MeSH term | MeSH ID | Detail |
---|---|---|
Brain Infarction | D020520 | 17 associated lipids |
Stroke | D020521 | 32 associated lipids |
Chemical and Drug Induced Liver Injury | D056486 | 39 associated lipids |
Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Yue HW and Hu XQ | [Pharmacologic value of radix Puerariae and puerarine on cardiovascular system]. | 1996 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:9387770 |
Wu P et al. | [Study on effect of Puerarin on nitric oxide system in rats' tissue and its mechanism]. | 2001 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:12577337 |
Xie RQ et al. | [Myocardial protection and mechanism of Puerarin Injection on patients of coronary heart disease with ischemia/reperfusion]. | 2003 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:14714357 |
Hou HG et al. | [Puerarin in the treatment of poisoning of acute organophosphorous compound with toxic myocarditis]. | 2008 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:18928024 |
Li DZ et al. | [Protective effect of puerarin on endothelial dysfunction of heat shock protein 60 induced specific immunity in apolipoprotein E-null mice]. | 2006 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:17569333 |
Xiao LZ et al. | [Study on the effect and mechanism of puerarin on the size of infarction in patients with acute myocardial infarction]. | 2004 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:15495821 |
Xiao LZ et al. | [Comparative study on effects of puerarin and granulocyte colony-stimulating factor in treating acute myocardial infarction]. | 2005 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:15842138 |
Wu XP et al. | [Protective effects of puerarin against myocardial injury in patients with hypertension during perioperational period]. | 2006 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:16613276 |
Li DY et al. | [Clinical significance of matrix metalloproteinase-9 and tissue factors secreted by cultured monocyte-derived macrophage of patients with coronary heart disease in vitro and the intervenient effect of puerarin on them]. | 2007 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:17879530 |
Han JQ et al. | [Effects of puerarin on the neurocyte apoptosis and p-Akt (Ser473) expressions in rats with cerebral ischemia/reperfusion injury]. | 2012 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:23173255 |