| MeSH term | MeSH ID | Detail |
|---|---|---|
| Liver Cirrhosis | D008103 | 67 associated lipids |
| Memory Disorders | D008569 | 33 associated lipids |
| Parkinson Disease | D010300 | 53 associated lipids |
| Urinary Incontinence | D014549 | 4 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Glucose Intolerance | D018149 | 13 associated lipids |
| Alcohol-Related Disorders | D019973 | 3 associated lipids |
| Infarction, Middle Cerebral Artery | D020244 | 35 associated lipids |
| Ventricular Remodeling | D020257 | 28 associated lipids |
| Neurotoxicity Syndromes | D020258 | 34 associated lipids |
SCHEMBL105486
Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with SCHEMBL105486?
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
PubChem Associated disorders and diseases
What pathways are associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with SCHEMBL105486?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with SCHEMBL105486?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with SCHEMBL105486?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with SCHEMBL105486?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with SCHEMBL105486?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with SCHEMBL105486
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Liu AC et al. | LC-MS/MS method for the determination of a new puerarin derivative and its application in pharmacokinetic studies in rats. | 2013 | Chin J Nat Med | pmid:24359785 |
| Song J et al. | Simultaneous determination of multiple marker constituents in concentrated Gegen Tang granule by high performance liquid chromatography. | 2007 | Chin Med | pmid:17578586 |
| Zhang L et al. | Intestinal absorbability of three Radix Puerariae isoflavones including daidzein, daidzin and puerarin. | 2011 | Chin Med | pmid:22108408 |
| Zhang Z et al. | Preventive effects of Flos Perariae (Gehua) water extract and its active ingredient puerarin in rodent alcoholism models. | 2010 | Chin Med | pmid:20974012 |
| Su SY and Hsieh CL | Anti-inflammatory effects of Chinese medicinal herbs on cerebral ischemia. | 2011 | Chin Med | pmid:21740583 |
| Wong SM et al. | Myocardial post-conditioning with Danshen-Gegen decoction protects against isoproterenol-induced myocardial injury via a PKCε/mKATP-mediated pathway in rats. | 2011 | Chin Med | pmid:21320349 |
| Yao M et al. | Quantitative analysis of two isoflavones in Pueraria lobata flowers from eleven Chinese provinces using high performance liquid chromatography. | 2010 | Chin Med | pmid:20416072 |
| Sang HF et al. | Effect of puerarin on neural function and histopathological damages after transient spinal cord ischemia in rabbits. | 2004 | Chin. J. Traumatol. | pmid:15294110 |
| Fan LL et al. | The protective effect of puerarin against myocardial reperfusion injury. Study on cardiac function. | 1992 | Chin. Med. J. | pmid:1576864 |
| Lu XR et al. | Puerarin beta-adrenergic receptor blocking effect. | 1987 | Chin. Med. J. | pmid:2885157 |
| Sheu SY et al. | Stimulatory effect of puerarin on bone formation through co-activation of nitric oxide and bone morphogenetic protein-2/mitogen-activated protein kinases pathways in mice. | 2012 | Chin. Med. J. | pmid:23075718 |
| Fan LL et al. | Pharmacologic studies on radix puerariae: effect of puerarin on regional myocardial blood flow and cardiac hemodynamics in dogs with acute myocardial ischemia. | 1985 | Chin. Med. J. | pmid:3938713 |
| Hao LN et al. | Inducible nitric oxide synthase and Fas/FasL with C3 expression of mouse retinal pigment epithelial cells in response to stimulation by peroxynitrite and antagonism of puerarin. | 2011 | Chin. Med. J. | pmid:21933599 |
| Fan LL et al. | Protective effect of puerarin against myocardial reperfusion injury. Myocardial metabolism and ultrastructure. | 1992 | Chin. Med. J. | pmid:1451545 |
| Qian Y et al. | Blocking effect of puerarin on calcium channel in isolated guinea pig ventricular myocytes. | 1999 | Chin. Med. J. | pmid:11717945 |
| O'Brien KA | Alternative perspectives: how chinese medicine understands hypercholesterolemia. | 2010 | Cholesterol | pmid:21490916 |
| Yan H et al. | Treating senile dementia with traditional Chinese medicine. | 2007 | Clin Interv Aging | pmid:18044136 |
| Kim Y et al. | Pharmacokinetics and Safety of DW1029M, a Botanical Drug for the Treatment of Diabetic Nephropathy, Following Single Doses in Healthy Subjects. | 2017 | Clin Pharmacol Drug Dev | pmid:28301092 |
| Li X et al. | Puerarin protects against endothelial dysfunction and end-organ damage in Ang II-induced hypertension. | 2017 | Clin. Exp. Hypertens. | pmid:28060542 |
| Wang D et al. | Automated On-Line Microdialysis Sampling Coupled with HPLC for Synchronous Determination of Puerarin in Subcutaneous Tissue and Plasma Following Topical Administration. | 2015 | Clin. Lab. | pmid:26554250 |