| MeSH term | MeSH ID | Detail |
|---|---|---|
| Coronary Disease | D003327 | 70 associated lipids |
| Ischemic Attack, Transient | D002546 | 42 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Cataract | D002386 | 34 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Arthritis | D001168 | 41 associated lipids |
| Angina, Unstable | D000789 | 14 associated lipids |
| Angina Pectoris | D000787 | 27 associated lipids |
SCHEMBL105486
Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with SCHEMBL105486?
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
PubChem Associated disorders and diseases
What pathways are associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with SCHEMBL105486?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with SCHEMBL105486?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with SCHEMBL105486?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with SCHEMBL105486?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with SCHEMBL105486?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with SCHEMBL105486
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Gang C et al. | Puerarin Suppresses Angiotensin II-Induced Cardiac Hypertrophy by Inhibiting NADPH Oxidase Activation and Oxidative Stress-Triggered AP-1 Signaling Pathways. | 2015 | J Pharm Pharm Sci | pmid:26158288 |
| Yu D et al. | Puerarin attenuates glucocorticoid-induced apoptosis of hFOB1.19 cells through the JNK- and Akt-mediated mitochondrial apoptotic pathways. | 2015 | Int. J. Mol. Med. | pmid:26101183 |
| Cheng W et al. | Puerarin improves cardiac function through regulation of energy metabolism in Streptozotocin-Nicotinamide induced diabetic mice after myocardial infarction. | 2015 | Biochem. Biophys. Res. Commun. | pmid:26079885 |
| Wenjun H et al. | The Protective Effect of Puerarin on Myocardial Infarction Reperfusion Injury (MIRI): A Meta-Analysis of Randomized Studies in Rat Models. | 2015 | Med. Sci. Monit. | pmid:26067875 |
| Cui SQ et al. | Puerarin protects against damage to spatial learning and memory ability in mice with chronic alcohol poisoning. | 2015 | Braz. J. Med. Biol. Res. | pmid:25831201 |
| Zheng G et al. | Effects of puerarin on lipid accumulation and metabolism in high-fat diet-fed mice. | 2015 | PLoS ONE | pmid:25822741 |
| Guo XF et al. | Synergistic antitumor effect of puerarin combined with 5-fluorouracil on gastric carcinoma. | 2015 | Mol Med Rep | pmid:25434307 |
| Liu AC et al. | Pre-treatment with puerarin affects pharmacokinetics of warfarin, but not clopidogrel, in experimental rats. | 2015 | Chin J Nat Med | pmid:25908622 |
| Lv H et al. | Puerarin enhances proliferation and osteoblastic differentiation of human bone marrow stromal cells via a nitric oxide/cyclic guanosine monophosphate signaling pathway. | 2015 | Mol Med Rep | pmid:25892538 |
| Zou ZJ et al. | Intervention effects of puerarin on blood stasis in rats revealed by a (1)H NMR-based metabonomic approach. | 2015 | Phytomedicine | pmid:25837270 |
| Gray SL et al. | Impact of kudzu and puerarin on sperm function. | 2015 | Reprod. Toxicol. | pmid:25828059 |
| Han P et al. | Puerarin suppresses high glucose-induced MCP-1 expression via modulating histone methylation in cultured endothelial cells. | 2015 | Life Sci. | pmid:25817234 |
| Wang Z et al. | Protective effects of edaravone combined puerarin on inhalation lung injury induced by black gunpowder smog. | 2015 | Int. Immunopharmacol. | pmid:25754765 |
| Zhang Y et al. | The Puerarin improves renal function in STZ-induced diabetic rats by attenuating eNOS expression. | 2015 | Ren Fail | pmid:25707518 |
| Yang X et al. | Puerarin decreases bone loss and collagen destruction in rats with ligature-induced periodontitis. | 2015 | J. Periodont. Res. | pmid:25645818 |
| Qu J et al. | Puerarin alleviates noise-induced hearing loss via affecting PKCγ and GABAB receptor expression. | 2015 | J. Neurol. Sci. | pmid:25592416 |
| Guo HD et al. | Large scale purification of puerarin from Puerariae Lobatae Radix through resins adsorption and acid hydrolysis. | 2015 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:25553536 |
| Wang X et al. | De novo transcriptome sequencing in Pueraria lobata to identify putative genes involved in isoflavones biosynthesis. | 2015 | Plant Cell Rep. | pmid:25547742 |
| Wang J et al. | Puerarin attenuates airway inflammation by regulation of eotaxin-3. | 2015 | Immunol. Lett. | pmid:25530546 |
| Kang OH et al. | Puerarin ameliorates hepatic steatosis by activating the PPARα and AMPK signaling pathways in hepatocytes. | 2015 | Int. J. Mol. Med. | pmid:25605057 |