| MeSH term | MeSH ID | Detail |
|---|---|---|
| Brain Infarction | D020520 | 17 associated lipids |
| Stroke | D020521 | 32 associated lipids |
| Chemical and Drug Induced Liver Injury | D056486 | 39 associated lipids |
SCHEMBL105486
Kakonein is a lipid of Polyketides (PK) class. Kakonein is associated with abnormalities such as Fatty Liver, Chronic liver disease, Morphologically altered structure, Hypertensive disease and Cardiovascular Diseases. The involved functions are known as protein expression, Extravasation, Liver damage, mRNA Expression and cell activation. Kakonein often locates in Body tissue, Hepatic, Microvilli, Cytoplasm and Membrane. The associated genes with Kakonein are TJP1 gene, CD14 gene, iberiotoxin, AT-Rich Interactive Domain-Containing Protein 1A and NKS1 gene. The related lipids are dehydrosoyasaponin I and Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of SCHEMBL105486, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with SCHEMBL105486?
SCHEMBL105486 is suspected in Chronic liver disease, Hypertensive disease, Cardiovascular Diseases, Myocardial Infarction, Cerebrovascular accident, Fatty Liver and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with SCHEMBL105486
PubChem Associated disorders and diseases
What pathways are associated with SCHEMBL105486
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with SCHEMBL105486?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with SCHEMBL105486?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with SCHEMBL105486?
Related references are published most in these journals:
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What genes are associated with SCHEMBL105486?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with SCHEMBL105486?
Knock-out
Knock-out are used in the study 'MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.' (Zhao J et al., 2011).
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NCBI Entrez Crosslinks
All references with SCHEMBL105486
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Yi T et al. | Enhancing both oral bioavailability and brain penetration of puerarin using borneol in combination with preparation technologies. | 2017 | Drug Deliv | pmid:28165806 |
| Kang H et al. | Puerarin inhibits M2 polarization and metastasis of tumor-associated macrophages from NSCLC xenograft model via inactivating MEK/ERK 1/2 pathway. | 2017 | Int. J. Oncol. | pmid:28101568 |
| Li X et al. | Puerarin protects against endothelial dysfunction and end-organ damage in Ang II-induced hypertension. | 2017 | Clin. Exp. Hypertens. | pmid:28060542 |
| Ge B et al. | Puerarin offsets the anticoagulation effect of warfarin in rats by inducing rCyps, upregulating vitamin K epoxide reductase and inhibiting thrombomodulin. | 2017 | Biopharm Drug Dispos | pmid:27925234 |
| Li L et al. | Puerarin suppression of Aβ-induced primary cortical neuron death is largely dependent on ERβ. | 2017 | Brain Res. | pmid:27923632 |
| Türer ÇC et al. | The Local Effect of Puerarin on Critical-Sized Calvarial Defects. | 2017 | J Craniofac Surg | pmid:27922959 |
| Wei S et al. | Effect of puerarin on transcriptome of astrocyte during oxygen-glucose deprivation/reoxygenation injury. | 2017 | Mol. Cell. Biochem. | pmid:27844252 |
| Cheng YF et al. | GPR30 Activation Contributes to the Puerarin-Mediated Neuroprotection in MPP-Induced SH-SY5Y Cell Death. | 2017 | J. Mol. Neurosci. | pmid:27796870 |
| Cong X et al. | Puerarin ameliorates heat stress-induced oxidative damage and apoptosis in bovine Sertoli cells by suppressing ROS production and upregulating Hsp72 expression. | 2017 | Theriogenology | pmid:27771118 |
| Liu Y et al. | Lyophilized Powder of Catalpol and Puerarin Protected Cerebral Vessels from Ischemia by Its Anti-apoptosis on Endothelial Cells. | 2017 | Int. J. Biol. Sci. | pmid:28367097 |
| Ma X et al. | Puerarin attenuates cisplatin-induced rat nephrotoxicity: The involvement of TLR4/NF-κB signaling pathway. | 2017 | PLoS ONE | pmid:28182789 |
| Zheng QH et al. | Efficacy and safety of puerarin injection in curing acute ischemic stroke: A meta-analysis of randomized controlled trials. | 2017 | Medicine (Baltimore) | pmid:28072733 |
| Jung HW et al. | The Root Extract of Pueraria lobata and Its Main Compound, Puerarin, Prevent Obesity by Increasing the Energy Metabolism in Skeletal Muscle. | 2017 | Nutrients | pmid:28054981 |
| Bacanlı M et al. | The antioxidant, cytotoxic, and antigenotoxic effects of galangin, puerarin, and ursolic acid in mammalian cells. | 2017 | Drug Chem Toxicol | pmid:27461151 |
| Wu L et al. | Protective Effects of Puerarin against Aβ 1-42-Induced Learning and Memory Impairments in Mice. | 2017 | Planta Med. | pmid:27420352 |
| KopeÄná-Zapletalová M et al. | Interaction of isoflavonoids with human liver microsomal cytochromes P450: inhibition of CYP enzyme activities. | 2017 | Xenobiotica | pmid:27312150 |
| Zhao J et al. | Plant Natural Product Puerarin Ameliorates Depressive Behaviors and Chronic Pain in Mice with Spared Nerve Injury (SNI). | 2017 | Mol. Neurobiol. | pmid:27013468 |
| Dong Z et al. | RGD modified and PEGylated lipid nanoparticles loaded with puerarin: Formulation, characterization and protective effects on acute myocardial ischemia model. | 2017 | Biomed. Pharmacother. | pmid:28236703 |
| Li W et al. | Puerarin attenuates the daunorubicin-induced apoptosis of H9c2 cells by activating the PI3K/Akt signaling pathway via the inhibition of Ca2+ influx. | 2017 | Int. J. Mol. Med. | pmid:29039532 |
| Wang L et al. | Puerarin Enhances Ca2+ Reuptake and Ca2+ Content of Sarcoplasmic Reticulum in Murine Embryonic Stem Cell-Derived Cardiomyocytes via Upregulation of SERCA2a. | 2017 | Cell. Physiol. Biochem. | pmid:29179218 |
| Wang J et al. | Novel cationic lipid nanoparticles as an ophthalmic delivery system for multicomponent drugs: development, characterization, in vitro permeation, in vivo pharmacokinetic, and molecular dynamics studies. | 2017 | Int J Nanomedicine | pmid:29158673 |
| Lin L et al. | The Effects and Possible Mechanisms of Puerarin to Treat Uterine Fibrosis Induced by Ischemia-Reperfusion Injury in Rats. | 2017 | Med. Sci. Monit. | pmid:28704345 |
| Kong H et al. | Pharmacokinetics and Tissue Distribution Kinetics of Puerarin in Rats Using Indirect Competitive ELISA. | 2017 | Molecules | pmid:28587251 |
| Liu X et al. | Puerarin suppresses LPS-induced breast cancer cell migration, invasion and adhesion by blockage NF-κB and Erk pathway. | 2017 | Biomed. Pharmacother. | pmid:28558356 |
| Tang H et al. | Puerarin attenuates myocardial hypoxia/reoxygenation injury by inhibiting autophagy via the Akt signaling pathway. | 2017 | Mol Med Rep | pmid:28393209 |
| Liu H et al. | Puerarin and zinc additively prevent mandibular bone loss through inhibiting osteoclastogenesis in ovariectomized rats. | 2017 | Histol. Histopathol. | pmid:27966208 |
| Shang Z et al. | Rapid profiling and identification of puerarin metabolites in rat urine and plasma after oral administration by UHPLC-LTQ-Orbitrap mass spectrometer. | 2017 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:29073480 |
| Deng HF et al. | Puerarin inhibits expression of tissue factor induced by oxidative low-density lipoprotein through activating the PI3K/Akt/eNOS pathway and inhibiting activation of ERK1/2 and NF-κB. | 2017 | Life Sci. | pmid:29037842 |
| Tan C et al. | Puerarin Improves Vascular Insulin Resistance and Cardiovascular Remodeling in Salt-Sensitive Hypertension. | 2017 | Am. J. Chin. Med. | pmid:28830209 |
| Zhang WG et al. | Puerarin Induces Hepatocellular Carcinoma Cell Apoptosis Modulated by MAPK Signaling Pathways in a Dose-dependent Manner. | 2017 | Anticancer Res. | pmid:28739736 |
| Wang K et al. | Puerarin inhibits amyloid β-induced NLRP3 inflammasome activation in retinal pigment epithelial cells via suppressing ROS-dependent oxidative and endoplasmic reticulum stresses. | 2017 | Exp. Cell Res. | pmid:28583762 |
| Cheng HH et al. | Effects of puerarin on intracellular Ca and cell viability of MDCK renal tubular cells. | 2017 | Environ. Toxicol. Pharmacol. | pmid:28384516 |
| Zhou X et al. | Puerarin attenuates renal fibrosis by reducing oxidative stress induced-epithelial cell apoptosis via MAPK signal pathways in vivo and in vitro. | 2017 | Ren Fail | pmid:28335679 |
| Wang X et al. | Molecular characterization of the C-glucosylation for puerarin biosynthesis in Pueraria lobata. | 2017 | Plant J. | pmid:28207970 |
| Hongyun H et al. | Puerarin provides a neuroprotection against transient cerebral ischemia by attenuating autophagy at the ischemic penumbra in neurons but not in astrocytes. | 2017 | Neurosci. Lett. | pmid:28192195 |
| Xue B et al. | Puerarin may protect against Schwann cell damage induced by glucose fluctuation. | 2017 | J Nat Med | pmid:28181078 |
| Gao Y et al. | An isoflavonoid-enriched extract from Pueraria lobata (kudzu) root protects human umbilical vein endothelial cells against oxidative stress induced apoptosis. | 2016 | J Ethnopharmacol | pmid:27717903 |
| Song XB et al. | Puerarin protects against cadmium-induced proximal tubular cell apoptosis by restoring mitochondrial function. | 2016 | Chem. Biol. Interact. | pmid:27717697 |
| Liu H et al. | Coadministration of puerarin (low dose) and zinc attenuates bone loss and suppresses bone marrow adiposity in ovariectomized rats. | 2016 | Life Sci. | pmid:27697446 |
| Wang C et al. | Protective effects of puerarin on acute lung and cerebrum injury induced by hypobaric hypoxia via the regulation of aquaporin (AQP) via NF-κB signaling pathway. | 2016 | Int. Immunopharmacol. | pmid:27643664 |
| Zhao L et al. | Protective Effects of Genistein and Puerarin against Chronic Alcohol-Induced Liver Injury in Mice via Antioxidant, Anti-inflammatory, and Anti-apoptotic Mechanisms. | 2016 | J. Agric. Food Chem. | pmid:27609057 |
| Xue Q et al. | Lyophilized Powder of Catalpol and Puerarin Protects Neurovascular Unit from Stroke. | 2016 | Int. J. Biol. Sci. | pmid:27019622 |
| Ma Y et al. | Puerarin Attenuates Anoxia/Reoxygenation Injury Through Enhancing Bcl-2 Associated Athanogene 3 Expression, a Modulator of Apoptosis and Autophagy. | 2016 | Med. Sci. Monit. | pmid:27011313 |
| Luo X et al. | Puerarin Exerts a Delayed Inhibitory Effect on the Proliferation of Cardiomyocytes Derived from Murine ES Cells via Slowing Progression through G2/M Phase. | 2016 | Cell. Physiol. Biochem. | pmid:27008508 |
| Jiang QD and Li XP | Effect of puerarin on the expression of NMU, NPY, and POMC genes in the hypothalamus. | 2016 | Genet. Mol. Res. | pmid:26985919 |
| Su HF et al. | Absorptive interactions of concurrent oral administration of (+)-catechin and puerarin in rats and the underlying mechanisms. | 2016 | Acta Pharmacol. Sin. | pmid:26972494 |
| Xu X et al. | Puerarin reduces apoptosis in rat hippocampal neurons culturea in high glucose medium by modulating the p38 mitogen activated protein kinase and c-Jun N-terminal kinase signaling pathways. | 2016 | J Tradit Chin Med | pmid:26946623 |
| Li W et al. | Puerarin Improves Diabetic Aorta Injury by Inhibiting NADPH Oxidase-Derived Oxidative Stress in STZ-Induced Diabetic Rats. | 2016 | J Diabetes Res | pmid:26881260 |
| Liu X et al. | Puerarin ameliorates cognitive deficits in streptozotocin-induced diabetic rats. | 2016 | Metab Brain Dis | pmid:26686502 |
| Liu CM et al. | Puerarin protects mouse liver against nickel-induced oxidative stress and inflammation associated with the TLR4/p38/CREB pathway. | 2016 | Chem. Biol. Interact. | pmid:26607348 |