor kappaB activation in lipopolysaccharide-induced peripheral blood mononuclear cells of patients with stable angina pectoris. | 2010 | Basic Clin. Pharmacol. Toxicol. | pmid:20346059 |
| Liu Y et al. | [Corneal penetration of PAMAM dendrimers-coated puerarin liposomes]. | 2010 | Zhongguo Zhong Yao Za Zhi | pmid:20349711 |
| Liu XJ et al. | The effects of genistein and puerarin on the activation of nuclear factor-kappaB and the production of tumor necrosis factor-alpha in asthma patients. | 2010 | Pharmazie | pmid:20225658 |
| Bai QH et al. | [Puerarin antagonizes activation effect of LPS on N9 microglia cells]. | 2010 | Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi | pmid:20230684 |
| Choi CH et al. | Enzymatic synthesis of glycosylated puerarin using maltogenic amylase from Bacillus stearothermophilus expressed in Bacillus subtilis. | 2010 | J. Sci. Food Agric. | pmid:20393999 |
| Zhao M et al. | Protective effect of puerarin on acute alcoholic liver injury. | 2010 | Am. J. Chin. Med. | pmid:20387222 |
| Luo CF et al. | Metabolites of puerarin identified by liquid chromatography tandem mass spectrometry: similar metabolic profiles in liver and intestine of rats. | 2010 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:20006564 |
| Hu W et al. | Puerarin inhibits adhesion molecule expression in tnf-alpha-stimulated human endothelial cells via modulation of the nuclear factor kappaB pathway. | 2010 | Pharmacology | pmid:20016245 |
| Shao HM et al. | [Inhibitory effect of flavonoids of puerarin on proliferation of different human acute myeloid leukemia cell lines in vitro]. | 2010 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:20416155 |
| Semalty A et al. | Development and evaluation of pharmacosomes of aceclofenac. | 2010 | Indian J Pharm Sci | pmid:21694988 |
| Tang YH et al. | [Apoptosis of NB4 cells induced by flavonoids of puerarin in vitro]. | 2010 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:20416161 |
| Gao C et al. | Pharmacokinetic interaction between puerarin and edaravone, and effect of borneol on the brain distribution kinetics of puerarin in rats. | 2010 | J. Pharm. Pharmacol. | pmid:20487220 |
| Zhang H et al. | Investigation of the inclusions of puerarin and daidzin with beta-cyclodextrin by molecular dynamics simulation. | 2010 | J Phys Chem B | pmid:20297792 |
| Kato E and Kawabata J | Glucose uptake enhancing activity of puerarin and the role of C-glucoside suggested from activity of related compounds. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20605096 |
| Liu X et al. | A validated stability-indicating HPLC method for the determination of PEGylated puerarin in aqueous solutions. | 2010 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:20580327 |
| Zhang R et al. | [Protective effect of puerarin against calcium overload after focal cerebral ischemia injury in rats]. | 2010 | Nan Fang Yi Ke Da Xue Xue Bao | pmid:20584654 |
| Yao W et al. | Preparation and characterization of puerarin-dendrimer complexes as an ocular drug delivery system. | 2010 | Drug Dev Ind Pharm | pmid:20545508 |
| Xu J et al. | PVA hydrogels containing beta-cyclodextrin for enhanced loading and sustained release of ocular therapeutics. | 2010 | J Biomater Sci Polym Ed | pmid:20507706 |
| Zhang Z et al. | Preventive effects of Flos Perariae (Gehua) water extract and its active ingredient puerarin in rodent alcoholism models. | 2010 | Chin Med | pmid:20974012 |
| Zhu G et al. | Puerarin protects dopaminergic neurons against 6-hydroxydopamine neurotoxicity via inhibiting apoptosis and upregulating glial cell line-derived neurotrophic factor in a rat model of Parkinson's disease. | 2010 | Planta Med. | pmid:20509103 |
| Malaivijitnond S et al. | Puerarin exhibits weak estrogenic activity in female rats. | 2010 | Fitoterapia | pmid:20117180 |
| Zheng J et al. | The effects of puerarin on CYP2D6 and CYP1A2 activities in vivo. | 2010 | Arch. Pharm. Res. | pmid:20195825 |
| Xu J et al. | Preparation and evaluation of a contact lens vehicle for puerarin delivery. | 2010 | J Biomater Sci Polym Ed | pmid:20178685 |
| Hien TT et al. | Molecular mechanism of suppression of MDR1 by puerarin from Pueraria lobata via NF-kappaB pathway and cAMP-responsive element transcriptional activity-dependent up-regulation of AMP-activated protein kinase in breast cancer MCF-7/adr cells. | 2010 | Mol Nutr Food Res | pmid:20077420 |
| Kim KM et al. | Puerarin suppresses AGEs-induced inflammation in mouse mesangial cells: a possible pathway through the induction of heme oxygenase-1 expression. | 2010 | Toxicol. Appl. Pharmacol. | pmid:20060010 |
| Pongkitwitoon B et al. | Enzyme-linked immunosorbent assay for total isoflavonoids in Pueraria candollei using anti-puerarin and anti-daidzin polyclonal antibodies. | 2010 | Planta Med. | pmid:20033865 |
| Deng Y et al. | [Preparation and lacrimal pharmacokinetics of eye drops of puerarin liposomes in rabbit tears]. | 2010 | Zhongguo Zhong Yao Za Zhi | pmid:20422993 |
| Yao H et al. | [The role of mitochondrial K+ channels in the cardioprotection of puerarin against hypoxia/reoxygenation injury in rats]. | 2010 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21328988 |
| Liang S et al. | P2X receptors and modulation of pain transmission: focus on effects of drugs and compounds used in traditional Chinese medicine. | 2010 | Neurochem. Int. | pmid:20863868 |
| Choi CW et al. | Yeast α-glucosidase inhibition by isoflavones from plants of Leguminosae as an in vitro alternative to acarbose. | 2010 | J. Agric. Food Chem. | pmid:20734984 |
| Chen TR et al. | Evaluation of quality of Radix Puerariae herbal medicine by isoflavonoids. | 2010 | J. Pharm. Pharmacol. | pmid:20609068 |
| Fan X et al. | Pharmacological neuroprotection after perinatal hypoxic-ischemic brain injury. | 2010 | Curr Neuropharmacol | pmid:21629441 |
| Chen CC et al. | Hazardous effects of curcumin on mouse embryonic development through a mitochondria-dependent apoptotic signaling pathway. | 2010 | Int J Mol Sci | pmid:21152277 |
| Li Q et al. | Neuroprotective properties of picroside II in a rat model of focal cerebral ischemia. | 2010 | Int J Mol Sci | pmid:21151457 |
| Xu R et al. | Two new flavones from Tridax procumbens Linn. | 2010 | Molecules | pmid:20877227 |
| Lee IK et al. | Compound K, a metabolite of ginseng saponin, induces mitochondria-dependent and caspase-dependent apoptosis via the generation of reactive oxygen species in human colon cancer cells. | 2010 | Int J Mol Sci | pmid:21614182 |
| O'Brien KA | Alternative perspectives: how chinese medicine understands hypercholesterolemia. | 2010 | Cholesterol | pmid:21490916 |
| Patel RP and Barnes S | Isoflavones and PPAR Signaling: A Critical Target in Cardiovascular, Metastatic, and Metabolic Disease. | 2010 | PPAR Res | pmid:21461045 |